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How To Sleep Your Way To Better Health

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We spend all our lives worrying about what is going on while we are awake, yet most people do not realize the importance of what happens when we are not. Sleep is the time when our body repairs from the mental and physical stress of the day. Hormones are secreted, lipids are formed, and proteins are synthesized during the bedtime hours, yet an estimated 60 million Americans suffer from sleep disorders or sleep deprivation. For millions of years, humans went to sleep at sundown and woke at sunrise. There was no switch to turn on artificial lights. All animals need to sleep, and we would be wise to follow in the footsteps of our ancestors.

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A 2013 study reported that there are over 2,000 genes that work differently whether we are awake or asleep.[1] Areas of DNA code for muscle repair and memory are active at night while other segments of DNA, such as adrenal hormones, are at work in the daytime. Our body functions in a totally different manner during sleep and awake time. Cells divide, tissues repair, and growth hormones are released during sleep. Sadly, the average time most Americans go to sleep is near midnight.

According to recent studies, a good night’s sleep improves learning. Whether it’s a new language, how to play the guitar, or how to perfect your golf swing, sleep helps enhance your learning and problem-solving skills. Sleep also helps you pay attention, make decisions, and be creative. Get adequate sleep to become a better spouse, parent, grandparent, child, boss, or employee.

 Poor Sleep is a Nightmare For Your Heart

An interesting study looked at sleep and cardiovascular events such as heart attack and stroke. During 10-15 years of follow-up, short sleepers (less than 6 hours) had a 23% higher risk of coronary artery disease compared to normal sleepers (more than 7 hours), even after adjustment for all other possible factors. Short sleepers with poor sleep quality had a 79% higher risk of heart disease when compared to normal sleepers with good sleep quality. On a side note, sleeping longer than 9 hours provided no benefit.[2] Data from 1964 found those people who slept 7-8 hours had the lowest chance of dying over a 3-year follow-up.

Scientists have known for years that heart attacks are more frequent in the morning hours. The blaring alarm clock and stress of the day ahead tip some people over the edge into an unstable heart situation. But this next problem is very easy to change. The practice known as Daylight Savings Time is totally useless in this modern age and interferes with our circadian rhythm. It is not normal to change our sleep cycle by following this antiquated practice. A 2013 study identified men are at a 70% increased risk of having a heart attack on the day after the time change and 20% more likely in the first week. This is extraordinary. Considering the fact that recent presidents Bush, Clinton, Bush, LBJ, and Eisenhower all had cardiovascular disease, maybe the current president should look into abandoning Daylight Savings Time? It may just save his life.[3]

 Get Your Blood Pressure Under Control

Add hypertension to the list of bad outcomes from a lack of sleep. Yes, not getting your Zs can lead to high blood pressure. Practicing for years as a typical cardiologist, I was frustrated by seeing patients on five anti-hypertensive drugs, yet their blood pressure was not controlled. Not once did it ever cross my mind that poor sleep could be a factor. I certainly never counseled a patient regarding the need for sleep. I was only getting 5-6 hours per night and envied other doctors who could get away with less. Now I pity those doctors leading the sleep-deprived lifestyle. Anyway, back to hypertension.

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A study in 2006 demonstrated that poor sleep doubles the risk of hypertension. This study even corrected for other factors such as the fact that poor sleepers may be more stressed, or are likely to be smokers. A similar article from 2013 found middle-age nurses had a higher risk of hypertension when they had poor sleep patterns.[4] In early 2014, a story about how poor sleep increases the risk of stroke in women made front-page news. In fact, for young women, the risk of a stroke was 8x higher in those admitting to five hours of sleep or less. The study found 10% of women age 65 and older had a stroke within four years if they had poor sleep. Another study found women who frequently feel drowsy during the daytime are at 58 percent higher risk for heart disease compared to those who rarely or never experience this symptom.[5]

Poor sleep is also associated with elevated markers of inflammation, such as CRP, TNF-alpha, fibrinogen, and interleukins. As we discussed, inflammation is caused by all the unhealthy things in our lives, from nutrition and chemicals to poor sleep. The more inflammation, the higher the risk of heart disease.[6] This is major news, and is a call to action for women to get more sleep.

 Sleep Your Way to Weight Loss

 Struggling to lose a few pounds? Poor sleep could be your problem. Recent studies suggest an association between sleep duration and weight gain. Sleeping less than five hours, or more than nine hours per night, appears to increase the likelihood of weight gain. In one study, recurrent sleep deprivation in men increased their preferences for high-calorie foods and their overall calorie intake. In another study, women who slept less than six hours a night were more likely to gain 11 pounds (5 kg) compared with women who slept seven hours a night. One explanation may be sleep duration affects the hormones regulating hunger—ghrelin and leptin—and stimulates the appetite. Another contributing factor may be lack of sleep leads to fatigue and results in less physical activity. Obviously, the longer you are awake, the more time there is to eat.[7]

Poor Sleep Is Also Associated With:

  1. Memory loss and Alzheimer’s.8
  2. Decreased immune system function.9
  3. Anxiety and irritability.
  4. Dying younger. One study found that women with short sleep duration and poor sleep quality had over 3x the risk of dying as those who slept over 7 hours.10

The cause(s) of sleep problems needs to be addressed. They might be physical, mental, or both. Even counting grass-fed sheep is not going to work if you are in a bad relationship or having issues at work. Foods not on the Paleo plan negatively affect sleep quality. It doesn’t matter what time you drank your coffee; the caffeine effect can last over 24 hours. If you wake up in the middle of the night, it may be because your blood sugar is dropping and your body is craving more food – usually junk food.

 Action Plan: Twenty Ways To A Better Night Sleep

Go to sleep just after sundown and wake at sunrise. Edison invented electricity 125 years ago. Our bodies will never adapt to it.

  1. Get the electronics out of your bedroom. Cell phones, cordless phones, Wi-Fi, and computers produce electromagnetic fields. Pay attention to electronics on the other side of the headboard wall. Remove smart meters.
  2. Do not watch TV in bed at night. Read a book or magazine.
  3. Find your cave. Turn off all lights and invest in good window coverings.
  4. Keep it cool. Most people find it difficult to sleep at either temperature extreme.
  5. Go Paleo and lose weight. Obese people are more prone to sleep apnea, a condition associated with cardiovascular and mental problems.
  6. Get rid of the alarm clock. If you need to wake early, go to bed early.
  7. Get an organic mattress. A synthetic foam mattress is loaded with off-gassing petrochemicals, flame-retardants, and other POPs (persistent organic pollutants). These conventional mattresses harbor dust mites, a source of allergies and inflammation.
  8. Use a natural laundry detergent and give up the fabric softener and dryer sheets. Your body wants to breathe air, not chemicals. The nasal, sinus, and airway congestion caused by allergies of these items can inhibit your sleep. Instead buy Seventh Generation, Dr. Bronner’s Sal Suds, or other ecofriendly brands.
  9. Do not take pharmaceutical sleep aids. Studies show an increased risk of heart attacks, aortic dissection, and cancer.11
  10. Shower at night. This helps to relax your body and your mind. Showering or bathing also washes the chemicals you accumulated all day off the skin.
  11. Avoid caffeine. Caffeine can last in your system for up to 48 hours.
  12. Avoid sugar. This is a major stimulant, so get rid of the ice cream before bed.
  13. Breathing techniques. Check out the free app from Saagara. My patients love it.
  14. Many studies confirm exercise improves sleep. Just don’t do it too close to bedtime.12 Practice yoga and Pilates. The benefits of yoga just keep piling up, including better sleep.13
  15. Get the stress out. There is nothing you can do about life’s problems while in bed. You cannot cope with stress if you are sleep deprived.
  16. Get sunshine. This helps to set your internal sleep clock.
  17. Just say no to alcohol. It is a major inhibitor of quality sleep. Passing out drunk does not count.
  18. Sleep alone. If your partner snores or tosses and turns all night, something has to give, likely your health.
  19. Take natural supplements.

Natural Sleep Supplements:

  1. Magnesium

 Several studies show magnesium can improve sleep quality and reduce nocturnal awakenings. Along with contributing to a good night’s sleep, this nutrient helps to maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong.

  1. Melatonin

A hormone that regulates the normal sleep/wake cycle, melatonin is useful as an occasional sleep aid, and is especially effective against jet lag. According to research, the body naturally produces melatonin after the sun goes down, letting us know it’s time to fall asleep. Supplemental melatonin assists with this process. Cherries also appear to boost melatonin. Take 60-90 minutes before sleep.

  1. L-theanine

An amino-acid derivative found in green tea, theanine is known to trigger release in the brain of GABA, a calming neurotransmitter, which promotes relaxation and reduces anxiety. Unfortunately, the body has difficulty absorbing GABA, which is the reason experts recommend theanine. This is easily absorbed and boosts levels of GABA. Avoid green tea after 3 pm.

  1. Valerian

Many experts recommended this herb to reduce the amount of time it takes to nod off. According to the NIH, valerian has sedative properties, and it may increase the amount of GABA.

  1. 5-HTP

A compound derived from the amino acid L-tryptophan, 5-HTP acts as a precursor to serotonin, which is a neurotransmitter essential for a good night’s sleep. A small 2009 study of eighteen people found those who took a product containing 5-HTP needed less time to fall asleep, slept longer, and reported improved sleep quality.

  1. Lavender

Aromatherapy with a couple sprays of lavender oil has many proponents. Several patients of mine are fans of this herb.

  1. Chamomile Tea

Most people find any herbal tea to be soothing at bedtime, but chamomile is known to work very well.

  1. Lemon Balm

In one study of people with minor sleep problems, 81% of those who took an herbal combination of valerian and lemon balm reported sleeping much better than those who took a placebo.

  1. Phenibut (β-Phenyl-γ-aminobutyric acid)

Phenibut is similar to GABA, but easily crosses the blood-brain barrier, allowing for better efficacy. This is a prescription drug in Russia. Phenibut should be used under the guidance of a physician, as it can be addictive.

  1. B vitamins

B12 as methylcobalamin and folate (B9) as methylfolate are critical for neurotransmitter formation (and many other functions). The vast majority of vitamins contain the cheap forms of B12 as cyanocobalamin and folate as folic acid. These synthetic variants do not work well in our bodies, given 50% of the population contain a genetic defect in methylation. Make sure you know your methylation genetics. Check with your natural doctor for dosing on B vitamins.

Your best bet is to speak with a natural doctor and see what supplements are right for you. If you are reading this article in the middle of the night, turn off your device and go to sleep.

YOU CAN LEARN MORE ABOUT THE AUTHOR, Dr. Jack Wolfson Here.

Sources:

 [1] BMC Genomics. 2013 May 30;14:362.

2 SLEEP 2011;34(11):1487-1492.

3 Am J Cardiol. 2013 Mar 1;111(5):631-5.

4Am J Hypertens. 2013 Jul;26(7):903-11. Hypertension. 2006 May;47(5):833-9.

5 Yigiang Zhan. Sleep Medicine Volume 15, Issue 7, Pages 833–839, July 2014

6 Physiol Behav. 2010 Dec 2;101(5):693-8

7 Journal of Sleep Research. 2011;20:298.

8 Neurobiology of Aging, 2014.

9 World J Gastroenterol. 2013 Dec 28;19(48):9231-9.

10 PLoS One. 2014 Apr 3;9(4):e91965.

11 China Medical University in Taiwan.

12 J Adolesc Health. 2012 Dec;51(6):615-22.

13 J Clin Oncol. 2013 Sep 10;31(26):3233-41; J Bodyw Mov Ther. 2013 Jan;17(1):5-10.

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Alternative News

Consider This Before Indulging In Legal Cannabis In Canada

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In Brief

  • The Facts:

    Cannabis is now legal in Canada for recreational and medicinal use.

  • Reflect On:

    Will the legalization of cannabis change our relationship and habits with cannabis? Should it?

For some Canadians, October 17th is a day they have been anticipating for a long time. For others, it may pass by without much notice. Yet, one thing is for sure. Eventually, virtually all Canadians will be impacted in one way or another by Canada’s decision to legalize cannabis. Parents. Children. Regular Users. Non-users. Teenagers. The Elderly. Those of all ages suffering from illnesses of all kinds.

And not only will this impact the everyday lives of people in Canada, most Canadian institutions will be going through a learning curve and devoting attention to this new phenomenon. The government. Law Enforcement Agencies. Growers and farms. Wholesalers and retailers. Advertisers and marketers. Who in Canada will be able to say they have not been touched by this one way or another, once the intoxicating and healing powers of cannabis become more accessible even than alcohol?

What Will Change

Some changes will happen immediately, some changes will evolve over time. Some people argue that Canada is not yet ready for all the implications of legalizing cannabis at this point, but the prevailing attitude is that things will sort themselves out in an orderly fashion over the next 1-3 years.

Law enforcement: The change in the criminal code means that limited possession of cannabis is no longer a crime, though people who are currently in jail for possession of cannabis are not being automatically let out of jail. Much of law enforcement rhetoric focuses on preventing youth from indulging in cannabis, in a fashion similar to the restrictions on alcohol. More likely, the majority of funds and manpower will be diverted to combating black market enterprises, given that the government now stands to gain $675 million per year in tax revenues from the sale of legal cannabis. Regulations for impaired driving as a result of cannabis consumption look to evolve over time as technologies for measuring impairment like alcohol ‘breathalizers’ improve.

Home Growing: Individuals will be permitted to grow up to four plants for their own use. While the sale of edibles (baked goods, drinks, etc) will not be allowed initially, individuals can make edibles at home for their own use.

Marketing and Retail: The way in which legal cannabis is promoted and sold to the public will likely go through a push-pull transition between advertising regulations and the way wholesalers and retailers will try to get around those regulations to sell their products. The same can probably be said for the business chain as a whole from growth to consumption.

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Usage in General: Usage in Canada is bound to increase, simply due to an increase in the availability for those who have not actively sought it out in the past, and the removal of the stigma of its illegality, as well as the social acceptance of the consumption of cannabis which is bound to grow over the next couple of years.

What Will Not Change

There are two things that will not change when cannabis is made legal in Canada on October 17th: cannabis and you.

Cannabis itself is not suddenly safer or better for you than it was before just because it has become legalized. The same decisions you were making on whether or not to indulge in the past still pretty much apply, so ubiquitous was its use despite being illegal. Will regulation make the quality of cannabis you receive better? Not necessarily. It may become more consistent, if less potent, if the quality controls in place are reliable. But remember, black market dealers and sellers had an intrinsic investment in the quality of their product if they were to hope to have regular customers.

By ‘you,’ I am referring to your deepest, truest sense of self, the person you are and who you want to be in the highest vision of yourself. This does not change with any change of regulation in the outer world, and certainly you have to be wary if this change of regulation arbitrarily changes the choices you make and impacts your habits, goals, and dreams.

What To Watch Out For

You may be one who will be inclined to be more open to the personal recreational use of cannabis once it becomes legal. With this comes the possibility of gradually developing a dependence, facilitated by a greater legal and social acceptability. It is important to take notice if recreational use begins to devolve into a catch-all means of escaping from the stress and discomfort of real-life problems, in ways that you get out of the habit of confronting problems and discomfort at their source.

The same can be said about the use of cannabis for medicinal purposes. No doubt, cannabis and CBD oil will be marketed as the healthy sedative for physical ailments and will also be touted as a curative agent for certain types of diseases. While this may be true in some particular cases, you have to be cautious about the claims made by sellers and marketers of the product, whose job is to sell rather than research and diagnose exactly what conditions will benefit from cannabis treatment, and even more particularly what strains of cannabis will work for given conditions.

There is a body of research about the curative effects of cannabis made from an Eastern holistic perspective, which treats each individual case not based on outward symptoms, as Western medicine does, but in terms the particular physiological, emotional and spiritual conditions an individual is in which seen to be at the root of the individual’s ailment. Hence, being wary of marketing practices does not mean avoid cannabis or CBD oil as medicinal treatment for a particular condition, but try to do so in consultation with an unbiased and trusted practitioner/researcher whose motives are healing your particular condition rather than making profits selling cannabis.

The Takeaway

The consumption of cannabis has the potential to be both consciousness-expanding and consciousness-numbing. It does have healing properties but you really have to do your due diligence and use it in a very disciplined way in order to truly gain healing benefits from it rather than getting into the habit of simply escaping from pains and difficulties that are part of a normal life. It is an exciting time for Canadians in that we are now more free to choose something that never should have been illegal to begin with. Let’s make sure this newfound freedom serves us in the best ways as individuals and as a community.

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In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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Awareness

Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

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References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

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Brain Imaging Shows Autistic Brains Contain HIGH Amounts of Aluminum

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In Brief

  • The Facts:

    A study published early in 2018 identified very high amounts of aluminum lodged in the brains of multiple people with autism.

  • Reflect On:

    We know little about where the heavy metals used as adjuvants in vaccines end up in the body. We now know that injected aluminum doesn't exit the body like aluminum intake from other sources. When injected, it ends up in the brain.

A study published earlier in 2018 should have made headlines everywhere, as it discovered historically high amounts of aluminum in autistic brains. The study was conducted by some of the worlds leading scientists in the field.

Five people were used in the study, four males and one female, all between the ages of 14-50. Each of their brains contained unsafe and high amounts of aluminum compared to patients with other diseases where high brain aluminum content is common, like Alzheimer’s disease, for example.

Of course, this caused people to downplay the study, citing a low sample group, but that’s not entirely a valid argument given the reason why this study was conducted. As cited in the study above, recent studies on animals, published within the past few years, have supported a strong connection between aluminum, and aluminum adjuvants used in human vaccinations, and Autism Spectrum Disorder (ASD.)

Studies have also shown that injected aluminum does not exit the body, and can be detected inside the brain even a year after injection. That being said, when we take aluminum in from sources such as food, the body does a great job of getting it out, but there is a threshold. It’s important to acknowledge that the aluminum found in the brain, could be due to the presence of aluminum adjuvants in vaccines. This latest study also identified the location of aluminum in these tissues, and where they end up. This particular study was done on humans, which builds upon, and still supports, the findings of the animal studies.

This is also important because the majority of studies that previously examined human exposure to aluminum have only used hair, blood and urine samples. The study also makes a clear statement regarding vaccines, stating that “Paediatric vaccines that include an aluminum adjuvant are an indirect measure of infant exposure to aluminum and their burgeoning use has been directly correlated with increasing prevalence of ASD.”

 Aluminum, in this case, was found in all four lobes of the brain.

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The aluminum content of brain tissues from donors with a diagnosis of ASD was extremely high (Table 1). While there was significant inter-tissue, inter-lobe and inter-subject variability the mean aluminium content for each lobe across all 5 individuals was towards the higher end of all previous (historical) measurements of brain aluminium content, including iatrogenic disorders such as dialysisencephalopathy[13][15][16][17][18][19]. All 4 male donors had significantly higher concentrations of brain aluminum than the single female donor. We recorded some of the highest values for brain aluminum content ever measured in healthy or diseased tissues in these male ASD donors

We Know, And Have Known, Aluminum Is Not Safe, Yet We Ignore It

When we talk about the ‘safe’ amount of aluminum here, there is no such thing. Aluminum is extremely toxic to any biological process, it’s not meant for us which is why it stayed deep within the Earth until we took it out. It has no place within us, and that’s simply due to the fact that it causes nothing but havoc. This makes it odd that we would put them in vaccinations despite the fact that for 100 years there has been no appropriate safety testing.

Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans.

The quote above comes from a study published in 2011, it’s 2018 now and we’ve come along way in our understanding. We are starting to see even more research confirming the statement above.

Almost every study you read regarding previous studies on aluminum adjuvants within vaccines emphasized how the nature of its bioaccumulation is unknown, and a serious matter. We now know that it goes throughout the body, into distant organs eventually ends up in the brain.

Another fairly recent study from 2015 points out:

Evidence that aluminum-coated particles phagocytozed in the injected muscle and its draining lymph notes can disseminate within phagocytes throughout the body and slowly accumulate in the brain further suggests that alum safety should be evaluated in the long term.(source)

The pictures below come from the recent 2018 study and show ‘bright spots’ that indicate heavy metals in the brain.

 

The more recent study discussed in this article is adding to that evidence. Below you can watch one of the most recent interviews with Dr. Eric Exly, one of the world’s foremost leading authors on the subject, and one of the authors of this most recent study. He is a Biologist (University of Stirling) with a Ph.D. in the ecotoxicology of aluminum. You can read more about his background here.

Take Away

People need to understand that despite media bullying, it’s ok to question vaccine safety, and there is plenty of reason to. There are many concerns, and heavy metals are one of them. In fact, the persistence and abundant presence of heavy metals in our environment, foods and medications is a concern, one that has been the clear cause for a variety of health ailments, yet it’s one that’s hardly addressed by the medical industry.

You can detox from this with items such as Spirulina, and waters that contain a high Silica content. There are studies that show various methods of detoxing can be used to get this lodged aluminum, or some of it, out of your body, organs and brain. This is where educating yourself regarding the medicinal value of food and nutrition is a key Perhaps this can be a motivation to better your diet, especially if you have, are someone, or know someone with an ASD diagnosis.

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