Psychedelic Mushrooms for Depression

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Psilocybin exposes the foolishness of pretenses,

By opening the curtains of the mind, you meet deep truth and your inner self;

 allowing you to be okay with who you really are.

Once you have accepted both the good and bad sides of truth and survived,

You are free, you are truly alive.

urlThe skin is so thin, the current of blue streams that are your veins flow rapidly beneath it and are begging to burst free.

“Freedom will be yours soon, and you will flow wildly and freely, the way you are meant to be,” you say.

The knife is too dull though. Breaking out the hunting knives, you try knife after knife. Not a single one penetrates your skin. You give up, not on the act alone, but on the method. Your mission still remains. If you cannot slit, you will saw. It was ignorant of you to think this would be painless anyhow, foolish beyond belief. But you do not remember how to believe, you just pine to bleed. Taking one last look at your loyal dog, you start sawing. Take a second to take this in, just like the blade serrating your skin.

The above is actually an account of my own experience with depression, after two years of failed anti-depressants, various herbs and counselors. Up until the very night I was introduced to the healing benefits of psilocybin, I slept with a knife in the drawer next to me. I sat on the floor at three AM night after night in the dark, knife in my lap. I do not know how much longer I could have gone. Lyme disease had taken me to the edge, to the gap between the walking dead and the already dead. The valley of the shadow of death.

Psychedelic mushrooms saved my life, and I know I am not the only one. The next day, after experimenting with the mushrooms, I took the knife downstairs and never looked back. My depression is non-existent now, along with the countless anti-depressant pills that used to flood my night stand. I can truly stand here today, and say with every ounce of my being, that psilocybin saved my life. 

- – -

Alright, let’s get to the alarming facts right off the bat –although quite frankly, they are all pretty alarming. With more than 350 million people suffering from depression across the globe, it is a no brainer that antidepressants are the number one drug prescribed by doctors [1].

“The truth is that even experts aren’t really sure how antidepressants work. There’s just a whole lot we don’t know about how the brain functions. [5]”

Perhaps that last sentence should be, “There’s just a whole lot we don’t know about how the antidepressants we prescribe so freely function.” How does anyone develop a pill without knowing how it will work in the brain? Do they just take their best guess and throw chemicals together, hoping it works when they use humans as guinea pigs? Admitting you do not know everything is a highly respectable act, except when you still continue to alter the brains of human beings without knowing the consequences after doing so.

The answer to how psychedelic mushrooms containing Psilocybin function in the brain to treat depression is far more simple and clear cut. There is an actual answer, as opposed to a slew of “educated” guesses. In depressed individuals, there is over activity in the anterior cingulate cortex. Psilocybin possesses the power to switch off the over activity in this part of the brain. [7] Then, rather than increasing levels of serotonin in the brain, Psilocybin binds to serotonin receptors and mimics them, causing the brain to function as if it has more serotonin without actually altering the levels themselves. This last part is a crucial defining fact in deciding between the safety of antidepressants and psychedelic mushrooms in treating depression.

A serious and potentially fatal syndrome called ‘Serotonin Syndrome,’ which occurs when serotonin levels become too high, can occur from taking antidepressants. Many render this rare, but considering antidepressants increase the chemical serotonin in the brain, developing serotonin syndrome is a possibility to consider; as ‘rare’ is not a synonym for ‘nonexistent.’  Psychedelic mushrooms, on the other hand, do not put you at risk of developing serotonin syndrome because Psilocybin merely mimics serotonin receptors rather than actually increasing serotonin levels.

While psychedelic mushrooms take approximately three hours to work, most antidepressants take two to four weeks to start working, because increasing levels of neurotransmitters is a gradual process [6]. Something about the fact that chemicals are unnaturally building up in your brain is a cause for slight concern, much less the fact that doctors and chemists are unsure of how exactly these antidepressants work.  Messing with chemicals and neurotransmitters in the brain without having a firm grip of how you are doing so does not seem rational, logical, or humane. However, most of us are conditioned from birth to trust our doctors and pharmaceutical companies.

There are not any noted side effects of psychedelic mushrooms, other than the ones you experience while under the influence of them. The laundry list of potential side effects from taking antidepressants includes:

  • Immune system problems: SSRI antidepressants cause serotonin to remain in the nerve junctions longer, interfering with immune cell signaling and T cell growth.
  • Still births are twice as likely if the mother is on antidepressants
  • There is a 40% higher risk of birth defects, such as cleft palate, if the mother is on antidepressants while pregnant.
  • 45% higher risk of having a stroke, as antidepressants affect the blood clotting process
  • Heart disease
  • Sudden cardiac death: your risk of sudden death doubles while on antidepressants.
  • Chest pains
  • Rapid heart beats
  • Headaches and migraines
  • Stiff neck
  • Difficulty urinating
  • Excessive perspiration
  • Insomnia for some,  chronic fatigue for others
  • Loss of appetite
  • Agitation
  • Shaking
  • Vertigo
  • Dry mouth
  • Constipation
  • Diarrhea
  • Blurred vision
  • Erectile dysfunction
  • Inability to orgasm
  • Low sex drive
  • And let’s not forget, serotonin syndrome

Close to a million lives are lost yearly due to suicide from depression, which comes out to three thousand suicide deaths a day [2]. Unfortunately, that alarming fact alone cannot wake the medical world up to see what they are doing is incorrect, and not working. From the outside looking in, one must admit it appears as if they are selfishly denying people the right to proper, harmless treatments such as Psilocybin containing mushrooms. Why would anyone do such a thing? That is a question we must continually ask ourselves in this day and age, as sincere concern for the public appears to be obsolete in various situations.

Death rates from antidepressants range around forty-thousand annually. Suicidal thoughts and feelings, as well as violent behavior are ironically common side effects of antidepressants. Even more ironic, is the fact that your risk for suicide is twice as high when taking SSRI antidepressants. Death rates from antidepressants are also 32% higher in females [3].

No valid evidence exists to confirm any deaths from magic mushrooms; and deaths from acute poisoning from such mushrooms has not been recorded in medical literature. However, it is imperative to remember there are actually poisonous mushrooms that are entirely different from the typical Psilocybin psychedelic mushrooms referred to in this text. In fact, blindly ingesting the wrong mushroom can prove to be fatal.

All in all, from chemistry explained, to side effects to no side effects, to forty thousand deaths a year to zero deaths a year, it is clear that psychedelic mushrooms can be a more appropriate, safe approach for treating depression. One can only hope for a world where one day we can go to a psychedelic psychologist, take psychedelic mushrooms in a controlled setting, and come out three hours later relieved of depression. Can you imagine? No more monthly doctor fees. No more monthly prescription fees. No more taking a pill a day. No more withdrawals. No more side effects.



  1. Andrews, Paul (2012). Things Your Doctor Should Tell You About Antidepressants. April 15, 2013 from Mad in America: Science, Psychiatry, and Community.
  2. Marcus, Marina, Yasamy, Taghi, Van Ommeren, Mark, Chisholm, Dan, and Sheknar Savena WHO Department of Mental Health and Substance Abuse. Depression: A Global Concern. Paper published by the World Health Organization
  3. Mercola (2011). They Cause 40,000 Deaths a Year, But They’re Handed Out Like Candy. Retrieved April 15, 2013.
  4. Freeman, Shanna (2011-2013). How Magic Mushrooms work. Retrieved April 15, 2013.
  5. Retrieved April 15, 2013
  6. Retrieved April 15 2013
  7. Video: Psilocybin and the Psychedelic State –Dr.Robin Carhart Harris


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CE provides a space for free thinkers to explore and discuss new, alternative information and ideas. The goal? Question everything, think differently, spread love and live a joy filled life.

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  10. sirexcedrin

    I have worked for one of the major big pharma corps for 15 years and I can tell you without reservation that big pharma is not your friend. Here’s the dirty inside secret about the efficacy of SSRI drugs: magnesium supplementation and 8 weeks of daily exercise like just walking or biking will ALWAYS outperform our drugs in EVERY case. Chain that fact together with an observation that tragic Columbine events are ALWAYS found associated with one or more of our fabulous anti-depressant SSRI drugs and NOT EVER brought on by magic mushrooms or cannabis or other natural entheogen plants. I think this article was very responsible.

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  15. Jacinda

    I have thought about this more but I just don’t know WHERE to find these types of mushrooms at all. I don’t know who to trust with things like this. I live in SF Bay, CA area and so many people here can get a marijuana card easy apparently but I don’t know where to go to even do that! I grew up in TX but don’t really know people into these sorts of things here. Does anyone have any advice for me?

    • Agent Smith

      I have the same trust issue. My suggestion is to learn to grow your own for yourself – that’s what I’m setting up to do now.

      From what I’ve heard, it’s legal in New Mexico. You’ll need to look into that first and decide what to do.

      • Jacinda

        Hmm, thanks. I actually found out my roomie who was in the Peace Corps back in the 60′s that she has a friend that is an artist and still did them but doesn’t have a contact anymore. She said to look for the Psychedelic Society people in my area or for Mycologists in this area. So that’s my next route before I try to grown them probably but will totally keep this in mind!

    • RW

      You should obtain spores and bring them forth yourself. this is the only way to share synergy with this entheogen. Trust me.

  16. xandah

    Wow, James! Ignoring your first sentence, that’s awesome pre-shroom reading! Excellent lol.
    Thanks ya’ll. Gotta be light somewhere in this fucking tunnel!

  17. Randy

    Magic mushrooms on CNN – Long lasting postive effects ..

    Pam Sakuda speaks on Psilocybin ability to Ease Anxiety for Cancer Patients facing DEATH

    Terminal Ovarian Cancer – Psilocybin Therapy

    Mushrooms and Spirituality

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  19. James

    One does not need drugs. Learn to control your thoughts. Meditate. Cleanse your self of any negative thoughts and feelings. Have nothing but positive thoughts. Feel the love. Feel euphoric. All day, every fucking day lol. Trust me it works. Ditch anyone who brings you down. Socialise. Give. Forgive. Help strangers. Compliment. Do the right thing. Release good energy. Attract good energy. Exercise. Eat HEALTHY. Read. Develop good hobbies. Don’t waste time. Get the most out of every day. Find your purpose in life. Make great accomplishments. Push your boundaries. Make good connections. Have friends with benefits. Life will be ok.

    Get ya shit together. Stop being in denial. Take life by the balls. Live in the moment. Let go of the past and stop coming up with gay excuses for your failure. Use your head. Life is not rocket science.

    Everyone goes through depression at some stage in their life. The more you think about it the worse it gets. Stop thinking about it.

    Nigga in tha know. Peace

  20. pete

    Anybody had any experience taking shrooms while taking a low dose of an SSRI ? I heard that it will diminish the effects of the shrooms ? Been struggling with depression for about fifteen years been on and off meds with little success,

    • yes. the effects are diminished a bit, you must take more than the average dosage. lots of information about this on the internet.

  21. herbsandfungus

    growing your own is your best bet and websites like mycotpia and the shroomery will help you in that department

  22. Muzza

    Great article, lets hope we can get people to start questioning the bullshit they have been fed. A great place to start is here.

  23. WordOfWarning

    This is a very irresponsible article. Nowhere do you mention the possibility of a bad trip or paranoia. It is illadvised to take hallucinogens when you are already in a negative mental state. It is very easy for your thoughts to go down a bad road that leads to seemingly endless hours of the worst mental hell you have ever experienced.
    This is coming from someone who has had benefits on their depression from mushrooms but I’ve also seen the dark side and it is genuinely scary. Even mentally healthy people can succumb to bad trips. I would also argue that mushrooms and all hallucinogens can become psychologically addictive. They may have helped me overcome my depression at times but overuse and abuse also led to my first psychosis. It’s a very mixed bag people. Psychedelics aren’t for everyone.

    • jeanette

      I’m glad SOMEONE pointed that^out!!!! Seriously, I think to each his own but I wouldn’t go encouraging depressed individuals who have no experience with dugs, like the above single mother, to use shrooms on a regular basis! I have done my fair share of shrooms and other hallucinogens and they did not cure my depression. They were an escape from reality, and as mentioned above it is easy for your mind to go down dark roads! Conditions must be right- right people, environment, and that’s not something that you can guarantee on a daily basis…when you have kids, a job etc..

    • Phil

      I completely agree. Irresponsible indeed. Psilocybin is highly volatile and even as you claim “that even experts aren’t really sure how antidepressants work.” I would be so bold as to say that experts know a whole lot more about the workings of antidepressants than they do about the workings of hallucinogens. The author may have had a good experience from use, but she seems completely oblivious to the risks involved. Even claiming that there are none???

      I’m no expert but I have experienced psychosis for a period of time after use. Some people never come out of it.

      • crg7

        It’s generally the people that have the most issues in their life that have bad trips. With psilocybin things become clearer, your own faults and flaws become unsettlingly apparent and the real work comes after the enlightenment with taking measures to effect positive change in your life. Shroons just help show you the way. For some it is too overwhelming and subsequently the ‘bad trip’ ensues.
        Setting and dosage are critical to having any success via shroon usage. I’d say no more than one half a gram is plenty for one to test the waters without having to be concerned about having a psychotic break. Hands down exponentially less lethal and more effective than any Harmaceutical antidepressant drug out there. Now ‘that’ stuff will only compound your problems in the long term.

        • Mark

          Wow! I take 3.5 grams when I take mushrooms. I guess that might be overkill judging from your .5 gram recommendation. It has seriously helped me though. I take Effexor XR and am tapering off use now since my trip. It not only helped my depression but has also helped my patience level and overall sense of well being and it has been 6 weeks since taking them. I think this will end up being a 3 to 4 time a year dosing to aid my depression and off the meds. I look forward to no more prescription meds.

          • Josh

            Mark, how did your effexor tapering go? Are you completely off? Do you still use mushrooms once in a while? How is your depression? I’m in the same boat, using mushrooms and trying to get off Effexor which is proving to be a nearly impossible feat after being ‘addicted’ to it for 10+ years. Thanks!

  24. How to be a friend
    In this Heresy WebTV episode, I talk about HOW TO BE A FRIEND, and share a personal story that impacted my definition of friend. We all have difficult moments in our lives. There are some moments in which a loved one is going through one of those difficult times and sometimes we don’t really know what to do to help. I share 3 simple but profound actions that can provide incredible support in those times. This Heresy TV

  25. Dustin

    I know for a fact that mushroom also are useful for severe migrain sufferers..I saw a story about a man that was on the brink of suicide..he takes mushrooms once every 3 months..he says “it saved my life”. They obviously have madicinal value..

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