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11 Hidden Causes Of Self-Harm & Psychiatric Disorders Almost No One Considers

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In Brief

  • The Facts:

    Policymakers and mental health providers are convinced that mental illness is organically formed or genetic. But there are 11 other proven contributors to the development of mental illness that we can no longer overlook.

  • Reflect On:

    What have you been led to believe about mental illness? And how many of these 11 hidden causes are embedded within your life or the life of a loved one?

Every day in the headlines we hear about another school shooting or another teen suicide. What is going on? Why aren’t we getting to the bottom of this? What are we doing to help prevent the next tragedy? As I learn about another, I get more and more frustrated that nothing is changing.

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We need to start taking a more in-depth look at why our children are so depressed, anxious, and angry – our lives depend on it. If not properly treated, obsessive thoughts turn into compulsive behavior, and we will hear about the next suicide or mass shooting when we turn on the news tomorrow.

What Is OCD?

Obsessive Compulsive Disorder (OCD) is categorized by the DSM-5 (the diagnostic manual and bible of psychiatry) as an anxiety disorder. However, it is a maladaptive coping skill that develops as a result of trying to manage the overwhelming fear or worry one feels. A person may start obsessively feeling nervous about a home intruder, so may check the alarm system or door locks fifty times before bed. One may fear the flu, so may wash their hands 50 times.

As an attempt to quiet the sense of alarm, the compulsion provides a “quick fix” for the negative intrusive thoughts.  It gives a temporary sense of power over the problem and helps someone feel like they are doing something about it. But it’s a trap because it just feeds into a vicious cycle. The more one follows the rituals, the more they need to do them.

The Darker Side of Obsessive Thoughts & Behaviours “Harm-OCD”

Intrusive thoughts can be benign, like song lyrics that continuously play in one’s head or obsessive behaviors like overly tidying one’s apartment. However, if paranoia, feelings of isolation, anger, and depression are already brewing it could lead to sinister thoughts like harming themselves or others.

Some believe that OCD can masquerade as psychosis as it closely mimics the symptoms of the psychiatric disorder schizophrenia. When a person gets lost inside their depressed and chaotic mind, they become infatuated with their depressive thoughts, violent video games, building bombs, guns, and revenge. Some begin planning their suicide, while others start stockpiling weapons to carry out the next mass shooting.

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A newer study published in the Journal of Molecular Psychiatry, concluded that “those with OCD are ten times more likely to commit suicide and patients with OCD are at significant risk of suicide, even in the absence of other psychiatric conditions.” Others with OCD have brutally violent thoughts of hurting others that consume one’s mind making it difficult separating visions from reality.

According to a study published in the Industrial Psychological Journal, anger attacks are associated with a surge of autonomic arousal. Symptoms include tachycardia, sweating, flushing, and a feeling of being out of control were present in half of the patients with obsessive-compulsive disorder, and they correlated with the presence of comorbid depression.

The Problem

Policymakers and mental health providers are so convinced that these individuals have an organic or genetic mental illness. They have called off the search for a better understanding of these conditions.  When they start recognizing the epidemic of teen suicide and teen violence, they call for more psychiatric labels and more psychiatrists to prescribe medication. However, they don’t acknowledge that medication does nothing to address the conditions that derail the mind in the first place. And, drugs often only mask symptoms without considering dangerous side-effects. Antidepressant medications are driving people to psychosis. In fact, Americans are admitted daily to psychiatric institutions as a direct result of psychosis caused by the drugs themselves.

The 11 Hidden Causes of Psychiatric Disorders Almost No One Considers

1. The Standard American Diet (SAD)

Neurotoxic chemicals and foods are void of essential nutrients and can lead to obsessive thoughts, depression and violent behavior.  There are extreme amounts of refined sugar/salt and thousands of chemicals allowed in the American food and drink supply. Many of them are harmless, but others such as artificial colors, flavors, preservatives, emulsifiers, high fructose corn syrup, sugar, hydrogenated vegetable oil, and glyphosate (GMOs) are not compatible with human bio-chemistry. They are destroying our immune system and causing many mental health symptoms. A CSPI report, Food Dyes: A Rainbow of Risks, further concludes that the nine artificial dyes approved in the United States are carcinogenic, cause hypersensitivity reactions and behavioral problems. Also, our food supply is so processed and refined that they do not contain adequate healthy protein and they strip away many vitamins and minerals that are essential to our health and replace it with synthetic substitutes.

In a 2014 article in the American Journal of Public Health, the relationship between diet and mental health in children and adolescents was evaluated. “There are numerous potential biological pathways by which diet quality may have an impact on mental health in children and adolescents.” First, a poor-quality diet that is lacking nutrient-dense foods may lead to nutrient deficiencies that have been associated with mental health issues. For example, the dietary intake of folate, zinc, and magnesium is inversely associated with depressive disorders, whereas dietary long-chain omega-3 fatty acids are inversely related to anxiety disorders.

2. Gut Dysbiosis

The gut microbiome has become a topic of major interest as of late, with a new focus specifically on psychiatric disorders. The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial immune and metabolic functions. In a June 2016 edition of the Journal of Molecular Psychiatry, the authors take a look at how microbes in the gut affect brain function, and how imbalances of gut bacteria can lead to mental illness. “Evidence is now emerging that, through interactions with the gut-brain axis, the bidirectional communication system between the central nervous system and the gastrointestinal tract, the gut microbiome can also influence neural development, cognition, mood, and behavior.”  Functional medicine M.D.s recognize how poor diet, pesticides, antibiotics, steroid use and other factors are influencing brain function by destroying healthy gut bacteria and negatively shaping the gut microbiome.

3. Food Sensitivities

Often not recognized in the mainstream mental health model, food allergies and sensitivities can wreck-havoc on mental health. The antibodies produced when a person consumes food that they have an intolerance to can cause intestinal permeability and trigger inflammation in the brain which can lead many mental health symptoms, including increased anxiety/OCD, insomnia, brain fog, hyperactivity, impulsivity, irritability, and rage. Overaggressive behaviors are provoked by an immune reaction to every-day foods. Reactions range from irritability to  aggression to psychosis. Some of the more common food intolerances are gluten, dairy, corn, soy, and nuts.

4. Pediatric Autoimmune Neuropsychiatric Disorders (PANDAS or PANS)

PANDAS is associated with an unresolved strep infection. It wreaks havoc on the immune and neurological system, causing brain encephalitis/inflammation. Symptoms associated with this autoimmune disorder are facial tics, OCD symptoms, anorexia, depression, paranoia, irritability, hyperactivity, sleep disturbances, and psychosis. Pediatric Autoimmune Neuropsychiatric Disorders (PANS) can be triggered by other infectious agents as well, including Epstein Barr and Lyme Disease. Many physicians who treat a large number of Lyme patients acknowledge that Lyme Disease can cause “Lyme Rage,” which includes psychosis and violent behavior. There are more than one hundred peer-reviewed medical journal articles linking tick-borne diseases to mental symptoms and quite a few that reference Lyme-induced rages.  As Dr. Kenneth Bock, MD points out in his book, “Healing New Childhood Epidemics,” PANDAS/PANS cook the brain of these kids.  The infection attacks the brain’s basal ganglia, causing severe thought malfunctions and maladaptive behavior. The affected person could fly into uncontrollable rages and violent behavior.

5. Genetic Mutations

Our genetic profile is not the end of our story. The environment in which we live and breathe, genetically modified foods and the chemicals we eat and inject have a direct influence on the expression of our genetic code, by altering the expression of genetic information. In the study of disease, researchers in the field of epigenetics are increasingly finding that the “turning on or off” of our DNA is affecting our mental health.

The MTHFR gene mutation inhibits the body’s ability to transform vitamin B12 into vital folate enzymes. A healthy MTHFR gene converts vitamin B12 to folate (B9), an essential vitamin for brain, spine, and nerve health. Deficiencies of essential B vitamins can lead to developmental problems, mood disturbances including increased anxiety and depression.

Faulty expression of the COMT gene can also cause a variety of problems including irritability, hyperactivity, mood swings, OCD, sleep issues, and lower frustration and pain tolerance.

The “Warrior Gene” MAO-A (Monoamine oxidase A) is one of the two genes that encode mitochondrial enzymes. It is responsible for catalyzing the oxidizing amines, such as serotonin, norepinephrine, dopamine, and adrenalin. Mutation of this gene results in Brunner syndrome. MAO dysfunction (too much or too little MAO enzyme activity) is thought to be responsible for many psychiatric and neurological disorders including depression, mood swings, OCD, schizophrenia, substance abuse, migraines, irregular sexual maturation.  It is also associated with behaviors associated with attention deficit disorder (ADD) and autism.

6. Heavy Metal Toxicity

Brain damage and inflammation can also be caused by heavy metal toxicity – like mercury, aluminum, and lead. They can promote aggressive, antisocial and violent behaviors. Lead exposure is known to cause learning and behavioral problems. The Journal of Child Psychology and Psychiatry published a study that demonstrates the strong relationship between high levels of lead levels in blood and hyperactivity, aggressive and antisocial behavior in children.

7. Emotional Wounds & Trauma

Heightened anxiety due to upsetting life events in a person’s life can lead to OCD and depression. The lower a person’s resiliency, the higher level of sensitivity and dysfunctional thinking is believed to make a sufferer more vulnerable to developing it. Stressful situations and traumatic event(s) that can lead to OCD include but are not limited to a death of a loved one, divorce, an accident, a move, school pressure and bullying, as well as an upsetting or abusive home environment.

8. Video Gaming & Too Much Screentime

Screens are being used more and more as a method of escaping from the stress of life. However, it may be backfiring. Disassociating in this way is taking teens away from the dealings of everyday life and is creating an alter reality where they are not learning how to foster real or meaningful relationships. A recent study published in the Journal of Clinical Psychological Science finds that “increased time spent with popular electronic devices — whether a computer, cell phone or tablet — might be contributing to an uptick in symptoms of depression and suicidal thoughts.” The study established a correlation between long hours of daily screen time and symptoms of alienation. A 2016 article in the New York Post, “It’s Digital Heroin: How Screens Turn Kids into Psychotic Junkies” discussed how addicting these screens are and how they are affecting our kid’s mental health. “Brain imaging research is showing that they affect the brain’s frontal cortex — which controls executive functioning, including impulse control — in exactly the same way, that cocaine does. Technology is so hyper-arousing that it raises dopamine levels — the feel-good neurotransmitter most involved in the addiction dynamic — as much as sex.”

9. Too Much Caffeine

Teens are lining up at coffee shops and consuming an alarming amount of caffeine-loaded energy drinks. Highly concentrated caffeine aggravates obsessive/upsetting thoughts and can set anxiety out of control. This central nervous system stimulant can cause dependency and withdrawal and cause insomnia as well. Although some studies point to the positive mental effects of caffeine, it makes sense that energy drinks could be a contributing factor for kids and teens feeling both homicidal and suicidal. Caffeine intoxication keeps the body in “fight or flight” mode. This can leave people feeling very frightened and threatened. According to the Journal of BJPsych Advances, “In psychiatric in-patient facilities, caffeine has been found to increase anxiety, hostility and psychotic symptoms.”

10. Sleep Deprivation

In a 2011 pediatric OCD study published in the Journal of Anxiety Disorders, researchers found a strong correlation between insufficient sleep and severe compulsive behavior. While kids with OCD sometimes only exhibit compulsions (without the obsessions), the study reflected children with both the mental and behavioral symptoms. A 2014 study published in the Journal of Psychiatric Research, implicated obsessions are a likely culprit behind disturbed sleep. Based on patients’ self-reported assessments, researchers found a link between insomnia symptoms and obsessive thoughts. Shorter sleep and delayed ability to get to sleep are associated with repeated negative and distressing thoughts that are repeated over and over again, such as “my life is not worth living.”

11. Psychostimulant Medication

It has been known for the last 35 year that stimulants have the potential to induce psychosis-like or manic-like symptoms in children. Psychotic symptoms from Ritalin can include hearing voices; visual hallucinations, urges to harm oneself, urges to harm someone else, suicide, severe anxiety, euphoria, grandiosity, paranoid delusions, confusion, increased aggression, and irritability.

Preventing Future Tragedies

Could future suicides and homicides be prevented? I believe so, and it starts with taking better care of our children.  We need to start acknowledging that people committing suicide or murder are medically ill; not mentally ill. And these causes of psychiatric symptoms need more attention.  We need more doctors to be trained in functional medicine to get to the root of the mental dis-ease. We need our insurance companies to pay for testing and treatments that will actually help our children.

We need more due diligence in our healthcare system.  And we need to stop the pharmaceuticals from leading us away from the truth. Just handing out medications to address symptoms and hoping the client follows through with recommended weekly individual psychotherapy appointments, is simply not enough. And quite honestly, these medications can be the final trigger in a homicidal or suicidal event.

I Am On A Mission

In 2012, I began counseling family members and first responders after the devastating tragedy at Sandy Hook Elementary School. This led me to finish my book Healing Without Hurting. I consult with thousands of moms through social media and conduct workshops for medical professionals to teach them about holistic and natural solutions for healing mental illness and spectrum disorders.

I know from experience that addressing underlying medical issues significantly enhances the life, the health and the happiness of our children and our family.  Also, I know my mission has been successful in helping to prevent such tragedies.


To receive more info on how you and your family can overcome ADHD, apraxia, anxiety and more without medication SIGN UP HERE.

A Quick Important Notice:

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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Scientists Break Down How Aging Is “Plastic” & We Can Manipulate It To Slow Down Aging

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In Brief

  • The Facts:

    Slowing down the ageing process is not about looks, it's about health, and feeling good. Scientists have discovered multiple healthy ways to regenerate our immune systems and repair our DNA, and caloric restriction/fasting is one of them.

  • Reflect On:

    Why are we told to eat three meals a day? Why are our national food guides more of a guide towards bad health rather than health? Why have many people stopped caring about health? To change the world, we have to change ourselves in multiple ways.

Can we reverse age regression, or slow it down? Given our research into Black Budget programs, it’s clear what we know in the mainstream scientific world differs greatly from the world of secrecy. We recently conducted an interview with a neuroscientist from the University of Arizona who also makes a clear distinction between mainstream science and Black Budget science.

From a mainstream scientific standpoint, it is reversible. At least in human cells and in mice. 

This is why it’s always interesting to ponder just how advanced the world might be. The U.S. air strike against Libya in 1986 used the F-111 fighter aircraft, for instance, but not the F-117A Nighthawk. The latter was still classified at the time, and keeping it secret was more important than using it for this mission. Then there’s the National Reconnaissance Office, which was founded in 1960 but remained completely secret for 30 years. What type of technology were/are they using? Does the NSA have computers that are far more advanced than ours? Can we teleport? Can we travel faster than the speed of light? Is there a secret space program? Can humans be cloned?

While these questions might conflict with many people’s belief systems, they represent valid concerns. Another question worth asking is, can we reverse age regression? We have no idea what military technology is capable of, or how far beyond us it has progressed. Considering the advancements in technology in the past century alone within the mainstream scientific/technical world, these things are hardly beyond our grasp.

But let’s take a look at what we do know. We are, after all, living in a world where science fiction is becoming a reality.

Aging Is Reversible

Today, scientists are actually able to tweak genes that turn adult cells back into embryonic-like ones. For example, it wasn’t long ago that researchers at the Salk Institute for Biological Studies reversed the aging of human and mouse cells, in vitro. The study was published in the journal Cell

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According to Juan Carlos Izpisua Belmonte, the study’s senior author and an expert in gene expression at Salk, “aging is something plastic that we can manipulate.” In living mice, they activated what are known as “Yamanaka factors,” which rejuvenated muscles that were damaged, as well as the pancreas in a middle-aged mouse. This extended the lifespan of the mouse, who also had a genetic mutation for Hutchinson-Gilford progeria syndrome, which causes rapid aging in children.

The researchers believe that this study suggests it’s not just possible to slow the aging process, but actually reverse it.

“I fully agree with the conclusions. This work indicated that epigenetic shift is parr responsible for aging, and reprogramming can correct these epigenetic errors. This will be the basis for future exciting developments.”

– Manuel Serrano from the Spanish National Cancer Research Center In Madrid

Epigenetics is the study of changes in organisms caused by gene expression, and gene expression can change due to a myriad of factors.

But, as Scientific American points out“The study also showed how fine the line can be between benefit and harm. When the researchers treated mice continually, some developed tumors and died within a week. When the scientists cut the treatment to two days out of seven, however, the mice benefited significantly.” 

The lead author also told Scientific American that they “currently think the brain’s hypothalamus—known as the seat of control for hormones, body temperature, mood, hunger and circadian rhythms—may also act as a regulator of aging.”

According to the Telegraph, with the success of these animals studies, scientists predict human trials to commence within 10 years.

Caloric Restriction and Fasting 

Did you know that, in all animal model studies, caloric restriction reverses signs of aging, slowing it down, and reverses age-related diseases? Research has shown that it reduces what’s called the PKA enzyme, which has been linked to aging, tumour progression, and cancer.

According to a review of fasting literature conducted in 2003“Calorie restriction (CR) extends lifespan and retards age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast. The mechanism or mechanisms through which this occurs are unclear.”

Fasting and caloric restriction have also shown to have a tremendous effect on the brain. As an article from John Hopkins Magazine reveals:

Dietary changes have long been known to have an effect on the brain. Children who suffer from epileptic seizures have fewer of them when placed on caloric restriction or fasts. It is believed that fasting helps kick-start protective measures that help counteract the overexcited signals that epileptic brains often exhibit. (Some children with epilepsy have also benefited from a specific high-fat, low-carbohydrate diet.) Normal brains, when overfed, can experience another kind of uncontrolled excitation, impairing the brain’s function.

A plate, fork and knife

Fasting has also been shown to regenerate the immune system and our organs. With regards to the brain, fasting challenges it, and your brain responds to that challenge by adapting stress response pathways that help your brain cope with stress and disease risk. The same changes that occur in the brain during fasting mimic the changes that occur with regular exercise — both increase the production of protein in the brain (neurotrophic factors), which in turn promotes the growth of neurons, the connection between neurons, and the strength of synapses. This is why it’s been found to completely reverse age-related neurodegenerative diseases.

Here is an excellent  TEDx talk given by Mark Mattson, the current Chief of the Laboratory of Neuroscience at the National Institute on Aging. He is also a professor of Neuroscience at Johns Hopkins University, and one of the foremost researchers of the cellular and molecular mechanisms underlying multiple neurodegenerative disorders, like Parkinson’s and Alzheimer’s disease.

We’ve published many articles on fasting, and to find out more information on how to do it, different strategies, and more science, you can start here. Below are a select few related articles:

Neuroscientist Shows What Fasting Does To Your Brain & Why Big Pharma Won’t Study It 

The Complete Guide To Fasting & Reversing Type 2 Diabetes: A Special Inter Interview With Dr. Jason Fung

Why Researchers Are Seeking FDA Approval For Fasting & Caloric Restriction For Cancer Treatment 

Scientists Discover That Fasting Triggers Stem Cell Regeneration & Fights Cancer

Reversing the Age of White Blood Cells

Elizabeth Parris, the CEO of Bioviva USA Inc, has become the very first human being to successfully, from a biological standpoint, reverse the age of her white blood cells, thanks to her own company’s experimental therapies. Bioviva utilizes intramural and extramural peer-reviewed research to create therapies for age-related diseases (Parkinson’s, Alzheimer’s, cancer, heart-disease), and now, they have reversed 20 years of ‘telomere shortening’ in a human for the first time.

Telomeres are short segments of DNA that cap the ends of every chromosome and act as a protective feature against wear and tear, which occurs naturally as the human body ages. As we age, these telomeres become shorter and shorter as our cells continue to divide more and more. Eventually, they become too short to protect the chromosome, which is what causes our cells to malfunction and age-related diseases to start setting in.

We published a story about this early last year, and you can read more about it here:

First Human Being Has Their DNA Manipulated To Make White Blood Cells 20 Years Younger

So, as you can see, even within the mainstream scientific world, we’re not too far off from reversing aging, or slowing it down to prevent age-related diseases. This research represents just the tip of the iceberg, and at our current rate of acceleration with regards to scientific and technological advancement, who knows where we will be in 20 years?

Would age reversal be “playing God?” It’s impossible to say. Perhaps “God” meant us to discover our own intelligence and ability and use these findings for good. Perhaps manipulating our own genes is part of our natural process of human evolution and development. This, however, is a completely separate topic, worthy of another article.

A Quick Important Notice:

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

SUPPORT CE HERE!

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22 Out Of 25 Popular Burger Chains Just Failed Their Antibiotic Use Report

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In Brief

  • The Facts:

    A recent study was done examining how well top fast food chains actually implemented their antibiotic use policies in their beef. 22 of 25 failed including McDonald's, Sonic, Burger King and In-N-Out.

  • Reflect On:

    Do you still eat fast food? If so, why do you find yourself doing so? What healthier choices can be made instead? If we want to see a healthier world, population and animal kingdom, we have to choose what we support more wisely.

The modern-day food industry seems to pay no attention to health. Thankfully, global consciousness is shifting in several ways including how we live as humans, view our health, our economy, education, politics, and the environment. You could say that humanity is going through one MASSIVE change.

Today, billions of animals in the United States alone are raised, tortured, and slaughtered for human consumption. This reckless production and consumption, in turn, has created enormous environmental and health problems that continue to accelerate. That being said, awareness on this issue (food) in particular, has come along way. We are seeing changes in the food guide, a shift towards plant-based diets, and more corporations catering to new choices people are making around food and health. This is a good thing!

One common trend helping to create change is the continues ‘bad press’ unhealthy players in the food industry are getting.

The latest news to come out regarding food quality within fast food comes from a report recently released by six major consumer and environmental groups. They graded America’s 25 largest burger chains and their use of antibiotics in their beef supply.

22 popular fast food restaurants completely failed, including giants like McDonald’s, Burger King, Sonic and In-N-Out.  The evaluation looked at each chain’s antibiotic use policies and whether these policies were truly implemented in their product. They also examined how transparent the chains were with their antibiotic use.

The Problem With Antibiotic Use

Antibiotics given to farm animals can lead to antibiotic-resistant bacteria, among other things. This is actually one of the top threats to global public health, which is exemplified by the fact that each year, more than 2 million Americans alone suffer from these infections.

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In September 1999, Albrecht and Schutte published “Homeopathy Versus Antibiotics in Metaphylaxis of Infectious Diseases: A Clinical Study in Pig Fattening and Its Significance to Consumers” in Alternative Therapies. The study compared outcomes for four randomly assigned groups of pigs that were given placebo, homeopathic treatment, a standard blend of antibiotics and other conventional drugs in a routine low prophylactic dose, or conventional drugs in a high therapeutic dose.

There were 1440 pigs involved in the study, which took place at an intensive livestock farm in Germany. The primary outcome measured was the incidence of respiratory disease, a common problem for pigs on such farms.

The results were astounding.

Homeopathic treatment was far superior to prophylactic doses of antibiotics in preventing respiratory disease. The prophylactic antibiotic treatment made it only 11 percent less likely (than placebo) that the pigs would become sick. But homeopathic remedies made it 40 percent less likely. When the antibiotics were raised to therapeutic levels, meaning a level that is only given when people or an animal was sick, it became 70 percent less likely that the pigs would become diseased.

The significance of this is that homeopathic treatment on animals would already be better than routine antibiotic treatment. When an animal is actually sick, the farmer would then have the choice to increase homeopathic or use a legitimately high-level dose of antibiotics. This, significantly less cost and significantly fewer antibiotics in meat.

The List

The Takeaway

Simple, avoid fast food. There are many out there who seem to believe that people will always consume this food, but we fail to recognize that it’s not just our choice. The “food” these corporations offer is highly addictive to people, and that’s done on purpose.

If we can connect with caring about our health, quality of life and well-being of animals and the planet, these are places you must steer away from. In general, eating meat does not support the health and wellbeing of us nor animals, but this is a choice we each make.

Recommended Articles

A Native American Perspective On Veganism

Plant-Based Protein VS. Protein From Meat: Which One Is Better For You? 

Doctor Explains How Humans Have A “Strict” Vegan Physiology

Vegan Activist James Aspey Beautifully Shows How To Consciously Inform People

9 Things That Happen When You Stop Eating Meat

Internal Medicine Physician Shares What Happens To Your Body When You Stop Eating Meat

Animals – Why Do We Love One But Eat The Other? 

The Heart Disease Rates of Meat-Eaters Versus Vegetarians & Vegans

Were Those Who Roamed The Earth Before US Nearly All Vegetarian?

A Quick Important Notice:

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

SUPPORT CE HERE!

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Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

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References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

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