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The Changing Face of Vaccinology

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Vaccines are “immunogenic formulations” intended to protect vaccinated individuals by inducing production of antibodies and cell-mediated immune responses to combat infectious (and sometimes noninfectious) conditions. Historians trace the roots of modern vaccinology—the science of vaccine development—to the dicey practices of smallpox inoculation and variolation that began in the 1700s. About a century later, in 1885, Pasteur developed and administered a rabies vaccine to humans. Although these and other early vaccines produced mixed real-world results and generated warnings of potentially serious postvaccinal complications, mass vaccination nonetheless took off without a backward glance.

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Even from the beginning, vaccination’s most avid proponents acknowledged the complex challenge of generating vaccine-mediated protection. The annoying persistence of vaccine failure prompted vaccine scientists to experiment continually with new vaccine technologies and move beyond the “three I’s” originated during Pasteur’s era (“isolating infectious agents, cultivating and inactivating them…and injecting the obtained product”). Twenty-first-century vaccine developers now draw on cutting-edge fields and techniques such as genetic and protein engineering, immune profiling, synthetic biology, combinatorial chemistry and bioinformatics. Their end goal is to “circumvent” a number of befuddling obstacles, including “hypervariable viruses,” pathogens that require repeat immunization, heterogeneous individual- and population-level vaccine outcomes—and declining public confidence in vaccine safety—to ensure seamless expansion of the modern vaccine “armamentarium.”

Traditional vaccines and safety concerns

Many traditional vaccines are built around a lab-weakened (attenuated) version of a live virus (or, less frequently, a bacterium). Examples of live-attenuated vaccines include measles-mumps-rubella (MMR), varicella (chickenpox), rotavirus, shingles and, in some countries, tuberculosis (BCG). Because live antigens provide continual “stimulation,” the Centers for Disease Control and Prevention (CDC) proclaims this type of vaccine “the closest thing to a natural infection.” Even in weakened form, however, live pathogens can mutate toward greater virulence and reversal of attenuation; these types of vaccines, therefore, always come with “a degree of unpredictability.” The live-attenuated shingles vaccine, for example, has been linked to serious vaccine-related adverse events such as asthma exacerbation, polymyalgia rheumatica, congestive heart failure and pulmonary edema.

Another longstanding type of vaccine, the toxoid vaccine, takes a disease-causing toxin initially generated by bacteria and weakens it using heat or chemicals, turning it into a toxoid. The weakened diphtheria and tetanus components of the DTaP vaccine are toxoids. Because these vaccines elicit weak immunity on their own, they generally come bundled with aluminum adjuvants to rev up the immune response—despite the known neurotoxicity of injected aluminum and the availability of safer alternatives. As with the live-attenuated vaccines, there is potential for “reversal of the toxoids to their toxigenic forms.”

Moreover, with insufficient inactivation, the pathogen may linger as a stealth agent capable of causing disease.

Production of inactivated vaccines involves growing viruses or bacteria under controlled conditions and killing them with heat, radiation or a chemical such as formaldehyde. These vaccines pack a less consistent immunological punch than the live-attenuated vaccines and, therefore, tend to be recommended in multiple doses “to build up and/or maintain immunity.” Modern-day examples include the inactivated polio vaccine, the hepatitis A vaccine, some influenza shots and the whole-cell pertussis vaccine. Health agencies tout the greater safety of inactivated vaccines (as compared to live-attenuated vaccines), but inactivated vaccines have displayed disturbing rates of adverse events in some subpopulations. Moreover, with insufficient inactivation, the pathogen may linger as a stealth agent capable of causing disease. A 2001 study presented immunological evidence that active bacterial toxins “residual” in whole-cell pertussis vaccine were responsible for a range of neurologic disturbances, including “local, systemic and neuronal reactions.”

Figure 1 (Source: Genscript)

 Risks of second-generation vaccines

In the latter part of the 20th century, vaccine scientists began moving beyond simple attenuation or inactivation of pathogens toward greater manipulation of genes and antigens as well as more complex strategies to activate and sustain immunity. The somewhat overlapping categories of subunit, recombinant, polysaccharide and conjugate vaccines all refer to vaccines that use specific components of a pathogen as antigens rather than the pathogen in its entirety.

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Subunit vaccines seek to zero in on and isolate “any specific part of the pathogen which has been demonstrated to stimulate a protective immune response.” Production of subunit vaccines can involve breaking apart a microbe with chemicals to collect the antigens of interest, or, increasingly, using recombinant DNA technology (gene splicing). Examples of the latter are the recombinant hepatitis B and human papillomavirus (HPV) vaccines. The hepatitis B vaccine—the first synthetic vaccine put into use—is made by inserting selected hepatitis B genes into common baker’s yeast (called an “expression system”) and then using the yeast to produce vaccine antigens. (In addition to yeast, current recombinant vaccines rely on bacteria, mammalian cells or insect cells as expression systems.) Yeast-based vaccines have been linked to a rise in autoimmunitydue to the similarity between a yeast component and human glycoproteins. Moreover, because subunit vaccines provide “no guarantee that immunological memory will be formed in the correct manner,” they “demand” the use of potent adjuvants. The Gardasil-9 vaccine (for HPV) contains more than twice the amount of aluminum adjuvant as Gardasil.

Live recombinant vector vaccines are reputed to be “safer than live vaccines made without recombinant technology and more effective than ‘killed’ vaccines,” but doubts about this assertion recently arose in the Philippines. The country suspended rollout of the world’s first approved vaccine for dengue (Dengvaxia) after reports emerged that the four-strain live recombinant vaccine had resulted in deaths and worsened disease outcomes.

…but Hib-related reports to the Vaccine Adverse Event Reporting System (VAERS) indicate that close to one-fifth of adverse reactions are serious…

Pathogenic bacteria that have an outer coating of sugar molecules called polysaccharides can fool the immune system and enhance the bacteria’s ability to cause disease. Over the past three to four decades, two types of vaccines have targeted those bacteria: the older unconjugated polysaccharide vaccines and polysaccharide conjugate vaccinesthat chemically attach bacterial coat antigens to a carrier protein. The Haemophilus influenzae type b (Hib) vaccine was the first conjugate vaccine to be licensed and added to the U.S. vaccine schedule, along with subsequent pneumococcal and meningococcal conjugate vaccines. Vaccine experts promote conjugate vaccines as safe and efficacious, but Hib-related reports to the Vaccine Adverse Event Reporting System (VAERS)—a passive reporting system that captures a tiny percentage of actual adverse reactions—indicate that close to one-fifth (17%) of adverse reactions are serious, including sudden infant death and neurologic and gastrointestinal conditions.

More risks on the horizon

Given that vaccines are one of the pharmaceutical industry’s most profitable product lines, with no product liability and 84% growth in global vaccine revenues predicted for 2014-2020, more are in the works. Many emerging technologies seem to be intended to close vaccination loopholes and expand vaccine markets. These include development of:

  • Fully synthetic conjugate vaccines for non-infectious conditions
  • Recombinant vaccines that use tobacco-based molecular farming
  • New vaccine delivery systems to “control the spatial and temporal presentation of antigens to [the] immune system thus leading to their sustained release and targeting”— including micro- and nanoparticulate systems such as “polymeric particles, liposomes, virus-like particles, virosomes, immunostimulating complexes (ISCOMs), emulsions, and inorganic nanobeads”
  • Adjuvant “systems” to boost immunogenicity, including squalene nanoemulsions
  • Mucosal vaccines, including mucosal DNA vaccines using live bacterial vectors
…FDA: ‘the technology used to make these vaccines actually exceeds the science and technology to understand how these vaccines work and to predict how they will work.’

Alarmingly, some scientists now are extolling the potential benefits of recombinant transmissible vaccines to overcome “challenging scenarios for efficient vaccine delivery.” When introduced into the host population, this type of vaccine would “spread autonomously and sufficiently to eradicate an existing pathogen or prevent future infection by a pathogen not yet present.” Stated another way, “for every individual that is immunized directly, additional individuals are immunized indirectly”—no consent required.

Current vaccine scientists who are busily celebrating a brave new world of “rational” and “directed” vaccine development would do well to heed remarks made by a Food and Drug Administration (FDA) official at the Center for Biologics Evaluation & Research (CBER) almost 20 years ago. At a 1999 vaccination forum, the Director of CBER’s Viral Products Division described grave vaccine safety challenges that were emerging in tandem with new vaccine technologies and frankly admitted that “the technology used to make these vaccines actually exceeds the science and technology to understand how these vaccines work and to predict how they will work” [emphasis added]. This startling statement suggests that now, more than ever, vaccine safety claims need to be rigorously and carefully evaluated.

In Part Two, World Mercury Project will explore how vaccine technologies are outpacing scientists’ ability to evaluate vaccine safety.

Sign up for free news and updates from Robert F. Kennedy, Jr. and the World Mercury Project. Your donation will help to support us in our efforts.

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Alternative News

12,000 Doctors Urge the FDA to Put Cancer Warnings on Cheese

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In Brief

  • The Facts:

    The Physicians Committee for Responsible Medicine (PCRM) recently submitted a citizen petition with the Food and Drug Administration (FDA) to change labeling on cheese to include a cancer warning.

  • Reflect On:

    Why have our federal health regulatory agencies and big food companies marketed dairy products as safe, healthy and necessary when the science clearly suggests otherwise.

What do doctors learn about nutrition in medical school? Shockingly and unfortunately, nothing. Why? Because nutrition does not bring in profit, and treating people with nutrition hasn’t seemed to be an option at all ever since the birth of the mainstream medical industry. The sad reality is that “the medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.” – Arnold Seymour Relman (source)

Thankfully, things are changing and changing fast. A lot of people are taking their nutritional education into their own hands, and many doctors are also educating themselves on the power of nutrition through the plethora studies and clinical evidence that’s available out there.

One of the latest examples of doctors educating themselves comes from the Physicians Committee for Responsible Medicine (PCRM), who recently submitted a citizen petition with the Food and Drug Administration (FDA) to change labeling on cheese to include a cancer warning.

Why? Because based on the research, cheese, and dairy from the animal of another is not good, but bad for us. This reality may be hard for many to believe given the fact that it’s been one of the stable food groups for so long. It’s time we start recognizing that “nutritional education” that we grow up with is a product of the big food companies and marketing, it’s not backed by any science and more people are starting to become aware of what the science is actually showing us.

The petition states:

Dairy cheese contains reproductive hormones that may increase breast cancer mortality risk. (This sentence is what they want on dairy cheese products).

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High-fat dairy products, such as cheese, are associated with an increased risk for breast cancer. Components in dairy such as insulin-like growth factor (IGF-1) and other growth hormones may be among the reasons for the increased risk for cancer.

To ensure that Americans understand the potential significant risks, and resulting long-term costs, of consuming dairy cheese products, the FDA should ensure that the notice above is prominently placed on product packaging and labeling for all dairy cheese products.

I find it interesting that they mention IGF-1 growth hormone.

A 2015 study published in Cell Metabolism is one of multiple studies that points out:

Mice and humans with Growth Hormone Receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents (n=6,381) aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality during an 18 year follow up period. These associations were either abolished or attenuated if the source of proteins was plant-based.

The study above corroborates with a lot of other research showing that animal protein skyrockets IFG-1 growth hormone, thus leading to a wide variety of diseases, in the long term, including cancer. The interesting thing is that protein from plants, as the study points out, “abolished or attenuated” these associations “if the source of proteins was plant-based.”

Fasting has been shown to reduce the risk and even reverse many age related diseases, like Parkinson’s and Alzheimer’s. It’s also been shown to regenerate stem cells and slow down the overall aging process, much of that is due to the fact that fasting drops our IGF-1 growth hormone levels.

A recent study conducted by researchers in California and France found that meat protein is associated with a very sharp increased risk of heart disease, while protein from nuts and seeds is actually beneficial for the human heart.

The study is titled “Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality: The Adventist Health Study-2 cohort,” It was a joint project between researchers from Loma Linda University School of Public Health in California and AgroParisTech and the Institut National de la Recherche Agronomique in Paris, France.

It was published in the International Journal of Epidemiology. The researchers found that people who ate large amounts of meat protein, which is a daily norm for many people, represented a portion of the human population that would experience a 60 percent increase in cardiovascular disease (CVD), while people who consumed large amounts of protein from nuts and seeds actually experienced a 40 percent reduction in CVD.

Dairy “Turning on Cancer.”

Doctor Colin Campbell. author of the “China Study”  discovered that animal protein (casein) can accelerate and “turn on” cancer, while plant based protein has the opposite effect.

“What I did during the early part of my career was nothing more than what traditional science would suggest. I made the observation that diets presumably higher in animal protein were associated with liver cancer in the Philippines. When coupled with the extraordinary report from India showing that casein fed to experimental rats at the usual levels of intake dramatically promoted liver cancer, it prompted my 27-year-long study The China Project, of how this effect worked. We did dozens of experiments to see if this was true and, further, how it worked.” – Dr Colin Campbell, (China Study)

Campbell is an American biochemist who specializes in the effect of nutrition on long term health. He is Professor Emeritus of Nutritional Biochemistry at Cornell University, he has a Ph.D. in nutrition, biochemistry, and microbiology. Scholars like Campbell and their work is so important in a world of medical education and academia that almost completely ignores nutrition.

Casein is the most relevant chemical carcinogen ever identified, make no mistake about it. (source)

Campbell went beyond mere correlation and found using animal studies he conducted that casein actually “turns on” cancer. When animals were fed a diet high in casein, the cancer increased dramatically. What’s even more interesting is when they decided to do a comparison using plant protein.

What we learned along the way is that we could turn on and turn off cancer. Turn it on by increasing casein consumption, turn it off by decreasing it or replacing it with plant protein. That was a really exciting thing that we could take nutrition and turn cancer on and off, I mean that, that was pretty startling. – Campbell (source)

The Takeaway

We are the only species on the planet that consumes the dairy of another animal after weaning.  The reduction of lactase activity after infancy is a genetically programmed event. Approximately 75 % of Earths population is lactose intolerant for a reason, because it’s perfectly natural. We are not meant to drink the milk of another animal and we had to evolve the gene to digest it.  The statistics vary from race to race and country to country but overall they show an abnormal amount of individuals who qualify. In some Asian countries, 90 percent of the population is lactose intolerant.

It seems the big food companies convinced us that it’s a requirement, and that it’s healthy. They used protein and calcium (both of which are present in a number of plant sources, for example) as mass marketing tools to push dairy products on the population in order to turn a very large profit, all at the health expense of human beings.

This is one of multiple examples off mass perception manipulation.

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Consciousness

California’s First Surgeon General: Screen Every Student For Childhood Trauma

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In Brief

  • The Facts:

    California's first surgeon general Dr. Nadine Burke Harris has a dream to screen children for childhood trauma before entering schools in an attempt to help them process these experiences to avoid developmental issues.

  • Reflect On:

    Is it time we take an entirely new societal and cultural approach to the emotional challenges we collectively face? Is it time we take personal responsibility for the communities we live within?

California’s first surgeon general, Dr. Nadine Burke Harris, has an ambitious goal to screen every student for childhood trauma before entering school. Dr. Harris has dedicated her career to changing the way society views and responds to childhood trauma. This is a worthwhile effort as research shows childhood trauma affects brain development and it will build a society that is more empathetic to all and unique situations.

Why it matters: While some feel this is not the job of state to determine this, and in the wrong hands this could appear to be a pharmaceutical nightmare, it appears Dr. Harris’ specifics are going in the right direction. Reframing ‘disorders’ doctors simply don’t seem to understand is an important step in helping kids.

“One thing that tipped me off was the number of kids being sent to me by schools — principals, teachers and administrators — with ADHD […] “What I found was that many of the kids were experiencing signs of adversity, and there seemed to be a strong association between adversity and the trauma they experienced and school functioning.”

Already, Dr. Harris’ research team has found that kids who had experienced severe trauma were 32 times more likely to be diagnosed with learning and behavioural problems than kids who had not. Further pointing to the fact that many of the challenges we face in society come from challenging times and emotions that never get processed.

We live in a time where emotional intelligence and self-awareness are extremely undeveloped across the globe, and this is not being taught to enough people, especially at a young age.

The conscious takeaway: There is no doubting the fact that we need more community in our world. And while people doubt the creation of community in the wrong hands, it doesn’t mean all have nefarious intentions. Raising awareness about topics such as this whereby a leader truly feels that blanket statements like ADHD don’t really tell us anything about a child and we must look deeper, is a great thing!

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Imagine a world where education and societal culture did focus on things like emotional intelligence and helping people process their challenging experiences? We all know telling someone to just ‘buck up and let it go’ hasn’t brought us to a good space, perhaps it’s time for an entire cultural shift? This, after all, has been what we have been creating here at Collective Evolution for the last 10 years.

This story very much plays into steps 2, 3 and 4 of the CE Protocol. Awakening neutrality within people, deprogramming our limitations and then living aligned with our true and authentic self.

“When you have a whole community making real change, you can have a big and lasting change.” – Dr. Nadine Burke Harris

Looking deeper: Currently, the approach to children who are ‘problems’ in school is to get rid of them or medicate them. In fact, there are over 20 million schoolchildren who are being prescribed stimulants and psychotropic drugs according to Citizens Commission on Human Rights. Most of the public is not even aware of this. While big pharma profits huge with an unconscious approach to these challenges, society suffers greatly.

It’s truly time for something different, and all you have to ask yourself is are we capable of creating more peace within our youth and society? If yes, a new approach is needed.

20 Million Schoolchildren Have Been Prescribed Psychiatric Drugs Known to Cause Suicidal Thoughts

More Public Schools Choosing Meditation Over Detention & Teaching Mindfulness Practices

 

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Awareness

7 Ways to Prevent and Even Reverse Heart Disease with Nutrition

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In Brief

  • The Facts:

    This article was written by Sayer Ji. Founder of Greenmedinfo.com. Posted here with permission.

  • Reflect On:

    Heart disease, while still the #1 cause of mortality in the developed world, can be prevented and even reversed with nutritional interventions, according to a growing body of scientific research.

Considering that heart disease is the #1 cause of death in the developed world, anything that can prevent or reduce cardiac mortality, or slow or even reverse the cardiovascular disease process, should be of great interest to health professionals and the general public alike.

Sadly, millions are still unaware of the extensive body of biomedical literature that exists supporting the use of natural compounds for preventing and even reversing heart disease, which we have indexed on GreenMedInfo.com.

Instead, they spend billions of healthcare dollars annually on highly toxic cholesterol-lowering pharmaceuticals such as statin drugs which have known cardiotoxicity, among 300 other proven side effects, simply because their doctors told them to do so. Bad advice is the rule and not the exception here. For instance, after decades of recommending a so-called ‘low dose’ aspirin to prevent heart disease and stroke, the weight of evidence now points to it being a cause of significantly more harm than good: Doctors Reverse Decades Old Aspirin Recommendation: Deadly Risks Outweigh Benefits for Heart Disease & Stroke

So, with this in mind, let’s look at a small but significant sample of natural, food-based alternatives to these drugs through the lens of the clinical and biomedical literature itself.

Three Natural Substances that Reduce the Risk of Heart-Related Death

  • Omega-3 Fatty Acids: There is a robust body of research indicating that the risk of sudden cardiac death is reduced when consuming higher levels of omega-3 fatty acids. Going all the way back to 2002, the New England Journal of Medicine published a study titled, “Blood levels of long-chain n-3 fatty acids and the risk of sudden death,” which found: “The n-3 fatty acids found in fish are strongly associated with a reduced risk of sudden death among men without evidence of prior cardiovascular disease.” Another 2002 study, published in the journal Circulation, found that Omega-3 fatty acid supplementation reduces total mortality and sudden death in patients who have already had a heart attack.[i] For additional research, view our dataset on the topic of Omega-3 fatty acids and the reduction of cardiac mortality. It should be noted that the best-selling cholesterol drug class known as statins may actually reduce the effectiveness of omega-3 fats at protecting the heart. This has been offered as an explanation as to why newer research seems to show that consuming omega-3 fats does not lower the risk of cardiac mortality.
  • Vitamin D: Levels of this essential compound have been found to be directly associated with the risk of dying from all causes. Being in the lowest 25% percent of vitamin D levels is associated with a 26% increased rate of all-cause mortality.[ii] It has been proposed that doubling global vitamin D levels could significantly reduce mortality.[iii] Research published in the journal Clinical Endocrinology in 2009 confirmed that lower vitamin D levels are associated with increased all-cause mortality but also that the effect is even more pronounced with cardiovascular mortality.[iv] This finding was confirmed the same year in the Journal of the American Geriatric Society, [v] and again in 2010 in the American Journal of Clinical Nutrition.[vi]
  • Magnesium: In a world gone mad over taking inorganic calcium supplementation for manufactured diseases such as T-score defined “osteopenia” or “osteoporosis,”despite their well-known association with increased risk of cardiac mortality, magnesium’s role in protecting against heart disease cannot be overstressed. It is well-known that even the accelerated aging of the heart muscle experienced by those in long space flight is due to magnesium deficiency. In 2010, the Journal of Biomedical Sciences reported that cardiovascular risks are significantly lower in individuals who excrete higher levels of magnesium, indicating its protective role.[vii] Another study published in the journal Atherosclerosis in 2011 found that low serum magnesium concentrations predict cardiovascular and all-cause mortality.[viii] Remember that when you are looking to ‘supplement’ your diet with magnesium go green. Chlorophyll is green because it has a magnesium atom at its center. Kale, for example, is far better a source of complex nutrition than magnesium supplements. But, failing the culinary approach, magnesium supplements can be highly effective at attaining a therapeutic and/or cardioprotective dose.

For an additional list of compounds that may reduce cardiac mortality, including cocoa, tea, wine and yes, even cholesterol itself, view our Reduce Cardiac Mortality page.

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Four Natural Compounds Which May Unclog the Arteries

  • Pomegranate: this remarkable fruit has been found in a human clinical study to reverse the carotid artery thickness (i.e. blockage) by up to 29% within 1 year[ix] There are a broad range of mechanisms that have been identified which may be responsible for this effect, including: 1) lowering blood pressure 2) fighting infection (plaque in arteries often contains bacteria and viruses) 3) preventing cholesterol oxidation 4) reducing inflammation.[x]
  • Arginine: Preclinical and clinical research indicates that this amino acid not only prevents the progression of atherosclerosis but also reverses pathologies associated with the process. (see also: Clogged Arteries and Arginine). One of the mechanisms in which it accomplishes this feat is by increasing the production of nitric oxide which is normally depressed in blood vessels where the inner lining has been damaged (endothelium) resulting in dysfunction.
  • Garlic: Not only has garlic been found to reduce a multitude of risk factors associated with arteriosclerosis, the thickening and hardening of the arteries, but it also significantly reduces the risk of heart attack and stroke.[xi] In vitro research has confirmed that garlic inhibits arteriosclerotic plaque formation.[xii] Aged garlic extract has also been studied to inhibit the progression of coronary artery calcification in patients receiving statin therapy.[xiii] And let us not forget, garlic’s benefits are extremely broad. We have identified over 150 diseases that this remarkable culinary and medicinal herb has been confirmed to be of potential value in treating and preventing and which can be viewed here: Garlic Health Benefits.
  • B-Complex: One of the few vitamin categories that has been confirmed in human studies to not only reduce the progression of plaque buildup in the arteries but actually reverse it is B-complex. A 2009 study published in the journal Stroke found that high dose B-complex vitamin supplementation significantly reduces the progression of early-stage subclinical atherosclerosis in healthy individuals.[xiv] More remarkably, a 2005 study published in the journal Atherosclerosis found a B-vitamin formula decreased the carotid artery thickness in patients at risk for cerebral ischemia.[xv] Another possible explanation for these positive effects is the role B-vitamins have in reducing the production of homocysteine, an artery and otherwise blood vessel scarring amino acid.[xvi]

For additional research on artery unclogging substances visit our page dedicated to the topic Unclogging Arteries.

Additional Heart Unfriendly Things To Avoid

No discussion of preventing cardiac mortality would be complete without discussing things that need to be removed in order to reduce risk, such as:

  • NSAIDs: Drugs like aspirin, ibuprofen, and Tylenol, have well-known association with increased cardiac mortality. Review six studies on the topic here: NSAID Cardiotoxicity.
  • Statin Drugs: It is the height of irony that the very category of drugs promoted to millions globally as the standard of care for primary and secondary prevention of cardiovascular disease and cardiac mortality are actually cardiotoxic agents, linked to no less than 300 adverse health effects. Statin drugs have devastating health effects. Explore the research here: Statin Drug Health Effects.
  • Wheat: while this connection is rarely discussed, even by those who promote grain-free and wheat free diets, wheat has profound cardiotoxic potential, along with over 200 documented adverse health effects: Wheat Toxicity. And why wouldn’t it, when the very countries that eat the most of it have the highest rate of cardiovascular disease and heart-related deaths? For an in-depth explanation read our article: Wheat’s Cardiotoxicity: As Serious As A Heart Attack.

Finally, for additional research on the topic of heart health promoting strategies visit our Health Guide: Heart Health. Interested in healing an injured heart? Read about cardiac tissue regeneration: 6 Bodily Tissues That Can Be Regenerated Through Nutrition.


References

[i] Roberto Marchioli, Federica Barzi, Elena Bomba, Carmine Chieffo, Domenico Di Gregorio, Rocco Di Mascio, Maria Grazia Franzosi, Enrico Geraci, Giacomo Levantesi, Aldo Pietro Maggioni, Loredana Mantini, Rosa Maria Marfisi, G Mastrogiuseppe, Nicola Mininni, Gian Luigi Nicolosi, Massimo Santini, Carlo Schweiger, Luigi Tavazzi, Gianni Tognoni, Corrado Tucci, Franco Valagussa,. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002 Apr 23;105(16):1897-903. PMID: 11997274

[ii] Michal L Melamed, Erin D Michos, Wendy Post, Brad Astor. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008 Aug 11;168(15):1629-37. PMID: 18695076

[iii] W B Grant. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr. 2011 Jul 6. Epub 2011 Jul 6. PMID: 21731036

[iv] Stefan Pilz, Harald Dobnig, Giel Nijpels, Robert J Heine, Coen D A Stehouwer, Marieke B Snijder, Rob M van Dam, Jacqueline M Dekker. Vitamin D and mortality in older men and women. Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. Epub 2009 Feb 18. PMID: 19226272

[v] Adit A Ginde, Robert Scragg, Robert S Schwartz, Carlos A Camargo. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults. J Am Geriatr Soc. 2009 Sep;57(9):1595-603. Epub 2009 Jun 22. PMID: 19549021

[vi] Karl Michaëlsson, John A Baron, Greta Snellman, Rolf Gedeborg, Liisa Byberg, Johan Sundström, Lars Berglund, Johan Arnlöv, Per Hellman, Rune Blomhoff, Alicja Wolk, Hans Garmo, Lars Holmberg, Håkan Melhus. Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am J Clin Nutr. 2010 Oct;92(4):841-8. Epub 2010 Aug 18. PMID: 20720256

[vii] Yukio Yamori, Takashi Taguchi, Hideki Mori, Mari Mori. Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world. J Biomed Sci. 2010;17 Suppl 1:S21. Epub 2010 Aug 24. PMID: 20804596

[viii] Thorsten Reffelmann, Till Ittermann, Marcus Dörr, Henry Völzke, Markus Reinthaler, Astrid Petersmann, Stephan B Felix. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011 Jun 12. Epub 2011 Jun 12. PMID: 21703623

[ix] Sayer Ji, Research: Pomegranate May Reverse Blocked Arteries

[x] GreenMedInfo.com, Pomegranate’s Health Benefits

[xi] G Siegel, A Walter, S Engel, A Walper, F Michel. [Pleiotropic effects of garlic]. Wien Med Wochenschr. 1999;149(8-10):217-24. PMID: 10483684

[xii] Günter Siegel, Frank Michel, Michael Ploch, Miguel Rodríguez, Martin Malmsten. [Inhibition of arteriosclerotic plaque development by garlic]. Wien Med Wochenschr. 2004 Nov;154(21-22):515-22. PMID: 15638070

[xiii] Matthew J Budoff, Junichiro Takasu, Ferdinand R Flores, Yutaka Niihara, Bin Lu, Benjamin H Lau, Robert T Rosen, Harunobu Amagase. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004 Nov;39(5):985-91. PMID: 15475033

[xiv] Howard N Hodis, Wendy J Mack, Laurie Dustin, Peter R Mahrer, Stanley P Azen, Robert Detrano, Jacob Selhub, Petar Alaupovic, Chao-ran Liu, Ci-hua Liu, Juliana Hwang, Alison G Wilcox, Robert H Selzer,. High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke. 2009 Mar;40(3):730-6. Epub 2008 Dec 31. PMID: 19118243

[xv] Uwe Till, Peter Röhl, Almut Jentsch, Heiko Till, Andreas Müller, Klaus Bellstedt, Dietmar Plonné, Horst S Fink, Rüdiger Vollandt, Ulrich Sliwka, Falko H Herrmann, Henning Petermann, Reiner Riezler. Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12. Atherosclerosis. 2005 Jul;181(1):131-5. Epub 2005 Feb 16. PMID: 15939064

[xvi] Claudio Maldonado, Chirag V Soni, Nathan D Todnem, Sathnur Pushpakumar, Dorothea Rosenberger, Srikanth Givvimani, Juan Villafane, Suresh C Tyagi. Hyperhomocysteinemia and sudden cardiac death: potential arrhythmogenic mechanisms. Curr Vasc Pharmacol. 2010 Jan;8(1):64-74. PMID: 19485933

Originally published: 2018-08-05

Aritcle updated: 2019-07-24


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