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Study Finds That Big Pharma Completely Lied About Serotonin Reuptake Inhibitors (SSRI) For Depression

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*Re-published article with a few minor changes

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The title of this article might give you the impression that my aim is to frighten you. I assure you it is not. The realities of the pharmaceutical industry are admittedly difficult to swallow, but this is important information given the fact that so many people are taking anti-depressant drugs. While these details may be disturbing, especially if you or someone you know takes anti-depressant drugs, it is important to move past the fear of information and really look at what has happened with the modern day medical industry and the pharmaceutical stranglehold that plagues it today.

“The medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.”  – (source)(source) Arnold Seymour Relman (1923-2014), Harvard Professor of Medicine and Former Editor-in-Chief of the New England Medical Journal

The most recent example of this kind of corruption comes from a study that was published last week in the British Medical Journal  by researchers at the Nordic Cochrane Center in Copenhagen. The study showed that pharmaceutical companies were not disclosing all information regarding the results of their drug trials. Researchers looked at documents from 70 different double-blind, placebo-controlled trials of selective serotonin reuptake inhibitors (SSRI) and serotonin and norepinephrine reuptake inhibitors (SNRI) and found that the full extent of serious harm in clinical study reports went unreported. These are the reports sent to major health authorities like the U.S. Food and Drug Administration.

Tamang Sharma, a PhD student at Cochrane and lead author of the study, said:

We found that a lot of the appendices were often only available upon request to the authorities, and the authorities had never requested them. I’m actually kind of scared about how bad the actual situation would be if we had the complete data. (source)

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Joanna Moncrieff, a psychiatrist and researcher at University College London, elaborates:

[This study] confirms that the full degree of harm of antidepressants is not reported. They are not reported in the published literature, we know that – and it appears that they are not properly reported in clinical study reports that go to the regulators and from the basis of decisions about licensing. (source)

Peter Gotzsche, a clinician researcher at Cochrane and the co-author of the study, actually tried to gain access to clinical trial reports almost a decade ago for anti-obesity pills. Unfortunately, the European Medicines Agency (EMA) denied them the reports:

They talked about commercial confidentiality although there was absolutely nothing in these reports that was commercially confidential. We explained that all this secrecy actually cost human lives, but they weren’t interested in that at all. (source)

It took years of requests and complaints for this to happen and, while Gotzsche is pleased they were able to achieve this breakthrough, he reminds us that similar progress has yet to made in the United States. He went on to state that researchers need better access to data from clinical trials to conduct assessments unimpeded by industry influence:

It’s deeply unethical when patients volunteer to benefit science and then we let drug companies decide that we cannot get access to the raw data. The testing of drugs should be a public enterprise. (source)

Moncrieff (quoted above) then goes on to express further concerns:

We really don’t have good enough evidence that antidepressants are effective and we have increasing evidence that they can be harmful. So we need to go into reverse and stop this increasing trend of prescribing [them]. (source)

This Is Not The First Time

This is not the first time that pharmaceutical companies have been caught manipulating science in order to get antidepressants onto the shelves. It was only a couple of months ago that an independent review found that the commonly prescribed antidepressant drug Paxil (paroxetine) is not safe for teenagers, even though a large amount of literature had already suggested this previously. The 2001 drug trial that took place, funded by GlaxoSmithKline, found that these drugs were completely safe, and used that ‘science’ to market Paxil as safe for teenagers.

John Ioannidis, an epidemiologist at Stanford University School of Medicine and co-author of the study, is also the author of the most widely accessed article in the history of the Public Library of Science (PLoS), titled Why Most Published Research Findings Are False. In the report, he states that “most current published research findings are false.” And this was more than 10 years ago — the situation has undeniably worsened in the interim.

This echoes the words of Dr. Richard Horton, the current Editor-In-Chief of one of the most reputable reviewed medical journals in the world:

The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue. Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness. (source)

The Editor in Chief of the New England Medical journal, which is also considered to be one of the best in the world, has made similar assertions:

It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgement of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of the New England Journal of Medicine. (source)

A couple of years ago, Lucia Tomljenovic, a PhD in biochemistry and a senior postdoctoral fellow in UBC’s Faculty of Medicine, uncovered documents that reveal vaccine manufacturers, pharmaceutical companies, and health authorities have known about multiple dangers associated with vaccines but chose to withhold them from the public. The documents were obtained from the UK Department of Health (DH) and the Joint Committee on Vaccination and Immunization (JCVI), who advise the Secretaries of State for Health in the UK about diseases preventable through immunizations. The JCVI made “continuous efforts to withhold critical data on severe adverse reactions and contraindications to vaccinations to both parents and health practitioners in order to reach overall vaccination rates.” She goes on to explain that,

The transcripts of the JCBI meetings also show that some of the Committee members had extensive ties to pharmaceutical companies and that the JCVI frequently co-operated with vaccine manufactures on the strategies aimed at boosting vaccine uptake. Some of the meetings at which such controversial items were discussed were not intended to be publicly available, as the transcripts were only released later, through the Freedom of Information Act (FOI). These particular meetings are denoted in the transcripts as “commercial in confidence,” and reveal a clear and disturbing lack of transparency, as some of the information was removed from the text (i.e., the names of the participants) prior to transcript release under the FOI section at the JCVI website. (source)

Below is a clip taken from the One More Girl documentary, a film which looks at the Gardasil vaccine, a medicine designed to prevent Human Papillomavirus. In it, Dr. Peter Rost, MD, a former vice president of one of the largest pharmaceutical companies in the world (Pfizer), shares the truth about the ties between the medical and pharmaceutical industry.

Rost is a former vice president of Pfizer, and a whistleblower of the entire pharmaceutical industry in general. He is the author of The Whistleblower, Confessions of a Healthcare Hitman. Considering his work experience, it would be an understatement to say that he is an insider expert on big pharma marketing.

It’s time to re-think current medical research and look at the bigger picture.

Related CE Article:

10 ways you can increase dopamine levels in your brain without the use of drugs. 

 

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The Mental Health Morass: Good for Pharma, Bad for Youth

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When several hundred Colorado high school students walked out of a post-school-shooting vigil last May to protest the event’s politicization, their departing chant was, “mental health, mental health.” While this response may have unsettled the event’s organizers, it was unsurprising in the context of widespread media accounts of an “epidemic of anguish” among American youth. According to this narrative, not only is “the increase in mental health issues among [U.S.] teens and young adults…nothing short of staggering,” but around the globe, mental illness is set to become the “next major global health challenge” and “pandemic of the 21st century.”

Without making light of the problem or minimizing anyone’s personal suffering, it is clear that one entity that stands to benefit mightily from a deepening mental health crisis is the pharmaceutical industry. Psychiatric medications have long been “growth superstars”—generating billions in sales for companies like Pfizer and Eli Lilly “as the U.S. became Prozac Nation, antipsychotics also became antidepressants, and ADHD [attention-deficit/hyperactivity disorder] a byword.” Already in the mid-2000s, a Harvard economist reported that spending on psychotropic drugs had substantially outpaced overall prescription drug spending—no mean feat given the drug market’s exponential growth.

Outsized drug company profits and clever marketing tactics have prompted many to question the industry’s “oversized role in determining how mental illness is treated.” Even in conventional medical circles, clinicians acknowledge the need for “radical change in the paradigm and practices of mental health care,” including interventions that emphasize prevention and non-pharmacologic treatment modalities. These sorts of recommendations are urgently needed—not least for the young people for whom there is scant evidence of psychotropic medication safety or efficacy.

Overlapping trends

Modern psychiatry situates an alphabet soup of diagnoses under the broad rubric of “mental, emotional and behavioral” (MEB) disorders. It is no longer uncommon for children and adolescents to receive one or more of these diagnoses: anxiety disorder; attention-deficit/hyperactivity disorder; autism spectrum disorder; bipolar disorder; conduct disorder; depression; disruptive behavior disorder; drug abuse or dependence; eating disorders; obsessive-compulsive disorder; oppositional defiant disorder; pervasive developmental disorder; post-traumatic stress disorder; and schizophrenia.

The proliferation of mental health diagnoses in young people overlaps considerably with trends in diagnosed neurodevelopmental disorders. In addition, mental health diagnoses frequently intersect with physical conditions such as asthma, diabetes and epilepsy, which are more often present in children with mental disorders than in children without such disorders. Pediatric hospital admissions for non-behavioral disorders result in higher costs and longer stays when they are comorbid with behavioral disorders.

One of the few large-scale surveys to focus on MEB disorders in children (rather than adults) was the National Comorbidity Survey-Adolescent Supplement (NCS-A), conducted from 2001 to 2004. The NCS-A found that half of U.S. youth (ages 13-18) had been diagnosed with at least one MEB disorder—including one in five with behavior disorders and three in ten with anxiety disorders—with the impairments rated as “severe” in roughly one-fourth of the affected teens. For many of the young people, onset and diagnosis occurred well before adolescence. Reviewing the evidence, the National Research Council and Institute of Medicine reported in 2009 that “early MEB disorders should be considered as commonplace as a fractured limb: not inevitable but not at all unusual.”

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The impact

Recent research has documented some of the impact of these “commonplace” diagnoses in young people. Between 2011 and 2015, for example, visits by U.S. youth to psychiatric emergency departments increased by 28%. By age group, the largest increase—54%—was seen in adolescents (as compared to younger children or youth in their early 20s), in whom the researchers also reported a 2.5-fold increase in suicide-related visits. As of 2010, mood disorders (which include both bipolar and depressive disorders) were the most frequent principal diagnosis given to hospitalized children ages 1-17—up 80% since 1997. The hospitalization rate for bipolar disorders increased fourfold between the two time points (1997–2010), especially in the 10-14 and 15-17 age groups.

Researchers describe comorbid ADHD as “nearly universal” among youth with bipolar disorder, with ADHD and anxiety disorders viewed as common precursors of bipolar disorder. The trend toward increased diagnosis of both ADHD and bipolar disorder has prompted increased use by young people of both inpatient and outpatient mental health services as well as an exponential increase in the prescribing of medication. In office-based settings, where mental health care for young people has increased more rapidly than for adults, psychotropic medication prescriptions for younger patients are often provided by physicians with no psychiatric training.

For both ADHD and bipolar disorder, pharmacologic treatment relies heavily on powerful psychostimulants, antipsychotics and mood stabilizers. Reporting on data collected in 2011–2012, researchers noted that a large proportion (44%) of very young children diagnosed with ADHD (2- to 5-year-olds) were taking medication, most commonly central nervous system stimulants. Nationally, a survey of children with special health care needs conducted in 2009–2010 found that 74% of ADHD-diagnosed children ages 4-17 had received medication in the past week.

Both the scientific community and mainstream media have raised questions about whether widespread administration of mind-altering psychostimulants to young children is safe or “meaningfully beneficial.” In 2016, a Washington Post reporter cited CDC findings when noting that “The long-term effects of those [ADHD] drugs on a young brain and body have not been well studied, and the side effects can be numerous, including poor appetite, sleeplessness, irritability and slowed growth.” Other risks of these freely prescribed drugs include the potential to actually worsen mania, foster addiction or lead to further medication. In the push for increased treatment, clinicians have largely ignored these risks.

In some states, special education funding policies create financial incentives to actively identify and medicate children with ADHD. In those states, children are “about 15 percent more likely to report having ADHD and…about 22 percent more likely to be taking medication for ADHD.” As a medical ethicist has commented, these patterns raise questions about the “muddier” aspects of psychiatric diagnosis and the variability “as regards who and what drive [diagnostic] practices.”

The selective serotonin reuptake inhibitors (SSRIs) commonly prescribed for depression and anxiety disorders have also raised serious concerns—particularly about their potential to promote suicidality, aggression or other unwanted outcomes in children and adolescents. In 2016, the Nordic Cochrane Centre systematically reviewed clinical study reports from 70 trials of SSRIs and similar drugs and described substantial under-reporting of harms. Even with the under-reporting, the reviewed evidence linked the drugs to a doubling in the risk of suicidality and aggression in children and adolescents.

Why is this happening?

Researchers have floated many hypotheses about the underlying causes of the burgeoning youth mental health crisis. But while the mainstream media have been more than willing to give airtime to social explanations such as smartphone use and academic stress, the public has seen far less discussion of other plausible factors such as the gut-brain connection. For example, there is a complex interplay between the gut microbiome, the immune response and vaccination—and experimental evidence links vaccines and vaccine adjuvants to adverse mental health symptoms. There is also ample experimental evidence showing that gut microbiota disruptions caused by subchronic and chronic exposure to glyphosate-based herbicides can increase anxiety and depression-like behaviors at virtually any age. Moreover, research findings are suggestive of potential transgenerational effects of both vaccines and glyphosate. Rather than acquiesce to the perpetuation of hair-splitting mental health diagnoses—and the pharmaceutical “solutions” that always seem to follow close behind—it would seem wise to scrutinize these pervasive environmental threats while keeping in mind the age-old question of cui bono.

Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

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12,000 Doctors Urge the FDA to Put Cancer Warnings on Cheese

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In Brief

  • The Facts:

    The Physicians Committee for Responsible Medicine (PCRM) recently submitted a citizen petition with the Food and Drug Administration (FDA) to change labeling on cheese to include a cancer warning.

  • Reflect On:

    Why have our federal health regulatory agencies and big food companies marketed dairy products as safe, healthy and necessary when the science clearly suggests otherwise.

What do doctors learn about nutrition in medical school? Shockingly and unfortunately, nothing. Why? Because nutrition does not bring in profit, and treating people with nutrition hasn’t seemed to be an option at all ever since the birth of the mainstream medical industry. The sad reality is that “the medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.” – Arnold Seymour Relman (source)

Thankfully, things are changing and changing fast. A lot of people are taking their nutritional education into their own hands, and many doctors are also educating themselves on the power of nutrition through the plethora studies and clinical evidence that’s available out there.

One of the latest examples of doctors educating themselves comes from the Physicians Committee for Responsible Medicine (PCRM), who recently submitted a citizen petition with the Food and Drug Administration (FDA) to change labeling on cheese to include a cancer warning.

Why? Because based on the research, cheese, and dairy from the animal of another is not good, but bad for us. This reality may be hard for many to believe given the fact that it’s been one of the stable food groups for so long. It’s time we start recognizing that “nutritional education” that we grow up with is a product of the big food companies and marketing, it’s not backed by any science and more people are starting to become aware of what the science is actually showing us.

The petition states:

Dairy cheese contains reproductive hormones that may increase breast cancer mortality risk. (This sentence is what they want on dairy cheese products).

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High-fat dairy products, such as cheese, are associated with an increased risk for breast cancer. Components in dairy such as insulin-like growth factor (IGF-1) and other growth hormones may be among the reasons for the increased risk for cancer.

To ensure that Americans understand the potential significant risks, and resulting long-term costs, of consuming dairy cheese products, the FDA should ensure that the notice above is prominently placed on product packaging and labeling for all dairy cheese products.

I find it interesting that they mention IGF-1 growth hormone.

A 2015 study published in Cell Metabolism is one of multiple studies that points out:

Mice and humans with Growth Hormone Receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents (n=6,381) aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality during an 18 year follow up period. These associations were either abolished or attenuated if the source of proteins was plant-based.

The study above corroborates with a lot of other research showing that animal protein skyrockets IFG-1 growth hormone, thus leading to a wide variety of diseases, in the long term, including cancer. The interesting thing is that protein from plants, as the study points out, “abolished or attenuated” these associations “if the source of proteins was plant-based.”

Fasting has been shown to reduce the risk and even reverse many age related diseases, like Parkinson’s and Alzheimer’s. It’s also been shown to regenerate stem cells and slow down the overall aging process, much of that is due to the fact that fasting drops our IGF-1 growth hormone levels.

A recent study conducted by researchers in California and France found that meat protein is associated with a very sharp increased risk of heart disease, while protein from nuts and seeds is actually beneficial for the human heart.

The study is titled “Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality: The Adventist Health Study-2 cohort,” It was a joint project between researchers from Loma Linda University School of Public Health in California and AgroParisTech and the Institut National de la Recherche Agronomique in Paris, France.

It was published in the International Journal of Epidemiology. The researchers found that people who ate large amounts of meat protein, which is a daily norm for many people, represented a portion of the human population that would experience a 60 percent increase in cardiovascular disease (CVD), while people who consumed large amounts of protein from nuts and seeds actually experienced a 40 percent reduction in CVD.

Dairy “Turning on Cancer.”

Doctor Colin Campbell. author of the “China Study”  discovered that animal protein (casein) can accelerate and “turn on” cancer, while plant based protein has the opposite effect.

“What I did during the early part of my career was nothing more than what traditional science would suggest. I made the observation that diets presumably higher in animal protein were associated with liver cancer in the Philippines. When coupled with the extraordinary report from India showing that casein fed to experimental rats at the usual levels of intake dramatically promoted liver cancer, it prompted my 27-year-long study The China Project, of how this effect worked. We did dozens of experiments to see if this was true and, further, how it worked.” – Dr Colin Campbell, (China Study)

Campbell is an American biochemist who specializes in the effect of nutrition on long term health. He is Professor Emeritus of Nutritional Biochemistry at Cornell University, he has a Ph.D. in nutrition, biochemistry, and microbiology. Scholars like Campbell and their work is so important in a world of medical education and academia that almost completely ignores nutrition.

Casein is the most relevant chemical carcinogen ever identified, make no mistake about it. (source)

Campbell went beyond mere correlation and found using animal studies he conducted that casein actually “turns on” cancer. When animals were fed a diet high in casein, the cancer increased dramatically. What’s even more interesting is when they decided to do a comparison using plant protein.

What we learned along the way is that we could turn on and turn off cancer. Turn it on by increasing casein consumption, turn it off by decreasing it or replacing it with plant protein. That was a really exciting thing that we could take nutrition and turn cancer on and off, I mean that, that was pretty startling. – Campbell (source)

The Takeaway

We are the only species on the planet that consumes the dairy of another animal after weaning.  The reduction of lactase activity after infancy is a genetically programmed event. Approximately 75 % of Earths population is lactose intolerant for a reason, because it’s perfectly natural. We are not meant to drink the milk of another animal and we had to evolve the gene to digest it.  The statistics vary from race to race and country to country but overall they show an abnormal amount of individuals who qualify. In some Asian countries, 90 percent of the population is lactose intolerant.

It seems the big food companies convinced us that it’s a requirement, and that it’s healthy. They used protein and calcium (both of which are present in a number of plant sources, for example) as mass marketing tools to push dairy products on the population in order to turn a very large profit, all at the health expense of human beings.

This is one of multiple examples off mass perception manipulation.

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Awareness

7 Ways to Prevent and Even Reverse Heart Disease with Nutrition

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In Brief

  • The Facts:

    This article was written by Sayer Ji. Founder of Greenmedinfo.com. Posted here with permission.

  • Reflect On:

    Heart disease, while still the #1 cause of mortality in the developed world, can be prevented and even reversed with nutritional interventions, according to a growing body of scientific research.

Considering that heart disease is the #1 cause of death in the developed world, anything that can prevent or reduce cardiac mortality, or slow or even reverse the cardiovascular disease process, should be of great interest to health professionals and the general public alike.

Sadly, millions are still unaware of the extensive body of biomedical literature that exists supporting the use of natural compounds for preventing and even reversing heart disease, which we have indexed on GreenMedInfo.com.

Instead, they spend billions of healthcare dollars annually on highly toxic cholesterol-lowering pharmaceuticals such as statin drugs which have known cardiotoxicity, among 300 other proven side effects, simply because their doctors told them to do so. Bad advice is the rule and not the exception here. For instance, after decades of recommending a so-called ‘low dose’ aspirin to prevent heart disease and stroke, the weight of evidence now points to it being a cause of significantly more harm than good: Doctors Reverse Decades Old Aspirin Recommendation: Deadly Risks Outweigh Benefits for Heart Disease & Stroke

So, with this in mind, let’s look at a small but significant sample of natural, food-based alternatives to these drugs through the lens of the clinical and biomedical literature itself.

Three Natural Substances that Reduce the Risk of Heart-Related Death

  • Omega-3 Fatty Acids: There is a robust body of research indicating that the risk of sudden cardiac death is reduced when consuming higher levels of omega-3 fatty acids. Going all the way back to 2002, the New England Journal of Medicine published a study titled, “Blood levels of long-chain n-3 fatty acids and the risk of sudden death,” which found: “The n-3 fatty acids found in fish are strongly associated with a reduced risk of sudden death among men without evidence of prior cardiovascular disease.” Another 2002 study, published in the journal Circulation, found that Omega-3 fatty acid supplementation reduces total mortality and sudden death in patients who have already had a heart attack.[i] For additional research, view our dataset on the topic of Omega-3 fatty acids and the reduction of cardiac mortality. It should be noted that the best-selling cholesterol drug class known as statins may actually reduce the effectiveness of omega-3 fats at protecting the heart. This has been offered as an explanation as to why newer research seems to show that consuming omega-3 fats does not lower the risk of cardiac mortality.
  • Vitamin D: Levels of this essential compound have been found to be directly associated with the risk of dying from all causes. Being in the lowest 25% percent of vitamin D levels is associated with a 26% increased rate of all-cause mortality.[ii] It has been proposed that doubling global vitamin D levels could significantly reduce mortality.[iii] Research published in the journal Clinical Endocrinology in 2009 confirmed that lower vitamin D levels are associated with increased all-cause mortality but also that the effect is even more pronounced with cardiovascular mortality.[iv] This finding was confirmed the same year in the Journal of the American Geriatric Society, [v] and again in 2010 in the American Journal of Clinical Nutrition.[vi]
  • Magnesium: In a world gone mad over taking inorganic calcium supplementation for manufactured diseases such as T-score defined “osteopenia” or “osteoporosis,”despite their well-known association with increased risk of cardiac mortality, magnesium’s role in protecting against heart disease cannot be overstressed. It is well-known that even the accelerated aging of the heart muscle experienced by those in long space flight is due to magnesium deficiency. In 2010, the Journal of Biomedical Sciences reported that cardiovascular risks are significantly lower in individuals who excrete higher levels of magnesium, indicating its protective role.[vii] Another study published in the journal Atherosclerosis in 2011 found that low serum magnesium concentrations predict cardiovascular and all-cause mortality.[viii] Remember that when you are looking to ‘supplement’ your diet with magnesium go green. Chlorophyll is green because it has a magnesium atom at its center. Kale, for example, is far better a source of complex nutrition than magnesium supplements. But, failing the culinary approach, magnesium supplements can be highly effective at attaining a therapeutic and/or cardioprotective dose.

For an additional list of compounds that may reduce cardiac mortality, including cocoa, tea, wine and yes, even cholesterol itself, view our Reduce Cardiac Mortality page.

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Four Natural Compounds Which May Unclog the Arteries

  • Pomegranate: this remarkable fruit has been found in a human clinical study to reverse the carotid artery thickness (i.e. blockage) by up to 29% within 1 year[ix] There are a broad range of mechanisms that have been identified which may be responsible for this effect, including: 1) lowering blood pressure 2) fighting infection (plaque in arteries often contains bacteria and viruses) 3) preventing cholesterol oxidation 4) reducing inflammation.[x]
  • Arginine: Preclinical and clinical research indicates that this amino acid not only prevents the progression of atherosclerosis but also reverses pathologies associated with the process. (see also: Clogged Arteries and Arginine). One of the mechanisms in which it accomplishes this feat is by increasing the production of nitric oxide which is normally depressed in blood vessels where the inner lining has been damaged (endothelium) resulting in dysfunction.
  • Garlic: Not only has garlic been found to reduce a multitude of risk factors associated with arteriosclerosis, the thickening and hardening of the arteries, but it also significantly reduces the risk of heart attack and stroke.[xi] In vitro research has confirmed that garlic inhibits arteriosclerotic plaque formation.[xii] Aged garlic extract has also been studied to inhibit the progression of coronary artery calcification in patients receiving statin therapy.[xiii] And let us not forget, garlic’s benefits are extremely broad. We have identified over 150 diseases that this remarkable culinary and medicinal herb has been confirmed to be of potential value in treating and preventing and which can be viewed here: Garlic Health Benefits.
  • B-Complex: One of the few vitamin categories that has been confirmed in human studies to not only reduce the progression of plaque buildup in the arteries but actually reverse it is B-complex. A 2009 study published in the journal Stroke found that high dose B-complex vitamin supplementation significantly reduces the progression of early-stage subclinical atherosclerosis in healthy individuals.[xiv] More remarkably, a 2005 study published in the journal Atherosclerosis found a B-vitamin formula decreased the carotid artery thickness in patients at risk for cerebral ischemia.[xv] Another possible explanation for these positive effects is the role B-vitamins have in reducing the production of homocysteine, an artery and otherwise blood vessel scarring amino acid.[xvi]

For additional research on artery unclogging substances visit our page dedicated to the topic Unclogging Arteries.

Additional Heart Unfriendly Things To Avoid

No discussion of preventing cardiac mortality would be complete without discussing things that need to be removed in order to reduce risk, such as:

  • NSAIDs: Drugs like aspirin, ibuprofen, and Tylenol, have well-known association with increased cardiac mortality. Review six studies on the topic here: NSAID Cardiotoxicity.
  • Statin Drugs: It is the height of irony that the very category of drugs promoted to millions globally as the standard of care for primary and secondary prevention of cardiovascular disease and cardiac mortality are actually cardiotoxic agents, linked to no less than 300 adverse health effects. Statin drugs have devastating health effects. Explore the research here: Statin Drug Health Effects.
  • Wheat: while this connection is rarely discussed, even by those who promote grain-free and wheat free diets, wheat has profound cardiotoxic potential, along with over 200 documented adverse health effects: Wheat Toxicity. And why wouldn’t it, when the very countries that eat the most of it have the highest rate of cardiovascular disease and heart-related deaths? For an in-depth explanation read our article: Wheat’s Cardiotoxicity: As Serious As A Heart Attack.

Finally, for additional research on the topic of heart health promoting strategies visit our Health Guide: Heart Health. Interested in healing an injured heart? Read about cardiac tissue regeneration: 6 Bodily Tissues That Can Be Regenerated Through Nutrition.


References

[i] Roberto Marchioli, Federica Barzi, Elena Bomba, Carmine Chieffo, Domenico Di Gregorio, Rocco Di Mascio, Maria Grazia Franzosi, Enrico Geraci, Giacomo Levantesi, Aldo Pietro Maggioni, Loredana Mantini, Rosa Maria Marfisi, G Mastrogiuseppe, Nicola Mininni, Gian Luigi Nicolosi, Massimo Santini, Carlo Schweiger, Luigi Tavazzi, Gianni Tognoni, Corrado Tucci, Franco Valagussa,. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002 Apr 23;105(16):1897-903. PMID: 11997274

[ii] Michal L Melamed, Erin D Michos, Wendy Post, Brad Astor. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008 Aug 11;168(15):1629-37. PMID: 18695076

[iii] W B Grant. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr. 2011 Jul 6. Epub 2011 Jul 6. PMID: 21731036

[iv] Stefan Pilz, Harald Dobnig, Giel Nijpels, Robert J Heine, Coen D A Stehouwer, Marieke B Snijder, Rob M van Dam, Jacqueline M Dekker. Vitamin D and mortality in older men and women. Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. Epub 2009 Feb 18. PMID: 19226272

[v] Adit A Ginde, Robert Scragg, Robert S Schwartz, Carlos A Camargo. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults. J Am Geriatr Soc. 2009 Sep;57(9):1595-603. Epub 2009 Jun 22. PMID: 19549021

[vi] Karl Michaëlsson, John A Baron, Greta Snellman, Rolf Gedeborg, Liisa Byberg, Johan Sundström, Lars Berglund, Johan Arnlöv, Per Hellman, Rune Blomhoff, Alicja Wolk, Hans Garmo, Lars Holmberg, Håkan Melhus. Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am J Clin Nutr. 2010 Oct;92(4):841-8. Epub 2010 Aug 18. PMID: 20720256

[vii] Yukio Yamori, Takashi Taguchi, Hideki Mori, Mari Mori. Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world. J Biomed Sci. 2010;17 Suppl 1:S21. Epub 2010 Aug 24. PMID: 20804596

[viii] Thorsten Reffelmann, Till Ittermann, Marcus Dörr, Henry Völzke, Markus Reinthaler, Astrid Petersmann, Stephan B Felix. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011 Jun 12. Epub 2011 Jun 12. PMID: 21703623

[ix] Sayer Ji, Research: Pomegranate May Reverse Blocked Arteries

[x] GreenMedInfo.com, Pomegranate’s Health Benefits

[xi] G Siegel, A Walter, S Engel, A Walper, F Michel. [Pleiotropic effects of garlic]. Wien Med Wochenschr. 1999;149(8-10):217-24. PMID: 10483684

[xii] Günter Siegel, Frank Michel, Michael Ploch, Miguel Rodríguez, Martin Malmsten. [Inhibition of arteriosclerotic plaque development by garlic]. Wien Med Wochenschr. 2004 Nov;154(21-22):515-22. PMID: 15638070

[xiii] Matthew J Budoff, Junichiro Takasu, Ferdinand R Flores, Yutaka Niihara, Bin Lu, Benjamin H Lau, Robert T Rosen, Harunobu Amagase. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004 Nov;39(5):985-91. PMID: 15475033

[xiv] Howard N Hodis, Wendy J Mack, Laurie Dustin, Peter R Mahrer, Stanley P Azen, Robert Detrano, Jacob Selhub, Petar Alaupovic, Chao-ran Liu, Ci-hua Liu, Juliana Hwang, Alison G Wilcox, Robert H Selzer,. High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke. 2009 Mar;40(3):730-6. Epub 2008 Dec 31. PMID: 19118243

[xv] Uwe Till, Peter Röhl, Almut Jentsch, Heiko Till, Andreas Müller, Klaus Bellstedt, Dietmar Plonné, Horst S Fink, Rüdiger Vollandt, Ulrich Sliwka, Falko H Herrmann, Henning Petermann, Reiner Riezler. Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12. Atherosclerosis. 2005 Jul;181(1):131-5. Epub 2005 Feb 16. PMID: 15939064

[xvi] Claudio Maldonado, Chirag V Soni, Nathan D Todnem, Sathnur Pushpakumar, Dorothea Rosenberger, Srikanth Givvimani, Juan Villafane, Suresh C Tyagi. Hyperhomocysteinemia and sudden cardiac death: potential arrhythmogenic mechanisms. Curr Vasc Pharmacol. 2010 Jan;8(1):64-74. PMID: 19485933

Originally published: 2018-08-05

Aritcle updated: 2019-07-24


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