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Study Shows Damage To ‘The Seat of The Soul’ After Aluminum-Adjuvanted Vaccination & Glyphosate

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“What basically seems to have happened — aluminium was not bioavailable, traditionally, in the world’s biota until the Industrial Revolution, and so, it just had no place in any biochemical reaction that was normal. And where it does occur, now, because we are increasingly surrounded by it,  we live in what’s called the Age of Aluminium. . . . It shows up in so many products. Again, it’s great stuff to make airplanes and computers out of, but it shows up in our food, it shows up in our water, it shows up in our air, it shows up in our medicines, including vaccines, it shows up in our antacids, and various things we take into our bodies. So we increasingly have this compound that is not part of any normal biochemical process, on Earth, for anything, that now can only go in and do havoc, which is exactly what it does. It causes all kinds of unusual biochemical reactions in the body, including in the brain.” (source)

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Above is a great quote from Dr. Christopher Shaw, a neuroscientist and professor at the University of British Columbia, illustrating how aluminum has infiltrated every aspect of our lives. It’s in our deodorant, it’s in our vaccines, it’s in our homes, and it’s in our food, and as he explains, while the body does a great job of eliminating it from the body, it does have a threshold.

He also explains how the aluminum in vaccines is different from that which occurs naturally. Adjuvants like aluminum (one of the most common) are a component of vaccines that potentates the immune response to an antigen. The adjuvant is basically used to invoke the desired immune response. This is why the body does not rid itself of the aluminum in this form, because that’s the whole point of adjuvants — they are meant to stick around and allow that antigen to be presented over and over again. It can’t be excreted because it must provide that prolonged exposure of the antigen to your immune system. This is why they put it into vaccines in the first place.

But there is no debating the toxicity of aluminum. This has been confirmed in scientific literature for a very long time. Here is a great video by Dr. Christopher Exley, a professor of Bioinorganic Chemistry at Keele University and an honorary professor at UHI Millennium Institute who is known as one of the world’s leading experts on aluminum toxicity.

Glyphosate, the main active ingredient found within Monsanto’s “Roundup” Herbicide, is (unfortunately) another ingredient that can be found almost everywhere. For example, a study from the U.S. Geological Survey, titled “Pesticides in Mississippi Air and Rain: A Comparison Between 1995 and 2007,” reveals that Roundup herbicide (aka glyphosate) and its toxic degradation byproduct AMPA were found in over 75% of the air and rain samples tested from Mississippi in 2007. Researchers weren’t surprised, given the fact that 2 million kilograms of glyphosate were applied statewide in 2007. (0)(5)

“So, what is the toxicological significance of the discovery of glyphosate in most air samples tested? In the month of August, 2007, if you were breathing in the sampled air you would be inhaling approximately 2.5 nanograms of glyphosate per cubic meter of air. It has been estimated the average adult inhales approximately 388 cubic feet or 11 cubic meters of air per day, which would equal to 27.5 nanograms (billionths of a gram) of glyphosate a day.”  (source)

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It’s been discovered in California wines, even “organic” ones, in our food, and in animal feed, a topic that remains a big time debate between citizens and Monsanto.

Almost all levels of science that are used to approve the products that surround us, from food to cosmetics and more, have been taken over by corporations, and many prominent scientists have been fighting against this blatant corruption for years.

This why John Ioannidis, an epidemiologist at Stanford University School of Medicine, published the most widely accessed article in the history of the Public Library of Science (PLoS), titled “Why Most Published Research Findings Are False.”

This was more than 10 years ago. but Dr Richard Horton, the current editor-in-chief of The Lancet, has discussed the same issue, revealing that half of all the published literature could be false. (source)

“It is commonly believed that Roundup is among the safest pesticides. This idea is spread by manufacturers, mostly in the reviews they promote, which are often cited in toxicological evaluations of glyphosate-based herbicides. However, Roundup was found in this experiment to be 125 times more toxic than glyphosate. Moreover, despite its reputation, Roundup was by far the most toxic among the herbicides and insecticides tested. This inconsistency between scientific fact and industrial claim may be attributed to huge economic interests, which have been found to falsify health risk assessments and delay health policy decisions.”

— R. Mesnage et al., Biomed Research International, Volume 2014 (2014) article ID 179691

A German study that concluded in June 2013 has discovered a significant amount of glyphosate in the urine of people and animals from all across Europe (1)(2)(3). Their analysis found that every urine sample contained concentrations of glyphosate at 5 to 20 times more than the limit for drinking water. Apart from being used increasingly in food production, glyphosate-based weedkillers are often sprayed onto railway lines, urban pavements, and roadsides.

The study examined urine from city workers, journalists, and lawyers who had no direct contact with glyphosate, so it’s interesting to see that it turned up in their urine samples — particularly since they were urban residents, not rural. Another study collected urine samples from 18 different countries from all over Europe and showed similar results.

And recently, amidst mounting evidence proving this to be true, the World Health Organization (WHO) finally admitted that this substance causes cancer.

Glyphosate, Aluminum, and the Pineal Gland

“What’s appalling is that we have known about these dangers for decades yet have done little about it. Nearly 20 years ago, scientists at the National Research Council called for swift action to protect young and growing bodies from pesticides. Yet today, U.S. children continue to be exposed to pesticides that are known to be harmful in places they live, learn and play.”

 Pesticide Action Network North America (PANNA) (source)

At the Third International Symposium on Vaccines in March 2014 and as part of the 9th International Congress on Autoimmunity, MIT scientist Dr. Stephanie Seneff gave a presentation titled “A Role for the Pineal Gland in Neurological Damage Following Aluminum-adjuvanted Vaccination.”

In her heavily cited paper, she explains how many common neurological disorders, like Autism and Parkinson’s, for example, have a common origin. These are: an insufficient supply of sulfate to the brain and enhanced toxic metal exposure (e.g., aluminum, mercury) due to our impaired ability to detoxify and eliminate them. She also shows that such metals interfere with sulfate synthesis, causing cellular debris to accumulate.

It goes on to explain that Heparan sulfate in the lysosomes is critical for recycling cellular debris, garbage, and damage that could lead to disease. Multiple studies have shown that a deficiency in Heparan sulfate levels leads to autism. In summary, the paper points to the idea that autism and Alzheimer’s disease, rates of which continue to rise, are caused by a severe deficiency in sulfate supplies to the brain, and that the Pineal Gland, which Rene Descartes called “the seat of the soul”  can synthesize sulfate stimulated by sunlight, and deliver it via melatonin sulfate. Aluminum, mercury, and glyphosate, working together, can derail this process. They work synergistically.

Personally, I believe the spiritual significance of the Pineal Gland, as well as the biological aspects of it to not be well understood, so it is troublesome that we know things like this can have an effect on it us not only physically, but spiritually as well.

“One of the consequences of insufficient sulfate in the brain is that it impairs the brain’s ability to eliminate heavy metals and other toxins. To make matters worse, those same toxic metals also interfere with sulfate synthesis. The net result can be an accumulation of cellular debris.”  

– Claire I. Viadro, MPH, PhD (source) 

Some interesting studies have been done when it comes to Heparin sulfate, which also plays a key role in fetal brain development, protecting against damaging free radicals. When it comes to the link between autism and sulfate deficiency, human and animal studies have both presented intriguing evidence.

In conclusion, the researchers state:

“In this paper, we have developed the argument that glyphosate, the active ingredient in the herbicide, Roundup, and aluminum, a pervasive toxic metal in our environment, operate synergistically to induce dysfunction in the pineal gland leading to the sleep disorder that is characteristic of multiple neurological diseases, including autism, ADHD, depression, Alzheimer’s disease, ALS, anxiety disorder and Parkinson’s disease. We further argue that impaired supply of melatonin and sulfate to the brain as a consequence of pineal damage can explain how the disrupted sleep can lead to more general neurological damage, and we propose that this is a significant component of the disease process. The steady increase in glyphosate usage on corn and soy crops aligns remarkably well with the increase in sleep disorder and in autism, as well as other neurological diseases. We have shown how disruption of CYP enzymes and promotion of anemia and hypoxia, due to both aluminum and glyphosate, and disruption of gut bacteria by glyphosate, can cause a pathology leading to deficiencies in both melatonin and sulfate in the cerebrospinal fluid that is characteristic of autism and Alzheimer’s disease. Insufficient sulfate leads to impaired lysosomal recycling of cellular debris, and insufficient melatonin leads to sleep disorder, vascular disease and impaired protection from ROS damage in the brain.”

Here is a an easy-to-understand breakdown of the paper, courtesy of Dr. Jess.

Below is an excellent interview with Dr. Seneff that provides an overview of who she is and what she does.

Related CE Articles:

The Effect of Aluminum in Vaccines on Humans

Groundbreaking China Study Links Immune Activation By Vaccination and Autism

A 100,000 Dollar Message From Robert F. Kennedy Jr to All American Journalists & Scientists

The Top 6 Reasons Why Parents Should Never Be Forced to Vaccinate Their Children

Monsanto, Pesticides, Vaccines & Autism: If We Continue on This Route, All Children Will Be Autistic By 2025

Federal Lawsuit Forces the US Government to Divulge Secret Files on Genetically Engineered Foods

For more of our articles on aluminum, you can click here.

To read more of our articles on glyphosate and Roundup, click here.

More On Aluminum In Vaccines, From A Previous Article

Chemicals that are commonly used in the production of vaccines, according to the CDC, are done so to improve the effectiveness of the vaccine. Adjuvants like aluminum (one of the most common) are a component of vaccines that potentates the immune response to an antigen. The adjuvant is basically used to invoke the desired immune response.

Aluminum has been added to vaccines for approximately 90 years, and since then, a lot of controversy, especially in recent years, has emerged regarding their safety and effectiveness.

This controversy comes as a result of a number of recent studies (some of which are presented in this article) outlining clear concerns over the use of aluminum in this manner, as well as the fact that over the past few years, billions of dollars have been paid to families with vaccine injured children.

There are a number of reasons why more parents are choosing not to vaccinate their children.

This is quite concerning, given the fact that recommended immunization rates have more than doubled in the past few decades. In some developed countries, by the time a child is 4 to 6 years old, they will have received a total of 126 antigenic compounds, along with high amounts of aluminum adjuvants through routine vaccinations.

Here are some eye opening reasons why so many people are starting to question the safety of administering vaccines that contain aluminum.

Below is a a video from Chris Shaw who you’ll more about later in the article

No Safety Assessments (Toxicity Studies) For Vaccine Ingredients

Again, aluminum has been added to vaccines for approximately 90 years, and one disturbing fact that many people still don’t know is that the Food and Drug Administration (FDA) and vaccine manufacturers themselves have not conducted or included appropriate toxicity studies/testing proving the safety of aluminum, or any other ingredients, for that matter. These ingredients have been put into vaccines based on the assumption that they are safe. Yes, you read that correctly. It’s kind of disturbing, isn’t it?

So because vaccines have been viewed as non-toxic substances, the FDA and vaccine manufactures have not conducted appropriate toxicity studies to prove the safety of vaccine ingredients – more specifically, aluminum.(source)

I have a document from 2002 from the US Food and Drug Administration (FDA)…discussing the assessment of vaccine ingredients…and testing specifically in animal models…Back then, the FDA states that the routine toxicity studies in animals with vaccine ingredients have not been conducted because it was assumed that these ingredients are safe, when I read this I was kind of pulling my hairs out [thinking] ‘So, this is your indisputable evidence of safety?’ – Dr. Lucija Tomlijenovic, PhD., a post-doctoral fellow at the University of British Columbia where she works in neurosciences and the Department of Medicine. (source)

She also has documents which reveal that vaccine manufacturers, pharmaceutical companies, and health authorities have known about multiple dangers associated with vaccines but chose to withhold them from the public. They show that health authorities and vaccine manufacturers made “continuous efforts to withhold critical data on severe adverse reactions and contraindications to vaccinations to both parents and health practitioners in order to reach overall vaccination rates, which they deemed were necessary for ‘herd immunity.’ ” (source)

If we take a look at the FDA’s website/guidelines, it’s not like this is a secret. The statement above (from Lucija) comes from their 2002 guidelines, which is a fairly recent document, but more than 10 years later, despite all of the studies demonstrating clear cause for concern, not much has changed.

Until recently, few licensed vaccines have been tested for developmental toxicity in animals prior to their use in humans. (source)

Despite their long use as active agents of medicines and fungicides, the safety levels of these substances have never been determined, either for animals or for adult humans—much less for fetuses, newborns, infants, and children. – Jose G. Dores, Professor at the University of Brasillia’s department of nutritional sciences. (source)

Aluminum Is An Experimentally Demonstrated Neurotoxin

A growing number of studies have linked the use of aluminum adjuvants to serious autoimmune outcomes in humans.  (source)(source)(source)(source)

The use of this adjuvant has been connected to all kinds of diseases, from autism to brain disease to Alzheimer’s and much more.

Experimental research … clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans –  Dr. Lucija Tomlijenovic (source)

There are numerous studies which have examined aluminum’s potential to induce toxic effects, and this is clearly established in medical literature, and has been for a long time. (source)

If significant aluminum load exceeds the body’s capacity to get rid of it, it is deposited into various tissues that include bone, brain, liver, heart, spleen, and muscle. Aluminum is found in cigarettes, cosmetics, food, medicines (aspirin), and much much more. It’s in our environment, and we are surrounded by it. This is concerning, because aluminum was not really around until the industrial revolution. Today, it shows up in so many products. And we know, from the work of Richard Flarend, that aluminum is commonly absorbed into the body, into areas it shouldn’t be, and has been found in various urine samples from multiple studies examining this topic… and that’s not just for aluminum in vaccines.

We increasingly have this compound that was not part of any biochemical process on Earth, that can now only go and do havoc, which is exactly what it does. It causes all kinds of unusual biochemical reactions. – Dr. Chris Shaw, a Neuroscientist and professor at the University of British Columbia

Here is a great video by Dr. Christopher Exley, Professor in Bioinorganic Chemistry at Keele University and Honorary Professor at UHI Millennium Institute. He is known as one of the world’s leading experts on aluminum toxicity.

The Body Reacts Differently To Aluminum Adjuvants In Vaccines Than To Aluminum Absorbed Into The Body From Food, Water, Medicine, etc…

Just imagine, you have a higher than normal body burden of aluminum. You are potentially accumulating it in certain areas in the body. You then receive multiple vaccinations, all of which contain some aluminum. In those multiple vaccinations, aluminum is acting as adjuvant and antigen, it sets off cascades of potential responses which I believe potentially can then cascade around the body, setting off potentially other stores of aluminum, whether they be in the brain, or the bone, the connective tissues, the places where we might expect to find high or raised levels of aluminum. Could this type of cascade effect explain why an aluminum adjuvant could then in some individuals only, produce such adverse effects? … Many of the adverse affects that you see in people who have suffered following vaccination are very similar to the known effects of aluminum intoxication. Dr. Christoper Exley (source)

One of the most common arguments to support the administration of aluminum into vaccines is the fact that a person usually accumulates more aluminum in their body each day from food alone, but what is not often considered is that your body has a different method of flushing it out of your system. They body is very good at doing this, usually through the kidneys, as illustrated by the video above.

But when you inject aluminum, it goes into a different compartment of your body. It doesn’t come into the same mechanism of excretion, and that’s the whole point of adjuvants, they are meant to stick around and allow that antigen to be presented over and over again. It can’t be excreted because it must provide that prolonged exposure of the antigen to your immune system. This is why they put it into vaccines in the first place. Something to think about.

Another great video here, a clip of Dr. Chris Shaw, a Neuroscientist and professor at the University of British Columbia, explaining the dangers of putting aluminum into vaccines as an adjuvant.

***HERE is an article that explores in depth (heavily sourced) why so many parents are choosing not to vaccinate their children. It’s important to present this information because these parents are often criticized and misunderstood.

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Long-Term Consequences of Mumps Vaccination: Many Unanswered Questions

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This is Part II of a two-part series on mumps. Part I discussed how mumps vaccination and the flawed mumps component of Merck’s MMR vaccine are fostering dangerous mumps outbreaks in adolescents and young adults.

It has been about five decades since the U.S. Food and Drug Administration (FDA) approved Merck’s first mumps vaccine. The company began launching combination MMR (measles, mumps and rubella) vaccines in the 1970s. Coincidentally—or not—an infertility crisis has been brewing over roughly the same time period, with dramatic declines in sperm counts and record-lowfertility levels. However, few investigators seem interested in assessing whether mumps outbreaks in highly vaccinated populations of teens and young adults could be having long-termeffects on fertility or other health indicators.

As described in Part I, childhood MMR vaccination has been an unmitigated disaster where mumps is concerned, deferring mumps infection to older ages and leaving adolescents and young adults vulnerable to serious reproductive complications. Public health reports show that the vast majority of mumps cases and outbreaks occur in youth who have been fully vaccinatedwith the prescribed two-dose MMR series, supporting a hypothesis of “waning immunity after the second dose.” FDA and Centers for Disease Control and Prevention (CDC) officials even admitthat mumps outbreaks in the post-vaccination era “typically involve young adults,” and that vaccination is failing to protect those who are college-age and above.

Myopically, many vaccine experts have called for a third MMR dose—or even “booster dosing throughout adulthood”—even though the FDA’s and CDC’s own research shows that MMR boosters in college-age youth barely last one year. As alleged in whistleblower lawsuits wending their way through the courts over the past eight years, Merck presented the FDA with a “falsely inflated efficacy rate” for the MMR’s mumps component, using animal antibodies and other fraudulent tactics to fool FDA—and the public—into believing that the vaccine was effective.

When infection arises after puberty, however, mumps is no laughing matter, presenting an increased risk of complications such as hearing loss, encephalitis and inflammation of the reproductive organs.

Mumps after puberty is no laughing matter

Around the time that the first mumps vaccine came on the market, the 1967 children’s classic The Great Brain humorously depicted mumps infection in childhood as a mere nuisance. The book’s young protagonist goes out of his way to intentionally infect himself with mumps so that he can beat his two brothers to the recovery finish line—and he experiences no adverse consequences other than his siblings’ annoyance.

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When infection arises after puberty, however, mumps is no laughing matter, presenting an increased risk of complications such as hearing loss, encephalitis and inflammation of the reproductive organs. About one in three postpubertal men with mumps develops orchitis(inflammation of the testes), which can damage sperm, affect testosterone production and contribute to subfertility and infertility. During a mumps outbreak in England in the mid-2000s, mumps orchitis accounted for 42% of all hospitalized mumps cases; the researchers attributed this outcome—which was the most common reason for hospitalization—to “the high attack rates in adolescents and young adults” that occurred “despite high coverage with two-dose MMR.” An analysis of a 2006 mumps outbreak in the U.S. reported that male patients were over three times more likely than female patients to experience complications, “due primarily to orchitis.”

An estimated 5% to 10% of postpubertal women will develop oophoritis (swelling of the ovaries) following mumps infection. Oophoritis is associated with premature menopause and infertility, but mumps-related oophoritis has garnered little notice.

Mumps infections are often asymptomatic or produce nonspecific symptoms such as fever, while cases of orchitis may present with no other mumps symptoms. Nonetheless, public health officials advise clinicians that orchitis is an instant cue to test for mumps virus, and testing often reveals elevated mumps antibodies. In a case report of MMR failure, British clinicians isolated a novel genetic strain of mumps virus from the patient’s semen two weeks after the onset of orchitis and found mumps RNA in the semen 40 days later; they also noted “the appearance of anti-sperm antibodies,” with “potential long-term adverse effects on the patient’s fertility.”

In 2017, researchers who reviewed 185 studies conducted in Western nations found that sperm counts had plummeted by 50% to 60% between 1973 and 2011—an average decrease of 1.4% annually. Commenting on this work, one analyst estimated that 20% to 30% of young men in Europe and North America have sperm concentrations associated with a reduced ability to father a child. Given estimates that as much as 40% of reproductive problems have to do with the male partner, there is agreement on the importance of “finding and eliminating [the] hidden culprits in the environment” that most researchers believe are to blame.

An estimated 5% to 10% of postpubertal women will develop oophoritis (swelling of the ovaries) following mumps infection. Oophoritis is associated with premature menopause and infertility, but mumps-related oophoritis has garnered little notice.

MMR’s and MMRV’s potential to impair fertility never studied

Merck has not evaluated either of its two MMR vaccines—the MMR-II and the MMR-plus-varicella (MMRV) vaccine—for their potential to impair fertility. Whether such testing would unearth direct effects on fertility (as appears to be possible with HPV vaccination in women) is thus unknown. However, mumps vaccination undeniably increases reproductive-age individuals’ risk of mumps infection and, in the process, increases the risk of fertility-altering complications. These facts alone should be attracting far more attention.

Unfortunately, because clinicians already tend to underdiagnose mumps infection and underestimate mumps complications, it is likely that they are failing to recognize possible vaccine-induced reproductive health consequences of mumps infection in their adolescent and young adult patients. In one university outbreak, “most physicians…did not suspect mumps,” and even when they became aware of the outbreak, “diagnosing mumps was not always straightforward.” Moreover, although differentiating between vaccine strains of mumps virus and wild types could provide valuable information, few clinicians have the capacity or inclination to perform testing of this type. A Japanese study of cerebrospinal fluid and saliva from patients with mumps complications found vaccine strain in nearly all of the samples and noted the information’s importance in helping determine whether the complications were vaccine-related.

Those who have sought to understand mumps vaccines’ poor performance point to a mixture of explanatory factors. These include waning immunity, the high population density and close quarters encountered in settings such as college campuses, incomplete vaccine-induced immunity to wild virus as well as viral evolution such that “the vaccine triggers a less potent reaction against today’s mumps viruses than those of 50 years ago.” However, some also quietly admit that individuals with “mild vaccine-modified disease” could be perpetuating the chain of transmission. This latter point ought to be raising questions about the logic and wisdom of administering further rounds of MMR boosters during outbreaks while ignoring the problems created by the doses already given.

… some individuals respond poorly to mumps vaccination and vaccine-induced antibody levels correlate poorly with protection from mumps infection, irrespective of the number of additional doses of mumps-containing vaccine they receive.

Most scientists appear to be either resigned to ongoing mumps outbreaks in vaccinated populations or actually accept periodic outbreaks as the cost of doing business. Publications by FDA and CDC researchers reveal these agencies’ awareness that some individuals respond poorly to mumps vaccination and that vaccine-induced antibody levels correlate poorly with protection from mumps infection, “irrespective of the number of additional doses of mumps-containing vaccine they receive.” Considering the effects on fertility, the generally abysmal track record of mumps vaccination and Merck’s fraudulent claims about efficacy, it is hard to fathom medical and public health experts’ complacency about current mumps vaccines and vaccine policies.


Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

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Legal Challenge Against Forced Vaccination Filed in New York City

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On April 15, 2019, a legal challenge was filed in the New York State Trial Court by Robert Krakow, Robert F. Kennedy, Jr. and Patricia Finn against the New York City Department of Health and Human Hygiene for their forced Measles-Mumps-Rubella vaccination. The legal team asked for a temporary restraining order against the mandate that the Judge will likely review and provide an ex parte decision. Children’s Health Defense is supporting these efforts.

Last week, Children’s Health Defense reported that the NYC Commissioner of Health declared a public health emergency, ordering all people who live, work or reside in four Brooklyn zip codes to be vaccinated with the Measles-Mumps-Rubella vaccine. Non-compliance with the order is a misdemeanor subject to criminal and civil fines, including imprisonment. Only those with documented immunity, medical contraindications or infants under six months are exempt from the vaccine mandate.

READ THE PETITION
READ THE MEMORANDUM OF LAW
READ THE AFFIRMATION

Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

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Magnesium Puts Psychiatric Drugs to Shame for Depression

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In Brief

  • The Facts:

    This article was written by Sayer Ji, Founder of Greenmedinfo.com where this article first appeared. Posted here with permission.

  • Reflect On:

    Is the priority of our federal health regulatory agencies and pharmaceutical companies human health, or profit? If there are more effective ways to treat several illnesses, why do they never mention them?

Depression is one of the most widely diagnosed conditions of our time, with over 3 million cases in the U.S. every year, and 350 million believed affected worldwide.1 Conventional medicine considers antidepressant drugs first-line treatments, including the newly approved injected postpartum drug costing $34,000 a treatment, to the tune of a 16 billion dollars in global sales by 2023. Despite their widespread use, these drugs are fraught with a battery of serious side effects, including suicidal ideation and completion — the last two things you would hope to see in a condition that already has suicidality as a co-morbidity. For this reason alone, natural, safe, and effective alternatives are needed more than ever before.

While research into natural alternatives for depression is growing daily — GreenMedInfo.com’s Depression database contains 647 studies on over 100 natural substances that have been studied to prevent or treat depression — it is rare to find quality human clinical research on the topic published in well-respected journals. That’s why a powerful study published in PLOS One titled, “Role of magnesium supplementation in the treatment of depression: A randomized clinical trial,” is so promising. Not only is magnesium safe, affordable, and easily accessible, but according to this recent study, effective in treating mild-to moderate symptoms of depression.

While previous studies have looked at the association between magnesium and depression,2-7 this is the first placebo-controlled clinical study to evaluate whether the use of over-the-counter magnesium chloride (248 mg elemental magnesium a day for 6 weeks) improves symptoms of depression.

The study design was a follows:

“ An open-label, blocked, randomized, cross-over trial was carried out in outpatient primary care clinics on 126 adults (mean age 52; 38% male) diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5–19. The intervention was 6 weeks of active treatment (248 mg of elemental magnesium per day) compared to 6 weeks of control (no treatment). Assessments of depression symptoms were completed at bi-weekly phone calls. The primary outcome was the net difference in the change in depression symptoms from baseline to the end of each treatment period. Secondary outcomes included changes in anxiety symptoms as well as adherence to the supplement regimen, appearance of adverse effects, and intention to use magnesium supplements in the future. Between June 2015 and May 2016, 112 participants provided analyzable data.”

The study results were as follows:

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“Consumption of magnesium chloride for 6 weeks resulted in a clinically significant net improvement in PHQ-9 scores of -6.0 points (CI -7.9, -4.2; P<0.001) and net improvement in Generalized Anxiety Disorders-7 scores of -4.5 points (CI -6.6, -2.4; P<0.001). Average adherence was 83% by pill count. The supplements were well tolerated and 61% of participants reported they would use magnesium in the future. Similar effects were observed regardless of age, gender, baseline severity of depression, baseline magnesium level, or use of antidepressant treatments. Effects were observed within two weeks. Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”

 For perspective, conventional antidepressant drugs are considering to generate an “adequate or complete treatment response” with a PHQ-9 score “decrease of 5 points or more from baseline.” At this level of efficacy, their recommended action is: “Do not change treatment; conduct periodic follow-up.” The magnesium’s score of -6.0 therefore represents the height of success within conventional expectations for a complete response, which is sometimes termed “remission.” In contradistinction, conventional antidepressant drugs result in nearly half of patients discontinuing treatment during the first month, usually due to their powerful and sometimes debilitating side effects.8

To summarize the main study outcomes:

  • There was a clinically significant improvement in both Depression and Anxiety scores.
  • 61% of patients reported they would use magnesium in the future.
  • Similar effects occurred across age, gender, severity of depression, baseline magnesium levels, or use of antidepressant treatments.
  • Effects were observed within two weeks.

 The study authors concluded:

“Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”

Beyond Depression: Magnesium’s Many Health Benefits & Where To Source It

Magnesium is a central player in your body’s energy production, as its found within 300 enzymes in the human body, including within the biologically active form of ATP known as MG-ATP. In fact, there have been over 3,751 magnesium binding sites identified within human proteins, indicating that it’s central nutritional importance has been greatly underappreciated.

Research relevant to magnesium has been accumulating for the past 40 years at a steady rate of approximately 2,000 new studies a year. Our database project has indexed well over 100 health benefits of magnesium thus far.  For the sake of brevity, we will address seven key therapeutic applications for magnesium as follows:

  • Fibromyalgia: Not only is magnesium deficiency common in those diagnosed with fibromyalgia, 9,10 but relatively low doses of magnesium (50 mg), combined with malic acid in the form of magnesium malate, has been clinically demonstrated to improve pain and tenderness in those to which it was administered.11
  • Atrial Fibrillation: A number of studies now exist showing that magnesium supplementation reduce atrial fibrillation, either by itself, or in combination with conventional drug agents.12
  • Diabetes, Type 2: Magnesium deficiency is common in type 2 diabetics, at an incidence of 13.5 to 47.7% according to a 2007 study. 13 Research has also shown that type 2 diabetics with peripheral neuropathy and coronary artery disease have lower intracellular magnesium levels. 14 Oral magnesium supplementation has been shown to reduce plasma fasting glucose and raising HDL cholesterol in patients with type 2 diabetes.15 It has also been shown to improve insulin sensitivity and metabolic control in type 2 diabetic subjects.16
  • Premenstrual Syndrome: Magnesium deficiency has been observed in women affected by premenstrual syndrome.17 It is no surprise therefore  that it has been found to alleviate premenstrual symptoms of fluid retention, 18 as well as broadly reducing associated symptoms by approximately 34% in women, aged 18-45, given 250 mg tablets for a 3-month observational period.20 When combined with B6, magnesium supplementation has been found to improve anxiety-related premenstrual symptoms.19
  • Cardiovascular Disease and Mortality: Low serum magnesium concentrations predict cardiovascular and all-cause mortality.21 There are a wide range of ways that magnesium may confer its protective effects. It may act like a calcium channel blocker,22it is hypotensive,23 it is antispasmodic (which may protect against coronary artery spasm),24 and anti-thrombotic.25 Also, the heart muscle cells are exceedingly dense in mitochondria (as high as 100 times more per cell than skeletal muscle), the “powerhouses” of the cell,” which require adequate magnesium to produce ATP via the citric acid cycle.
  • Migraine Disorders: Blood magnesium levels have been found to be significantly lower in those who suffer from migraine attacks.26,27 A recent Journal of Neural Transmission article titled, “Why all migraine patients should be treated with magnesium,” pointed out that routine blood tests do not accurately convey the true body magnesium stores since less than 2% is in the measurable, extracellular space, “67% is in the bone and 31% is located intracellularly.”28The authors argued that since “routine blood tests are not indicative of magnesium status, empiric treatment with at least oral magnesium is warranted in all migraine sufferers.” Indeed, oral magnesium supplementation has been found to reduce the number of headache days in children experiencing frequent migranous headaches,29and when combined with l-carnitine, is effective at reducing migraine frequency in adults, as well.30
  • Aging: While natural aging is a healthy process, accelerated aging has been noted to be a feature of magnesium deficiency,31especially evident in the context of long space-flight missions where low magnesium levels are associated with cardiovascular aging over 10 times faster than occurs on earth.32 Magnesium supplementation has been shown to reverse age-related neuroendocrine and sleep EEG changes in humans.33 One of the possible mechanisms behind magnesium deficiency associated aging is that magnesium is needed to stabilize DNA and promotes DNA replication. It is also involved in healing up of the ends of the chromosomes after they are divided in mitosis.34

 It is quite amazing to consider the afformentioned side benefits of magnesium consumption or supplementation within the context of the well-known side effects of pharmaceutical approaches to symptom

management of disease. On average, conventional drugs have 75 side effects associated with their use, including lethal ones (albeit sometimes rare). When considering magnesium’s many side benefits

and extremely low toxicity, clearly this fundamental mineral intervention (and dietary requirement) puts pharmaceutical approaches to depression to shame.

Best Sources of Magnesium In The Diet

The best source of magnesium is from food, and one way to identify magnesium-containing foods are those which are green, i.e. chlorophyll rich. Chlorophyll, which enable plants to capture solar energy and convert it into metabolic energy, has a magnesium atom at its center. Without magnesium, in fact, plants could not utilize the sun’s light energy.

Magnesium, however, in its elemental form is colorless, and many foods that are not green contain it as well. The point is that when found complexed with food cofactors, it is absorbed and utilized more efficiently than in its elemental form, say, extracted from limestone in the form of magnesium oxide.

 The following foods contain exceptionally high amounts of magnesium. The portions described are 100 grams, or a little over three ounces.

  • Rice bran, crude (781 mg)
  • Seaweed, agar, dried (770 mg)
  • Chives, freeze-dried (640 mg)
  • Spice, coriander leaf, dried (694 mg)
  • Seeds, pumpkin, dried (535 mg)
  • Cocoa, dry powder, unsweetened (499 mg)
  • Spices, basil, dried (422 mg)
  • Seeds, flaxseed (392 mg)
  • Spices, cumin seed (366 mg)
  • Nuts, brazilnuts, dried (376 mg)
  • Parsley, freeze-dried (372 mg)
  • Seeds, sesame meal (346 mg)
  • Nut, almond butter (303 mg)
  • Nuts, cashew nuts, roasted (273 mg)
  • Soy flour, defatted (290 mg)
  • Whey, sweet, dried (176 mg)
  • Bananas, dehydrated (108 mg)
  • Millet, puffed (106 mg)
  • Shallots, freeze-dried (104 mg)
  • Leeks, freeze-dried (156 mg)
  • Fish, salmon, raw (95 mg)
  • Onions, dehydrated flakes (92 mg)
  • Kale, scotch, raw (88 mg)

 Fortunately, for those who need higher doses, or are not inclined to consume magnesium rich foods, there are supplemental forms commonly available on the market. Keep in mind, for those who wish to take advantage of the side benefit of magnesium therapy, namely, its stool softening and laxative properties, magnesium citrate or oxide will provide this additional feature.

For those looking to maximize absorption and bioavailability magnesium glycinate is ideal, as glycine is the smallest amino acid commonly found chelated to magnesium, and therefore highly absorbable.

For more information on natural solutions to resolving depression, download our free e-book on the topic “21st Century Solutions to Depression.” 

References:

1) World Health Organization. Depression fact sheet no. 369 2012 [cited 2016 December 20]. Available from: http://www.who.int/mediacentre/factsheets/fs369/en/.

2) Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45–52. Pmid:19085527.

3) Huang JH, Lu YF, Cheng FC, Lee JN, Tsai LC. Correlation of magnesium intake with metabolic parameters, depression and physical activity in elderly type 2 diabetes patients: a cross-sectional study. Nutrition J. 2012;11(1):41. pmid:22695027; PubMed Central PMCID: PMC3439347.

4) Tarleton EK, Littenberg B. Magnesium intake and depression in adults. J Am Board Fam Med. 2015;28(2):249–56. Pmid:25748766

5) Yary T, Lehto SM, Tolmunen T, Tuomainen T-P, Kauhanen J, Voutilainen S, et al. Dietary magnesium intake and the incidence of depression: a 20-year follow-up study. J Affect Disord. 2016;193:94–8. Pmid:26771950

6) Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362–70. pmid:16542786

7) N Engl J Med. 2000 Dec 28;343(26):1942-50. Managing depression in medical outpatients.

8)  Damiano Piovesan, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio. 3,751 magnesium binding sites have been detected on human proteins. BMC Bioinformatics. 2012 ;13 Suppl 14:S10. Epub 2012 Sep 7. PMID: 23095498

9) G Moorkens, B Manuel y Keenoy, J Vertommen, S Meludu, M Noe, I De Leeuw. Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue. Magnes Res. 1997 Dec;10(4):329-37. PMID: 9513929

10)  J Eisinger, A Plantamura, P A Marie, T Ayavou. Selenium and magnesium status in fibromyalgia. Magnes Res. 1994 Dec;7(3-4):285-8. PMID: 7786692

11)  I J Russell, J E Michalek, J D Flechas, G E Abraham. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol. 1995 May;22(5):953-8. PMID: 8587088

12) GreenMedInfo.com, Atrial Fibrillation and Magnesium (5 studies)

13)  Phuong-Chi T Pham, Phuong-Mai T Pham, Son V Pham, Jeffrey M Miller, Phuong-Thu T Pham . Hypomagnesemia in patients with type 2 diabetes. Clin J Am Soc Nephrol. 2007 Mar;2(2):366-73. Epub 2007 Jan 3. PMID: 17699436

14)  M de Lordes Lima, T Cruz, J C Pousada, L E Rodrigues, K Barbosa, V Canguçu. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998 May;21(5):682-6. PMID: 9589224

15) Y Song, K He, E B Levitan, J E Manson, S Liu. Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials. Cardiovasc Toxicol. 2008;8(3):115-25. Epub 2008 Jul 8. PMID: 16978367

16)  Martha Rodríguez-Morán, Fernando Guerrero-Romero. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003 Apr;26(4):1147-52. PMID: 12663588

17)  F Facchinetti, P Borella, G Sances, L Fioroni, R E Nappi, A R Genazzani. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991 Aug;78(2):177-81. PMID: 2067759

18)  A F Walker, M C De Souza, M F Vickers, S Abeyasekera, M L Collins, L A Trinca. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health. 1998 Nov;7(9):1157-65. PMID: 9861593

19)  S Quaranta, M A Buscaglia, M G Meroni, E Colombo, S Cella. Pilot study of the efficacy and safety of a modified-release magnesium 250 mg tablet (Sincromag) for the treatment of premenstrual syndrome. Am J Gastroenterol. 2008 Dec;103(12):2972-6. PMID: 17177579

20) M C De Souza, A F Walker, P A Robinson, K Bolland. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000 Mar;9(2):131-9. PMID: 10746516

21) Thorsten Reffelmann, Till Ittermann, Marcus Dörr, Henry Völzke, Markus Reinthaler, Astrid Petersmann, Stephan B Felix. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011 Jun 12. Epub 2011 Jun 12. PMID: 21703623

22) Andrea Rosanoff, Mildred S Seelig. Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals. J Am Coll Nutr. 2004 Oct;23(5):501S-505S. PMID: 15466951

23)  GreenMedInfo.com, Magnesium’s Hypotensive Properties.

24) GreenMedInfo.com, Magnesium’s Antispasmodic Properties.

25) Joen R Sheu, George Hsiao, Ming Y Shen, Yen M Lee, Mao H Yen . Antithrombotic effects of magnesium sulfate in in vivo experiments. Int J Hematol. 2003 May;77(4):414-9. PMID: 12774935

26) Afshin Samaie, Nabiollah Asghari, Raheb Ghorbani, Jafar Arda. Blood Magnesium levels in migraineurs within and between the headache attacks: a case control study. Pan Afr Med J. 2012 ;11:46. Epub 2012 Mar 15. PMID: 22593782

27) Mahnaz Talebi, Dariush Savadi-Oskouei, Mehdi Farhoudi, Solmaz Mohammadzade, Seyyedjamal Ghaemmaghamihezaveh, Akbar Hasani, Amir Hamdi. Relation between serum magnesium level and migraine attacks. Neurosciences (Riyadh). 2011 Oct ;16(4):320-3. PMID: 21983373

28) Alexander Mauskop, Jasmine Varughese. Why all migraine patients should be treated with magnesium. J Neural Transm. 2012 May ;119(5):575-9. Epub 2012 Mar 18. PMID: 22426836

29)  Fong Wang, Stephen K Van Den Eeden, Lynn M Ackerson, Susan E Salk, Robyn H Reince, Ronald J Elin. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Eur J Endocrinol. 2009 Apr;160(4):611-7. Epub 2009 Jan 29. PMID: 12786918

30) Ali Tarighat Esfanjani, Reza Mahdavi, Mehrangiz Ebrahimi Mameghani, Mahnaz Talebi, Zeinab Nikniaz, Abdolrasool Safaiyan. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Biol Trace Elem Res. 2012 Dec ;150(1-3):42-8. Epub 2012 Aug 17. PMID: 22895810

31) David W Killilea, Jeanette A M Maier. A connection between magnesium deficiency and aging: new insights from cellular studies. Magnes Res. 2008 Jun;21(2):77-82. PMID: 18705534

32) GreenMedInfo.com, What We Learned From The Accelerated Aging of Astronauts

33) Katja Held, I A Antonijevic, H Künzel, M Uhr, T C Wetter, I C Golly, A Steiger, H Murck. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002 Jul;35(4):135-43. PMID: 12163983

34) William J Rowe. Correcting magnesium deficiencies may prolong life. Clin Interv Aging. 2012 ;7:51-4. Epub 2012 Feb 16. PMID: 22379366


Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.


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