Creating change through transforming consciousness. Learn more about CE's Mission!

Next Story

  We're creating viewer supported news. Become a member!

A landmark study has revealed that an overactive gene may be rooted in the origins of neurological disease. 

advertisement - learn more

Schizophrenia, a devastating neurological disorder characterized by delusional thoughts and hallucinations, affects about 1% of the total population. The exact cause of schizophrenia has been mostly elusive until now, as scientists recently made headway in the disorder’s origins, the journal Nature reports.

Researchers discovered that overactive genes that regulate a process called synaptic pruning, in which the brain sheds weak or redundant connections between neurons as it matures, are likely involved in the onset of schizophrenia. People who carry genes that accelerate or intensify that pruning are at higher risk of developing schizophrenia than those who do not.

Scientists from Harvard Medical School, Boston Children’s Hospital, and the Broad Institute teamed up and began by focusing on a location on the human genome known as the MHC, which was most strongly associated with schizophrenia in previous genetic studies. This area of the human genome is commonly associated with the immune response, giving credence to a possible connection between autoimmune disease and neurological disorders like schizophrenia.

Using advanced statistical methods, the team found that the MHC locus contained four common variants of a gene called C4, and that those variants produced two kinds of proteins, C4-A and C4-B.

The team analyzed the genomes of more than 64,000 people and found that people with schizophrenia were more likely to have the overactive forms of C4-A than control subjects.

advertisement - learn more

The authors concluded that too much C4-A could mean too much pruning — which would explain not only the thinner prefrontal layers in schizophrenia, but also the reason that the disorder most often shows itself in people’s teenage years or early twenties.

While the news may be an exciting advancement, the discovery of a gene variant alone is not enough to claim a direct cause of schizophrenia, Nature reports. However, the discovery will offer young adolescents showing early symptoms of schizophrenia a better chance of slowing or stopping further progression.

We’re all very excited and proud of this work,” said the study’s lead researcher, Dr. Eric S. Lander. “But I’m not ready to call it a victory until we have something that can help patients.”

Get Your FREE In Depth Numerology Reading

Your life path number can tell you A LOT about you.

With the ancient science of Numerology you can find out accurate and revealing information just from your name and birth date.

Get your free numerology reading and learn more about how you can use numerology in your life to find out more about your path and journey. Get Your free reading.

Get Your FREE In Depth Numerology Reading

Free & customized Numerology reading from your name & birth date. Click here.


No more articles

CE3: The Shift

Discover why we are living in the most important time in human history in our latest documentary!

Check your email for the film link!