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These Popular Antibiotics Are Prescribed To Millions Every Year & They Have Detrimental Effects. Everyone Needs To Be Aware Of This

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It’s Worse Than You Know

In a May, 2014 letter to the U.S. Senate, Doctor Jay S. Cohen said of fluoroquinolones, “In my 40+ years in pharmacovigilance, FQs (fluoroquinolones) surpass Vioxx and Thalidomide in the degree of permanent harm done.”  Let that sink in for a bit.

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Fluoroquinolones – cipro/ciprofloxacin, levaquin/levofloxacin, avelox/moxifloxacin and floxin/ofloxacin – drugs that are seen as simple antibiotics (though they do severe cellular harm and are more appropriate for use as chemotherapy drugs), that are prescribed more than 20 million times per year in the U.S. alone – are doing more harm than Vioxx – a drug that led to more than 140,000 American heart attacks, and Thalidomide – a drug that has caused birth-defects and deaths of thousands of children world-wide.

Vioxx has been removed from the market, and the use of Thalidomide is severely restricted.  Fluoroquinolones, on the other hand, are prescribed with abandon, despite the fact that hundreds of studies have shown that they do severe cellular damage and thousands of patients have filed reports with the FDA noting that a variety of severe health problems have been experienced after taking a fluoroquinolone.

Transgenerational Side-Effects

I have argued that fluoroquinolones have transgenerational ill effects and that children are suffering because of the epigenetic effects of fluoroquinolones (HERE and HERE).  I have never hoped to be wrong about anything more than my assertions that fluoroquinolones are related to autism, but the possibility exists – because we really don’t know what the transgenerational effects of microbiome destruction and depletion of mitochondrial DNA are – and fluoroquinolones do, indeed, both obliterate the microbiome and deplete the only non-redundant form of DNA that we have – mitochondrial DNA.  (1)

Direct Damage Done by Fluoroquinolones

There are certainly plenty of direct victims of fluoroquinolones, even if indirect/transgenerational effects are not considered.  As Doctor Cohen noted, the degree of permanent harm done by them is horrifying.  Fluoroquinolones destroy musculoskeletal tissue (tendons, cartilage, bone, muscle, etc.) throughout the body (2), damage the nervous systems (central, peripheral and autonomic), and more.  Fluoroquinolone toxicity syndrome mimics autoimmune diseases (including rheumatoid arthritis, lupus, Sjögren’s syndrome, etc.), fibromyalgia, chronic fatigue syndrome / M.E., autonomic nervous system diseases (like POTS), leaky gut syndrome and even psychiatric disorders like bipolar disorder and severe depression.

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If someone with some resources would do a proper epidemiological study that takes the tolerance thresholds for fluoroquinolones (people typically don’t react to their first dose – they only react once their threshold for mitochondrial damage is crossed) and delayed reactions (the “vicious cycle” of mitochondrial damage and oxidative stress makes it so that damage is accelerated as time goes on – and thus delayed severe reactions are common) into account, perhaps the connection would be made between fluoroquinolones – drugs that not only deplete mitochondrial DNA but also destroy the microbiome and lead to adverse gene expression – and the chronic “mysterious” diseases that have been on the rise since the introduction of cipro on the market by Bayer in 1983. (Of course, fluoroquinolones are not the only cause of these diseases – fluoroquinolones are just one category of pharmaceuticals that damage mitochondria and lead to oxidative stress.  Other pharmaceuticals do the same.  But the harm done by fluoroquinolones specifically and pharmaceuticals generally, and the role that they play in these diseases, is horribly under-recognized.)

When the Cellular Damage Done is Realized

Once people realize that a pharmaceutical, a popular antibiotic no less, has done damage to their mitochondrial DNA, and has led to harm in them and their children, I hope that all of the top executives at Bayer (makers of cipro and avelox) and Johnson & Johnson (makers of levaquin) are put on trial.  Causing people to be chronically ill is bad enough – but people seem to let pharmaceutical companies off the hook when they do it.  Damaging our DNA – DNA that has been adapted and perfected over billions of years – is trial-worthy.

When the top Bayer and J&J executives and scientists are confronted about the damage that their drugs did, they will likely say that they didn’t know – they had no idea that their “antibiotics” (they’re chemo drugs) were so harmful.

This is what should be said to them in return –

“What did you think was going to happen? What did you think would happen in a person’s body when the DNA of the bacteria in their microbiome was unraveled? (3)  

What did you think would happen when their mitochondrial DNA was depleted?  Did it not occur to you that mitochondria are ancient bacterium and that when you interfere with the replication process for bacterial DNA, you do the same thing to mitochondrial DNA? (4)

What did you think would happen when your drugs depleted magnesium and iron from a patient’s cells? (5 6) 

What did you think would happen when you killed all of the good bacteria in a patient’s gut?  What did you think would happen when your drugs triggered a massive amount of oxidative stress to be inflicted in your patient’s body? (7 8 9)

What did you think would happen when you depleted all of their antioxidants? (10)

 What did you think would happen when your drugs caused chromosomal aberrations in immune system cells? (11)

What did you think would happen when you gave chemo drugs to your patients who have a simple infection, not cancer? (12)

Did you think that it wouldn’t damage them?  Or did you know that fluoroquinolones would do severe cellular damage, but you just didn’t care?  Did you mistake a tolerance threshold for mitochondrial damage (13) for safety?  Or did you know that these were the perfect drugs – chemo drugs disguised as antibiotics that induce chronic, multi-symptom illness – and that with these drugs you could make customers for life?”

Willful Ignorance

At best, the top executives and scientists at Bayer and Johnson & Johnson didn’t think.  They didn’t consider the fact that fluoroquinolones are topoisomerase inhibitors – and that they work by dismantling and adducting to DNA – as opposed to disrupting cell walls like innocuous antibiotics such as penicillin or cephalosporins.  If one is to give them far more credit than they deserve, maybe there is the possibility that they didn’t make the connections.  Maybe they didn’t notice that many of the chronic diseases of modernity that fluoroquinolone toxicity mimics – fibromyalgia, chronic fatigue syndrome, rheumatoid arthritis, multiple sclerosis, irritable bowel syndrome, etc. – have gone up along with the use of fluoroquinolones (and other mitochondria damaging drugs).  Maybe they let denial of mitochondrial damage, delayed reactions and tolerance thresholds protect their precious egos and shareholders.  But neither denial nor willful ignorance are legitimate excuses.  They never have been, and they never will be.  The top executives and scientists at Bayer and J&J, along with those at the FDA, should have known how dangerous and damaging fluoroquinolones are.

The Connections

The connection is not difficult to make.  Pharmaceuticals damage mitochondria (they’re vulnerable little organelles that also happen to be quite important).  Damaged mitochondria produce reactive oxygen species (ROS) which is also known as oxidative stress.  ROS / oxidative stress is associated with (by “associated with” I mean causes, but shhhh, you can’t say that while being scientific) every single chronic disease there is – including, but not limited to; Alzheimer’s (14) , Parkinson’s (15), chronic fatigue syndrome / M.E. (16), fibromyalgia (17), Gulf War Syndrome (18), autism (19), many psychiatric diseases (20), etc.  Of course, the details of how pharmaceuticals damage mitochondria and how oxidative stress leads to those diseases is incredibly complicated, but the top scientists and executives at Bayer and J&J, and the “regulators” at the FDA, should be smart enough to read the source documents listed below and to know that the drugs that they produce/approve are dangerous.

After all, it was stated in 1992 that:

“the interaction (of fluoroquinolones) with DNA is still of great concern because of the possible long-term genotoxicity of quinolone compounds, which are increasingly adopted as first-choice antibiotics for the treatment of many infections, and because it addresses the real mechanism of action of this class of molecules.” (5)

Paying attention to how pharmaceuticals interact with DNA is probably a good idea.

Many pharmaceuticals damage mitochondria.  Not all of them interrupt the production of enzymes that are vital for the replication and transcription of DNA though.  Fluoroquiolones do.  They also form poisonous metabolites (thanks carboxylic acid molecule!) (21) and leach all of the magnesium (22) and iron out of cells.  It’s not exactly fun to go through.  Fluoroquinolones are damaging people – on a cellular level – severely – and because of delayed reactions, tolerance thresholds and ignorance of everyone in the medical system, victims have no idea what hit them.

People are Sick – Pharma Companies Should be Held Responsible for Their Role

People are sick. They are chronically ill and are suffering.  Neither doctors nor anyone in the pharmaceutical industry have any idea how to put them back together again.  Doctors have no idea how to help those suffering from Fluoroquinolone Toxicity Syndrome or any other chronic “mysterious” disease. They don’t even know how to administer the correct tests to give them an accurate diagnosis.  So they blame the patients – for their diet or lifestyle or pain. But the patients are not to blame.  The drugs are to blame.

The people who make, sell, and fail to regulate these drugs are to blame.  They should be held accountable.

A Brilliant TED Talk About Willful Blindness –

 

Numbered sources:

  1. Molecular Pharmacology, “Delayed Cytotocicity and Cleavage of Mitochondrial DNA in Ciprofloxacin Treated Mammalian Cells
  2. Physical Medicine and Rehabilitation (PM & R) “Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population
  3. Mechanisms in Medicine, video, “Fluoroquinolones: Mechanisms of Action and Resistance
  4. PNAS, “Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase
  5. PNAS, Biochemistry, “Quinolone Binding to DNA Mediated by Magnesium Ions
  6. Turkish Journal of Hemotology, “Ciprofloxacin: A Novel Therapeutic Agent for Iron Overload?
  7. Science Translational Medicine, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
  8. Journal of Young Pharmacists, “Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients
  9. Chemistry and Biology, “Trovofloxacin, a Fluoroquinolone Antibiotic with Hepototoxic Potential, Causes Mitochondrial Peroxinitrate Stress in a Mouse Model of Underlying Mitochondrial Dysfunction
  10. Molecular Neurobiology, “The Glutathione System: A New Drug Target in Neuroimmune Disorders.”
  11. Nepal Medical College Journal, “Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
  12. Current Medicinal Chemistry, “Recent Advances in the Discovery and Development of Quinolones and Analogs as Antitumor Agents
  13. Molecular Interventions, “Mechanisms of Pathogenesis in Drug Hepatoxicity Putting the Stress on Mitochondria
  14. Free Radical Biology and Medicine, “Oxidative Stress Hypothesis in Alzheimer’s Disease
  15. Neuroscience Bulletin, “Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes
  16. International Journal of Clinical and Experimental Medicine, “Chronic fatigue syndrome and mitochondrial dysfunction
  17. Muscle & Nerve, “Mitochondrial myopathy mimicking fibromyalgia syndrome.”
  18. Nature Preceedings, “Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder
  19. Frontiers in Physiology, “Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
  20. Oxidative Medicine and Cellular Longevity, “Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
  21. Expert opinion on Drug Metabolism & Toxicology, “Metabolic activation of carboxylic acids.”
  22. Antimicrobial Agents and Chemotherapy, “Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.”

More Information:  Information about Fluoroquinolones and Fluoroquinolone Toxicity Syndrome can be found on the author’s web sites, www.floxiehope.com and www.fqwallofpain.com.

Free Franco DeNicola Screening: The Shift In Consciousness

We interviewed Franco DeNicola about what is happening with the shift in consciousness. It turned out to be one of the deepest and most important information we pulled out within an interview.

We explored why things are moving a little more slowly with the shift at times, what is stopping certain solutions from coming forward and the important role we all play.

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Boy or Girl – Baby Gender Selection Issues

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Some parents have the possibility to opt for gender selection; however, being able to decide whether to have a baby boy or girl is a controversial issue.

Many couples expecting a baby do not think it’s a big issue whether they have a boy or a girl; however there are several medical, social, and personal reasons that could influence parents to recur to some form of gender selection.

Like many other controversial practices, the legality of gender selection, also known as sex selection, varies from country to country.

The Legality of Baby Gender Selection

The United States has perhaps some of the most relaxed laws regarding baby gender selection in the world. Most European countries and Australia, on the other hand, have bans on sex selection and only allow it for medical reasons. For example, if a parent is a carrier of a mutation or gene with more chances of manifesting itself in a certain gender, baby gender selection is valid. However, if parents simply wish to balance the ratio of boys and girls in their family, they are not allowed to recur to sex selection.

This has generated a form of medical tourism in which couples from countries where gender selection is illegal, like the UK, travel to the US in order to be able to choose whether to have a baby boy or girl.

On the other hand, sex selection is illegal in the two most populated countries on Earth, China and India. In these countries, baby gender selection has been performed clandestinely for many years and for reasons other than family balancing or avoiding genetic diseases. In these societies, having a baby boy is preferred mainly for cultural and economic reasons. Parents believe that boys have better chances of earning income and eventually support them when they reach an old age.

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Methods of Baby Gender Selection

There are two major types of gender selection methods: the first one is called sperm sorting, and involves separating X-chromosome sperm from Y-chromosome sperm by flow cytometry, a purification technique in which chromosomes are suspended in a stream of sperm and identified by an electronic detector before being separated. Intra-uterine insemination or in-vitro fertilization can then be performed with the enriched sperm. The success rates for this method vary from 80% to 93%.

The other method, called pre-implantation genetic diagnosis, consists in generating several embryos through in-vitro fertilization, which are then genetically tested to determine a baby’s gender. The chosen embryos can then be implanted. This method has a success rate of almost 100%; however, it can be quite expensive, costing up to $15,000.

Issues Regarding Baby Gender Selection

While there are few objections against baby gender selection when it is performed for medical reasons, it has become a highly controversial issue when it is used for balancing the number of boys or girls in families. Some people raise the obvious ethical question of whether people who opt for gender selection are “playing God” by manipulating whether to have a baby boy or girl. Others believe that new parents will raise a baby more appropriately if he or she belongs to their preferred gender.

Gender Imbalance Caused by Baby Gender Selection

Gender selection has caused demographic concern in China and India since it has contributed to generate a gender imbalance in the populations of those countries. In some regions of China, for example, the sex ratio for newborns is 118:100, boys to girls. This phenomenon has in turn been associated with social problems such as an increase in violence and prostitution.

It seems like a logical solution for governments around the globe to legalize baby gender selection but to analyze the personal reasons why each couple intends to select a baby boy or girl. Gender selection for medical reasons should even be encouraged, since it could prevent serious genetic diseases such as cystic fibrosis, Huntington’s disease, and Haemophilia A. Balancing the gender ratio of a family should be accepted if by doing this, a healthy family environment is created. On the other hand, China and India have shown that baby gender selection as a result of a bias towards a particular gender can not only create a gender imbalance in the population, but contribute to social problems as well.

Free Franco DeNicola Screening: The Shift In Consciousness

We interviewed Franco DeNicola about what is happening with the shift in consciousness. It turned out to be one of the deepest and most important information we pulled out within an interview.

We explored why things are moving a little more slowly with the shift at times, what is stopping certain solutions from coming forward and the important role we all play.

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Organic Certification: What the USDA Organic Label Means

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In Brief

  • The Facts:

    Organic and natural labels mean different things, and various types of labels tells you what percentage of ingredients are actually organic. We'll explore what to look for.

  • Reflect On:

    Do you sometimes buy products thinking they are organic or fully natural based on their wording? Have you later found out that those products aren't natural or organic at all? Read labels more closely at grocery stores to be aware.

Don’t get conned by fraudulent claims of “natural” or “organic.” Learn what to look for, and why it’s important, to ensure you’re getting the quality you are paying for.

The industrial age of the 20th century brought about changing agricultural practices that have generated increasing alarm about the effects of these practices on the environment and health. The use of chemical fertilizers and pesticides, antibiotics, hormones, irradiated and genetically altered food and fiber products has created a groundswell of rightful concern. It has led to the growing demand for non-toxic, organic products that many are willing to pay a higher price for to ensure the healthful purity of food and clothing provided for their families.

With such profit opportunities, it’s little wonder that the lucrative organic product market has suffered abuse with so-called “organic” labels being fraudulently placed on products that have not earned the right. As a result of pressure from farming and consumer groups, legislation for the standardization of organic certification was introduced in the 1980s. It has been updated to include more vigorous enforcement and control methods since, with the current standards established in 2002 by the USDA.

The Standards of USDA Organic Certification

Specific standards must be met in order to legally claim a product as USDA certified organic. Organic producers must utilize methods that conserve water, maximize soil health, and reduce air pollution. The specific standards to earn USDA organic certification include:

Free of synthetic chemicals such as insecticides, herbicides, fertilizers, hormones, antibiotics, and additives

Free from irradiation and genetically modified organisms

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Agricultural products grown on land that has been free of prohibited substances for a period of three years

Animals used for meat, eggs, milk or other animal products must be exclusively fed foods that are organically grown, may not be given antibiotics or hormones, and must have access to outdoors.

Clean and sanitized harvesting and processing equipment throughout the process from harvest to finished, packaged product

Detailed chain-of-handling records from the field through final sales

Physical separation of certified organic products from non-organic products throughout the process of production

Regular on-site inspections from USDA-approved inspectors to ensure compliance

Understanding the Certified Organic Label

Once the rigorous process of certification has been completed, organic producers may place the USDA certified organic seal on their products. Currently, there are four levels of certified organic products, with a specific definition of the percentage of organic ingredients the final products contains. They are as follows:

• 100% organic: all production methods and ingredients are USDA certified organic.

• Organic: at least 95% of the production methods and ingredients are USDA certified organic with remaining ingredients included on the National List of allowed ingredients.

• Made With Organic Ingredients: at least 70% of the ingredients are USDA certified organic with remaining ingredients included on the National List of allowed ingredients.

• No organic wording or seal: less than 70% of the ingredients are USDA certified organic and no claims may be made on the front or back of the product.

Manufacturers or producers who knowingly label a product “organic” when it does not meet the USDA standards are subject to fines up to $11,000 per violation.

Why Organic Certification is Important

When you see the official USDA organic certification seal on food, clothing, and bedding products, you can be assured that these products have met the meticulous standards required and are free of chemicals, toxins, antibiotics, and hormones. When you see the USDA certified organic label, you will understand the value of the higher priced organic products as compared to non-organically produced products.

With the current stringent organic certification requirements enforced by regular inspections from USDA accredited agents, the USDA certified organic label has great meaning and importance to the consumer. Look for the label to know that you are getting the quality you are paying for.

Free Franco DeNicola Screening: The Shift In Consciousness

We interviewed Franco DeNicola about what is happening with the shift in consciousness. It turned out to be one of the deepest and most important information we pulled out within an interview.

We explored why things are moving a little more slowly with the shift at times, what is stopping certain solutions from coming forward and the important role we all play.

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WHO Finds Global Lack Of Inactivity Rising Especially In Wealthier Countries — What You Can Do

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In Brief

  • The Facts:

    Inactivity is on the rise and it's the cause of a wide range of health concerns. Our population is only becoming more inactive, not less, and it's time to change that.

  • Reflect On:

    There are many factors of our modern world that make us less active. Our jobs, driving rather than walking/biking, too much screen time. What can you do differently to bring more activity into your life? What story stops you from starting?

The World Health Organization (WHO) estimates that more than a quarter of the entire population on this planet are not getting enough physical exercise, this number has barely improved since 2001. There are many factors that contribute to this, but just how much damage are we doing by failing to be active?

The lack of physical exercise raises the risk of many health problems, such as heart disease, type-2 diabetes and various types of cancers.

Interestingly, according to their study published in The Lancet Global Health, higher income countries, such as the UK, were among the least active population. Women were also found to be more sedentary throughout the world, excluding two regions in Asia.

The study looked at self-reported data on activity levels from 358 population based surveys covering 168 countries and included 1.9 million people.

The populations of higher income countries, which include the UK and USA showed an increase in the proportion of inactive people and had actually risen from 32% in 2001 to 37% in 2016, in the lower income countries it remained at 16%.

Those who were classified as inactive did less than 150 minutes of moderate exercise and around 75 minutes of intense activity per week.

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It was found that women were less active than men overall, except for in South and Central Asia, the Middle East, North Africa and higher-income Western countries. The authors believe that this was caused by a few different factors including extra childcare duties and cultural perspectives that may have made it more difficult for them to exercise.

Why More Inactivity In Wealthier Countries?

According to the researchers, in the wealthier countries, many of the jobs have transitioned to more office or desk jobs, meaning a more sedentary type of lifestyle. On top of that much of the population of these countries drive automobiles or take public transit to and from work which in many cases accounts for a lot of their time.

In the lower income countries, many of the jobs require the people to be more active, are physically demanding and people often have to walk to and from their jobs.

The WHO has had a goal to reduce the global levels of inactivity by 10% by 2025, the authors of the study feel that at the rate we are currently going, this target will be missed.

Lead author of the study, Dr. Regina Guthold said, “Unlike other major global health risks, levels of insufficient physical activity are not falling worldwide, on average, and over a quarter of all adults are not reaching the recommended levels of physical activity for good health.”

Regions with increasing levels of insufficient physical activity are a major concern for public health and the prevention and control of non-communicable diseases.”

Co-author, Dr. Fiona Bull added, “Addressing these inequalities in physical activity levels between men and women will be critical to achieving global activity targets and will require interventions to promote and improve women’s access to opportunities that are safe, affordable and culturally acceptable.”

According to the WHO,

Exercise guidelines for 19- to 64-year-olds

How much?

  • at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous aerobic activity every week
  • strength exercises on two or more days a week that work all the major muscles
  • break up long periods of sitting with light activity

What is moderate aerobic activity?

  • Walking fast, water aerobics, riding a bike on level ground or with a few hills, doubles tennis, pushing a lawn mower, hiking, skateboarding, rollerblading, volleyball, basketball

What counts as vigorous activity?

  • Jogging or running, swimming fast, riding a bike fast or on hills, singles tennis, football, rugby, skipping rope, hockey, aerobics, gymnastics, martial arts

What activities strengthen muscles?

  • lifting weights, working with resistance bands, doing exercises that use your own body weight, such as push-ups and sit-ups, heavy gardening, such as digging and shovelling, yoga

What activities are both aerobic and muscle-strengthening?

  • circuit training, aerobics, running, football, rugby, netball, hockey

Final Thoughts

I was surprised to see that the WHO didn’t touch on inactivity due to too much screen time — watching television, Netflix, Facebook scrolling, messaging, texting, browsing etc. Certainly, the increase in screen time plays a roll with the amount of inactivity, especially in the higher income countries. If you are someone who spends too much time staring at a screen, then it is important to consider the above information. Can you limit your screen time and replace it with something active? Or would you consider jumping rope, or rebounding while watching the television? Our health is our greatest wealth and having awareness about an issue is the first way to create change and take responsibility for our lives.

Could you walk or bike to work instead of drive? What about trying a new sport? Could you commit to adding a few hours each week of physical activity? These small decisions could have a profound impact on your health, longevity and overall well-being.

Much Love

Free Franco DeNicola Screening: The Shift In Consciousness

We interviewed Franco DeNicola about what is happening with the shift in consciousness. It turned out to be one of the deepest and most important information we pulled out within an interview.

We explored why things are moving a little more slowly with the shift at times, what is stopping certain solutions from coming forward and the important role we all play.

Watch the interview here.
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