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How Big Pharma Chooses Which Drugs To Develop

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Pharmaceutical manufacturers are businesses, not healthcare companies. Their business is making profitable drugs that will be widely prescribed by doctors and used by as many consumers as possible. As business people, their primary loyalty is to their shareholders. All decisions on which compounds to develop into drugs and which to bring to market are driven by profit, the competitive landscape, and speed to market.

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“The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue. Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness.” Dr. Richard Horton, the current editor-in-chief of the Lancet

There are several key therapeutic areas that are dependable money makers and have the potential to produce possible blockbusters: drugs to treat cardiovascular disease, diabetes, cancer, and central nervous system disorders. Many of the diseases that these drugs treat are lifestyle related illnesses. If many of these symptom sufferers led a healthy lifestyle, they could reverse and/or prevent many of these diseases. But Pharma is not in the disease prevention business. They are in the disease treatment business. Doctors are not taught to promote wellness and prevent disease, they are taught to treat disease. So, prescriptions are dispensed as first line therapy for most symptoms.

When consumers feel they can control their symptoms and ultimately, their health, by just popping a pill, they mistakenly believe that they are also overcoming their disease. But by not changing their lifestyle, they are just masking the symptoms. For example, in the case of cardiovascular disease (CVD) and diabetes, by not choosing a healthier diet and by retaining extra weight (especially abdominal body fat), patients remain prone to other diseases and will subsequently require more medications. Patients who take daily medication are also unknowingly taxing their organs incrementally. It is in Pharma’s best interest that you not make lifestyle changes, but instead choose to take their drugs to treat your symptoms. Your disease may stabilize, but it will not reverse. If you will not change your disease-causing lifestyle, you will become dependent on the drug to manage your symptoms. Any side effects of the drug will lead to more drugs to treat those symptoms. It’s a vicious cycle that keeps Big Pharma profitable.

“The medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.”  – (source)(source) Arnold Seymour Relman (1923-2014), Harvard Professor of Medicine and Former Editor-in-Chief of the New England Medical Journal

So how do pharmaceutical companies choose which drugs to develop? They look at what have been blockbusters (big sellers) in the past and make more of those. Hypertension is great example of a blockbuster gateway drug. The Framingham Heart Study, under the direction of the National Heart, Lung, and Blood Institute (NHLBI), began studying cardiovascular disease (CVD) in 1948. After each study, they report their findings. In 1967, the Framingham Heart Study reported: “Physical activity found to reduce the risk of heart disease, and obesity to increase the risk of heart disease.”1 Yet physicians were not trained to recommend increased physical activity to their hypertensive patients. They were trained to prescribe drugs to treat hypertension (HT). Guidelines were set as to what constituted HT and at what number doctors should prescribe medication to reduce blood pressure.2

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In 2015, The New York Times reported that SPRINT, the study on 9,300 men and women who were at risk of heart disease, would be terminated early because the results were so compelling that the researchers wanted to publish as soon as possible. As a result of the published data, doctors and prescribing nurses were trained to prescribe HT medicines to people with lower diastolic and systolic numbers than they had prior to the published study. More patients on more meds. Nowhere are patients taught that hypertension can be lowered immediately with a 20 minute walk.3

Not only were the “favorable” data pushed down through the medical community, they were “pulled through” the patient community via major news publications such as The New York Times. Even more compelling, major media via magazine advertisements and promotional news spots on television called video news releases (VNRs) were used to reinforce the consumer messaging. All medical communications and consumer information is produced by Pharma’s ad agency. The SPRINT trial (Systolic Blood Pressure Intervention Trial) was designed with the outcome in mind. As soon as they reached their desired conclusion, the study was stopped to deliver the “good news” to the public and to change the protocol for what determines HT. Now, doctors were prescribing HT meds earlier to patients who might not be at risk in the interest of protecting their vasculature from possible future heart disease.

As an aside, the SPRINT study was named by the advertising agency used to brand the clinical trial. Controlled brand building generates excitement and allows the marketing message dissemination to begin with a catchy name that connotes a positive forward-thinking movement. These names are not pulled out of the air. They are carefully crafted by expert marketers who know how to prep and sell the target market on the concept they endeavor to get adopted by program, protocol, and product advocates. The advocates are Thought Leaders in CVD who are already talking about the trial before it has even been completed, thus influencing lower-tier prescribers all the way down the chain to your own General Practitioner.

The protocol was written in advance of the study by the medical education agency, a subsidiary of the advertising agency, and the spin began long before the trial did. As a result, a soon-to-be launched new HT medication was not only embraced, but reached blockbuster status right out of the gate. The SPRINT trial was funded by the NHLBI and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Those organizations received their grant money from the pharmaceutical industry, most notably from the company whose drug was planned to launch upon the release of the new data.

“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of the New England Journal of Medicine” Dr. Marcia Angell, a physician and long time Editor in Chief of the New England Medical Journal (NEMJ)

In summary, I’ll quote J. Michael Pearson, CEO of Valeant Pharmaceuticals, who flat out admitted on April 13, 2016 that his first responsibility is to the shareholders, not to the furthering of healthcare outcomes and the consumers of their drug products. Instead of investing in new breakthroughs, Valeant relies on lucrative drug acquisitions and price hikes. “If products are sort of mispriced and there’s an opportunity, we will act appropriately in terms of doing what I assume our shareholders would like us to do.”4

More and more, it is only the wealthy who can afford quality healthcare, not the average consumer with modest healthcare insurance plans. In 2016, 56 of Valeant’s drugs increased in price by 66 percent. Their latest drug acquisition prompted a 550 percent price increase. “My primary responsibility is to Valeant shareholders. We can do anything we want to do. We will continue to make acquisitions, we will continue to move forward.” Stock prices for Valeant rose 1,000 percent since Pearson became CEO.5 With that message coming from the top, it’s easy to see how patients are the ones who will suffer from Pharma’s greed. Pharmaceuticals continue to make choices based on how much money they will make, not on how many patients they can help.

SOURCES

1 https://www.framinghamheartstudy.org/about-fhs/research-milestones.php

2 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904478/

3 http://www.nytimes.com/2015/09/12/health/blood-pressure-study.html?_r=0

4 http://www.cbc.ca/news/business/valeant-senate-deposition-1.3533698

5 http://usuncut.com/class-war/valeant-ceo-shareholder-profit/

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Round UFO Seen Hovering Over Indian Prime Minister’s Residence – “Details Cannot Be Revealed”

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“Multiple government agencies were pressed into action,” a statement made by an Indian correspondent to CNN a few days ago  According to the Hindustan Times, “special commissioner of police and Delhi police chief spokesperson Depends Pathak confirmed the sighting but said details of the incident cannot be revealed.

“The sighting was reported but nothing threatening was found. More details cannot be shared keeping security reasons in mind,” Pathak added. This was also reported across multiple mainstream outlets.

This follows the release of footage from the Pentagon, and a massive wake up call article written in the New York Times,  as well as a big article on the topic by Christopher Mellon in the Washington Post, he served as deputy assistant secretary of defense for intelligence in the Clinton and George W. Bush administrations. He is a private equity investor and an adviser to the To the Stars Academy for Arts and Science.

To the Stars Academy are the ones who released the Pentagon UFO videos a couple of months ago.

It’s important to remember that these are establishment mouthpieces, and they have all but lost the people’s trust in covering events in an accurate and unbias manner. Documents, along with award-winning mainstream media journalists have made this quite obvious, and there are multiple examples that seem to be happening all the time, like the recent coverage in Syria, for example. The real portrayers of fake news seem to be the ones who created that title in the first place…

Why has the establishment, or a fraction of it, chosen to release this information? All they’ve done with information is use it to deceive the masses for ulterior motives, those motives include, for example, the ‘war on terror’ as well as the ‘war on drugs.’ Now the UFO/ET topic is too big to hide, so they are choosing to control the disclosure narrative to essentially protect themselves and their cover-up.

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What’s Next For Disclosure?

The UFO topic is becoming quite strange, because never before in history have we seen this type of mainstream media coverage. It’s hard to think that it’s not being used for reasons to “heighten” national security interests, perhaps a reason to justify space? After all, Donald Trump is now talking about creating a military space force, despite the fact that multiple high ranking military whistle-blowers, as well as the biggest military computer hack of all time that went mainstream in 2010, uncovers enough evidence to support the idea that space has already, quite possibly, been militarized.

Are they planning a false flag alien invasion? Or is a faction within the Deep State really trying to let the world know that something is going on here? Is this a process of slow disclosure to prepare us for the inevitable? Extraterrestrial contact.

If one thing is for certain, our plant is quite something…We don’t live in a world of transparency, the majority of people on the planet do not even want to think about the world, and what’s going on. The term “ignorance is bliss” is understandable, but one should not project any type of hate towards any type of activism…

It’s going to be interesting to see where the mainstream is going to take this. Unfortunately, much of the mainstream coverage and release seem to justify a “threat narrative.” Regardless of the fact that contained within the millions of pages of UFO-related documents, that have been released by multiple governments worldwide, many instances do mention “evasive” manoeuvres. Former Canadian Defence Minister Paul Helyer once said, “Decades ago, visitors from other planets warned us about where we were headed and offered to help. But instead, we, or at least some of us, interpreted their visits as a threat, and decided to shoot first and ask questions after.”

Perhaps that’s true, perhaps multiple races, some with good intentions and some with malevolent intent have visited us? This would line up with much of the testimony and research regarding a reptilian influence on Earth. Perhaps, as astronaut Storey Musgrave said at a UFO conference, there are trillions of races out there, “and they’re doing star travel.”  You can see a quick clip here, along with two other astronauts.

Just imagine the implications of such a truth? there is another way, whether it’s wormholes or warping space, there’s got to be a way to generate energy so that you can pull it out of the vacuum, and the fact that they’re here shows us that they found a way.”  Jack Kasher, Ph.D, a professor emeritus of physics at the University of Nebraska.

Intelligent beings from other star systems have been and are visiting our planet Earth. They are variously referred to as Visitors, Others, Star People, ETs, etc. . . . They are visiting Earth NOW; this is not a matter of conjecture or wishful thinking.

– Theodore C. Loder III, Phd, Professor Emeritus of Earth Sciences, University of New Hampshire

There are hundreds of statements from people like the above mentioned, to complement the documents and military whistle-blowers.

Do We Really Know What’s Going On?

Can we really say we know what is going on? To a degree, yes. We know that we’ve been lied to for decades regarding the existence of strange aerial objects that defy our understanding and belief. There is also a great deal of evidence to suggest some are extraterrestrial. There is also a great deal of evidence suggesting human governments are in contact with ET beings.

This information leaves no aspect of humanity untouched. The biggest thing we can do for disclosure right now is to continue to look at ourselves. We need to look at what we are allowing to happen on our planet right now via a controlling cabal/elite and come to terms with this reality.

We can change the human experience any-time we want, but what is going to take? So far, we’ve seen activism shift many problems. There are a lot of people out there doing a lot of good, but we still have major issues that need to be sorted out. What the global citizenry truly wants, is peace. That peace begins within each of us as Change Starts Within.

It’s time to start questioning our opinions, perspectives, beliefs in our systems today and ask why we choose to support them. It’s time to find out what stops us from having peace within ourselves within our own emotional turmoil we have in our lives. These shifts, in fact, effect collective consciousness and begin opening the door for others to change too.

The conscious and intelligent manipulation of the organized habits and opinions of the masses is an important element in democratic societyThose who manipulate this unseen mechanism of society constitute an invisible government which is the true ruling power of our country. We are governed, our minds are moulded, our tastes formed, our ideas suggested, largely by men we have never heard of.

– Edward Bernays (“the father of public relations”), Propaganda, 1928 (note that Bernays’ book, Propaganda, begins with the above quote).

It’s time for Earth to experience a new paradigm, and even though we fear stepping out of our comfort zone, we must.

Related CE Podcast Episode for self-exploration: Ep#17: Who You Truly Are

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Second FBI Informant Tried To Entrap Trump Campaign With $2 Million Offer For Hillary Dirt: Roger Stone

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In Brief

  • The Facts:

    Trump aide alleges that an FBI informant tried to spy on and infiltrate the campaign, and entrap them in a deal to exchange cash for Hillary intel.

  • Reflect On:

    If Trump was not an outsider, why was the Deep State so interested in spying and trying to infiltrate his campaign? What do we make of our election process when this is the type of behaviour taking place? Time to evolve?

We had been reporting a great deal during the 2016 campaign that if Hillary made her way into office it would have been the Deep State plan going to perfect tune once again. We talked about a great deal of corruption associated with her as a person, her foundation and her administration.

When Trump ended up in office we talked about this as a divide or fork in the Deep State that Trump was essentially disrupting the longtime running plan that had been going on for decades, as well as playing a key role in pushing for deeper reflections for humanity. This is why we see, for example, a full-on mainstream media barrage against Trump. The cabal is using their voices to attack and confuse the public about the ‘outsider’ that got his way in.

Now, as time goes on, more is being revealed about the shady nature of the 2016 election, as with any, and more is coming forward about not only the previous administration but Hillary’s campaign. We all know what they did to push Bernie Sanders out, the same was being done to Trump.

More Scandals

(Zerohedge) Now, Trump campaign aides Roger Stone and Michael Caputo say that a meeting Stone took in late May, 2016 with a Russian appears to have been an “FBI sting operation” in hindsight, following bombshell reports in May that the DOJ/FBI used a longtime FBI/CIA asset, Cambridge professor Stefan Halper, to perform espionage on the Trump campaign.

“When Stone arrived at the restaurant in Sunny Isles, he said, Greenberg was wearing a Make America Great Again T-shirt and hat. On his phone, Greenberg pulled up a photo of himself with Trump at a rally, Stone said. –WaPo”

The meeting went nowhere – ending after Stone told Greenberg “You don’t understand Donald Trump… He doesn’t pay for anything.” The Post independently confirmed this account with Greenberg.

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After the meeting, Stone received a text message from Caputo – a Trump campaign communications official who arranged the meeting after Greenberg approached Caputo’s Russian-immigrant business partner.

“How crazy is the Russian?” Caputo wrote according to a text message reviewed by The Post. Noting that Greenberg wanted “big” money, Stone replied: “waste of time.” -WaPo

Stone and Caputo now think the meeting was an FBI attempt to entrap the Trump administration – showing the Post evidence that Greenberg, who sometimes used the name Henry Oknyansky, “had provided information to the FBI for 17 years,” based on a 2015 court filing related to his immigration status.

He attached records showing that the government had granted him special permission to enter the United States because his presence represented a “significant public benefit.”

Between 2008 and 2012, the records show, he repeatedly was extended permission to enter the United States under a so-called “significant public benefit parole.” The documents list an FBI agent as a contact person. The agent declined to comment.

Greenberg did not respond to questions about his use of multiple names but said in a text that he had worked for the “federal government” for 17 years.

“I risked my life and put myself in danger to do so, as you can imagine,” he said. -WaPo

“Wherever I was, from Iran to North Korea, I always send information to” the FBI, Greenberg told The Post. “I cooperated with the FBI for 17 years, often put my life in danger. Based on my information, there are so many arrests criminal from drugs and human trafficking, money laundering and insurance frauds.”

Stone and Caputo say it was a “sting operation” by the FBI:

“I didn’t realize it was an FBI sting operation at the time, but it sure looks like one now,” said Stone.

“If you believe that [Greenberg] took time off from his long career as an FBI informant to reach out to us in his spare time, I have a bridge in Brooklyn that I want to sell you,” Caputo said in an interview.

Greenberg told WaPo he stopped working with the FBI “sometime after 2013.”

In terms of the timeline, here’s where the Greenberg meeting fits in:

April 26, 2016 – Maltese professor Joseph Mifsud allegedly tells Trump campaign aide George Paoadopoulos that the Russians had dirt on Hillary Clinton

Papadopoulos’ statement of offense also detailed his April 26, 2016, meeting with Mifsud at a London hotel. Over breakfast Mifsud told Papadopoulos “he had just returned from a trip to Moscow where he had met with high-level Russian governmental officials.” Mifsud explained, “that on that trip he (the Professor) learned that the Russians had obtained ‘dirt’ on then-candidate Clinton.” Mifsud told Papadopoulos “the Russians had emails of Clinton.” -The Federalist

May 10, 2016 – Papadopoulos tells former Australian Diplomat Alexander Downer during an alleged “drunken barroom admission” that the Russians had information which “could be damaging” to Hillary Clinton.

Late May, 2016 – Stone is approached by Greenberg with the $2 million offer for dirt on Clinton

Related CE Podcast: Trump, Alt News, & Disclosure W/ Jordan Sather

July 2016 – FBI informant (spy) Stefan Halper meets with Trump campaign aide Carter Page for the first time, which would be one of many encounters.

July 31, 2016 – the FBI officially launches operation Crossfire Hurricane, the code name given to the counterintelligence operation against the Trump campaign.

September 2016 – Halper invites Papadopoulos to London, paying him $3,000 to work on an energy policy paper while wining and dining him at a 200-year-old private London club on September 15.

Foggy memory

Stone and Caputo say they didn’t mention the meeting during Congressional testimony because they forgot, chalking it up to unimportant “due diligence.” Apparently, random offers for political dirt in exchange for millions are so common in D.C. that one tends to forget.

Stone and Caputo said in separate interviews that they also did not disclose the Greenberg meeting during testimony before the House Permanent Select Committee on Intelligence because they had forgotten about an incident that Stone calls unimportant “due diligence” that would have been “political malpractice” not to explore. -WaPo

While Greenberg and Stone’s account of the meeting mostly checked out (after Greenberg initially denied Stone’s account), Greenberg said that a Ukrainian friend named “Alexi” who was fired by the Clinton Foundation attended as well, and was the one asking for the money – while Stone said Greenberg came alone to the meeting.

“We really want to help Trump,” Stone recalled Greenberg saying during the brief encounter.

Greenberg says he sat at a nearby table while Alexei conducted the meeting. “Alexei talks to Mr. Stone, not me,” he wrote.

The Clinton Founation has denied ever employing anyone with the first name of Alexi.

Caputo’s attorney on Friday sent a letter amending his House testimony, and he plans to present Caputo’s account of the Greenberg incident to the Office of Inspector General for the Department of Justice, which has announced it is examining the FBI’s use of informants during the Russia probe. Stone said his attorney has done the same. -WaPo

Second FBI informant

Caputo hinted at the interaction in late May when he said that there were multiple government informants who approached the Trump campaign:

“Let me tell you something that I know for a fact,” Caputo said during a May 21 interview on Fox News. “This informant, this person [who] they tried to plant into the campaign … he’s not the only person who came into the campaign. And the FBI is not the only Obama agency who came into the campaign.”

“I know because they came at me,” Caputo added. “And I’m looking for clearance from my attorney to reveal this to the public. This is just the beginning.”

Stone told the Post that he may be indicted by Special Counsel Robert Mueller and charged “with a crime unrelated to the election in order to silence him,” and that he anticipates the meeting with Greenberg may be used to try and pressure him to testify against President Trump (leaving no stone unturned), which he told the Post he would never do.

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Chilling “Before And After” Photos Of Libya Go Viral

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In Brief

  • The Facts:

    A man takes pictures of Libya before and after post Hillary Clinton-NATO “liberation” of Libya. The reality is chilling.

  • Reflect On:

    What was the real reason Gadaffi was removed from power? Why was Hillary Clinton so proud of killing this man only to leave the country in devastation? Are we doing the right thing by supporting these politicians?

In the year 2000, a Libyan man took several photos of himself situated at various spots across the city of Benghazi, Libya. 18 years later, he recently revisited the exact same locations to take photos of the spectacular, beautiful human trafficking laden, NATO liberated mess of modern day Libya under the rule of the United Nation’s backed regime.

When we think about how western nations have gone into countries and destructed what they had, took over and ‘rebuilt’ as it’s often called, we have this image of something being done that is ‘right.’ What we don’t consider is all of the innocent people who are killed, the REAL reasons why western countries are looking to take over others, why they create, fund and aggressively push the idea of terrorism and so forth.

“Utter devastation” is how Libya is described today, after a coalition of over 19 countries and NATO took out the regime, in an incredible show of force that seems to resemble what they want to do to Syria or Iran today if you observe the pattern.

The man’s before and after photos have gone viral, with 50,000 retweets at least after being posted to an account that tends to feature other historical images of Libya while it was under the rule of the enemy of both Al Qaeda and the West, Gaddafi, between 1969 and 2011.

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Via Zerohedge…

It appears people do still care about Libya even if the political elites in Paris, London, and Washington who destroyed the country have moved on. Though we should recall that British foreign secretary Boris Johnson was caught on tape in a private meeting last year saying Libya was ripe for UK investment, but only after Libyans “clear the dead bodies away.”

We previously detailed in Libya’s Slave Auctions And African Genocide: What Hillary Knew how Libya went from being a stable, modernizing secular state to a hellhole of roving jihadist militias, warring rival governments, and open-air slave auctions of captured migrants.

Yet what the viral photos confirm is that Libya was once a place of sprawling hotels, wide and clean city streets, functioning infrastructure, and lively neighborhoods. But these very places are now bullet-ridden ruins rotting amidst the political backdrop of the ‘Mad Max’ style chaos unleashed immediately after US-NATO’s bombing the country into regime change.

Hillary still says that she has no regrets even after Obama timidly voiced a half-hearted and too-little-too-late Libya mea culpa of sorts in 2016.

Though Hillary’s beloved Libyan Al Qaeda …”rebels” — legitimized and empowered through broad support from the West — are now among the very militias hosting slave auctions and fueling the European refugee crisis, she’s never so much as hinted that regime change in Libya left the country and much of the region in shambles. Instead, she simply chose to conclude her role in the tragic story of Libya with her crazed and gleeful declaration of “we came, we saw, he died.”

Regime change enthusiasts everywhere please take note of what your blind jingoism has wrought.

A year before the NATO bombing of Libya the UN Development Programme (UNDP) assigned a Human Development Index (HDI) ranking of 53 to Libya (out of 169 countries ranked, Libya ranked highest on the African continent).

Right up until the eve of NATO’s air campaign against the Libyan state, international media outlets understood and acknowledged the country’s high human development rankings, though it later became inconvenient to present the empirical data. A February 2011 BBC report is a case in point.

The 2011 war and aftermath created a failed state with a once economically independent population now turned largely dependent on foreign aid and relief.

Currently considered to be at “emergency levels” of need, prior to NATO intervention Libya was not even on the World Food Program’s radar, yet is now considered a dire humanitarian disaster zone.

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