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The Changing Face of Vaccinology

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Vaccines are “immunogenic formulations” intended to protect vaccinated individuals by inducing production of antibodies and cell-mediated immune responses to combat infectious (and sometimes noninfectious) conditions. Historians trace the roots of modern vaccinology—the science of vaccine development—to the dicey practices of smallpox inoculation and variolation that began in the 1700s. About a century later, in 1885, Pasteur developed and administered a rabies vaccine to humans. Although these and other early vaccines produced mixed real-world results and generated warnings of potentially serious postvaccinal complications, mass vaccination nonetheless took off without a backward glance.

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Even from the beginning, vaccination’s most avid proponents acknowledged the complex challenge of generating vaccine-mediated protection. The annoying persistence of vaccine failure prompted vaccine scientists to experiment continually with new vaccine technologies and move beyond the “three I’s” originated during Pasteur’s era (“isolating infectious agents, cultivating and inactivating them…and injecting the obtained product”). Twenty-first-century vaccine developers now draw on cutting-edge fields and techniques such as genetic and protein engineering, immune profiling, synthetic biology, combinatorial chemistry and bioinformatics. Their end goal is to “circumvent” a number of befuddling obstacles, including “hypervariable viruses,” pathogens that require repeat immunization, heterogeneous individual- and population-level vaccine outcomes—and declining public confidence in vaccine safety—to ensure seamless expansion of the modern vaccine “armamentarium.”

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Traditional vaccines and safety concerns

Many traditional vaccines are built around a lab-weakened (attenuated) version of a live virus (or, less frequently, a bacterium). Examples of live-attenuated vaccines include measles-mumps-rubella (MMR), varicella (chickenpox), rotavirus, shingles and, in some countries, tuberculosis (BCG). Because live antigens provide continual “stimulation,” the Centers for Disease Control and Prevention (CDC) proclaims this type of vaccine “the closest thing to a natural infection.” Even in weakened form, however, live pathogens can mutate toward greater virulence and reversal of attenuation; these types of vaccines, therefore, always come with “a degree of unpredictability.” The live-attenuated shingles vaccine, for example, has been linked to serious vaccine-related adverse events such as asthma exacerbation, polymyalgia rheumatica, congestive heart failure and pulmonary edema.

Another longstanding type of vaccine, the toxoid vaccine, takes a disease-causing toxin initially generated by bacteria and weakens it using heat or chemicals, turning it into a toxoid. The weakened diphtheria and tetanus components of the DTaP vaccine are toxoids. Because these vaccines elicit weak immunity on their own, they generally come bundled with aluminum adjuvants to rev up the immune response—despite the known neurotoxicity of injected aluminum and the availability of safer alternatives. As with the live-attenuated vaccines, there is potential for “reversal of the toxoids to their toxigenic forms.”

Moreover, with insufficient inactivation, the pathogen may linger as a stealth agent capable of causing disease.

Production of inactivated vaccines involves growing viruses or bacteria under controlled conditions and killing them with heat, radiation or a chemical such as formaldehyde. These vaccines pack a less consistent immunological punch than the live-attenuated vaccines and, therefore, tend to be recommended in multiple doses “to build up and/or maintain immunity.” Modern-day examples include the inactivated polio vaccine, the hepatitis A vaccine, some influenza shots and the whole-cell pertussis vaccine. Health agencies tout the greater safety of inactivated vaccines (as compared to live-attenuated vaccines), but inactivated vaccines have displayed disturbing rates of adverse events in some subpopulations. Moreover, with insufficient inactivation, the pathogen may linger as a stealth agent capable of causing disease. A 2001 study presented immunological evidence that active bacterial toxins “residual” in whole-cell pertussis vaccine were responsible for a range of neurologic disturbances, including “local, systemic and neuronal reactions.”

Figure 1 (Source: Genscript)

 Risks of second-generation vaccines

In the latter part of the 20th century, vaccine scientists began moving beyond simple attenuation or inactivation of pathogens toward greater manipulation of genes and antigens as well as more complex strategies to activate and sustain immunity. The somewhat overlapping categories of subunit, recombinant, polysaccharide and conjugate vaccines all refer to vaccines that use specific components of a pathogen as antigens rather than the pathogen in its entirety.

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Subunit vaccines seek to zero in on and isolate “any specific part of the pathogen which has been demonstrated to stimulate a protective immune response.” Production of subunit vaccines can involve breaking apart a microbe with chemicals to collect the antigens of interest, or, increasingly, using recombinant DNA technology (gene splicing). Examples of the latter are the recombinant hepatitis B and human papillomavirus (HPV) vaccines. The hepatitis B vaccine—the first synthetic vaccine put into use—is made by inserting selected hepatitis B genes into common baker’s yeast (called an “expression system”) and then using the yeast to produce vaccine antigens. (In addition to yeast, current recombinant vaccines rely on bacteria, mammalian cells or insect cells as expression systems.) Yeast-based vaccines have been linked to a rise in autoimmunitydue to the similarity between a yeast component and human glycoproteins. Moreover, because subunit vaccines provide “no guarantee that immunological memory will be formed in the correct manner,” they “demand” the use of potent adjuvants. The Gardasil-9 vaccine (for HPV) contains more than twice the amount of aluminum adjuvant as Gardasil.

Live recombinant vector vaccines are reputed to be “safer than live vaccines made without recombinant technology and more effective than ‘killed’ vaccines,” but doubts about this assertion recently arose in the Philippines. The country suspended rollout of the world’s first approved vaccine for dengue (Dengvaxia) after reports emerged that the four-strain live recombinant vaccine had resulted in deaths and worsened disease outcomes.

…but Hib-related reports to the Vaccine Adverse Event Reporting System (VAERS) indicate that close to one-fifth of adverse reactions are serious…

Pathogenic bacteria that have an outer coating of sugar molecules called polysaccharides can fool the immune system and enhance the bacteria’s ability to cause disease. Over the past three to four decades, two types of vaccines have targeted those bacteria: the older unconjugated polysaccharide vaccines and polysaccharide conjugate vaccinesthat chemically attach bacterial coat antigens to a carrier protein. The Haemophilus influenzae type b (Hib) vaccine was the first conjugate vaccine to be licensed and added to the U.S. vaccine schedule, along with subsequent pneumococcal and meningococcal conjugate vaccines. Vaccine experts promote conjugate vaccines as safe and efficacious, but Hib-related reports to the Vaccine Adverse Event Reporting System (VAERS)—a passive reporting system that captures a tiny percentage of actual adverse reactions—indicate that close to one-fifth (17%) of adverse reactions are serious, including sudden infant death and neurologic and gastrointestinal conditions.

More risks on the horizon

Given that vaccines are one of the pharmaceutical industry’s most profitable product lines, with no product liability and 84% growth in global vaccine revenues predicted for 2014-2020, more are in the works. Many emerging technologies seem to be intended to close vaccination loopholes and expand vaccine markets. These include development of:

  • Fully synthetic conjugate vaccines for non-infectious conditions
  • Recombinant vaccines that use tobacco-based molecular farming
  • New vaccine delivery systems to “control the spatial and temporal presentation of antigens to [the] immune system thus leading to their sustained release and targeting”— including micro- and nanoparticulate systems such as “polymeric particles, liposomes, virus-like particles, virosomes, immunostimulating complexes (ISCOMs), emulsions, and inorganic nanobeads”
  • Adjuvant “systems” to boost immunogenicity, including squalene nanoemulsions
  • Mucosal vaccines, including mucosal DNA vaccines using live bacterial vectors
…FDA: ‘the technology used to make these vaccines actually exceeds the science and technology to understand how these vaccines work and to predict how they will work.’

Alarmingly, some scientists now are extolling the potential benefits of recombinant transmissible vaccines to overcome “challenging scenarios for efficient vaccine delivery.” When introduced into the host population, this type of vaccine would “spread autonomously and sufficiently to eradicate an existing pathogen or prevent future infection by a pathogen not yet present.” Stated another way, “for every individual that is immunized directly, additional individuals are immunized indirectly”—no consent required.

Current vaccine scientists who are busily celebrating a brave new world of “rational” and “directed” vaccine development would do well to heed remarks made by a Food and Drug Administration (FDA) official at the Center for Biologics Evaluation & Research (CBER) almost 20 years ago. At a 1999 vaccination forum, the Director of CBER’s Viral Products Division described grave vaccine safety challenges that were emerging in tandem with new vaccine technologies and frankly admitted that “the technology used to make these vaccines actually exceeds the science and technology to understand how these vaccines work and to predict how they will work” [emphasis added]. This startling statement suggests that now, more than ever, vaccine safety claims need to be rigorously and carefully evaluated.

In Part Two, World Mercury Project will explore how vaccine technologies are outpacing scientists’ ability to evaluate vaccine safety.

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Boosting Your Mood and Improving Your Health With Vitamin D

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In Brief

  • The Facts:

    Vitamin D is essential for proper immune functioning and alleviation of inflammation.

  • Reflect On:

    Are you or someone you love suffering from depression or an autoimmune disorder? When is the last time you checked your Vitamin D levels?

Before you begin...

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Take a moment and breathe. Place your hand over your chest area, near your heart. Breathe slowly into the area for about a minute, focusing on a sense of ease entering your mind and body. Click here to learn why we suggest this.

Are you or someone you love suffering from depression or an autoimmune disorder? It appears vitamin D deficiency may be to blame.

Vitamin D is essential for proper immune functioning and alleviation of inflammation. The beneficial effects of vitamin D on protective immunity are due in part to its impact on the innate immune system and has numerous effects on cells within the immune system. Vitamin D is also involved in maintaining the proper balance of several minerals in the body. And, it helps to ward off the flu and many viruses and treat them. The latest research links vitamin D deficiency to many disease states. These disease states include cancer, osteoporosis, heart disease, depression, arthritis, and just about every other degenerative disease.

 “Vitamin D reduces depression. In a randomized, double-blind study, People with depression who received vitamin D supplements noticed a marked improvement in their symptoms.” – Journal of Internal Medicine

According to the Nutrition Research Journal, as many as 80% of people are deficient in vitamin D. Inadequate exposure to sunshine, poor eating habits, malabsorption, the VDR genetic mutation, and accelerated catabolism due to certain medications, dark skin pigment color, and too much sunscreen can be to blame. 

A doctor can check vitamin D levels with a simple blood test. Many mainstream doctors will suggest that you are within normal limits if your levels are 20-30ng/mL. However, for optimal health, the Endocrine Society and many functional medicine M.D.s and naturopaths will recommend levels of between 40-70 ng/mL for both children and adults. These doctors will also recommend a more aggressive replenishment program. For example, at age five, my son’s level was 24. The pediatrician recommended 500iu daily of supplementation, while our naturopath recommended 5,000iu daily for six months before retesting. Six months later, his levels were almost normal. 

“Through several mechanisms, vitamin D can reduce risk of infections. Those mechanisms include inducing cathelicidins and defensins that can lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lungs, leading to pneumonia, as well as increasing concentrations of anti-inflammatory cytokines” – PubMed

How to Increase Your Vitamin D Levels

Get enough sun. Vitamin D3, “the sunshine vitamin,” is the only vitamin your body that is made, with the help of the sun. So be sure to get enough sun exposure to help the body make this essential nutrient. Hold off trying to protect ourselves from the rays of the sun at every turn by slathering sunscreen. Allow yourself to play outside, garden, and enjoy the rays in moderation.

If you must use some sunscreen, avoid chemical sunscreens made with toxic chemicals that cause thyroid dysfunction, endocrine disruption, allergies, organ toxicity, reproductive toxicity, skin cancer, development, brain, and metabolism problems. Shop for natural mineral-zinc-based certified products instead. When exposed to scorching climates or in the sun for extended periods, we use sunscreens by Babyganics, Badger, Babo Botanicals, and Goddess Garden products.

Eat a well-balanced diet, with foods higher in vitamin D. Although it is believed that we only get twenty percent from the foods we eat. Some foods higher in D include cod liver oil, fish, oysters, eggs, and mushrooms. 

Get checked for the VDR mutation. A blood test will determine if you have mutations in the vitamin D receptor. The consequence can be lower vitamin D levels and the inability to absorb vitamin calcium and many other minerals properly. According to a 2020 scientific report, supplementation of vitamin D can help improve VDR gene expression, so more supplementation may be necessary if you have this mutation.

“Something so simple. Vitamin D supplementation could improve the health status of millions and so becomes an elegant solution to many of our health problems today.” – Carol L. Wagner, MD – Medical University of South Carolina

Supplementation 101. Supplementation is often critical if you cannot properly metabolize or absorb enough vitamin D or not get enough sunshine. In areas with long winters and specific populations of people with darker skin color, supplementation may be even more critical. There are many supplements on the market. However, many tablet forms are not as bioavailable and harder to absorb. Therefore, it has been recommended that liquid forms are better. In addition, liquid D is often suspended in olive oil, which helps the vitamins to absorb more easily since it is fat soluble. One of my favorite brands is by Seeking Health. It does not contain any impurities or allergy-inducing ingredients. 

Final Thoughts

Boosting the immune system naturally works on your body’s innate wisdom. It supports the body to operate like a well-oiled machine, protects it from unwanted pathogens and disease, and helps ensure a healthy body and mind.

To receive more info on how you and your family can overcome ADHD, apraxia, anxiety, and more without medication SIGN UP HERE or purchase my book Healing without Hurting.

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If you have been wanting to build your self awareness, improve your.critical thinking, become more heart centered and be more aware of bias, this is the perfect course!

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General

Are Lockdowns Affecting Children?

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CE Staff Writer 2 minute read

In Brief

  • The Facts:

    We spoke to activist and mother Stephanie Sibbio about her co-creation of an organization called 100 Million Moms which seeks to empower women to stand up against injustices.

  • Reflect On:

    Are we choosing virus mitigation methods that are short sighted and harmful over the long term? Are they more harmful than the virus itself?

Before you begin...

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Take a moment and breathe. Place your hand over your chest area, near your heart. Breathe slowly into the area for about a minute, focusing on a sense of ease entering your mind and body. Click here to learn why we suggest this.

The potential downsides of lockdowns during pandemics have been explored quite a bit – and the truth is the scientific community is quite divided on whether it’s the right move. On one hand a case can be made for effectiveness of lockdowns, but at quite a cost, while on the other hand many have shown lockdowns to be ineffective in slowing spread. How a study is organized and conducted can also dramatically change results.

Interestingly a study in Nature showed that “less disruptive and costly NPIs can be as effective as more intrusive, drastic, ones (for example, a national lockdown).” This essentially states that governments could choose effective ways to mitigate virus spread effectively without inducing unwanted and long term side effects on society as a whole via lockdowns – regardless, lockdowns are still widely being used.

One question we might have is, what about factors that are not so easy to measure right away? Things like long term psychological damage of being constantly stressed, out of touch with community and friends, and confined to our homes. What affects are children experiencing in their development and learning? We may not know exactly for quite some time.

I felt inspired to speak to a mother who has not only be asking this question with regards to her child, but who has decided to do something to push back against government measures, like lockdowns, that many citizens and scientist don’t agree with.

Along with another activist, Stephanie Sibbio created a movement called 100 Million Moms who, as their Instagram states, are a rights-based movement empowering moms all over the world to stand up against injustice. We advocate for natural health & medical freedom.

I spoke to Stephanie about how she has seen lockdowns affecting children, and her story in co-creating 100 Million Moms. In this discussion you will learn how you can get involved as well.

Further Discussion

A large meta analysis on mask wearing has shown that children are having physiological issues and learning challenges with prolonged mask wearing.

A group of doctors did a panel worth considering that discusses the potential harms of lockdowns and the science that supports the idea.

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Health

Rare Mineral Can Remove Harmful Toxins & Heavy Metals With Just 30 Seconds a Day

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Before you begin...

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Take a moment and breathe. Place your hand over your chest area, near your heart. Breathe slowly into the area for about a minute, focusing on a sense of ease entering your mind and body. Click here to learn why we suggest this.

These days many people are struggling with fatigue, heart and respiratory issues, brain fog and memory challenges, and on top of that, cancer rates are increasing year after year. At times these issues can be a result of cumulative stress and emotional trauma, and other times it can be the result of our overly toxic environments at home, at work and in our cities.

Most disease, cancers and health problems we experience are rooted in toxicity. Mercury, arsenic, lead, cadmium, pesticides, and volatile organic compounds just scratch the surface of what our bodies have to fight against daily.

By some estimates, we are exposed to over 80,000 chemicals in our daily lives, just from the food we eat, water we drink, and air we breathe. These toxins build up in our bodies affecting our sleep, memory, concentration, weight, and even inflammation (1, 2, 3, 4).

Toxins can be found everywhere, including:

  • Food (pesticides, herbicides, chemical additives)
  • Pollutants (the air you breathe)
  • Skincare and Personal Care Items
  • Household Items (couches, chairs, beds, Paint, keys)
  • Water (a common source of heavy metals)

Our body’s are natural detoxifiers, kidneys, liver, and lymphatic system is designed to keep our bodies clean. Hence detox is not needed. But as our lives become more toxin filled, our bodies have a difficult time keeping up and this is why over toxicity leading to disease is become a prevalent issue. Thankfully, there are natural solutions that can help. One of those solutions is a powerful mineral, created through a reaction of volcanic ash and seawater, that can eliminate dangerous toxins from the body, down to the cellular level.

Its negative-charge and honeycomb shape acts as a natural chelator, binding to positively-charged toxins and ushering them out of the body, quickly and effectively.

Zeolite Clinoptilolite: A Mineral for Detox

If you’ve heard of the zeolite Clinoptilolite, it’s because this type of zeolite has been widely studied for its ability to:

  • Flush heavy metals from the body, including toxic lead (5)
  • Provide alkalizing minerals to support a healthy pH
  • Protect kidney function by detoxing heavy metals (6)
  • Strengthen the immune system through removing toxins (7)
  • Protect against leaky gut by strengthening the intestinal wall (8)
  • And much more, as extensive clinical research shows (9)

The detoxification and health benefits of the zeolite Clinoptilolite are astounding. It’s hundreds of times more effective than activated charcoal, a commonly known and used detoxifier that can detox the gut but comes with harsh side effects.

The zeolite Clinoptilolite can bind to toxins throughout the whole body and has an affinity for toxins only, so it never removes beneficial minerals, and there are no negative side effects.

The truth of the matter is though, not all zeolite products work, and all are not created equally. In fact, we stayed away from zeolite here at CE for a while due to the fact we could not find a reliable source.

Most zeolite products are not capable of cleansing at the cellular level. To go beyond the gut and reach into cells for a deep detox, the zeolite must be nanosized. When the zeolite is nanosized and suspended in water molecule clusters, this natural detoxifier can travel throughout the body, even past the blood-brain barrier.

What brings on things like clearer thinking, ease in recalling tasks, improved mood and much more is the fact that your brain is now free of neurotoxic heavy metals.

But to take out heavy metals and other toxins, the zeolite must also be cleansed and pre-filled with alkalizing minerals. Why? The fact is, when mined, zeolite comes filled with environmental pollutants because that’s what zeolites are good at in nature – absorbing toxins.

However, if a zeolite is already filled with toxins, it can’t take any more from your body. That’s why most zeolites sold today don’t work, and why we haven’t recommended one before.

The Most Effective Zeolite on the Market Backed by Science

After doing extensive research, we started taking a zeolite product in December of 2020 from Pure Body Extra by a company called Touchstone Essentials. Their cleansing process and nanosizing technology is hands-down the most advanced we’ve seen, yielding the only zeolite on the market that can effectively detoxify the entire body on a cellular level.

This zeolite uses nanosized Clinoptilolite to access toxins everywhere in the body. These particles are so small they are invisible to the naked eye and need to be magnified thousand-fold. And it’s backed up by the gold standard in instrumentation – Malvern particle size testing.

This nanometer size means they can get to a cellular level, and it also means the collective surface area of the zeolite particles creates a vast filter that mops up toxins within hours.

And because these zeolite particles are encapsulated within water molecule clusters, it is delivered in a liquid spray that is easy to use (just a few sprays, morning, noon, and night) with no odor, no taste, and no hassle.

Pure Body Extra has also been cleansed of existing pollutants so that it more effectively removes heavy metals throughout your body. This is all proven with third-party independent clinical testing. Not only that, the zeolite particles are pre-filled with alkalizing minerals. That way, the zeolite “swaps” a beneficial mineral for a toxin every time.

In all our research, this zeolite product has the most rigorous research and testing.

 

Why We’re Recommending it Today

We take Pure Body Extra every single day and have been blown away by the results. We were so impressed that we reached out to the company about making this zeolite available to our readers.

It turns out, Touchstone is as passionate about prevention and natural treatments as we are, so they agreed to reserve 500 bottles of Pure Body Extra at an incredibly low price, exclusively for our readers. Which is why we’re recommending it to you now. It’s truly a miraculous product.

A Special Offer for Our Readers Only

Normally, this remarkable detoxifier sells on their website for $79.95, which is why we were shocked when Touchstone said they’d offer it to our readers for just $5. They’ll even include free shipping. We asked them how they could possibly offer it at such a low price, and this is what the company said.

“We’re on a mission to touch one million families with goodness. We know if we just get the product in people’s hands, the results are so good, people reorder it again and again. We’re happy to make a difference in people’s lives.”

When you subscribe to a monthly shipment today, not only is your first bottle $5, but you’ll lock in a 20% off member discount and free shipping every month after that. Of course, the 100% Risk-Free Guarantee remains.

There’s zero risk. You can cancel your subscription any time (before the next shipment), or return your shipment within 30 days for a full refund. They’ll even refund your $5 if you’re not happy with the product, less return shipping of course.

Imagine being free of disease-causing heavy metals, nitrosamines, volatile organic compounds, and pesticides in just 30 seconds a day, with no harsh side effects.

It’s only available to the first 500 people as that is what has been reserved for our audience, and at only $5, they’re selling quickly.

In today’s toxin-filled world, our body’s detoxification system simply can’t keep up with the daily onslaught. We all need to reduce our toxin load if we want to live happy, healthy lives.

 

Dive Deeper

Click below to watch a sneak peek of our brand new course!

Our new course is called 'Overcoming Bias & Improving Critical Thinking.' This 5 week course is instructed by Dr. Madhava Setty & Joe Martino

If you have been wanting to build your self awareness, improve your.critical thinking, become more heart centered and be more aware of bias, this is the perfect course!

Click here to check out a sneak peek and learn more.

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