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Anxiety & Depression: What Sufferers & Those Who Love Them Should Know

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In Brief

  • The Facts:

    Anxiety and Depression can be caused primarily by biological and genetic factors, psychological and trauma issues, environmental issues, or a combination of these.

  • Reflect On:

    Consider that due to A&D’s popular stigma, a narrow-visioned belief system, and the severity of these conditions, it’s wise to keep an open mind and learn more in order to be more compassionate and helpful to those suffering.

Clinical anxiety and depression (“A&D”) are often terrifying experiences, especially when we don’t know what’s happening to us and don’t have support. An overview and relatively comprehensive information guide to self-treatment and professional support can be invaluable and what I will try to share with you here. When I was caught in the vortex of A&D, I searched long and hard for insider information to help me. I couldn’t find very much and the therapists I initially saw didn’t help much either, until I found the right kind of therapists with experience in A&D.

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This article shares some of what I learned on my successful journey through A&D out to the other side (which at one time I thought I’d never see). It contains much of what I wish I had known when I was in the midst of that storm. I also share some facts and commonly misunderstood aspects of these conditions. Part of the reason for much of the conflicting information out there is the many ideologies and limited understanding perpetuated by people who had mild events, who haven’t been through serious A&D themselves, and who have not been in close contact with others who have A&D.

I have been through extreme anxiety and depression myself, had A&D sufferers as patients, and lived intimately with sufferers while I was in treatment. With this said, I am a Chinese medicine physician, not a psychotherapist, and this article is not intended to substitute for professional psychotherapy or psychiatry help, which I think are crucial for anyone in severe A&D.

So, I speak both personally and objectively about these extremely challenging conditions. My hope is that you will be saved some of the grief I suffered and this writing will help wisely inform your choices.

The Stigma

The most common mental illness in America is anxiety; this is followed by depression, the latter which affects more people worldwide than any other mental illness. I call A&D “evil twins” because they were nothing short of hell to get through, more so than any experience I’ve ever had, including massive grief and nearly becoming paralyzed as a teenager.

The stigma—a societally perpetuated fear, attack, and mischaracterization—on mental illness has developed because of a lack of understanding, fear, and perpetuating false perceptions that serve no one, especially not the sufferers. When your brain goes out on you, as your knee or hip might, it’s devastating because you no longer can guide your life in the way you once did. Except our brains affect every aspect of our lives, not just gait and movement. When we lose our inner world to A&D, we simultaneously lose our outer world because nothing makes much sense anymore and it can become impossible to navigate the simplest tasks.

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Most recover from mental illness, just as we do from other illnesses. In fact, between 70 and 90 percent of the individuals who are treated for their illness have a reduction in symptoms and improved quality of life. So, getting proper and prompt treatment is crucial.

We have a long way to go in our understanding, acceptance, and treatment of these disorders, all of which will undoubtedly help the victims of these hellish diseases receive more compassionate care and financial assistance.

Mental illness is not usually some scary monster that makes us “crazy.” And no, mental illness is not well-correlated with mass shootings; this false meme only increases the stigma on mental illness; insightful and revelatory articles on the subject are here and here.

It’s also helpful not to describe mental illness sufferers with pejorative, vague terms like “crazy” that offer little meaningful information and are more judgmental than anything else. Mental illness is a disease process, like the flu or diabetes. The latter affect the lungs and pancreas, respectively, and mental illness affects primarily the brain, endocrine and nervous system, also parts of the body.

While we can learn from A&D, and important “messages” and psychological growth can be gleaned from them, this may not be the best perspective to take when afflicted. Sometimes we just have to get through them, as we would the flu, and get our physiology balanced again, encompassing both psychological and physiological treatment (mind and body). Most often, some combination of both cognitive and emotional learning, as well as good old-fashioned biomedical help, are in order.

Because of the stigma, we might resist identifying, admitting, and therefore seeking help for mental illness for fear of being marginalized, embarrassed, or ridiculed. But, as with most other disease processes, the sooner we get treatment the better for recovery. So, if you or a loved one is suffering from mental illness, try to cut through the misinformation and fears that sabotage healing and get help. Usually those who have suffered mental illness are able to understand and empathize with other sufferers, as can an experienced therapist.

Yin & Yang ‘Evil’ Twins

There are different types of anxiety, just as there are different types of depression.

In this article, I refer to anxiety primarily as severe anxiety that is more than everyday worry or anxiousness that comes and goes. Clinical anxiety is persistent anxiety that is considered an “anxiety disorder.” It usually doesn’t go away on its own, can get worse without proper treatment, and can be accompanied by anxiety or panic attacks.

I discuss depression primarily in the context of severe depression which is known as clinical depression, or major depressive disorder (MDD). Depression is more than low mood and normal sadness. It’s more than being bummed out that it’s raining or  that you missed a movie date, or feeling “off.” In fact, depression causes us to perceive extreme negativity in things that would normally cause us only mild discomfort. This is consistent with the well-known adage among sufferers that “depression lies.” Well, anxiety also causes us to believe the worst, and it also lies. Both evil twins distort our beliefs about most of reality that we otherwise wouldn’t when we are regulated (“normal” and manageable) in mind and body.

Depression and anxiety are neurological partners and often co-occur, just like Yin and Yang. Anxiety is Yang (outward, activating) and depression is Yin (inward, quiescent). True to the interdependence of Yin and Yang, depression gives rise to anxiety. And anxiety can give rise to depression, especially when it begins to exhaust our resources. Both usually affect normal sleep patterns and cause insomnia. In atypical depression, one may actually sleep longer than usual. In either case, these evil twins are a menace and in my own battle with them some years ago I could hardly determine which was worse.

Depression and anxiety also often affect relationships, ability to make even the simplest decisions, ability to work and carry out once ordinary daily tasks, and otherwise live a normal life. Suicidal ideation and suicidal plans are also common symptoms. A&D can become utterly crippling and can totally consume us, especially without proper treatment. Again, the sooner they are treated, usually leads to quicker and better recovery. A more complete list of symptoms for depression can be found here and for anxiety here.

Not Necessarily A Reason

If you are anxious or depressed, you might think there is a reason for this beyond genetics and physiological imbalance, and that this reason can be identified. Like many, you might think there is a psychodynamic reason for this, which refers to some aspect of your psyche beyond its mere physiology. Examples include past trauma, lifestyle circumstances, childhood issues, unconscious forces, or other inter-relational events that affects your state of mind. This is not always the case, and it can be impossible to determine what caused your downfall.

In most cases, focusing on what is going on rather than why it’s happening is more helpful for recovery. In other words, first just try to get better by any means and leave any inquiry into why for later. An exception to this is if your A or D has actually been precipitated by a cause, which I address just below. With this said, recovering from depression often takes action, not a lot of thinking, except to trust what others in the know encourage you to “reframe” (think about from a different perspective). As one good therapist said to me, “Jack you won’t be able to think your way out of this.” Boy, did I learn the truth of that as time went on.

Anxiety and depression, like other mental illnesses, often have a genetic component, meaning you inherit the predisposition (called a “diathesis”). If any, or several, family members suffer, you might carry the genetics, making you more likely to sustain either. Often, a stressful life event can trigger genetic predispositions and even epigenetically activate (alter genetic expression of) these syndromes. Many stressful factors and physiological changes acting together and compounding one another can precipitate A&D episodes.

Once we are more regulated (balanced and homeostatic), we will likely have a clearer perspective on our condition. We may then understand more of the why. With this said, sometimes the primary reason we fall into anxiety or depression is due to an identifiable cause, and learning about and working through the issue(s) can help us recover. It’s best to talk to a good therapist with A&D experience to determine the best course of treatment.

If we are very anxious or depressed, it’s only logical to think that something is making us anxious or depressed. In other words, if I am depressed I might think that I must be depressed about something. After all, our emotions are signals of something, right? Well, sometimes yes and sometimes no, and often some of both. Feeling of anxiety or depression often have no meaning and value other than to make us suffer, so it’s helpful during either to not take our feelings or thoughts too much to heart.

Clinical depression and anxiety are disorders, and there is not necessarily a psychodynamic cause behind them. In fact, depression is thought to be some 50% attributable to genetics, according to studies at Stanford. This means that in many cases it’s truly not your fault (not that it is anyway), and depression is not easy to control or navigate on our own, any more than we would be able to heal from cancer or a heart attack on our own.

We need help, and in a fiercely independent culture where we think we are supposed to be able to manage everything on our own, we might try to go it on our own, which can compound our distress. It’s especially important to have support through mental illness, not only from professionals but from supportive family and friends. This necessity poses a bit of a catch-22 because depression and some forms of anxiety cause us to want to retreat and isolate ourselves. While this can feel good in the short-term it’s often not advisable, which is why in A&D we often have to act counter-intuitively…to go against what feels good in the moment in service of what is going to help us heal little by little for the long run.

Feeling understood, accepted, and genuinely supported are crucial for healing from A&D. It’s just as important that we treat ourselves with ultimate kindness, that we become our own best friend.

Recovery

Very often, and more commonly among some popular online psychology gurus, unconditional acceptance is offered as a way out of any troubling psychological dynamic. Some even promote shadow work as the proper psychological medicine for such ails. While I consider shadow work crucial for becoming a human being of integrity, it’s not necessarily the best way through clinical anxiety and depression, or at least not initially.

Some degree of unconditional acceptance is helpful in any therapeutic process, but it must also be carefully integrated with tough love when it comes to healing from mental illness. This is because healing from mental illness often requires what’s called opposite action: that we do the opposite of what seems intuitively right, that we do what we don’t feel like doing. Opposite action is usually what is counter-intuitive. Opposite action is doing what we don’t feel like doing, or don’t think will help, but which indeed is helpful. For example, unconditionally accepting that a depressed person doesn’t feel like exercising, and therefore won’t, may not help him get better. This is because exercise is considered important medicine for recovery from anxiety and depression and it’s usually best to get some, any, exercise even though a depressed person—and less frequently, an anxious one—doesn’t feel like it.

Weaving compassion and tough love together, we might respond this way, in a compassionate yet clear tone, to someone who is depressed: “I hear you don’t want to exercise and you feel that you can’t do it, but it’s important that you try to move around, even for a few minutes.” We can also speak to ourselves (self-talk) this way if we have depression. If anxiety is predominant, we might legitimately need to rest (possibly in addition to exercise), because anxiety taxes our resources and tires us out. So does depression. Please remember to speak gently and kindly, even when firm, to anyone with A&D; you just can’t imagine how horrendous it is if you haven’t suffered it yourself.

Curiously, and contrary to popular belief, stress hormones are usually raging inside someone who can’t seem to get off the couch. Because depression causes real biological fatigue, a person with severe depression may truly not be able to exercise at all. In this case, pure unconditional understanding is helpful.  Maybe the next day, encouragement to walk even a few steps is a good idea, and the next hour or day, a few more. When I was in recovery, I began with 3 minutes of walking, which I increased from there. Prior to falling ill, I was exercising every day and could hike for hours. When I feel into depression, 3 minutes seemed like a marathon. Often, a depressed person needs to override real or perceived inertia in order to feel better in the long run, while not overdoing it. Slow and steady usually wins this race.

While anxiety or depression might cause us to feel like we’re going to die, it’s not a good idea to freak out about this feeling, which is to become “anxious about being anxious.” Feeling as if you’re going to die is how the brain automatically interprets intense fear. Again, these diseases “lie,” making us believe a reality that is not real except in our temporary perception of it. And this is key: the perceptions and imaginations we have while ill are temporary, just like it can feel like we will never get better, or that we will be forever bedridden, if we have the flu. We can and do get better. Life can turn around on a dime, and we need others to hold this hope and reasonable reality for us if we are unable to, which is often the case because it’s very, very difficult to believe this when in the midst of severe anxiety or depression.

While empathy can be generated, only those who have been through the gauntlet of A&D truly know what it’s like. If you have not experienced them, trust me, it’s virtually impossible to fathom, and it’s worse than you can imagine. Prior to my bout, I worked in a medical clinic treating people with these disorders. While I sensed their distress, as I do with anyone suffering, in hindsight I see that I could never have truly understood their experience. After having passed through them, I am back at work in the clinic and my empathy and compassion are much deeper, and I can relate on all levels to the utter confusion and terror of these states. While I can never know precisely what another is feeling, suffering from the same disorder gives a new order of relatability.

When clinically depressed and anxious, I responded best to those who spoke slowly and gently and who actually heard what I was saying and were able to understand me. Even if you don’t understand what it’s like to have clinical anxiety or depression, you can still empathize to a degree by remembering times you have suffered greatly. Indeed, part of why I have written this article is to give an outside’s perspective if a loved one of yours is suffering.

Disclaimer: while I have written about the dangers of the happiness and positivity craze and not ignoring our difficult thoughts and feelings, this approach is usually not helpful during the distorted experience of A&D , anymore than it’s helpful to give too much weight and attention to our difficult thoughts and intense feelings when we are upset or melancholy due to a bad night’s sleep, an argument, feeling excessively stressed, being hungry and having low blood sugar, or being sick with the flu, as examples. Hint: Getting poor sleep, common during A&D, can make depression feel worse. So, when I didn’t sleep well, I would remind myself throughout the day, “Don’t take anything you think or feel today too seriously.” I was already not taking things too seriously, and when I wouldn’t sleep well, this was especially the case.

A&D are distorted states and a Catch-22: it’s virtually impossible to think clearly about anything in these states because the very brain we think with is imbalanced, and this imbalance affects the quality of our thinking. But it’s not black and white: there are usually some thoughts and moments of intuition or revelation that you can recognize as more sane than others, that more resemble “the old you.” Attach to these, trust these, even if they are short-lived; use them as anchors.

It’s crucial to leverage any positive experience, any foothold we have, to regain regulation and better functioning, so we spiral upward and not downward. This leverage might be the hope someone else holds for us, the part of our thinking that does realize we are distorted and can let go of these distortions more easily, the ability to exercise, to laugh, to quiet our mind, to do anything rewarding and fulfilling, a medication or supplement that helps us feel and/or think better. Whatever. We use any leverage we can to gain more of ourselves back. During A&D, we try to invest our attention in the things that help us recover in the same way we would invest money wisely in order to grow our profits. Sometimes we don’t have any leverage, which is just one more reason it’s valuable to have others who can hold us (up) and remind us when we can’t.

Meditation & Mindfulness

I have been a meditator for years. However, I found that sitting meditation with eyes closed (mindfulness style) was not helpful for me during A&D. My mind was so disturbed and distorted that I couldn’t help but get stuck ruminating on my negative automatic thoughts and perceptions. Such rumination made me feel worse and is actually contraindicated in depression and anxiety. What I needed was a break from these thoughts, and sorry, but while suffering anxiety and depression I did not have the regulation and mental resiliency to just “let the bad thoughts go.”

Indeed, the vaunted capacity and quality for “awareness” is not constant and immutable; it varies with physiological and neurochemical changes. I was not in a place to be any closer to my negative thinking and feeling; I needed a break from them, as far away as I could get from them actually, so that my psyche could begin to find its balance again by way of the “mind healing the mind,” as I discuss below. For me this meant letting my mind get a break from itself.

So, silent, eyes-closed, sitting meditation just wasn’t my medicine. But it might be yours, especially if you are suffering from mild depression, also known as “subthreshold depression,” and anxiety. Therefore, disregard what I say if it doesn’t fit for you for whatever reason. I just want those who suffer from meditating during A&D to know they are not alone and to feel empowered to ditch it if they want to and not suffer more than they have to.

In researching this topic I came across a bold and helpful article by Therese Borchard, echoing my sentiments about mindfulness meditation. She quotes the work of Jon Kabat-Zinn, the “Dalai Lama” of the mindfulness meditation world, who says in his book:

“It may be wise to not undertake the entire program while in the midst of an episode of clinical depression. Current evidence suggests that it may be prudent to wait until you have gotten the necessary help in climbing out of the depths and are able to approach this new work of working with your thoughts and feelings, with your mind and spirit unburdened by the crushing weight of acute depression.”

In response to this statement, and how her depression wasn’t really helped by mindfulness meditation, she reflects:

In hindsight, I wish there was more than one paragraph in Zinn’s book about when mindfulness isn’t the solution, about when it’s better to swim laps or ride your bike into town or call a friend you haven’t talked to in a while. I still would have taken the course — and I do feel like I benefited immensely from it — but I would have been more forgiving of myself that it didn’t “work” like everyone else’s magic.

And in response to her meditation teacher finally agreeing with her, she goes on to say:

He confirmed what I was thinking during that moment and what has been my experience: mindfulness is better at keeping a person from getting depressed than from pulling a person out of depression.”

Indeed, this is the result of a study that found this to be true: that MBCT (Mindfulness Based Cognitive Therapy), which “revolves around mindfulness meditation,” can help to prevent a depressive relapse. And anxiety too.

We now know that via neuroplasticity (re-wiring the brain) we can use our minds to heal our minds; this happens because the quality of our thoughts affects the biological functioning of our brains to, among other functions, produce a more balanced flow of neurochemicals. The trick in A&D, however, is to have enough good mind (mental leverage) to be mindful enough to affect our impoverished mind back into balance. This is one way that CBT (cognitive behavioral therapy) therapy is crucially helpful in A&D. It’s this good thinking that helps us do the right things for ourselves (self care), such as distraction to give ourselves a break from the onslaught of negative thoughts and feelings that are both symptoms of A&D and causes for it worsening.

Thinking positive thoughts actually has a corresponding positive physiological effect. So does smiling, even if we don’t feel happy. In other words, merely by thinking positive thoughts (very tough during severe depression and/or anxiety) can make us feel and think better. Similarly, the mere act of smiling can make us feel happier by changing our neurophysiology.So, it’s generally a good idea to try to smile during depression, and to do so counter-inuitively and in opposite action to what we feel like doing—namely, not smiling.

Many meditation practitioners might tell you it’s fine to feel worse and this is part of the “meditation process.” When I was not ill (and presently), I agree, sitting with distressing thoughts and feelings is difficult yet still helpful. But not during A&D. I also remember feeling worse about myself because meditation would bring me intimately closer to my distorted thinking (including suicidal thoughts), which was tough to get away from even with eyes open and active. This was not okay, and when I finally gave up trying to meditate my way to health, I felt relieved and fared better.

What I did find helpful, however, was ordinary mindfulness: being mindful of my distorted negative and anxious thoughts. And, I didn’t need to sit with my eyes closed for this. As alluded to above, this is the basis of CBT therapy, which helped immensely. I found it easier to let go of distressing thoughts (“thought defusion“) and feelings (“emotional defusion“) while active. To do this, I practiced not spinning stories or buying into the apparent importance and truth of my thoughts and emotions, which are distorted during A&D. “Distraction,” which I mentioned also helped, is a DBT technique. As for Therese Borchard, walking with friends, exercising, writing, watching TV and listening to music, reading, playing games—anything that took me away from ruminating—was helpful. By giving my mind a break from itself, after some time my physiology and neurochemistry became more balanced and I could see my disturbing thoughts and feelings more accurately for what they were: distorted, unhelpful, and largely meaningless.

In sum, be as mindful as you can and let go of beating yourself up if you can’t or don’t want to sit and meditate—it’s okay. Ironically, this can help your mind heal your mind, which is supposed to be a benefit from mindfulness meditation.

Medicine

I am a holistic physician practicing Chinese medicine. I and many of my colleagues, even M.Ds, try to stay away from pharmaceuticals. When I was in the early days of A&D, I never imagined I would need to be on anti-depressants. I was mortified by the thought of it and resisted them for months, until it got so bad that I welcomed anything that would help. Lesson: just as Western medicine is helpful for many conditions that holistic therapy cannot tackle, such as surgery and life support, pharmaceuticals can be life-saving to those with A&D. And, yes, I tried just about every holistic treatment available. So did a wise and now level-headed elder friend of mine who said this to me during a recent discussion:

I tried all the alternative prescriptions for A&D recovery . . . like diet and herbs and acupuncture and supplements and exercise and massage etc., etc . . . and I tried them with enormous commitment and dedication, and yet I STILL had to end up taking antidepressants. Im sure the other stuff helped . . . but alone it was NOT enough to save my life . . . it was ‘Big Pharma’ and a couple of awesome Psychiatrists who saved my life.

In the end, I don’t know if the medication helped me, and I don’t regret taking the pills. Just like Western medicine generally, pharmaceutical companies gets a bad rap, and often for good reason. We therefore might conclude that all their medications are unnecessary and useless. This is not only unfair, but unwise. While many more people are on antidepressants than should be, for many sufferers these drugs offer relief from an illness as debilitating as any around. You can listen to what world-renowned professor and depression survivor Robert Sapolosky has to say about depression. Adding insult to injury, many who take antidepressants are further shamed or stigmatized in addition to the stigmatization they already endure. Alternative medicine’s propaganda and stigmatizing of pharma medications likely causes more damage and additional suffering than necessary.

With this said, I tried every means possible to relieve my symptoms by natural means and none worked well enough, not even close. I felt like a failure for this, which added (unnecessarily) to my distress. Finally—and too late in the game—I had to go to the big guns. So, by all means, give the natural remedies a try. In the case of severe A&D, this decision should be made with the aid of your health care professional/s. But if nothing works well enough, don’t be afraid to consult with a psychiatrist for meds. Antidepressant and other medications, even with their potential side-effects, can provide much-needed relief. Yes, it can get so bad that any relief is desired as soon as possible.

With this said, anti-depressant medications don’t always work the first time around. In fact, for moderate to severe depression, they are effective about 50% of the time. A period of trial and error is often needed to find medication that works best for any individual, and they usually take between 4 and 8 weeks to take effect. I encourage you to partner closely with your doctor and mental health professionals. You are the expert on your symptoms and you doctor needs to hear what you’re experiencing. This will help you work together to find the right medication, or combination of medications.

For some, and by no means all, anxiolytics (anti-anxiety meds) and antidepressants help resolve anxiety and depression, respectively. Remember, there isn’t always a psychodynamic reason why we get anxious or depressed. Medication can also be helpful to help us get a foothold and begin to dig ourselves out of the trenches. They can help regulate us so that our prefrontal cortex (the rational, self-reflective part of the brain that shuts down in depression) comes “back on line” enough that we can absorb, remember, and comprehend crucial information and gain necessary perspective on our illness to be able to navigate it in ways that support our recovery. In these cases, medication does not mask mental illness or act as a harmful crutch, but helps us recover from it. Once we make strides and are able to exercise and function more normally, we may not need the medication. The choice to come off or get on medication, however, should be made with the help of a doctor.

Even if a person’s depression or anxiety is due to psychodynamic issues, medication can help to regulate the mind so that any identifiable issues that precipitated the illness can be productively worked through. Again, in acute A&D it’s difficult, to say the least, to perceive anything clearly enough to make strides. But again, it can be helpful to do so, especially with the help of a good therapist. Indeed, medication in combination with psychotherapy has been shown to be more helpful than medication alone for recovery from major depression (which often presents with its evil twin sister, anxiety).

Again, antidepressants are not for everyone, and the research literature clearly states this. But for some, they are an invaluable component to recovery. Since suicidality is a symptom of depression, medication literally saves lives. With this said, and ironically, antidepressants have been shown to increase suicidal ideation and behaviors in a “small number of children and teens,” so specific precaution and monitoring is needed for this age group. These are specifics to discuss with a qualified health professional.And, if you’ve been severely clinically anxious or depressed, you likely know the desperation to do anything to get out from the dark shroud of severe depression and the relentless inferno of anxiety. From my own experience, witnessing others go through the gauntlet, as well as from researching the subject, I endorse whatever helps someone get through without creating a bigger problem.

Psychoterapy

Two of the most helpful therapies for depression and anxiety are CBT (cognitive behavioral therapy) and DBT (dialectical behavior therapy). Here’s the classic DBT handbook authored by its developer, though my experience is that the book is not a substitute for working with a therapist, even a DBT-trained therapist. Part of this reason, is that in severe A&D, it can be tough to read a single line, much less a chapter or a book, make any sense of them, identify the proper advice for you and then, after all that, put the suggestions into action.

As mentioned previously, acting counter-intuitively, or what is called “opposite action” in DBT terms, can make a big difference. This includes not listening to our warped feelings and cognitive distortions (faulty perceptions and bad ideas). This is also why “intuition” and “trusting our feelings” as guides for how to act during A&D can be counter-productive and outright disastrous. An ordinary example we can all relate to is not wanting to get outside or get out of bed to take a shower or go for a walk. But once we do we feel better. Same for depression, unless we truly can’t get up for physiological reasons not due to an apparent lack of motivation.

As mentioned, psychological depth work is not usually appropriate in severe depression unless a significant cause of the disorder is due to these psychodynamic causes and one is regulated (functional) enough to undergo the process of hashing through past hurts and the emotional upheaval this causes. In severe A&D, depth work is usually not a recipe for success because bringing up more dysregulation and intense emotion when balance and stability are needed can sabotage recovery. Again, it’s difficult to see any issue accurately during A&D. Getting counsel from a good therapist with experience treating these conditions is invaluable and usually best to help assess what is appropriate to guide treatment.

Lastly, I want to mention that when medication and talk therapy don’t help enough, other treatments for depression you can consider include: ECT (electroconvulsive therapy) and rTMS (repetitive Transcranial Magnetic Stimulation). Even psilocybin mushrooms seem to have helped some, but opinions vary and the evidence is yet scant.

Other Factors

Biochemistry shifts with age, stress, diet, hormonal changes, environmental factors, genetic/epigenetic expression, and anomalous brain wiring. All these can cause significant mood changes. So, if you are anxious or depressed, it might not be due to something you are doing or have control over—that you can put your finger on and fix. It might be largely genetic and triggered by a stressful life event. OCD (obsessive-compulsive disorder), for example, is an anxiety disorder that causes anxiety for no logical reason (other than anxiety!). OCD and other anxiety disorders amplify usually mild issues or events and make them seem multiple times worse than for a person with more common responses to everyday anxiety.

OCD, GAD (Generalized Anxiety Disorder) and depression cause us to think that events themselves are causing our distress and they are responsible for our feelings and perceptions. It’s actually more our highly distorted response to events that causes our suffering. Anxiety and depression latch onto whatever we might think about. Our mind is “latches onto” and spins tornadoes from what would otherwise be mildly distressing events. This is why therapy in general, and specifically being able to witness and be aware of our reactions (a key tenet of CBT), is so helpful to recovery; it allows a more regulated and balanced version of us to guide our responses to disturbing thoughts and feelings, rather than being so caught up in our negatively-generated and alarming thoughts and feelings that they take over and own us.

Psychodynamic triggers can indeed trigger unpleasant emotional states but are not the cause of all, or even most, of anxiety, depression, and other mood changes. With this said, sometimes our anxiety and low moods are signals for real-life issues, past or present trauma, lifestyle, coping, and other unhelpful dynamics that need to be addressed. Often, it’s some combination of both real-life events and underlying anxious or dysthymic (low mood) tendencies to which we are genetically predisposed and/or triggered into that cause anxiety and depression.

In cases of mild and even moderate A&D that have their source in life issues, sorting out the impacts of such dynamics with a trained and sympathetic therapist and/or psychiatrist is a good way to learn more. When psychodynamic issues are at the root of depression or anxiety and go unaddressed, chances are that suffering will continue, even if temporarily masked by medication. Again, skillful timing and personalized treatment are key here. If the cause is more biological in nature, medication is a modern miracle that can help recovery.

Anxiety and depression are illnesses like any other biological illness, it’s just that they occur primarily in the brain. We are more familiar with less stigmatized diseases such as diabetes, migraines, or Alzheimer’s and cancer. These are diseases that largely happen to people, just like mental illness. But with mental illness, somehow we have the idea, in whole or in part, that someone with depression or anxiety can just snap out of it and that they have control over their condition. We wouldn’t say this to someone with diabetes or cancer; neither should we address an anxious or depressed person this way. An astute friend recently commented this in response to an on-line post I made about A&D:

“There is a mountain of stigma, judgement, opinionating and misinformation to be overcome by people who are trying to live with and manage their Anxiety and Depression (as though just being afflicted with these dreadful conditions it isn’t hard enough already.) No need to take on the shame or misinformed projections of people who ‘think they know’ what these illnesses are, and where they come from and what you should do to manage them. Beware of rejecting what modern medicine has to offer you, and double beware of people who think they know what is best for you. Take any lifeline that is offered to you, and relinquish your attachments to romantic notions of recovery entirely through excessive self examination and compulsive scab picking of deep emotional wounds (which can be extremely dangerous for people who are very unwell). The causes of your illness might be extremely complex, and your recovery is likely to require a multi-faceted and uniquely personal set of strategies, which may well include medication. Hugs to anyone out there wrestling with A&D.”

—Darielle Bydegrees

Time For Compassion

For all our similarities, we are complex biological organisms with many nuanced differences. Just like other animals have personality types, oddities, seeming imperfections, and unique gifts, so do we. Yet, we seem to think that just because we are conscious and self-reflective creatures that we should be able to fix our anomalies, or even that they are in our control, especially when it comes to the mind. This myth perpetuates suffering, violence, and abuse when we treat others with judgement, condemnation, and meanness according to this flawed perception. People with severe depression and anxiety can’t just snap out of it or get over it, at least not quickly, the way you or I (when well) would normally shift a low mood or worry. Clinical depression and anxiety are different animals and sometimes lifelong events.

If we are significantly anxious or depressed this does not necessarily mean that something is complexly wrong with us, or that we can fix our predicament by digging into our current or past issues or venting our emotions. It might mean we need medicine, just as we would for any other less stigmatized form of physiological illness towards which we are culturally less judgmental. Because mental illness happens in the brain, it effects our thoughts and emotions more than other biological illnesses. Usually it means that we need both medicine (pharma, herbal, and/or nutraceuticals) and the support of caring, informed, and understanding health professionals who aren’t pigeon-holed and attached to a one-size-fits-all approach.

Images and stories of “crazy” and “unpredictable” people with anxiety, or even depression, perpetuate our irrational fears and judgement of these debilitating conditions. Such people are usually not violent unto others. Those who carry unresolved pain and trauma are more likely candidates for this.

Most people with mental illness suffer in shame and silence and are some of the most vulnerable, tender, compassionate and empathic people I know. So, let’s break the mould together, lift the mythic curse of judging mental illness due to our usually innocent ignorance of these menacing and crippling invisible illnesses. We do this in part through opening our minds and humbly learning about them so that our beliefs about these conditions can match reality. This in turn informs how we help sufferers and those who love them.


Some resources for Depression & Anxiety:

Books:

The Upward Spiral by Alex Korb, CBT for healing through depression

The Noonday Demon by Andrew Solomon, on depression

The Imp of the Mind: on OCD and intrusive, bad thoughts

Videos:

“The Refugees” by Andrew Solomon at The Moth

Depression, Too, Is a Thing with Feathers by Andrew Solomon
Depression Talk at Stanford by Robert Sapolsky
Sam Harris and Robert Sapolsky: from 48.00 minutes to the end

Disclaimer: The information in this article is not intended to diagnose or treat any disease, or substitute for professional help. It is based on the author’s personal and clinical experience, research, and direct observations. The author is not a psychotherapist.


Jack Adam Weber, L.Ac., MA, is Chinese medicine physician, having graduated valedictorian of his class in 2000. He has authored hundreds of articles, thousands of poems, and several books. Weber is an activist for embodied spirituality and writes extensively on the subjects of holistic medicine, emotional depth work, and mind-body integration, all the while challenging his readers to think and act outside the box. Weber’s latest creation is the Nourish Practice, a deeply restorative, embodied meditation practice as well as an educational guide for healing the wounds of childhood. His work can be found at jackadamweber.com, on Facebook, or Twitter, where he can also be contacted for life-coaching and medical consultations.

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Awareness

Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

You can join the Greenmedinfo newsletter here for updates and more information about the world of health

References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

A Quick Important Notice:

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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Awareness

Brain Imaging Shows Autistic Brains Contain HIGH Amounts of Aluminum

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In Brief

  • The Facts:

    A study published early in 2018 identified very high amounts of aluminum lodged in the brains of multiple people with autism.

  • Reflect On:

    We know little about where the heavy metals used as adjuvants in vaccines end up in the body. We now know that injected aluminum doesn't exit the body like aluminum intake from other sources. When injected, it ends up in the brain.

A study published earlier in 2018 should have made headlines everywhere, as it discovered historically high amounts of aluminum in autistic brains. The study was conducted by some of the worlds leading scientists in the field.

Five people were used in the study, four males and one female, all between the ages of 14-50. Each of their brains contained unsafe and high amounts of aluminum compared to patients with other diseases where high brain aluminum content is common, like Alzheimer’s disease, for example.

Of course, this caused people to downplay the study, citing a low sample group, but that’s not entirely a valid argument given the reason why this study was conducted. As cited in the study above, recent studies on animals, published within the past few years, have supported a strong connection between aluminum, and aluminum adjuvants used in human vaccinations, and Autism Spectrum Disorder (ASD.)

Studies have also shown that injected aluminum does not exit the body, and can be detected inside the brain even a year after injection. That being said, when we take aluminum in from sources such as food, the body does a great job of getting it out, but there is a threshold. It’s important to acknowledge that the aluminum found in the brain, could be due to the presence of aluminum adjuvants in vaccines. This latest study also identified the location of aluminum in these tissues, and where they end up. This particular study was done on humans, which builds upon, and still supports, the findings of the animal studies.

This is also important because the majority of studies that previously examined human exposure to aluminum have only used hair, blood and urine samples. The study also makes a clear statement regarding vaccines, stating that “Paediatric vaccines that include an aluminum adjuvant are an indirect measure of infant exposure to aluminum and their burgeoning use has been directly correlated with increasing prevalence of ASD.”

 Aluminum, in this case, was found in all four lobes of the brain.

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The aluminum content of brain tissues from donors with a diagnosis of ASD was extremely high (Table 1). While there was significant inter-tissue, inter-lobe and inter-subject variability the mean aluminium content for each lobe across all 5 individuals was towards the higher end of all previous (historical) measurements of brain aluminium content, including iatrogenic disorders such as dialysisencephalopathy[13][15][16][17][18][19]. All 4 male donors had significantly higher concentrations of brain aluminum than the single female donor. We recorded some of the highest values for brain aluminum content ever measured in healthy or diseased tissues in these male ASD donors

We Know, And Have Known, Aluminum Is Not Safe, Yet We Ignore It

When we talk about the ‘safe’ amount of aluminum here, there is no such thing. Aluminum is extremely toxic to any biological process, it’s not meant for us which is why it stayed deep within the Earth until we took it out. It has no place within us, and that’s simply due to the fact that it causes nothing but havoc. This makes it odd that we would put them in vaccinations despite the fact that for 100 years there has been no appropriate safety testing.

Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans.

The quote above comes from a study published in 2011, it’s 2018 now and we’ve come along way in our understanding. We are starting to see even more research confirming the statement above.

Almost every study you read regarding previous studies on aluminum adjuvants within vaccines emphasized how the nature of its bioaccumulation is unknown, and a serious matter. We now know that it goes throughout the body, into distant organs eventually ends up in the brain.

Another fairly recent study from 2015 points out:

Evidence that aluminum-coated particles phagocytozed in the injected muscle and its draining lymph notes can disseminate within phagocytes throughout the body and slowly accumulate in the brain further suggests that alum safety should be evaluated in the long term.(source)

The pictures below come from the recent 2018 study and show ‘bright spots’ that indicate heavy metals in the brain.

 

The more recent study discussed in this article is adding to that evidence. Below you can watch one of the most recent interviews with Dr. Eric Exly, one of the world’s foremost leading authors on the subject, and one of the authors of this most recent study. He is a Biologist (University of Stirling) with a Ph.D. in the ecotoxicology of aluminum. You can read more about his background here.

Take Away

People need to understand that despite media bullying, it’s ok to question vaccine safety, and there is plenty of reason to. There are many concerns, and heavy metals are one of them. In fact, the persistence and abundant presence of heavy metals in our environment, foods and medications is a concern, one that has been the clear cause for a variety of health ailments, yet it’s one that’s hardly addressed by the medical industry.

You can detox from this with items such as Spirulina, and waters that contain a high Silica content. There are studies that show various methods of detoxing can be used to get this lodged aluminum, or some of it, out of your body, organs and brain. This is where educating yourself regarding the medicinal value of food and nutrition is a key Perhaps this can be a motivation to better your diet, especially if you have, are someone, or know someone with an ASD diagnosis.

A Quick Important Notice:

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

SUPPORT CE HERE!

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The CDC’s Influenza Math Doesn’t Add Up: Exaggerating the Death Toll to Sell Flu Shots

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In Brief

  • The Facts:

    The flu shot is irresponsibly marketed, unnecessary and in some cases dangerous. This perspective comes from many people and health professionals, yet it's a narrative that's constantly ignored.

  • Reflect On:

    Is a flu shot really necessary? Are our immune systems suffering from a lack of real immunity? Are vaccines doing more harm than good?

Every year at about this time, public health officials and their media megaphones start up the drumbeat to encourage everyone (including half-year-old infants, pregnant women and the invalid elderly) to get a flu shot. Never mind that more often than not the vaccines don’t work, and sometimes even increase the risk of getting sick.

To buttress their alarmist message for 2018-2019, representatives from the Centers for Disease Control and Prevention (CDC) and other health agencies held a press conference and issued a press release on September 27, citing a particularly “record-breaking” (though unsubstantiated) 80,000 flu deaths last year. Having “medical experts and public health authorities publicly…state concern and alarm (and predict dire outcomes)” is part and parcel of the CDC’s documented playbook for “fostering public interest and high…demand” for flu shots. CDC’s media relations experts frankly admit that “framing” the current flu season as “more severe than last or past years” or more “deadly” is a highly effective strategy for garnering strong interest and attention from both the media and the public.

If accurate, 80,000 deaths would represent an enormous (and mystifying) one-year jump—tens of thousands more flu deaths compared to the already inflated numbers presented for 2016 (and every prior year).

Peter Doshi (associate editor at The BMJ and a MIT graduate) has criticized the CDC’s “aggressive” promotion of flu shots, noting that although the annual public health campaigns deliver a “who-in-their-right-mind-could-possibly-disagree message,” the “rhetoric of science” trotted out each year by public health officials has a “shaky scientific basis.” Viewed within the context of Doshi’s remarks, the CDC’s high-flying flu numbers for 2017-2018 raise a number of questions. If accurate, 80,000 deaths would represent an enormous (and mystifying) one-year jump—tens of thousands more flu deaths compared to the already inflated numbers presented for 2016 (and every prior year). Moreover, assuming a roughly six-month season for peak flu activity, the 80,000 figure would translate to an average of over 13,300 deaths per month—something that no newspaper last year came close to reporting.

The CDC’s statistics are impervious to independent verification because they remain, thus far, unpublished—despite the agency’s pledge on its website to base its public health pronouncements on high-quality data derived openly and objectively. Could the CDC’s disappointment with influenza vaccination coverage—which lags far behind the agency’s target of 80%—have anything to do with the opacity of the flu data being used to peddle the unpopular and ineffective vaccines?

Fudging facts

There are a variety of reasons to question the precision with which the CDC likes to imbue its flu statistics. First, although the CDC states that it conducts influenza mortality surveillance with its partner agencies, there is no actual requirement for U.S. states to report adult flu deaths to the CDC. (In public health parlance, adult influenza deaths are not “reportable” or “nationally notifiable.”) In fact, the only “flu-associated deaths” that the CDC requires states and other jurisdictions to report are deaths in children—180 last year.

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…when actual death certificates are tallied, influenza deaths on average are little more than 1,000 yearly.

How did the CDC reach its as-yet-unpublished conclusion—widely shared with the media—that 79,820 American adults in addition to 180 children died from the flu in 2017-2018? The agency states that it relies on death certificate data. However, members of the Cochrane research community have observed that “when actual death certificates are tallied, influenza deaths on average are little more than 1,000 yearly.”

Other knowledgeable individuals have also noted that the death records system in the U.S. is subjective, incomplete and politicized, and have suggested that citizens should adopt a “healthy skepticism about even the most accepted, mainstream, nationally reported CDC or other ‘scientific’ statistics.” This skepticism may be especially warranted for the influenza stats, which are so inextricably intertwined with the CDC’s vaccination agenda that the statistical techniquesand assumptions that the agency uses focus specifically on “project[ing] the burden of influenza that would have occurred in the absence of vaccination.”

skepticism may be especially warranted for the influenza stats, which are so inetricably intertwined with the CDC’s vaccination agenda.

Notwithstanding its incessant use of influenza statistics to justify its flu vaccine policies, the CDC tries to have it both ways, cautioning that because “influenza activity reporting…is voluntary,” influenza surveillance in the U.S. “cannot be used to ascertain how many people have become ill with influenza during the influenza season.” A larger problem is that the vital statistics that form the basis of the CDC’s surveillance data conflate deaths from pneumonia and influenza (P&I). The CDC concedes that this conflation complicates the challenge of specifically estimating flu deaths:

The system “tracks the proportion of death certificates processed that list pneumonia or influenza as the underlying or contributing cause of death. This system…does not provide an exact number of how many people died from flu” [emphasis added].

Curiously, the CDC presented its cause-of-death data slightly differently prior to 2015. Through 2014, the agency’s annual National Vital Statistics Reports included tables showing influenza deaths and pneumonia deaths as separate line items. Those reports made it abundantly clear that pneumonia deaths (at least as transmitted by death certificates) consistently and dramatically outstripped influenza deaths. The table below illustrates this pattern for 2012-2014.

Starting in 2015, the annual vital statistics reports began displaying P&I together and eliminated the distinct line items. At present, only one tool remains to examine mortality associated with influenza as distinct from pneumonia—the CDC’s interactive FluView dashboard—which provides weekly national breakdowns. The dashboard shows the same general pattern as in the annual reports—that is, lower numbers of influenza deaths and much higher numbers of pneumonia deaths. Bearing in mind all the shortcomings and potential biases of death certificate data, dashboard reports for the first week of March (week 9) for the past three years show 257 influenza deaths versus 4,250 pneumonia deaths in 2016, and 534 and 736 flu deaths (versus over 4,000 annual pneumonia deaths) in 2017 and 2018, respectively.

When clinicians in outpatient settings do order testing, relatively few of the “flu” specimens—sometimes as low as 1%—actually test positive for influenza.

Semantic shenanigans

Semantics also play a key role in the CDC’s slippery communications about “flu.” For example, CDC’s outpatient surveillance focuses on the broad category of “influenza-like illness” (ILI)—an almost meaningless term describing general symptoms (fever, cough and/or sore throat) that any number of non-influenza viruses are equally capable of triggering. Cochrane lists several problems with the reliance on ILI to make inferences about influenza:

  • There is “no reliable system to monitor and quantify the epidemiology and impact of ILI” and no way of knowing what proportion of ILI is caused by influenza.
  • There are almost no reliable data on the number of ILI-related physician contacts or hospitalizations—and no one knows what proportion of ILI doctor visits and hospitalizations are due to influenza.

“Pneumonia,” too, is a catch-all diagnosis covering lung infections caused by a variety of different agents: viruses (non-influenza as well as influenza), bacteriafungiair pollutants and many others. Interestingly, hospitalization is a common route of exposure to pneumonia-causing pathogens, and mortality from hospital-acquired pneumonia exceeds 60%. In a plausible scenario, an adult hospitalized for suspected (but unconfirmed) “flu” could acquire a lethal pneumonia bug in the hospital, and their death might be chalked up to “flu” regardless of the actual facts, particularly because clinicians do not necessarily order influenza testing. When clinicians in outpatient settings do order testing, relatively few of the “flu” specimens—sometimes as low as 1%—actually test positive for influenza. Over the past couple of decades, the proportion of specimens testing positive has averaged around 15%—meaning that about 85% of suspected “flu” specimens are not, in fact, influenza.

Roughly four-fifths of the vaccine injury and death cases settled through the National Vaccine Injury Compensation Program are flu-vaccine-related.

Propaganda with a purpose

It takes little subtlety to recognize that the principal reason for flu hyperbole is to sell more vaccines. However, more and more people—even infectious disease specialists—are realizing that flu shots are fraught with problems. Roughly four-fifths of the vaccine injury and death cases settled through the National Vaccine Injury Compensation Program are flu-vaccine-related. A University of Toronto-based expert recently stated, “We have kind of hyped this vaccine so much for so long we are starting to believe our own hype.”

Pro-flu-vaccination studies—through their skillful placement in prestigious journals—tend to drown out other influenza studies that should be ringing warning bells. Published peer-reviewed studies show that:

  • Previous influenza vaccination, particularly in those who get a flu shot every year, diminishes or “blunts” the already low effectiveness of flu shots.
  • Getting vaccinated against influenza increases susceptibility to other severe respiratory viruses and also to other strains of influenza.
  • Mothers who receive influenza vaccines during pregnancy face an increased risk of miscarriages and their offspring face elevated risks of birth defects and autism.

A systematic review of influenza vaccine trials by Cochrane in 2010 urges the utmost caution. Noting that “studies funded from public sources [have been] significantly less likely [than industry-funded studies] to report conclusions favorable to the vaccines,” and citing evidence of “widespread manipulation of conclusions,” the Cochrane reviewers’ bottom line is that “reliable evidence on influenza vaccines is thin.” We should all keep those words in mind the next time the CDC and the media try to mischaracterize flu facts and science.

CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured.  Your support is essential to CHD’s successful mission. Please visit our crowdfunding page.

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