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French Breast Implant Founder Used Industrial Silicone & Fuel Solvents In PIP Implants Is Appealing His Sentence

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The toxic chemicals in the fraudulent shells and fillers of PIP breast Implants seep out into surrounding body tissue, migrate into body organs, can cross the placenta and can be found in breast milk.

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These toxic chemicals make women very sick and many report debilitating symptoms directly linked to silicone toxicity.  Jan Spivey and Marie Robinson Co – Founders of PIP Action Campaign

Established in 1991, French company Poly Implant Prothese (known as PIP) was found guilty of fraud in 2013, along with its founder, Jean- Claude Mas, who was sentenced to four years in jail.

To the thousands of women who were mislead into thinking these implants were produced in a ‘safe’ manner, and have since suffered immeasurably, both physically and emotionally, this four year sentence seemed like an incredible insult. When Jean-Claude was found guilty for fraud he was fined a mere 75,000 euros, and has since spent approximately 18 months in jail.

At one point in time, PIP was the third largest breast implant manufacturer in the world, producing up to 100,000 implants each year.

Not willing to spend four years in prison, Jean-Claude has asked for an appeal, and his case began last week in France, sparking outrage in the victims who are terrified they may now never see him face his crimes.

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This is Jean-Claude Mas, the founder of PIP, being charged with fraud. He was sentenced to 4 years and is now asking for an appeal.

What Was Found In PIP Implants? 

When the truth was revealed about what was in these faulty breast implants, women were horrified. Instead of using medical grade silicone, PIP elected instead to use the much cheaper industrial silicone. This type of silicone is untested and not licensed for use in the human body.

Not coincidentally, PIP implants had a 500% higher risk of leaking and or rupturing than other models on the market.

Other chemicals found in PIP implants included: Toluene * Acetone Xylene Cyclohexane Ethylbenzene *D6 * Chloroform * Dichloromethane * Ethanol * Ethyl Acetate * D4* D5*  Platinum * Caesium* Methanol * Isopropanol * 1-Butanol * Butyl * Benzophenone * di-2-ethylexyl phthalate. (source)

TÜV Rheinland, the German notified body, was responsible for ensuring that PIP implants complied with the regulations, issuing a CE certificate which tells buyers and surgeons that the implants are safe. PIP implants were then sent out into the market, where they were used in approximately 500,000 women in many countries worldwide.

Upon further investigation into the ingredients of PIP implants, it was discovered that the manufacturer had also added Baysilone (a fuel additive), as well as Silopren and Rhodorsil – both of which are used as electrical cable coatings.

PIP also made male chest, buttock, and testicle implants with their industrial silicone.

It’s important to note that these chemicals have never been tested for their effects on humans. (source).

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“It’s not a debate about cosmetic surgery …
It’s a serious health problem
Women affected by PIP implants want justice.
In silence we must live with our pain…
The anguish of the scandal
Robbed of rights, uncertainty
Fear, helplessness and loneliness.
Humiliated for defending our dignity
Here is the reality no-ones sees
that others caused.”

Pip Action Campaign

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Toulene – just one of the many concerning chemicals added to PIP implants.

Jean-Claude On What He Did

Statements by Jean-Claude Mas, Founder of PIP

Throughout the entire duration of the 2013 investigations, Jean-Claude Mas kept a provocative and scornful stance that particularly shocked the different protagonists of the case.

  • He confessed in particular during his hearing at the police that he had given the order to “hide the truth in 1993” from the German certification body TÜV.
  • He then detailed all fraud without the slightest embarrassment, and without showing any remorse, saying “I knew this gel was not approved, but I did this knowingly because the PIP gel had better value for money.”
  • Subsequently, and despite the exponential number of complainants and severity of the effects highlighted by physicians, Jean-Claude Mas continued to declare that his gel “did not pose a risk to human health.”
  • Speaking about the complainants, Jean-Claude Mas declared that, “These people are frail or are doing it for the money. I lived well at the time.” That is to say, he lived with a fixed salary of 30,000 euros a month.
  • Right from the start of the trial he explained that he did not “make anyone take any risks” and that “the PIP gel was not approved but was approvable,” adding that “toxicity wise, it’s the same” (as authorized Nusil gel). (source)

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There is 100% evidence that all cohesive silicone gel Implants, including the “new and improved” implants, “gel bleed” inside the body while still intact, exposing the body to platinum as well as 40+ toxic ingredients and heavy metals. (source) (source)

Victims Terrified This Man Will Not Pay For His Crimes

When three of the UK’s largest cosmetic surgery providers of PIP implants refused to help women, some turned to the NHS (National Health Service) instead and were able to have their PIP implants removed. But some women are still waiting and have received no help or compensation. Many are still incredibly ill and in desperate need of medical intervention.

As you can see below from these truly grotesque photos, PIP implants were often removed looking just like this. For this particular victim, both sides had severely ruptured, so the silicone had to be scraped out of her breast cavity. This woman will now also have silicone in her body that cannot ever be fully removed, since it travels throughout the body.  The red bits are scar tissue which also had to be removed. .

It is estimated that over 40,000 women in the UK received these PIP implants. You can read here how PIP implants have affected other women worldwide.

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PIP Implants – both severely ruptured. You can see videos here of surgeons at Aurora Clinics in the UK removing PIP implants. Warning, you need a pretty strong stomach to watch.

Breast Implant Manufacturers: Should Any Be Trusted?

Over the years we have heard from countless women who are saline and silicone breast implant patients and who have suffered from complications, involving both short- and long-term health conditions believed to be related to their implants. Implants rupture and leak. Implants sometimes migrate. Implants often harden and cause capsular contracture.
Nearly all will need to be replaced at some point.

Reported conditions involve local infectionsnecrosishematomaconnective tissue disorders and immune disorders like fibromyalgiarheumatoid arthritischronic fatigue syndromemultiple sclerosislupusSjogren’s syndrome and others. National Cancer Institute studies indicate that women who have breast implants are at increased risk of brain cancerlung canceremphysemapneumonia and suicide.

Although research paid for by implant companies disagrees, those findings need to be evaluated by independent researchers. And now we learn that a rare type of immune system cancer, anaplastic large-cell lymphoma (ALCL), is found growing near the capsule of scar tissue around the breast implant. The risk of developing ALCL for women with implants was significantly higher than that found in women without breast implants.

From Terry O’Neill, President, National Organization for Women (NOW) Foundation – Presented to the U.S. Food and Drug Administration, General and Plastic Surgery Devices Panel Review of Post-Approval Studies for Silicone Gel-Filled Breast Implants on August 30, 2011 (source)

The breast augmentation industry is worth billions. With an estimated 5-10 million women worldwide undergoing this procedure each year, it’s obvious that this industry is worth a lot of money. It is equally clear that it is not in the best interests of many of these companies for women to know how many risks and complications are involved.

By the late 90’s, approximately 400,000 USA women had filed and won a massive lawsuit with Dow Corning, who also made dangerous implants which ruptured at an alarming rate, with silicone leaking into women’s bodies, causing an untold amount of damage to their health. Some women have since died after having these implants put in.

Women Take Note: Silicone Is Found in ALL Implants On The Market Today

While much of the public may think that Dow’s case is old news and that the newer implants aren’t as dangerous, many women today who have these so-called ‘newer and safer’ implants are telling a much different story, reporting ruptures and ill health.

Women are often misguided into thinking that saline implants ‘only contain saline.’ This is false. The outer shell on all implants is made with silicone and a mix of other chemicals and heavy metals.

It’s vital to know that silicone, once it has leaked from the implants, cannot be removed from the body.

The distributor Sientra (who until recently handled the market for the ‘Silimed‘ implants, had this brand removed from the market because of “contamination fears,” where manufacturing particles such as cotton and silica were found in the implants) was also previously quite open about their findings and wrote in their own data sheet that their breast implants can cause adverse effects and complications such as:

  • Reoperation (additional surgeries)
  • Implant removal with or without replacement
  • Implant rupture
  • Capsular contracture
  • Wrinkling
  • Asymmetry
  • Implant displacement
  • Implant palpability/visibility
  • Scarring
  • Ptosis
  • Pain
  • Infection (including Toxic Shock Syndrome)
  • Hematoma
  • Seroma
  • Breast feeding difficulties
  • Calcium deposits
  • Extrusion
  • Necrosis
  • Delayed wound healing
  • Breast tissue atrophy/chest wall deformity
  • Lymphadenopathy
  • Connective tissue disease (CTD)
  • CTD signs and symptoms
  • Neurological disease
  • Neurological signs and symptoms
  • Cancer
  • Lymphoma
  • Suicide
  • Changes in nipple and breast sensation
  • Potential effects on offspring. (source FDA’s website)

Read The Manufacturer’s Data Sheets

Often women do not receive true informed consent before signing up to have breast implants. I know I didn’t. At the time, back in 2007, I did not even think to question if implants could be dangerous.

In my case, my own vanity overrode my sensibility.

These warnings are quite clearly listed in many brands, however. Mentor’s data sheets, for example, are well known for their “newer, safer cohesive gel implants” that many women tout as safe.

Mentor warns about many of the possible risks and complications. If all women read this in detail before they decided yes to this operation, would they end up going ahead with the procedure?  I think many would not.

While I think it’s important that Mentor makes these risks clear, it is likely that if something were to go wrong you would then be unable to sue because you had been warned ahead of time.

Again, I urge you to be very sure you know what you could be in for before saying yes.

Safety Studies Not All Completed

Other studies that were meant to be completed to prove the safety of ‘newer and improved implants’ were not at all carried out adequately. According to the article “FDA Questions Studies Of Implant Safety,” Mentor, who make the Memory Gel implants, had lost a whopping 79% of the women involved in the study. Allergan, who make Natrelle implants, also lost 40% of their women only two years after the study began.

  • Both of these companies now have their implants used in countless breast augmentations worldwide.
  • We only have to look at the case of PIP to see that manufacturers can get away with using toxic and dangerous ingredients, at least for a while. Jean-Claude had his toxic implants on the market for approximately ten years before they were recalled.
  • If you are to ask for full ingredient listings of a certain brand, the companies do not respond to emails (give it a try yourself and see!) and they certainly do not list these important details on their websites.
  • I’ve managed to find only a short list from the FDA of what is in the shells or inside of both saline and silicone implants.

Detected Heavy Metals in Implant Shell and/or Gel:

  • Barium
  • Bromine
  • Cesium
  • Chromium
  • Germanium
  • Nickel
  • Platinum
  • Tin
  • Zirconium
  • Aluminum (source)

A Warning To Women

If you are going to have something put into your body, you need to know, and have the right to know, exactly what the device is made of.

The appeal case of Jean-Claude and other members of PIP continues and I hope to update you in the near future.

I am personally praying for justice for the women affected by these toxic implants.

Until then, please think very carefully about what you may already have in your body (even if they are not PIP implants), and if you are considering having breast implants, please do a lot more research before you make this life-changing decision that could possibly detrimentally affect your health and well-being.


Forty-seven thousand women in the UK are thought to have been exposed to non-compliant PIP implants. The PIP health fraud has affected more than 500,000 women worldwide.

In addition to suffering a shocking array of symptoms, women have genuine concerns for their children exposed during pregnancy or while breast feeding. Women have rights as patients and consumers and as victims of crime.

Many women have sustained terrible injuries, many have been traumatised, virtually all express anxiety at facing an uncertain future.

Yet they have been denied their rights to a duty of care, denied access to healthcare and treatment, their consumer rights have been undermined and their right to justice obstructed by regulatory failings and powerful industry lobbies operating in the European Union and beyond.

PIP is not just about a devious, delusional manufacturer, but a corrupted regulatory system for medical devices which is failing all women.

Jan Spivey Co-Founder of PIP Action Campaign and Survivor Of PIP 

Further research 

RADIO INTERVIEW WITH JAN SPIVEY, JESS LEWIS AND TRACEY AHMET

If you are alarmed by this issue, please sign this petition here:

Breast Implants – The Ticking Time Bomb

pipactioncampaign.org

Breast Implant Awareness

Dr Susan Kolbs Newsletter

Facebook Groups

facebook.com/groups/PIPAction

facebook.com/groups/TITS Committee The Implant Truth Survivors 

facebook.com/groups/breastimplantsthetickingtimebomb

Report Your PIP Implants

Experienced an adverse event you associate with your PIP?

facebook.com/events/658956837514741

United Kingdom gov.uk/report-problem-medicine-medical-device

USA fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm

Australia tga.gov.au/reporting-medical-device-problems

France Report PIP implant issues here

Thank you to Sophia Lamere for assisting with the French translation.

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In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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Long-Term Consequences of Mumps Vaccination: Many Unanswered Questions

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This is Part II of a two-part series on mumps. Part I discussed how mumps vaccination and the flawed mumps component of Merck’s MMR vaccine are fostering dangerous mumps outbreaks in adolescents and young adults.

It has been about five decades since the U.S. Food and Drug Administration (FDA) approved Merck’s first mumps vaccine. The company began launching combination MMR (measles, mumps and rubella) vaccines in the 1970s. Coincidentally—or not—an infertility crisis has been brewing over roughly the same time period, with dramatic declines in sperm counts and record-lowfertility levels. However, few investigators seem interested in assessing whether mumps outbreaks in highly vaccinated populations of teens and young adults could be having long-termeffects on fertility or other health indicators.

As described in Part I, childhood MMR vaccination has been an unmitigated disaster where mumps is concerned, deferring mumps infection to older ages and leaving adolescents and young adults vulnerable to serious reproductive complications. Public health reports show that the vast majority of mumps cases and outbreaks occur in youth who have been fully vaccinatedwith the prescribed two-dose MMR series, supporting a hypothesis of “waning immunity after the second dose.” FDA and Centers for Disease Control and Prevention (CDC) officials even admitthat mumps outbreaks in the post-vaccination era “typically involve young adults,” and that vaccination is failing to protect those who are college-age and above.

Myopically, many vaccine experts have called for a third MMR dose—or even “booster dosing throughout adulthood”—even though the FDA’s and CDC’s own research shows that MMR boosters in college-age youth barely last one year. As alleged in whistleblower lawsuits wending their way through the courts over the past eight years, Merck presented the FDA with a “falsely inflated efficacy rate” for the MMR’s mumps component, using animal antibodies and other fraudulent tactics to fool FDA—and the public—into believing that the vaccine was effective.

When infection arises after puberty, however, mumps is no laughing matter, presenting an increased risk of complications such as hearing loss, encephalitis and inflammation of the reproductive organs.

Mumps after puberty is no laughing matter

Around the time that the first mumps vaccine came on the market, the 1967 children’s classic The Great Brain humorously depicted mumps infection in childhood as a mere nuisance. The book’s young protagonist goes out of his way to intentionally infect himself with mumps so that he can beat his two brothers to the recovery finish line—and he experiences no adverse consequences other than his siblings’ annoyance.

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When infection arises after puberty, however, mumps is no laughing matter, presenting an increased risk of complications such as hearing loss, encephalitis and inflammation of the reproductive organs. About one in three postpubertal men with mumps develops orchitis(inflammation of the testes), which can damage sperm, affect testosterone production and contribute to subfertility and infertility. During a mumps outbreak in England in the mid-2000s, mumps orchitis accounted for 42% of all hospitalized mumps cases; the researchers attributed this outcome—which was the most common reason for hospitalization—to “the high attack rates in adolescents and young adults” that occurred “despite high coverage with two-dose MMR.” An analysis of a 2006 mumps outbreak in the U.S. reported that male patients were over three times more likely than female patients to experience complications, “due primarily to orchitis.”

An estimated 5% to 10% of postpubertal women will develop oophoritis (swelling of the ovaries) following mumps infection. Oophoritis is associated with premature menopause and infertility, but mumps-related oophoritis has garnered little notice.

Mumps infections are often asymptomatic or produce nonspecific symptoms such as fever, while cases of orchitis may present with no other mumps symptoms. Nonetheless, public health officials advise clinicians that orchitis is an instant cue to test for mumps virus, and testing often reveals elevated mumps antibodies. In a case report of MMR failure, British clinicians isolated a novel genetic strain of mumps virus from the patient’s semen two weeks after the onset of orchitis and found mumps RNA in the semen 40 days later; they also noted “the appearance of anti-sperm antibodies,” with “potential long-term adverse effects on the patient’s fertility.”

In 2017, researchers who reviewed 185 studies conducted in Western nations found that sperm counts had plummeted by 50% to 60% between 1973 and 2011—an average decrease of 1.4% annually. Commenting on this work, one analyst estimated that 20% to 30% of young men in Europe and North America have sperm concentrations associated with a reduced ability to father a child. Given estimates that as much as 40% of reproductive problems have to do with the male partner, there is agreement on the importance of “finding and eliminating [the] hidden culprits in the environment” that most researchers believe are to blame.

An estimated 5% to 10% of postpubertal women will develop oophoritis (swelling of the ovaries) following mumps infection. Oophoritis is associated with premature menopause and infertility, but mumps-related oophoritis has garnered little notice.

MMR’s and MMRV’s potential to impair fertility never studied

Merck has not evaluated either of its two MMR vaccines—the MMR-II and the MMR-plus-varicella (MMRV) vaccine—for their potential to impair fertility. Whether such testing would unearth direct effects on fertility (as appears to be possible with HPV vaccination in women) is thus unknown. However, mumps vaccination undeniably increases reproductive-age individuals’ risk of mumps infection and, in the process, increases the risk of fertility-altering complications. These facts alone should be attracting far more attention.

Unfortunately, because clinicians already tend to underdiagnose mumps infection and underestimate mumps complications, it is likely that they are failing to recognize possible vaccine-induced reproductive health consequences of mumps infection in their adolescent and young adult patients. In one university outbreak, “most physicians…did not suspect mumps,” and even when they became aware of the outbreak, “diagnosing mumps was not always straightforward.” Moreover, although differentiating between vaccine strains of mumps virus and wild types could provide valuable information, few clinicians have the capacity or inclination to perform testing of this type. A Japanese study of cerebrospinal fluid and saliva from patients with mumps complications found vaccine strain in nearly all of the samples and noted the information’s importance in helping determine whether the complications were vaccine-related.

Those who have sought to understand mumps vaccines’ poor performance point to a mixture of explanatory factors. These include waning immunity, the high population density and close quarters encountered in settings such as college campuses, incomplete vaccine-induced immunity to wild virus as well as viral evolution such that “the vaccine triggers a less potent reaction against today’s mumps viruses than those of 50 years ago.” However, some also quietly admit that individuals with “mild vaccine-modified disease” could be perpetuating the chain of transmission. This latter point ought to be raising questions about the logic and wisdom of administering further rounds of MMR boosters during outbreaks while ignoring the problems created by the doses already given.

… some individuals respond poorly to mumps vaccination and vaccine-induced antibody levels correlate poorly with protection from mumps infection, irrespective of the number of additional doses of mumps-containing vaccine they receive.

Most scientists appear to be either resigned to ongoing mumps outbreaks in vaccinated populations or actually accept periodic outbreaks as the cost of doing business. Publications by FDA and CDC researchers reveal these agencies’ awareness that some individuals respond poorly to mumps vaccination and that vaccine-induced antibody levels correlate poorly with protection from mumps infection, “irrespective of the number of additional doses of mumps-containing vaccine they receive.” Considering the effects on fertility, the generally abysmal track record of mumps vaccination and Merck’s fraudulent claims about efficacy, it is hard to fathom medical and public health experts’ complacency about current mumps vaccines and vaccine policies.


Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

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Legal Challenge Against Forced Vaccination Filed in New York City

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On April 15, 2019, a legal challenge was filed in the New York State Trial Court by Robert Krakow, Robert F. Kennedy, Jr. and Patricia Finn against the New York City Department of Health and Human Hygiene for their forced Measles-Mumps-Rubella vaccination. The legal team asked for a temporary restraining order against the mandate that the Judge will likely review and provide an ex parte decision. Children’s Health Defense is supporting these efforts.

Last week, Children’s Health Defense reported that the NYC Commissioner of Health declared a public health emergency, ordering all people who live, work or reside in four Brooklyn zip codes to be vaccinated with the Measles-Mumps-Rubella vaccine. Non-compliance with the order is a misdemeanor subject to criminal and civil fines, including imprisonment. Only those with documented immunity, medical contraindications or infants under six months are exempt from the vaccine mandate.

READ THE PETITION
READ THE MEMORANDUM OF LAW
READ THE AFFIRMATION

Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

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Awareness

Magnesium Puts Psychiatric Drugs to Shame for Depression

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In Brief

  • The Facts:

    This article was written by Sayer Ji, Founder of Greenmedinfo.com where this article first appeared. Posted here with permission.

  • Reflect On:

    Is the priority of our federal health regulatory agencies and pharmaceutical companies human health, or profit? If there are more effective ways to treat several illnesses, why do they never mention them?

Depression is one of the most widely diagnosed conditions of our time, with over 3 million cases in the U.S. every year, and 350 million believed affected worldwide.1 Conventional medicine considers antidepressant drugs first-line treatments, including the newly approved injected postpartum drug costing $34,000 a treatment, to the tune of a 16 billion dollars in global sales by 2023. Despite their widespread use, these drugs are fraught with a battery of serious side effects, including suicidal ideation and completion — the last two things you would hope to see in a condition that already has suicidality as a co-morbidity. For this reason alone, natural, safe, and effective alternatives are needed more than ever before.

While research into natural alternatives for depression is growing daily — GreenMedInfo.com’s Depression database contains 647 studies on over 100 natural substances that have been studied to prevent or treat depression — it is rare to find quality human clinical research on the topic published in well-respected journals. That’s why a powerful study published in PLOS One titled, “Role of magnesium supplementation in the treatment of depression: A randomized clinical trial,” is so promising. Not only is magnesium safe, affordable, and easily accessible, but according to this recent study, effective in treating mild-to moderate symptoms of depression.

While previous studies have looked at the association between magnesium and depression,2-7 this is the first placebo-controlled clinical study to evaluate whether the use of over-the-counter magnesium chloride (248 mg elemental magnesium a day for 6 weeks) improves symptoms of depression.

The study design was a follows:

“ An open-label, blocked, randomized, cross-over trial was carried out in outpatient primary care clinics on 126 adults (mean age 52; 38% male) diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5–19. The intervention was 6 weeks of active treatment (248 mg of elemental magnesium per day) compared to 6 weeks of control (no treatment). Assessments of depression symptoms were completed at bi-weekly phone calls. The primary outcome was the net difference in the change in depression symptoms from baseline to the end of each treatment period. Secondary outcomes included changes in anxiety symptoms as well as adherence to the supplement regimen, appearance of adverse effects, and intention to use magnesium supplements in the future. Between June 2015 and May 2016, 112 participants provided analyzable data.”

The study results were as follows:

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“Consumption of magnesium chloride for 6 weeks resulted in a clinically significant net improvement in PHQ-9 scores of -6.0 points (CI -7.9, -4.2; P<0.001) and net improvement in Generalized Anxiety Disorders-7 scores of -4.5 points (CI -6.6, -2.4; P<0.001). Average adherence was 83% by pill count. The supplements were well tolerated and 61% of participants reported they would use magnesium in the future. Similar effects were observed regardless of age, gender, baseline severity of depression, baseline magnesium level, or use of antidepressant treatments. Effects were observed within two weeks. Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”

 For perspective, conventional antidepressant drugs are considering to generate an “adequate or complete treatment response” with a PHQ-9 score “decrease of 5 points or more from baseline.” At this level of efficacy, their recommended action is: “Do not change treatment; conduct periodic follow-up.” The magnesium’s score of -6.0 therefore represents the height of success within conventional expectations for a complete response, which is sometimes termed “remission.” In contradistinction, conventional antidepressant drugs result in nearly half of patients discontinuing treatment during the first month, usually due to their powerful and sometimes debilitating side effects.8

To summarize the main study outcomes:

  • There was a clinically significant improvement in both Depression and Anxiety scores.
  • 61% of patients reported they would use magnesium in the future.
  • Similar effects occurred across age, gender, severity of depression, baseline magnesium levels, or use of antidepressant treatments.
  • Effects were observed within two weeks.

 The study authors concluded:

“Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”

Beyond Depression: Magnesium’s Many Health Benefits & Where To Source It

Magnesium is a central player in your body’s energy production, as its found within 300 enzymes in the human body, including within the biologically active form of ATP known as MG-ATP. In fact, there have been over 3,751 magnesium binding sites identified within human proteins, indicating that it’s central nutritional importance has been greatly underappreciated.

Research relevant to magnesium has been accumulating for the past 40 years at a steady rate of approximately 2,000 new studies a year. Our database project has indexed well over 100 health benefits of magnesium thus far.  For the sake of brevity, we will address seven key therapeutic applications for magnesium as follows:

  • Fibromyalgia: Not only is magnesium deficiency common in those diagnosed with fibromyalgia, 9,10 but relatively low doses of magnesium (50 mg), combined with malic acid in the form of magnesium malate, has been clinically demonstrated to improve pain and tenderness in those to which it was administered.11
  • Atrial Fibrillation: A number of studies now exist showing that magnesium supplementation reduce atrial fibrillation, either by itself, or in combination with conventional drug agents.12
  • Diabetes, Type 2: Magnesium deficiency is common in type 2 diabetics, at an incidence of 13.5 to 47.7% according to a 2007 study. 13 Research has also shown that type 2 diabetics with peripheral neuropathy and coronary artery disease have lower intracellular magnesium levels. 14 Oral magnesium supplementation has been shown to reduce plasma fasting glucose and raising HDL cholesterol in patients with type 2 diabetes.15 It has also been shown to improve insulin sensitivity and metabolic control in type 2 diabetic subjects.16
  • Premenstrual Syndrome: Magnesium deficiency has been observed in women affected by premenstrual syndrome.17 It is no surprise therefore  that it has been found to alleviate premenstrual symptoms of fluid retention, 18 as well as broadly reducing associated symptoms by approximately 34% in women, aged 18-45, given 250 mg tablets for a 3-month observational period.20 When combined with B6, magnesium supplementation has been found to improve anxiety-related premenstrual symptoms.19
  • Cardiovascular Disease and Mortality: Low serum magnesium concentrations predict cardiovascular and all-cause mortality.21 There are a wide range of ways that magnesium may confer its protective effects. It may act like a calcium channel blocker,22it is hypotensive,23 it is antispasmodic (which may protect against coronary artery spasm),24 and anti-thrombotic.25 Also, the heart muscle cells are exceedingly dense in mitochondria (as high as 100 times more per cell than skeletal muscle), the “powerhouses” of the cell,” which require adequate magnesium to produce ATP via the citric acid cycle.
  • Migraine Disorders: Blood magnesium levels have been found to be significantly lower in those who suffer from migraine attacks.26,27 A recent Journal of Neural Transmission article titled, “Why all migraine patients should be treated with magnesium,” pointed out that routine blood tests do not accurately convey the true body magnesium stores since less than 2% is in the measurable, extracellular space, “67% is in the bone and 31% is located intracellularly.”28The authors argued that since “routine blood tests are not indicative of magnesium status, empiric treatment with at least oral magnesium is warranted in all migraine sufferers.” Indeed, oral magnesium supplementation has been found to reduce the number of headache days in children experiencing frequent migranous headaches,29and when combined with l-carnitine, is effective at reducing migraine frequency in adults, as well.30
  • Aging: While natural aging is a healthy process, accelerated aging has been noted to be a feature of magnesium deficiency,31especially evident in the context of long space-flight missions where low magnesium levels are associated with cardiovascular aging over 10 times faster than occurs on earth.32 Magnesium supplementation has been shown to reverse age-related neuroendocrine and sleep EEG changes in humans.33 One of the possible mechanisms behind magnesium deficiency associated aging is that magnesium is needed to stabilize DNA and promotes DNA replication. It is also involved in healing up of the ends of the chromosomes after they are divided in mitosis.34

 It is quite amazing to consider the afformentioned side benefits of magnesium consumption or supplementation within the context of the well-known side effects of pharmaceutical approaches to symptom

management of disease. On average, conventional drugs have 75 side effects associated with their use, including lethal ones (albeit sometimes rare). When considering magnesium’s many side benefits

and extremely low toxicity, clearly this fundamental mineral intervention (and dietary requirement) puts pharmaceutical approaches to depression to shame.

Best Sources of Magnesium In The Diet

The best source of magnesium is from food, and one way to identify magnesium-containing foods are those which are green, i.e. chlorophyll rich. Chlorophyll, which enable plants to capture solar energy and convert it into metabolic energy, has a magnesium atom at its center. Without magnesium, in fact, plants could not utilize the sun’s light energy.

Magnesium, however, in its elemental form is colorless, and many foods that are not green contain it as well. The point is that when found complexed with food cofactors, it is absorbed and utilized more efficiently than in its elemental form, say, extracted from limestone in the form of magnesium oxide.

 The following foods contain exceptionally high amounts of magnesium. The portions described are 100 grams, or a little over three ounces.

  • Rice bran, crude (781 mg)
  • Seaweed, agar, dried (770 mg)
  • Chives, freeze-dried (640 mg)
  • Spice, coriander leaf, dried (694 mg)
  • Seeds, pumpkin, dried (535 mg)
  • Cocoa, dry powder, unsweetened (499 mg)
  • Spices, basil, dried (422 mg)
  • Seeds, flaxseed (392 mg)
  • Spices, cumin seed (366 mg)
  • Nuts, brazilnuts, dried (376 mg)
  • Parsley, freeze-dried (372 mg)
  • Seeds, sesame meal (346 mg)
  • Nut, almond butter (303 mg)
  • Nuts, cashew nuts, roasted (273 mg)
  • Soy flour, defatted (290 mg)
  • Whey, sweet, dried (176 mg)
  • Bananas, dehydrated (108 mg)
  • Millet, puffed (106 mg)
  • Shallots, freeze-dried (104 mg)
  • Leeks, freeze-dried (156 mg)
  • Fish, salmon, raw (95 mg)
  • Onions, dehydrated flakes (92 mg)
  • Kale, scotch, raw (88 mg)

 Fortunately, for those who need higher doses, or are not inclined to consume magnesium rich foods, there are supplemental forms commonly available on the market. Keep in mind, for those who wish to take advantage of the side benefit of magnesium therapy, namely, its stool softening and laxative properties, magnesium citrate or oxide will provide this additional feature.

For those looking to maximize absorption and bioavailability magnesium glycinate is ideal, as glycine is the smallest amino acid commonly found chelated to magnesium, and therefore highly absorbable.

For more information on natural solutions to resolving depression, download our free e-book on the topic “21st Century Solutions to Depression.” 

References:

1) World Health Organization. Depression fact sheet no. 369 2012 [cited 2016 December 20]. Available from: http://www.who.int/mediacentre/factsheets/fs369/en/.

2) Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45–52. Pmid:19085527.

3) Huang JH, Lu YF, Cheng FC, Lee JN, Tsai LC. Correlation of magnesium intake with metabolic parameters, depression and physical activity in elderly type 2 diabetes patients: a cross-sectional study. Nutrition J. 2012;11(1):41. pmid:22695027; PubMed Central PMCID: PMC3439347.

4) Tarleton EK, Littenberg B. Magnesium intake and depression in adults. J Am Board Fam Med. 2015;28(2):249–56. Pmid:25748766

5) Yary T, Lehto SM, Tolmunen T, Tuomainen T-P, Kauhanen J, Voutilainen S, et al. Dietary magnesium intake and the incidence of depression: a 20-year follow-up study. J Affect Disord. 2016;193:94–8. Pmid:26771950

6) Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362–70. pmid:16542786

7) N Engl J Med. 2000 Dec 28;343(26):1942-50. Managing depression in medical outpatients.

8)  Damiano Piovesan, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio. 3,751 magnesium binding sites have been detected on human proteins. BMC Bioinformatics. 2012 ;13 Suppl 14:S10. Epub 2012 Sep 7. PMID: 23095498

9) G Moorkens, B Manuel y Keenoy, J Vertommen, S Meludu, M Noe, I De Leeuw. Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue. Magnes Res. 1997 Dec;10(4):329-37. PMID: 9513929

10)  J Eisinger, A Plantamura, P A Marie, T Ayavou. Selenium and magnesium status in fibromyalgia. Magnes Res. 1994 Dec;7(3-4):285-8. PMID: 7786692

11)  I J Russell, J E Michalek, J D Flechas, G E Abraham. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol. 1995 May;22(5):953-8. PMID: 8587088

12) GreenMedInfo.com, Atrial Fibrillation and Magnesium (5 studies)

13)  Phuong-Chi T Pham, Phuong-Mai T Pham, Son V Pham, Jeffrey M Miller, Phuong-Thu T Pham . Hypomagnesemia in patients with type 2 diabetes. Clin J Am Soc Nephrol. 2007 Mar;2(2):366-73. Epub 2007 Jan 3. PMID: 17699436

14)  M de Lordes Lima, T Cruz, J C Pousada, L E Rodrigues, K Barbosa, V Canguçu. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998 May;21(5):682-6. PMID: 9589224

15) Y Song, K He, E B Levitan, J E Manson, S Liu. Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials. Cardiovasc Toxicol. 2008;8(3):115-25. Epub 2008 Jul 8. PMID: 16978367

16)  Martha Rodríguez-Morán, Fernando Guerrero-Romero. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003 Apr;26(4):1147-52. PMID: 12663588

17)  F Facchinetti, P Borella, G Sances, L Fioroni, R E Nappi, A R Genazzani. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991 Aug;78(2):177-81. PMID: 2067759

18)  A F Walker, M C De Souza, M F Vickers, S Abeyasekera, M L Collins, L A Trinca. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health. 1998 Nov;7(9):1157-65. PMID: 9861593

19)  S Quaranta, M A Buscaglia, M G Meroni, E Colombo, S Cella. Pilot study of the efficacy and safety of a modified-release magnesium 250 mg tablet (Sincromag) for the treatment of premenstrual syndrome. Am J Gastroenterol. 2008 Dec;103(12):2972-6. PMID: 17177579

20) M C De Souza, A F Walker, P A Robinson, K Bolland. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000 Mar;9(2):131-9. PMID: 10746516

21) Thorsten Reffelmann, Till Ittermann, Marcus Dörr, Henry Völzke, Markus Reinthaler, Astrid Petersmann, Stephan B Felix. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011 Jun 12. Epub 2011 Jun 12. PMID: 21703623

22) Andrea Rosanoff, Mildred S Seelig. Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals. J Am Coll Nutr. 2004 Oct;23(5):501S-505S. PMID: 15466951

23)  GreenMedInfo.com, Magnesium’s Hypotensive Properties.

24) GreenMedInfo.com, Magnesium’s Antispasmodic Properties.

25) Joen R Sheu, George Hsiao, Ming Y Shen, Yen M Lee, Mao H Yen . Antithrombotic effects of magnesium sulfate in in vivo experiments. Int J Hematol. 2003 May;77(4):414-9. PMID: 12774935

26) Afshin Samaie, Nabiollah Asghari, Raheb Ghorbani, Jafar Arda. Blood Magnesium levels in migraineurs within and between the headache attacks: a case control study. Pan Afr Med J. 2012 ;11:46. Epub 2012 Mar 15. PMID: 22593782

27) Mahnaz Talebi, Dariush Savadi-Oskouei, Mehdi Farhoudi, Solmaz Mohammadzade, Seyyedjamal Ghaemmaghamihezaveh, Akbar Hasani, Amir Hamdi. Relation between serum magnesium level and migraine attacks. Neurosciences (Riyadh). 2011 Oct ;16(4):320-3. PMID: 21983373

28) Alexander Mauskop, Jasmine Varughese. Why all migraine patients should be treated with magnesium. J Neural Transm. 2012 May ;119(5):575-9. Epub 2012 Mar 18. PMID: 22426836

29)  Fong Wang, Stephen K Van Den Eeden, Lynn M Ackerson, Susan E Salk, Robyn H Reince, Ronald J Elin. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Eur J Endocrinol. 2009 Apr;160(4):611-7. Epub 2009 Jan 29. PMID: 12786918

30) Ali Tarighat Esfanjani, Reza Mahdavi, Mehrangiz Ebrahimi Mameghani, Mahnaz Talebi, Zeinab Nikniaz, Abdolrasool Safaiyan. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Biol Trace Elem Res. 2012 Dec ;150(1-3):42-8. Epub 2012 Aug 17. PMID: 22895810

31) David W Killilea, Jeanette A M Maier. A connection between magnesium deficiency and aging: new insights from cellular studies. Magnes Res. 2008 Jun;21(2):77-82. PMID: 18705534

32) GreenMedInfo.com, What We Learned From The Accelerated Aging of Astronauts

33) Katja Held, I A Antonijevic, H Künzel, M Uhr, T C Wetter, I C Golly, A Steiger, H Murck. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002 Jul;35(4):135-43. PMID: 12163983

34) William J Rowe. Correcting magnesium deficiencies may prolong life. Clin Interv Aging. 2012 ;7:51-4. Epub 2012 Feb 16. PMID: 22379366


Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.


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