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Magnesium: The Safe First Line of Defense for Clinical Depression

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This article was written by Ali Le Vere for Greenmedinfo.com. It’s republished here with their permission. For more information from Greenmedinfo, you can sign up for the newsletter here.

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The science supporting the efficacy of magnesium for major depression and other psychiatric disorders, testing for magnesium deficiency, and which forms and dosages are most effective.

Depression, a life-threatening psychiatric disorder, lies at the confluence of biochemical, hormonal, immunological, and neurodegenerative variables, which intersect to generate the pro-inflammatory state with which depression is associated. A major public health issue, depression is estimated to become one of the top three contributors to the global burden of diseases within a few years. Not only does depression consume a sizable portion of health care expenditures, but it is considered to be an independent risk factor for metabolic, cardiovascular, and neuropsychiatric disorders (1).

Current treatments are predicated upon a misguided serotonin theory of depression, and are accompanied by a laundry list of deleterious side effects ranging from sexual dysfunction to homicidality (2, 3, 4). Antidepressant medications likewise significantly increase the risk of all-cause mortality, or death from any cause, as well as heart disease, leading researchers to deem this class of pharmaceuticals as harmful to the general population (5). This, in combination with data indicating that antidepressants are clinically equivalent to placebo, render them an unfavorable option (6), especially considering that they offer little in the way of resolving the root cause.

Magnesium: The Miracle Mineral

Rather than resorting to psychotropic drugs, it would be prudent to explore whether magnesium (Mg) supplementation improves depression, since this essential mineral is implicated in the pathophysiology of this disorder. Magnesium may be indeed branded as miraculous given its essentiality as a cofactor to over three hundred enzymatic reactions (7). It is second only to potassium in terms of the predominant intracellular cations, or ions residing in cells that harbor a positive charge (7).

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Magnesium is fundamentally involved in protein production, synthesis of nucleic acids, cell growth and division, and maintenance of the delicate electrolyte composition of our cells (7). It also imparts stability to the membranes of the energy factories of our cells called mitochondria (7). As articulated by researchers, “The physiological consequences of these biochemical activities include Mg’s central roles in the control of neuronal activity, cardiac excitability, neuromuscular transmission, muscular contraction, vasomotor tone, and blood pressure” (7).

The biological effects of magnesium are widespread. When deficient, magnesium is correlated with systemic inflammation. Not only does magnesium sufficiency promote cardiovascular health, relaxing the smooth muscles that comprise blood vessels and preventing high levels of vascular resistance that cause hypertension, but it also plays a role in musculoskeletal health and prevents sarcopenia, osteoporosis, and fractures (8). Magnesium is essential to regulation of sleep (9) and vitamin D metabolism (10) as well as neural plasticity and cognitive function.

However, food processing and industrial agriculture, including monoculture crop practices and the use of magnesium-devoid fertilizers, have led to soil erosion and depletion of magnesium content in our food (7). Magnesium is likewise removed from most drinking water supplies, rendering magnesium deficiency an inevitability (11). As such, our daily intake of magnesium has steadily declined from 500 milligrams (mg) per day to 175 mg per day (7). The nutrient-poor, energy-dense dietary patterns which have come to dominate the industrialized landscape are also insufficient in the fiber-rich fruits and vegetables which contain magnesium.

Animal Studies Propose a Role for Magnesium in Depression

Preliminary animal studies pointed to a role of magnesium in depression, as depletion of magnesium in the diet of mice lead to enhanced depression- and anxiety-related behavior such as increased immobility time in the forced swim test (12). In the forced swim test, a common assay for examining depression-like behavior in rodents, the animal is confined to a container filled with water and observed as it attempts to escape. The time in which the animal exhibits immobility is used as a barometer of despair, indicating that the animal has succumbed to a fate of drowning (1).

This model is confirmed by studies showing that administering substances with antidepressant properties such as Hypericum perforatum, also known as St. John’s Wort, can significantly decrease the time the animal spends without locomotor activity (12). In addition, the time the animal spends immobilized is influenced by many of the factors that are changed as a consequence of depression in humans, such as drug-withdrawal-induced anhedonia, impaired sleep, and altered food consumption (1).

Human Studies Confirm the Role of Magnesium in Depression

There is a paucity of research on the influence of specific micronutrients in depression and results are inconsistent, but several studies have revealed low serum magnesium in this mood disorder. It is well-documented, for example, that dietary magnesium deficiency in conjunction with stress can lead to neuropathologies and symptoms of psychiatric disorders. Researchers echo this sentiment, stating that, “Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability” (11, p. 362).

The Hordaland Health study in Western Norway illustrated an inverse association between standardized energy-adjusted magnesium intake and depression scores, meaning that people who consumed less magnesium had higher rates of depression (13). When the serum and cerebrospinal fluid of acutely depressed patients diagnosed with major depressive disorder or bipolar patients in a depressive episode were compared to healthy controls, the calcium to magnesium ratio was found to be elevated in the former (14). Calcium and magnesium are minerals which antagonize one another and compete for absorption, since each of these minerals is a divalent cation (a positive ion with a valence of two). Suicidality, one of the primary manifestations of severe depression, is accompanied by low cerebrospinal fluid levels of magnesium despite normal calcium levels, lending credence to the role of magnesium in positive emotionality (15).

Magnesium Effective in Bipolar Disorder, Fibromyalgia, PMS, and Chronic Fatigue Syndrome

A formulation of magnesium aspartate hydrochloride known as Magnesiocard has been shown to invoke mood-stabilizing effects in patients with severe rapid cycling bipolar disorder in one open study label (16). In half of the patients treated, this magnesium preparation had results equivalent to lithium, the standard of care for this patient population, such that the researchers suggested: “The possibility that Magnesiocard could replace or improve the efficacy of lithium as a preventive treatment of manic-depressive illness merits further clinical investigation” (16, p. 171). When used as an adjunctive therapy in severe, therapy-resistant mania, magnesium sulphate infusions significantly reduced the use of lithium, benzodiazepines and neuroleptics, so much so that the researchers concluded that it “may be a useful supplementary therapy for the clinical management of severe manic agitation” (17, p. 239).

In another randomized trial of elderly patients with type 2 diabetes and magnesium deficiency, elemental magnesium administered at 450 mg per day was found to have equivalent efficacy to 50 mg of the antidepressant drug Imipramine in treating depressive symptoms (18). Magnesium citrate taken at 300 mg per day has likewise been shown to decrease depression and other symptoms in patients with fibromyalgia as indicated by significant decreases in the fibromyalgia impact questionnaire (FIQ) and Beck depression scores (19).

Data also indicate that supplementation with 360 mg of magnesium administered to women with premenstrual syndrome (PMS) three times a day in the second half of the cycle is effective for so-called negative affect and other premenstrual-related mood symptoms (20). Lastly, intramuscular magnesium sulphate administered every week for six weeks has been proven to be effective in improving emotional state and other parameters in chronic fatigue syndrome (CFS) (21).

Mechanism of Action for Antidepressant Effects of Magnesium

According to researchers, “Biological systems discussed to be involved in the pathophysiology of affective disorders and the action of mood stabilizing drugs are affected by Mg, such as the activity of the hypothalamus–pituitary–adrenocortical (HPA) system, corticotropin releasing factor (CRF)-, GABA- and glutamatergic (via NMDA receptors) neurotransmission and several transduction pathways including protein kinase C” (12). Not only that, but magnesium elicits similar effects on nocturnal hormonal secretion and sleep brain waves to lithium salts, which are used as a treatment modality for bipolar disorder, supporting the role of magnesium as a mood stabilizer (22).

Magnesium operates as an agonist, or a stimulatory molecule, for γ-aminobutyric acid (GABA) receptors (22). GABA is the main inhibitory neurotransmitter in the central nervous system. By binding to the GABA receptor and replicating the effects of GABA, magnesium may alleviate anxiety. Magnesium may also elicit its antidepressant effects by acting as an inorganic antagonist of N-methyl-d-aspartic acid (NMDA) receptor function (Poleszak et al., 2007). Receptor antagonists are ligands, or substances, which bind to a receptor but inhibit its activity rather than activating it. NMDA receptors, which occur on the surface of nerve cells, are activated in part by glutamate, one of the excitatory amino acids in the brain.

Researchers state that, “Dysfunction of NMDA receptors seems to play a crucial role in the neurobiology of disorders such as Parkinson’s diseaseAlzheimer’s diseaseepilepsy, ischemic stroke, anxiety and depression,” such that, “ligands interacting with different sites of NMDA receptor complex are widely investigated as potential agents for the treatment of a variety of neuropsychiatric disorders” (22). In fact, drug inhibitors at the NMDA receptor complex, such as ketamine, demonstrate antidepressant effects (23, 24), but also induce such severe side effects that their clinical utility is limited (31). Magnesium, on the other hand, may have a similar mechanism of action by interfering with NMDA receptor activation without the adverse consequences of drug-induced NMDA receptor blockade (25).

Recent Study Proves Efficacy of Oral Magnesium for Depression

A recent open-label, randomized, cross-over trial was conducted in outpatient primary care clinics on 126 adults diagnosed with depression (26). During the intervention, 248 mg of elemental magnesium chloride per day, obtained from four 500 mg tablets, was administered for six weeks and compared to six weeks of no treatment, and subjects were evaluated for changes in depressive symptoms (26).

Magnesium administration results in clinically significant improvements in scores on both the Patient Health Questionnaire-9 (PHQ-9), a validated measure of the severity of depression and response to treatment, as well as the Generalized Anxiety Disorders-7 (GAD-7), a sensitive self-reported screening tool for severity of anxiety disorders (26). Impressively, results appeared in as little as two weeks, representing the dramatic improvement that nutrient restoration can facilitate (26). Impressively, however, magnesium exerted anti-depressant effects regardless of baseline magnesium level. It also exhibited efficacy independent of the gender, age, or baseline severity of depression of subjects, as well as their use of antidepressant medications (26). The authors of the study conclude, “Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity” (26).

Populations At Risk for Magnesium Deficiency

Half of the population of the United States was found to consume less than the recommended amount of magnesium when estimated a decade ago (27). Not only is magnesium lost with certain medical conditions, but this mineral is excreted as a consequence of biological activities such as sweating, urinating, and defecating as well as excess production of stress hormones (7, 11). In addition, because low magnesium has been correlated with various disease states, increasing magnesium status may mitigate risk of these diseases.

For instance, researchers note that, “Low magnesium intakes and blood levels have been associated with type 2 diabetes, metabolic syndrome, elevated C-reactive protein, hypertension, atherosclerotic vascular disease, sudden cardiac death, osteoporosis, migraine headache, asthma, and colon cancer” (27, p. 153). In addition, magnesium deficiency at a cellular level “elicits calcium-activated inflammatory cascades independent of injury or pathogens” (27, p. 153). Low magnesium is associated with systemic inflammation, and inflammation is at the root of most chronic and degenerative diseases.

Testing for Magnesium and Food Sources of Magnesium

While the first inclination of some physicians may be to test magnesium levels for an objective parameter of deficiency, the widely used serum or plasma magnesium does not accurately reflect magnesium levels stored in other tissues (28, 29). In addition, both this hematological index of magnesium status, referred to as total magnesium, and the erythrocyte magnesium level, indicative of the levels of magnesium inside red blood cells, are not negatively affected until severe magnesium deprivation has occurred (7). Therefore, these testing methodologies are not accurate enough to catch preliminary or subclinical magnesium deficiency.

Good food sources of magnesium include pumpkin and squash seed kernels, Brazil nuts, almonds, cashews, peanuts, pine nuts, quinoa, spinach, Swiss chard, beet greens, potatoes, artichoke hearts, dates, bananas, coconut milk, prickly pear, black beans, lima beans, soybeans, and seafood sources including halibut, abalone, anchovy, caviar, conch, crab, oyster, scallop, snail, and pollock. However, it is important to note that magnesium can be leeched from vegetables when food is boiled, and that fiber in excess can decrease magnesium absorption by increasing gastrointestinal motility (7).

Most Bioavailable Forms of Magnesium

As elucidated by the researchers, “Over-the-counter magnesium can be offered as an alternative therapy to those patients hesitant to begin antidepressant treatment and is easily accessible without a prescription” (26). Because the soil is no longer enriched in magnesium, supplementation may be warranted. Organic salts of magnesium, including the acetate, ascorbate, aspartate, bicitrate, gluconate, and lactate forms are more soluble and biologically active over the magnesium mineral salts such as magnesium oxide, magnesium carbonate, magnesium chloride, and magnesium sulfate (7).

However, case studies have shown remarkably rapid recovery from major depression, in less than seven days, when magnesium glycinate and magnesium taurinate are administered at dosages of 125 to 300 mg with each meal and at bedtime (11). Magnesium threonate may also be explored as a therapeutic option, as it may have better penetrance of the blood brain barrier and restore neurological levels of magnesium. This form, which is delivered directly to the brain, may improve cerebral signaling pathways and synaptic connections between nerve cells as well as support learning and memory, although the studies have been conducted in animal models (30).

Researchers report that magnesium is usually effective for treating depression in general use, and that comorbid conditions occurring in these case studies, including “traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited” by magnesium supplementation (11, p. 362). Barring abnormal kidney function, the Institute of Medicine sets the upper tolerable limit for intake at 350 mg of elemental magnesium per day, but there are few adverse side effects documented unless consumed in inordinate doses (26).

Before changing your medication or nutraceutical regimen, always consult a functional or integrative medical doctor for contraindications. However, given the benign nature of magnesium supplementation and the ubiquity of magnesium insufficiency, depressedpatients should be offered this as a first line strategy alongside a holistic root-cause resolution approach to treating depression (26).

For additional research on magnesium, visit our database on the subject. 

References

1. Yankelevitch-Yahav, R. et al. (2015). The Forced Swim Test as a Model of Depressive-like Behavior. Journal of Visualized Experiments,  97, 52587.

2. Srilakshmi, P., & Versi, L. (2012). Review of sexual dysfunction due to selective serotonin repute inhibitors. AP Journal of Psychological Medicine, 13(1), 28-31.

3. Dording, C.M. et al. (2002). The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists. Annals of Clinical Psychiatry, 14(3), 143-147.

4. Moore, T.J., Glenmullen, J., & Furberg, C.D. (2010). Prescription drugs associated with reports of violence towards others. PLoS One, 5, e15337.

5. Maslej, M.M. et al. (2017). The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis. Psychotherapy and Psychosomatics, 86, 268-282.

6. Antonuccio, D.O., Burns, D.D., & Danton, W.G. (2002). Antidepressants: A Triumph of Marketing Over Science? Prevention & Treatment, Volume 5(25).

7. Newhouse, I., & Finstad, E.W. (2000). The Effects of Magnesium Supplementation on Exercise Performance. Journal of Sports Medicine, 10(3), 195-200.

8. Welch, A.A., Skinner, J., & Hickson, M. (2017). Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort. Nutrients, 9(11), E1189. doi: 10.3390/nu9111189.

9. Abbasi, B. et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Science, 17(12), 1161-1169.

10. Mursu, J. et al. (2015). The association between serum 25-hydroxyvitamin D3 concentration and risk of disease death in men: modification by magnesium intake. European Journal of Epidemiology, 30(4), 343-347.  doi: 10.1007/s10654-015-0006-9.

11. Eby, G.A., & Eby, K.L. (2006). Rapid recovery from major depression using magnesium treatment. Medical Hypotheses, 67(2), 362-370.

12. Singewald, N. et al. (2004). Magnesium-deficient diet alters depression- and anxiety-related behavior in mice–influence of desipramine and Hypericum perforatum extract. Neuropharmacology, 47(8), 1189-1197.

13. Jacka, F.N. et al. (2009). Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Australian and New Zealand Journal of Psychiatry, 43(1), 45-52. doi: 10.1080/00048670802534408.

14. Levine, J. et al. (1999). High serum and cerebrospinal fluid Ca/Mg ratio in recently hospitalized acutely depressed patients. Neuropsychobiology, 39(2), 63-70.

15. Banki, C.M. et al. (1995). Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biological Psychiatry, 20, 163-171.

16. Chouinard, D. et al. (1990). A pilot study of magnesium aspartate hydrochloride (Magnesiocard) as a mood stabilizer for rapid cycling bipolar affective disorder patients. Progress in Neuro-Psychopharmacology, Biology, and Psychiatry, 14, 171-180.

17. Heiden, A. et al. (1999). Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy. Psychiatry Research, 3, 239-246.

18. Barragán-Rodríguez, L., Rodríguez-Morán, M., & Guerrero-Romero, F. (2008). Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnesium Research, 21(4), 218-223.

19. Bagis, S. et al. (2013). Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia? Rheumatology International, 33(1), 167-172. doi: 10.1007/s00296-011-2334-8.

20. Facchinetti, F. et al. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and Gynecology, 78(2), 177-181.

21. Cox, I.M. et al. (1991). Red blood cell magnesium and chronic fatigue syndrome. The Lancet, 337(8744), 757-760.

22. Held, K. et al. (2002). Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry, 35(4), 135-143.

23. Zarate, C.A. Jr. et al. (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry, 63, 856-864.

24. Berman, R.M. et al. (2000). Antidepressant effect of ketamine in depressed patients. Biological Psychiatry, 47, 351-354.

25. Poleszak, E. et al. (2007). NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Elsevier Pharmacology Biochemistry and Behavior, 88(2).

26. Tarleton, E.K. et al. (2017). Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One, 12(6), e0180067. doi: 10.1371/journal.pone.0180067.

27. Rosanoff, A., Weaver, C.M., & Rude, R.K. (2012). Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutrition Reviews, 70(3), 153-164. doi: 10.1111/j.1753-4887.2011.00465.x.

28. Altura, B.T. et al. (1994). Characterization of a new ion selective electrode for ionized magnesium in whole blood, plasma, serum, and aqueous samples. Scandinavian Journal of Clinical Lab Investigations, 54(Suppl. 217), 21–36.

29. Weller, E. et al. (1998). Lack of effect of oral Mg-supplementation on Mg in serum, blood cells and calf muscle. Medical Science Sports Exercise, 30, 1584–1591.

30. Slutsky, I. et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165-177. doi: 10.1016/j.neuron.2009.12.026.

31. Willetts, J., Balster, R.L., & Leander, J.D. (1990). The behavioral pharmacology of NMDA receptor antagonists. Trends in Pharmacological Science, 11, 423-428.

Ali Le Vere holds dual Bachelor of Science degrees in Human Biology and Psychology, minors in Health Promotion and in Bioethics, Humanities, and Society, and is a Master of Science in Human Nutrition and Functional Medicine candidate. Having contended with chronic illness, her mission is to educate the public about the transformative potential of therapeutic nutrition and to disseminate information on evidence-based, empirically rooted holistic healing modalities. Read more at @empoweredautoimmune on Instagram and at www.EmpoweredAutoimmune.com: Science-based natural remedies for autoimmune disease, dysautonomia, Lyme disease, and other chronic, inflammatory illnesses.

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Awareness

Studies Show We Can Heal With Sound, Frequency & Vibration

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In Brief

  • The Facts:

    Multiple studies and examples have shown how sound, frequency and vibration can literally alter physical material matter. Research has also shown that sound, frequencies and vibration can be used as a significant healing method for various ailments.

  • Reflect On:

    How plausible would it be for these interventions to become a regular part of therapy, just as much as pharmaceutical drugs are now?

Cymatics is a very interesting topic. It illustrates how sound frequencies move through a particular medium such as water, air, or sand and as a result directly alter physical matter. There are a number of pictures all over the internet as well as youtube videos that demonstrate how matter (particles) adjust to different sounds and different frequencies of sound.

When it comes to ancient knowledge, sound, frequency and vibration have always been perceived as powerful forces that can influence and alter life all the way down to the cellular level. Sound healing methods are often used by Shamans, who employ drums and singing to access trance states. Research has even demonstrated that drumming and singing can can be used to slow fatal brain disease, and it can generate a sense of oneness with the universe . Sound therapy is getting more popular, and it can have many medical applications, especially within the psychological and mental health realms.

Sound, frequency and vibration are used all throughout the animal kingdom, and there are many examples. If we look at the wasp, they use antennal drumming to alter the caste development or phenotype of their larvae. Conventional thinking has held for quite some time that differential nutrition alone can explain why one larvae develops into a non-reproductive worker and one into a reproductive female (gyne).  However, this is not the case, according to a 2011 study:

“But nutrition level alone cannot explain how the first few females to be produced in a colony develop rapidly yet have small body sizes and worker phenotypes. Here, we provide evidence that a mechanical signal biases caste toward a worker phenotype. In Polistes fuscatus, the signal takes the form of antennal drumming (AD), wherein a female trills her antennae synchronously on the rims of nest cells while feeding prey-liquid to larvae. The frequency of AD occurrence is high early in the colony cycle, when larvae destined to become workers are being reared, and low late in the cycle, when gynes are being reared. Subjecting gyne-destined brood to simulated AD-frequency vibrations caused them to emerge as adults with reduced fat stores, a worker trait. This suggests that AD influences the larval developmental trajectory by inhibiting a physiological element that is necessary to trigger diapause, a gyne trait.”

This finding indicates that the acoustic signals produced through drumming within certain species carry biologically meaningful information (literally: ‘to put form into’) that operate epigenetically (i.e. working outside or above the genome to affect gene expression).

Pretty fascinating, isn’t it? Like many other ancient lines of thought, this has been backed by modern day scientific research.

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Cancer 

Another example comes from cancer research. In his Tedx talk, “Shattering Cancer with Resonant Frequencies,” Associate Professor and Director of Music at Skidmore College, Anthony Holland, tells the audience that he has a dream. That dream is to see a future where children no longer have to suffer from the effects of toxic cancer drugs or radiation treatment, and today he and his team believe they have found the answer, and that answer is sound. Holland and his team wondered if they could affect a cell by sending a specific electric signal, much like we do with LCD technology. After searching the patent database for a device that could accomplish this, they came across a therapeutic device invented by New Mexico physician Dr. James Bare. The device uses a plasma antenna that pulses on and off, which, as Holland explains, is important because a constant pulse of electricity would produce too much heat and therefore destroy the cell. For the next 15 months, Holland and his team searched for the exact frequency that would directly shatter a living microorganism. The magic number finally came in the form of two inputs, one high frequency and one low. The high frequency had to be exactly eleven times higher than the low, which in music is known as the 11th harmonic. At the 11th harmonic, micro organisms begin to shatter like crystal glass.

After consistently practicing until they became efficient at the procedure, Holland began working with a team of cancer researchers in an attempt to destroy targeted cancer cells. First they looked at pancreatic cancer cells, eventually discovering these cells were specifically vulnerable between 100,000 – 300,000 Hz.

Next they moved onto leukemia cells, and they were able to shatter the leukemia cells before they could divide. But, as Holland explains in his talk, he needed bigger stats in order to make the treatment a viable option for cancer patients.

In repeated and controlled experiments, the frequencies, known as oscillating pulsed electric field (OPEF) technology, killed an average of 25% to 40% of leukemia cells, going as high as 60% in some cases. Furthermore, the intervention even slowed cancer cell growth rates up to 65%.

You can read more about the story, find sources, and watch that TEDx talk here.

Another example occurred in  1981, when biologist Helene Grimal partnered with composer Fabien Maman to study the relationship of sound waves to living cells. For 18 months, the pair worked with the effects of 30-40 decibel sounds on human cells. With a camera mounted on a microscope, the researchers observed uterine cancer cells exposed to different acoustic instruments (guitar, gong, xylophone) as well as the human voice for 20-minute sessions.

They discovered that, when exposed to sound, cancer cells lost structural integrity until they exploded at the 14-minute mark. Far more dramatic was the sound of a human voice — the cells were destroyed at the nine-minute mark.

After this, they decided to work with two women with breast cancer. For one month, both of the women gave three-and-a-half-hours a day to “toning” or singing the scale. Apparently, the woman’s tumor became undetectable, and the other woman underwent surgery. Her surgeon reported that her tumor had shrunk dramatically and “dried up.” It was removed and the woman had a complete recovery and remission.

These are only a few out of multiple examples that are floating around out there.

Let’s not forget about when Royal Rife first identified the human cancer virus using the world’s most powerful microscope. After identifying and isolating the virus, he decided to culture it on salted pork. At the time this was a very good method for culturing a virus. He then took the culture and injected it into 400 rats, which, as you might expect, created cancer in all 400 rats very quickly. The next step for Rife was where things took an interesting turn. He later found a frequency of electromagnetic energy that would cause the cancer virus to diminish completely when entered into the energy field.  You can read more about that story here.

More Research

A 2014 study published in the Journal of Huntington’s Disease found that two months of drumming intervention in Huntington’s patients (considered an irreversible, lethal neurodegenerative disease) resulted in “improvements in executive function and changes in white matter microstructure, notably in the genu of the corpus callosum that connects prefrontal cortices of both hemispheres.” The study authors concluded that the pilot study provided novel preliminary evidence that drumming (or related targeted behavioral stimulation) may result in “cognitive enhancement and improvements in callosal white matter microstructure.”

A 2011 Finnish study observed that stroke patients who were given access to music as cognitive therapy had improved recovery. Other research has shown that patients suffering from loss of speech due to brain injury or stroke regain it more quickly by learning to sing before trying to speak. The phenomenon of music facilitating healing in the brain after a stroke is called the “Kenny Rogers Effect.”

A 2012 study published in Evolutionary Psychology found that active performance of music (singing, dancing and drumming) triggered endorphin release (measured by post-activity increases in pain tolerance), whereas merely listening to music did not. The researchers hypothesized that this may contribute to community bonding in activities involving dance and music-making.

According to a study published by the National Institute of Health, “Music effectively reduces anxiety for medical and surgical patients and often reduces surgical and chronic pain. [Also,] Providing music to caregivers may be a strategy to improve empathy, compassion, and care.” In other words, music is not only good for patients, it’s good for those who care for them as well.

Below is an interesting interview with Dr. Bruce Lipton. You can view his curriculum vitae here.

The Takeaway

The information presented in this article isn’t even the tip of the iceberg when it comes the the medical applications of sound, frequency and vibration, which are all obviously correlated. One thing is clear, however, which is that there are many more methods out there, like the ones discussed in this article, that should be taken more seriously and given more attention from the medical establishment. It seems all mainstream medicine is concerned about is making money and developing medications that don’t seem to be representative of our fullest potential to heal. “Alternative” therapies shouldn’t be labelled as alternative, they should be incorporated into the norm.

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In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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Awareness

Mental Health Problems—The Sad “New Normal” on College Campuses

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College campuses are witnessing record levels of student mental health problems, ranging from depression and anxiety disorders to self-injurious behaviors and worse. A clinician writing a few years ago in Psychology Today proclaimed it neither “exaggeration” nor “alarmist” to acknowledge that young Americans are experiencing “greater levels of stress and psychopathology than any time in the nation’s history”—with ramifications that are “difficult to overstate.”

The problems on college campuses are manifestations of challenges that begin sapping American children’s health at younger ages. For example, many students enter college with a crushing burden of chronic illness or a teen-onset mental health diagnosis that has made them dependent on psychotropic or other medications. The childhood prevalence of different forms of cognitive impairment has also increased and is associated with subsequent mental health difficulties. In addition, a majority of American students are now unprepared academically for their college careers, as evidenced by historically low levels of achievement on standardized tests. Once in college, large proportions of students—increasingly characterized as emotionally fragile—blame mental health challenges for significantly interfering with their ability to perform. The outcomes of these trends—including rising suicide rates among students and declining college completion rates—bode poorly for young people’s and our nation’s future.

… more than three in five (63%) respondents reported experiencing overwhelming anxiety in the past year, while two in five (42%) reported feeling so depressed that it was difficult to function.

Crippling anxiety and depression

A 2018 survey at 140 educational institutions asked almost 90,000 college students about their health over the past 12 months. The survey found that more than three in five (63%) respondents reported experiencing “overwhelming anxiety” in the past year, while two in five (42%) reported feeling “so depressed that it was difficult to function.” Students also reported that anxiety (27%), sleep difficulties (22%) and depression (19%) had adversely affected their academic performance.

In the same survey, 12% of college students reported having “seriously considered suicide.” Another study, which looked at college students with depression, anxiety and attention-deficit/hyperactivity disorder (ADHD) who had been referred by college counseling centers for psychopharmacological evaluation, found that the same proportion—12%—had actually made at least one suicide attempt. Half of the students in the latter study had previously received a prescription for medication, most often antidepressants.

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Colleges are feeling the squeeze, with demand growing nationally for campus mental health services. A study by Penn State’s Center for Collegiate Mental Health reported an average 30% to 40% increase in students’ use of counseling centers between 2009 and 2015 at a time when enrollment grew by just 5%. According to Penn State’s report, the “increase in demand is primarily characterized by a growing frequency of students with a lifetime prevalence of threat-to-self indicators.”

College vaccines

Most colleges expect new students to have had the full complement of CDC-recommended childhood vaccines and to top up before college matriculation with any vaccines or doses that they may have previously missed. In particular, universities are likely to emphasize tetanus-diphtheria-pertussis (Tdap) and measles-mumps-rubella (MMR) boosters; the human papillomavirus (HPV) vaccine; meningococcal vaccination; and annual flu shots.

… found particularly strong associations for three disorders common on college campuses—anorexia nervosa, obsessive-compulsive disorder and anxiety disorders—and observed a surge in diagnosed disorders after influenza vaccination (one of the vaccines that college students are most likely to get).

It is unlikely that clinics are issuing warnings to freshly vaccinated college students about potential adverse consequences to watch out for, yet two universities (Penn State and Yale) made news in 2017 when their researchers published a study showing a temporal relationship between newly diagnosed neuropsychiatric disorders and vaccines received in the previous three to twelve months. Although the researchers analyzed health records for 6- to 15-year-old children, not college students, they found particularly strong associations for three disorders common on college campuses—anorexia nervosa, obsessive-compulsive disorder and anxiety disorders—and observed a surge in diagnosed disorders after influenza vaccination (one of the vaccines that college students are most likely to get). They also detected significant temporal associations linking meningitis vaccination to both anorexia and chronic tic disorders.

To distance themselves from too strongly implicating vaccines, these researchers later proposed several less controversial mechanisms to explain their findings, including the presence of predisposing inflammatory or genetic factors. One of the researchers even suggested that the “trauma” of getting “stuck with needles” might be triggering the adverse neuropsychiatric outcomes.

This absurd sidestepping ignores considerable experimental evidence from both animals and humans linking the immune responses produced by vaccines (and vaccine adjuvants) to adverse mental health symptoms. In fact, some researchers vaccinate healthy animals or people on purpose just to study this phenomenon. For example:

  • A study intentionally injected mice with the vaccine used against tuberculosis (BCG vaccine) to induce “depression-like behavior,” finding that the vaccine-induced depression was resistant to treatment with standard antidepressants.
  • Another study in mice found that both the antigens and the aluminum adjuvant in the Gardasil HPV vaccine produced significantly more behavioral abnormalities, including depression, in the exposed mice compared to unexposed mice.
  • University of California researchers followed healthy undergraduates for one week before and one week after influenza vaccination; in the absence of any physical symptoms, they detected increased post-vaccination inflammation that was associated with more mood disturbances—especially “depressed mood and cognitive symptoms.”
  • Another study of influenza vaccination compared vaccine recipients who had preexisting depression and anxiety to “mentally healthy” recipients, finding that both groups had “decreased positive affect” following vaccination; however, the vaccine’s impact on mood was “more pronounced for those with anxiety or depression.”
  • Neuroscientists at Oxford injected healthy young adults with typhoid vaccine to explore “the link between inflammation, sleep and depression,” finding that the vaccine “produced significant impairment in several measures of sleep continuity” in the vaccine group compared to placebo; the researchers noted in their conclusions that impaired sleep is both a “hallmark” and “predictor” of major depression.
  • Another group of UK researchers who likewise injected healthy young adult males with the typhoid vaccine found that, within hours, the vaccine had produced measurable social-cognitive deficits.

Interestingly, a study conducted in 2014 found that vaccine-mental health effects may cut both ways. Researchers who assessed self-reported depression and anxiety (and other measures) in 11-year-olds before and up to six months after routine vaccination found that children who reported more initial depressive and anxious symptoms had a stronger vaccine response(defined by “elevated and persistently higher antibody responses”) and that this association remained even after controlling for confounders. Given that this type of overactive vaccine response can be a harbinger of autoimmunity, some researchers have urged more attention to these “bidirectional” effects.

… we are kidding ourselves if we ignore the possible contribution of a cumulative vaccine load that has children receiving dozens of doses by age 18 …

afe spaces or safe vaccines?

As “safe spaces” multiply on college campuses, and elite private institutions offer dumbed-down for-credit courses like “The Sociology of Miley Cyrus” or “Beginning Dungeons and Dragons,” it is time to take stock of the health challenges—both mental and physical—that are sabotaging college students’ chances of success. Researchers already have noted a disturbing mismatchbetween available cognitive abilities and the types of “non-routine analytical-cognitive” skills that our nation will increasingly need in the future. While variables such as student debt certainly factor into college students’ stress equation, we are kidding ourselves if we ignore the possible contribution of a cumulative vaccine load that has children receiving dozens of doses by age 18—and piles on even more when kids go off to college.


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Awareness

Vaccine Rhetoric vs. Reality—Keeping Vaccination’s Unflattering Track Record Secret

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Note: This is Part VI in a series of articles adapted from the second Children’s Health Defense eBook: Conflicts of Interest Undermine Children’s Health. The first eBook, The Sickest Generation: The Facts Behind the Children’s Health Crisis and Why It Needs to End, described how children’s health began to worsen dramatically in the late 1980s following fateful changes in the childhood vaccine schedule.]

A concerted and “heavy-handed” effort is under way to censor information that contradicts the oversimplified sound bites put forth by public health agencies and the media about vaccines. However, while brazen, in-your-face censorship—and attacks on health freedom—have ratcheted up to an unprecedented degree,  officialdom’s wish to keep vaccination’s unflattering track record out of the public eye is nothing new.

There is a chasm between vaccine rhetoric and reality for most if not all vaccines, but four vaccines—varicella (chickenpox), rotavirus, human papillomavirus (HPV) and pertussis-containing vaccines—offer especially instructive before-and-after case studies. Analysis of the U.S. experience with these vaccines raises important questions. First, why did the Food and Drug Administration (FDA) race to approve—and why does the Centers for Disease Control and Prevention (CDC) heavily promote—vaccines such as varicella and rotavirus when there is little public health justification for them? Second, why are federal agencies ignoring the many serious risks that have surfaced in the vaccines’ wake—problems unheard of before the vaccines’ introduction?

With the rollout of mass varicella vaccination, shingles started cropping up to an unprecedented extent in both children and adults, eliminating boosting for adults and shifting downward the average age at which shingles occurs.

Varicella and rotavirus vaccines

The rationale for the varicella and rotavirus vaccines was dubious from the start. In the U.S. and other wealthy countries, varicella and rotavirus were nearly universal and mostly benign childhood infections; in those settings, the pre-vaccine impact of the two conditions was largely measured in terms of “healthcare costs, missed daycare, and loss of time from work for parents/guardians” rather than in terms of serious illness or mortality.

Childhood chickenpox infections served an important purpose for all, conferring lifelong immunity to infected children while boosting adult immunity to the related shingles (herpes zoster) virus. With the rollout of mass varicella vaccination, shingles started cropping up to an unprecedented extent in both children and adults, eliminating boosting for adults and shifting downward the average age at which shingles occurs. Vaccine waning also began increasing young adults’ risk for varicella outbreaks and complications later in life, presenting “perverse public health implications.” Meanwhile, the CDC and its local public health partners worked hard to conceal these unwanted chickenpox vaccine outcomes from the public.

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Rotavirus vaccines have had a similarly checkered history. Soon after their introduction in the U.S., reports emerged of a substantially increased risk in infants of an otherwise rare bowel complication called intussusception. The FDA knew about the problem during the prelicensing regulatory review process but ignored it. Although the agency subsequently withdrew its approval for one of the problematic rotavirus vaccines, it was not until after an estimated 500,000 children received at least one million doses. The FDA never explained the “precise mechanism” by which the discontinued vaccine caused intussusception.

Two rotavirus vaccines that display the same intussusception risks are still on the U.S. market. Both are contaminated with foreign DNA from porcine viruses capable of causing severe immunodeficiency in pigs. Had the presence of these “adventitious agents” been discovered prior to vaccine licensure, the FDA probably would have been forced to shelve the vaccines, yet they remain on the vaccine schedule to this day.

The speed with which the FDA gave them [HPV vaccines Gardasil and Gardasil-9] the go-ahead—despite obvious red flags regarding their safety—illustrates the insincerity of the agency’s assertions that its vaccine approval process is committed to minimizing risks.

HPV vaccines

The HPV vaccines Gardasil and Gardasil-9 (manufactured by Merck) represent perhaps an even more compelling case study of risk-laden vaccines that should have attracted strong up-front regulatory scrutiny—but didn’t. The speed with which the FDA gave them the go-ahead—despite obvious red flags regarding their safety—illustrates the insincerity of the agency’s assertions that its vaccine approval process is committed to minimizing risks.

The FDA not only gave the quadrivalent Gardasil a free pass but has repeatedly reapproved it and the nine-valent Gardasil-9 for wider use. (Gardasil-9 is a newer formulation that contains more than twice the amount of neurotoxic aluminum adjuvant as Gardasil.) In 2009, the FDA also okayed GlaxoSmithKline’s HPV vaccine, Cervarix, but Merck’s FDA-facilitated stranglehold on the market prompted the company to withdraw Cervarix from the U.S. in 2016. Merck is now aggressively expanding its Gardasil “franchise” into other countries, generating unprecedentedworldwide demand, while continuing to “rev up” U.S. sales.

Since 2006, the FDA’s Gardasil-related decisions have included:

  • 2006: Granting fast-tracked approval for the original quadrivalent Gardasil vaccine (girls and women aged 9 to 26 years)
  • 2009: Approving Gardasil’s use in boys and men (ages 9-26)
  • 2014: Approving Gardasil-9 (girls ages 9-26, boys ages 9-15)
  • 2015: Approving Gardasil-9 for boys ages 16-26
  • 2018: Approving Gardasil-9 for older women and men (ages 27-45)

An eight-month investigation by Slate identified numerous troubling aspects of the clinical trials that encouraged U.S. and European regulators to approve Gardasil. The Slate reporter also criticized regulators for allowing “unreliable methods to be used to test the vaccine’s safety.” These included Merck’s use of “a convoluted method” that made it difficult to objectively evaluate and report side effects; its failure to document “symptom severity, duration, outcome, or overall seriousness”; restriction of adverse event reporting to just 14 days following each injection; and reliance on the subjective opinion of clinical trial investigators regarding “whether or not to report any medical problem as an adverse event.” Not infrequently, clinical trial participants who shared complaints of debilitating symptoms with trial investigators were dismissed with the response, “This is not the kind of side effects we see with this vaccine.”

The author of the Slate investigation reported:

Experts I talked to were baffled by the way Merck handled safety data in its trials. According to…a professor…who studies side effects, letting investigators judge whether adverse events should be reported is “not a very safe method of doing things, because it allows bias to creep in.” …Of the short follow-up…,“It’s not going to pick up serious long-term issues, which is a pity. Presumably, the regulators believe that the vaccine is so safe that they don’t need to worry beyond 14 days.”

Two years after Gardasil’s initial approval, Judicial Watch pronounced it a “large-scale public health experiment.” Post-licensure studies carried out since then confirm that HPV vaccines have grave risks, including impaired fertilitydemyelinating diseasechronic limb paincirculatory abnormalities and autoimmune illness, to name just some of the disabilities reported in the aftermath of HPV vaccines’ introduction. Overall, the “rate of reported serious adverse reactions (including deaths) from HPV vaccination” is many times higher than the cervical cancer mortality rate.

Recent data suggest that HPV vaccines may be increasing cervical cancer risks.

In a February 2019 letter to the CDC, Children’s Health Defense Chairman Robert F. Kennedy, Jr. noted, “During Gardasil’s clinical trials, an extraordinary 49.5% of the subjects receiving Gardasil reported serious medical conditions within seven months of the start of the clinical trials. Because Merck did not use a true placebo in its clinical trials, its researchers were able to dismiss these injuries as sad coincidences.” A current civil case brought on behalf of a 24-year-old who has suffered from systemic autoimmune dysregulation since receiving her third Gardasil vaccine at age 16 alleges that Merck “committed fraud during its clinical trials and then failed to warn [vaccine recipients] about the high risks and meager benefits of the vaccine.” The trial’s legal team is benefiting from the support of an “A-team” of plaintiffs’ law firms and attorneys, including Kennedy, Jr.

Recent data suggest that HPV vaccines may be increasing cervical cancer risks. A 2017 study out of Australia—which has heavily promoted routine HPV vaccination since 2007—reported an increased risk of difficult-to-detect malignant cervical lesions among the HPV-vaccinated. In all countries where HPV vaccination coverage is high, including Australia, official cancer registries show “an increase in the incidence of invasive cervical cancer” in the vaccinated age groups. In England, “2016 national statistics showed a worrying and substantial increase in the rate of cervical cancer…at ages 20-24”—the first HPV-vaccinated cohort.

The proper decision would be to take HPV vaccines off the market, but the FDA and CDC continue to look the other way. Both agencies’ unwavering support for Gardasil has clearly helped Merck’s commercial bottom line, so much so that the CDC director at the time of Gardasil’s approval (Julie Gerberding) went on to be appointed president of Merck’s profitable vaccine division (worth $5 billion globally) in 2009. The agencies’ willingness to aggressively promote HPV vaccination despite its readily apparent dangers illustrates a “public health flimflam” of the first order. Before the U.S. introduction of HPV vaccination, a decades-long pattern of declining cervical cancer rates was already well underway, thanks to routine cervical cancer screening. HPV vaccines have never even been proven to prevent cervical cancer. In 2016, researchers admitted that they would be unable to ascertain HPV vaccines’ long-term efficacy for “at least another 15-20 years.”

Officials also seem to have little interest in modern evidence documenting many vaccines’ inability to provide the promised protection, even when vaccine coverage is widespread.

Pertussis-containing vaccines

Alongside their many misplaced claims about various vaccines’ rationale and safety record, the FDA and CDC—as echo chambers for the vaccine industry—also have misinformed the public about vaccine effectiveness. Back in 1899, doctor William Bailey (vaccination enthusiast and member of the State Board of Health in Louisville, Kentucky) was more honest, cautioning that “nothing is gained by claiming too much” about vaccine-induced immunity and stating that “the degree of immunity may vary with time and circumstance”—presaging the troublesome modern phenomena of vaccine failure and waning immunity. In the present day, officials are only too willing to “claim too much,” conveniently ignoring historical evidence that reductions in infectious disease had little to do with vaccines and far more to do with improvements in sanitation and nutrition. Officials also seem to have little interest in modern evidence documenting many vaccines’ inability to provide the promised protection, even when vaccine coverage is widespread.

The acellular version of pertussis (whooping cough)—a component of U.S. vaccines such as DTaP and Tdap—is one of the vaccines noted for its abysmal effectiveness. The vaccine is supposed to protect against the respiratory infection caused by Bordetella pertussis. Instead, according to recent studies, pertussis is making a “surprising” comeback; between 1990 and 2005, pertussis epidemics increased in the U.S. “in both size and frequency,” and over half of all cases occurred in highly vaccinated adolescents aged 10 to 20 years old. In fact, not only is pertussis at its highest level since the mid-1950s, but, according to CDC researchers, it is showing signs of being vaccine-resistant. The CDC researchers also note “substantial heterogeneity among vaccine recipients in terms of the durability of the protection they receive.”

… the researchers concluded in 2017 that all currently available evidence suggests that DTP vaccine may kill more children from other causes than it saves from diphtheria, tetanus or pertussis …

West Africa has used the DTP vaccine since the 1980s—formulated with a whole-cell pertussis component instead of acellular pertussis—and it has an even more horrifying safety and effectiveness record than its acellular counterparts. Research published in 2017 by a prestigious team of international scientists and led by vaccinology expert Dr. Peter Aaby found that DTP vaccination had a negative effect on child survival, with fivefold higher mortality in young DTP-vaccinated infants (ages three to five months) compared to as-yet-unvaccinated infants. When the researchers published results in 2018 for slightly older DTP-vaccinated children (ages six months to three years), they continued to observe more than double the risk of death as similarly situated unvaccinated children. Explaining that vaccines can increase susceptibility to other infections, the researchers concluded in 2017 that “all currently available evidence suggests that DTP vaccine may kill more children from other causes than it saves from diphtheria, tetanus or pertussis” and added in 2018 that “all studies of the introduction of DTP have found increased overall mortality.”

Learning from history

Efforts to counter the official vaccine narrative with evidence about negative consequences date back to the days of smallpox. A doctor practicing in the 1870s observed that smallpox mortality doubled (from roughly 7% to 15%) after adoption of smallpox vaccination. During an outbreak in 1871 and 1872, this doctor stated, faith in vaccination received a “rude…shock” when “[e]very country in Europe was invaded with a severity greater than had ever been witnessed during the three preceding centuries.” The doctor also noted that “many vaccinated persons in almost every place were attacked by small-pox before any unvaccinated persons took the disease.” In this individual’s estimation, these facts were “sufficient to overthrow the entire theory of the protective efficacy of vaccination.”

In the present era, federal agencies continue to tout difficult-to-justify but money-spinning vaccines as beneficial, even in the face of substantial evidence to the contrary. Now, more than ever, it is important to illuminate the risks and downsides that public health agencies do not want us to know about.

Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

Help Support Collective Evolution

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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