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Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

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This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

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Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

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Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

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References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

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3 Powerful Tools to Help Overcome the Emotional Toll of the Pandemic

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In Brief

  • The Facts:

    The pandemic has had a significant effect on our lives. Possibly without realizing it, many are suffering from a form of Post-Traumatic Stress Disorder (PTSD).

  • Reflect On:

    If you feel stressed or feel that you have PTSD resulting from this pandemic, try these suggestions before resorting to medication or maladaptive coping strategies.

Before you begin...

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Take a moment and breathe. Place your hand over your chest area, near your heart. Breathe slowly into the area for about a minute, focusing on a sense of ease entering your mind and body. Click here to learn why we suggest this.

The pandemic has had a significant effect on our lives. Possibly without realizing it, many are suffering from a form of Post-Traumatic Stress Disorder (PTSD). Every news cycle paralyzes us with fear of a new variant. Some feel grief over who or what they have lost or continue to have feelings of social disconnectedness. Despite what we have all been through, we need to start moving forward with our lives and truly live again. We must recognize that we have more control over our physical and mental health than advertised. The truth is that there are many helpful things that we can do.

PTSD is a stress-related disorder that may develop after exposure to a traumatic event or ordeal in which death or severe physical harm was a threat or occurred. Those with PTSD may experience agitation, irritability, hostility, hypervigilance, self-destructive behavior, social isolation, flashbacks, fear, anxiety, depression, attention difficulty, loneliness, insomnia, or nightmares.

Trauma can lead to feelings of powerlessness, but powerlessness can also keep us trapped in a PTSD cycle. The psychological imprint of trauma rewires the brain. There’s an old saying in neuroscience: “neurons that fire together wire together.” Our brain neurons begin firing in the amygdala, the emotional part of our brains, during a traumatic event. People can get stuck in an emotional loop, and the rational voice in their heads does not weigh in. This looping can cause a person to respond disproportionately to stress – freezing, panicking, or acting out in anger. Some dissociate or enter a trance-like state. Maladaptive coping skills can sometimes develop. Cutting, burning, overeating, drinking, drugs, overspending, etc., is all an attempt to dampen our painful emotional feelings. So, to avoid getting stuck in a PTSD cycle, we must act and take our power back.

Time to seek out the most effective help so that we can feel calm and in control again. What can we do?

1. Boost Your Immune System

If you fear getting sick, it’s time to live a healthier lifestyle and boost your immune system. Sadly, we are taught (with the help of pharmaceutical dollars) that health comes from a needle or a pill. Our “experts” recommend masks, hand-washing, social distancing, and mRNA vaccines. Still, they seldom suggest a healthy diet, supplements, and other natural remedies to help improve our health and support the body to fight off illness and disease. Click here for my article that includes 16 Tips on Boosting Immunity.

2. Embrace Spirituality

Over the last 20 years, I have been honored to have worked with many great therapists, healers, spiritual leaders, and trauma survivors to witness the power of Spirituality in healing. Spirituality is an inner belief system providing an individual with meaning and purpose in life. Whether it involves a higher power, nature, religious rituals, meditation, mindfulness, or prayer, the premise is to stay connected to the core of who we are. That place of stillness within us holding the memory of wholeness, peace, inner strength, and balance – despite what has happened. A spiritual philosophy or practice can provide us with a bigger context for our experiences and clarify our purpose. Spiritual methods also connect us with a sense of community and support. Finding our tribe is essential in the face of trauma and loss. The spiritual journey often allows us to go inside ourselves and listen to our inner guidance and “knowingness.” The inner voice may know, for instance, that the virus will not hurt us, or what we are being told by the media is untrue. Spirituality also helps us shift our perspective from “why me” to “what can I do about it. It brings us a sense of power and control.

3. Guided Imagery & Bilateral Stimulation

Both tools are essential for the trauma therapy toolbox. They are noninvasive and helpful for overcoming the effects of trauma. Guided imagery can help us alter the negative or stressful pictures and thoughts in our minds and help us create new, more peaceful ones—a form of instilling positive affirmations. Before you read on, I thought you might like to download my 10-minute exercise. This science-based, comprehensive video will help you to cultivate a sense of inner peace and give you a way to help overcome the effects of this pandemic – GET IT HERE

Is There Science Behind This?

Science, yes. Magic, no. This method requires regular practice if you want to make lasting, long-term changes to the ways that you think and feel. The good news is that both guided imagery and bilateral stimulation are widely practiced and well-established practices. However, I recommend that if you are still struggling after repeated listening, you find a qualified trauma therapist to continue the work you have already started.

A Look At The Research

Guided imagery is a behavioral technique using a series of verbal suggestions to guide oneself or others in visualizing an image in the mind to bring a desired response in the way of a reduction in stress, anxiety, or pain. A growing list of empirical literature supports the use of these techniques in various physical and emotional conditions. Guided imagery resulted in a clinically significant reduction in PTSD and related symptoms in a returning, combat-exposed active-duty military population. Positive affirmations can positively affect the brain’s circuitry. There is MRI evidence suggesting that specific neural pathways are increased when people practice self-affirmation tasks.

Numerous research articles have established that bilateral stimulation is one of the most effective treatments for post-traumatic stress disorder (PTSD). Some therapists practice Eye Movement Desensitization and Reprocessing (EMDR), a combination of psychotherapy and bilateral stimulation. EMDR is very effective for treating a wide range of mental health issues due to emotional and physical trauma. During bilateral stimulation, patients tend to “process” the memory in a way that leads to a peaceful resolution. And, often results in increased insight regarding both previously disturbing events and long-held negative thoughts about the self.

“Bilateral Stimulation induces a fundamental change in brain circuitry, similar to what happens in REM sleep. It allows the person undergoing treatment to process and incorporate traumatic memories into general association networks in the brain. This therapy helps the individual integrate and understand the memories within the larger context of their life experience.” – Robert Stickgold, Ph.D., Harvard Medical School

Takeaway

If you feel stressed or feel that you have PTSD resulting from this pandemic, try the above suggestions and download my helpful video before resorting to medication or maladaptive coping strategies. Also, you can discover the many mind-body practices you can do at home to help manage stress more successfully and so much more. SIGN UP HERE to receive your free download today. To purchase my book Healing Without Hurting, click here.

Dive Deeper

Click below to watch a sneak peek of our brand new course!

Our new course is called 'Overcoming Bias & Improving Critical Thinking.' This 5 week course is instructed by Dr. Madhava Setty & Joe Martino

If you have been wanting to build your self awareness, improve your.critical thinking, become more heart centered and be more aware of bias, this is the perfect course!

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Boosting Your Mood and Improving Your Health With Vitamin D

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In Brief

  • The Facts:

    Vitamin D is essential for proper immune functioning and alleviation of inflammation.

  • Reflect On:

    Are you or someone you love suffering from depression or an autoimmune disorder? When is the last time you checked your Vitamin D levels?

Before you begin...

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Take a moment and breathe. Place your hand over your chest area, near your heart. Breathe slowly into the area for about a minute, focusing on a sense of ease entering your mind and body. Click here to learn why we suggest this.

Are you or someone you love suffering from depression or an autoimmune disorder? It appears vitamin D deficiency may be to blame.

Vitamin D is essential for proper immune functioning and alleviation of inflammation. The beneficial effects of vitamin D on protective immunity are due in part to its impact on the innate immune system and has numerous effects on cells within the immune system. Vitamin D is also involved in maintaining the proper balance of several minerals in the body. And, it helps to ward off the flu and many viruses and treat them. The latest research links vitamin D deficiency to many disease states. These disease states include cancer, osteoporosis, heart disease, depression, arthritis, and just about every other degenerative disease.

 “Vitamin D reduces depression. In a randomized, double-blind study, People with depression who received vitamin D supplements noticed a marked improvement in their symptoms.” – Journal of Internal Medicine

According to the Nutrition Research Journal, as many as 80% of people are deficient in vitamin D. Inadequate exposure to sunshine, poor eating habits, malabsorption, the VDR genetic mutation, and accelerated catabolism due to certain medications, dark skin pigment color, and too much sunscreen can be to blame. 

A doctor can check vitamin D levels with a simple blood test. Many mainstream doctors will suggest that you are within normal limits if your levels are 20-30ng/mL. However, for optimal health, the Endocrine Society and many functional medicine M.D.s and naturopaths will recommend levels of between 40-70 ng/mL for both children and adults. These doctors will also recommend a more aggressive replenishment program. For example, at age five, my son’s level was 24. The pediatrician recommended 500iu daily of supplementation, while our naturopath recommended 5,000iu daily for six months before retesting. Six months later, his levels were almost normal. 

“Through several mechanisms, vitamin D can reduce risk of infections. Those mechanisms include inducing cathelicidins and defensins that can lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lungs, leading to pneumonia, as well as increasing concentrations of anti-inflammatory cytokines” – PubMed

How to Increase Your Vitamin D Levels

Get enough sun. Vitamin D3, “the sunshine vitamin,” is the only vitamin your body that is made, with the help of the sun. So be sure to get enough sun exposure to help the body make this essential nutrient. Hold off trying to protect ourselves from the rays of the sun at every turn by slathering sunscreen. Allow yourself to play outside, garden, and enjoy the rays in moderation.

If you must use some sunscreen, avoid chemical sunscreens made with toxic chemicals that cause thyroid dysfunction, endocrine disruption, allergies, organ toxicity, reproductive toxicity, skin cancer, development, brain, and metabolism problems. Shop for natural mineral-zinc-based certified products instead. When exposed to scorching climates or in the sun for extended periods, we use sunscreens by Babyganics, Badger, Babo Botanicals, and Goddess Garden products.

Eat a well-balanced diet, with foods higher in vitamin D. Although it is believed that we only get twenty percent from the foods we eat. Some foods higher in D include cod liver oil, fish, oysters, eggs, and mushrooms. 

Get checked for the VDR mutation. A blood test will determine if you have mutations in the vitamin D receptor. The consequence can be lower vitamin D levels and the inability to absorb vitamin calcium and many other minerals properly. According to a 2020 scientific report, supplementation of vitamin D can help improve VDR gene expression, so more supplementation may be necessary if you have this mutation.

“Something so simple. Vitamin D supplementation could improve the health status of millions and so becomes an elegant solution to many of our health problems today.” – Carol L. Wagner, MD – Medical University of South Carolina

Supplementation 101. Supplementation is often critical if you cannot properly metabolize or absorb enough vitamin D or not get enough sunshine. In areas with long winters and specific populations of people with darker skin color, supplementation may be even more critical. There are many supplements on the market. However, many tablet forms are not as bioavailable and harder to absorb. Therefore, it has been recommended that liquid forms are better. In addition, liquid D is often suspended in olive oil, which helps the vitamins to absorb more easily since it is fat soluble. One of my favorite brands is by Seeking Health. It does not contain any impurities or allergy-inducing ingredients. 

Final Thoughts

Boosting the immune system naturally works on your body’s innate wisdom. It supports the body to operate like a well-oiled machine, protects it from unwanted pathogens and disease, and helps ensure a healthy body and mind.

To receive more info on how you and your family can overcome ADHD, apraxia, anxiety, and more without medication SIGN UP HERE or purchase my book Healing without Hurting.

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Click below to watch a sneak peek of our brand new course!

Our new course is called 'Overcoming Bias & Improving Critical Thinking.' This 5 week course is instructed by Dr. Madhava Setty & Joe Martino

If you have been wanting to build your self awareness, improve your.critical thinking, become more heart centered and be more aware of bias, this is the perfect course!

Click here to check out a sneak peek and learn more.

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Awareness

Most Diabetic, Heart Disease & Alzheimer’s Deaths Categorized As “Covid” Deaths (UK)

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CE Staff Writer 10 minute read

In Brief

  • The Facts:

    According to professor of evidence based medicine at Oxford Dr. Carl Heneghan , who is also an emergency GP, most diabetic, heart disease & alzheimer's deaths were categorized as COVID deaths in the United Kingdom.

  • Reflect On:

    How many deaths have actually been a result of COVID? Why is this pandemic surrounded with so much controversy? Why does mainstream media fail at having appropriate conversations about 'controversial' evidence/opinions?

Before you begin...

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 Dr. Carl Heneghan has an interesting view on the pandemic, not only is he a professor of evidence-based medicine at Oxford University, he also works Saturday shifts as an emergency GP. This allows him to see healthcare from both the academic perspective as well as the healthcare experience, more specifically, it allows him to see COVID from both perspectives.

What Happened: In a recent article he wrote for The Spectator, he writes the following,

It’s hard to imagine, let alone measures, the side effects of lockdowns. The risk with the government’s ‘fear’ messaging is that people become so worried about burdening the NHS that they avoid seeking medical help. Or by the time they do so, it can be too late. The big rise in at-home deaths (still ongoing) points to that. You will be familiar with the Covid death toll, updated in the papers every day. But did you know that since the pandemic, we’ve had 28,200 more deaths among diabetics that we’d normally expect? That’s not the kind of figure they show on a graph at No. 10 press conference. For people with heart disease, it’s 17,100. For dementia and Alzheimer’s, it’s 22,800. Most were categorised as Covid deaths: people can die with multiple conditions, so they can fall into more than one of these categories. It’s a complicated picture. But that’s the problem in assessing lockdown. you need to do a balance of risks.

Evidence-based medicine might sound like a tautology — what kind of medicine isn’t based on evidence? I’m afraid that you’d be surprised. Massive decisions are often taken on misleading, low-quality evidence. We see this all the time. In the last pandemic, the swine flu outbreak of 2009, I did some work asking why the government spent £500 million on Tamiflu: then hailed as a wonder drug. In fact, it proved to have a very limited effect. The debate then had many of the same cast of characters as today: Jonathan Van-Tam, Neil Ferguson and others. The big difference this time is the influence of social media, whose viciousness is something to behold. It’s easy to see why academics would self-censor and stay away from the debate, especially if it means challenging a consensus.

This is something that’s been a concern since the beginning of the pandemic. For example, a report published during the first wave in the British Medical Journal  titled Covid-19: “Staggering number” of extra deaths in community is not explained by covid-19″ has suggested that quarantine measures in the United Kingdom, as a result of the new coronavirus, may have already killed more UK seniors than the coronavirus has during the months of April and May.

According to the data, COVID-19, at the time of publication, only accounted for 10,000 of the 30,000 excess deaths that have been recorded in senior care facilities during the height of the pandemic. The article quotes British Health officials stating that these unexplained deaths may have occurred because quarantine measures have prevented seniors from accessing the health care that they need.

Fast forward to more recent research regarding lockdowns, and these concerns have grown. Professor Anna-Mia Ekström and Professor Stefan Swartling Peterson have gone through the data from UNICEF and UNAIDS, and came to the conclusion that at least as many people have died as a result of the restrictions to fight COVID as have died of COVID. You can read more about that here.

These are just a few of many examples. You can read more about the hypothesized “catastrophic” impacts of lockdown, here.

When it comes to what he mentions about academics shying away from debate, especially if their research goes against the grain, we’ve a seen a lot of that too. Here’s a great example you can read about from Sweden regarding zero deaths of school children during the first wave despite no masks mandates or lockdown measures. Jonas F Ludvigsson, a paediatrician at Örebro University Hospital and professor of clinical epidemiology at the Karolinska Institute is quitting his work on COVID-19 because of harassment from people who dislike what he has discovered.

Why This Is Important: Heneghan’s words are something that many people have been concerned about when it comes to the deaths that are attributed to COVID-19. How many of them are actually a result of COVID? The truth seems to be that we don’t really know. But one thing we do know is that total death toll caused by COVID doesn’t seem to be quite accurate.

That being said, we do know that people with comorbidities are more susceptible to illness and death from COVID, and that’s something to keep in mind. For people with underlying health conditions, covid, just like flu or pneumonia, can be fatal.

Ontario (Canada) Public Health has a page on their website titled “How Ontario is responding to COVID-19.” On it, they clearly state that deaths are being marked as COVID deaths and are being included in the COVID death count regardless of whether or not COVID actually contributed to or caused the death. They state the following:

Any case marked as “Fatal” is included in the deaths data. Deaths are included whether or not COVID-19 was determined to be a contributing or underlying cause of death…”

This statement from Ontario Public Health echoes statements made multiple times by Canadian public health agencies and personnel. According to Ontario Ministry Health Senior Communications Advisor Anna Miller:

As a result of how data is recorded by health units into public health information databases, the ministry is not able to accurately separate how many people died directly because of COVID versus those who died with a COVID infection.

In late June 2020, Toronto (Ontario, Canada) Public Health tweeted that:

“Individuals who have died with COVID-19, but not as a result of COVID-19 are included in the case counts for COVID-19 deaths in Toronto.”

It’s not just in Canada where we’ve seen these types of statements being made, it’s all over the world. There are multiple examples from the United States that we’ve covered since the start of the pandemic.

For example, Dr. Ngozi Ezike, Director of the Illinois Department of Public Health stated the following during the first wave of the pandemic:

If you were in hospice and had already been given a few weeks to live and then you were also found to have COVID, that would be counted as a COVID death, despite if you died of a clear alternative cause it’s still listed as a COVID death. So, everyone who is listed as a COVID death that doesn’t mean that was the cause of the death, but they had COVID at the time of death.

Also during the first wave, the Colorado Department of Public Health and Environment had to announce a change to how it tallies coronavirus deaths due to complaints that it inflated the numbers.

As you can see, we’ve struggled to find an accurate way to go about tallying COVID deaths since the start, creating more fear and hysteria around total numbers that are plastered constantly in front of citizens by news stations. That being said, a lot of people who are dying of COVID do have co-morbidities as well. But as the professor says, “it’s a complicated picture” and hard to figure out, and probably something we will never figure out.

There’s been a lot of “fear mongering” by governments and mainstream media, and some believe that lockdowns and masks are simply being used as a psychological tool to keep that fear constant, which in turn makes it easier to control people and make them comply.

Meanwhile, there are a lot of experts in the field who are pointing to the fact that yes, COVID is dangerous, but it does not at all warrant the measures that are being taken, especially when the virus has a 99.95 percent survival rate for people over the age of 70. There are better ways to protect the vulnerable without creating even more chaos that lockdown measures have created, and are creating throughout this pandemic.

That said, it’s also important to note that some calls for lockdown measures are focused on stopping hospitals from becoming overwhelmed. Why do some places with very restrictions see no hospital capacity issues? Why do some places with a lot of restrictions see hospital capacity issues? Why do we also see the opposite for both in some areas? These questions appear to be unanswered still. That being said. Hospitals have always been overwhelmed. This is not a new phenomenon.

The main issue here is not who is right or wrong, it’s the censorship of data, science, and opinions of experts in the field. The censorship that has occurred during this pandemic has been unprecedented.

Science is being suppressed for political and financial gain. COVID-19 has unleashed state corruption on a grand scale, and it is harmful to public health. Politicians and industry are responsible for this opportunistic embezzlement. So too are scientists and health experts. The pandemic has revealed how the medical-political complex can be manipulated in an emergency—a time when it is even more important to safeguard science. –  Dr. Kamran Abbasi, recent executive editor of the prestigious British Medical Journal (source)

This censorship alone has been an excellent catalyst for people to question what we are constantly hearing from mainstream media, government, and political scientists. Any type of information that calls into question the recommendations or the information we are receiving from our government seems to be subjected to this type of censorship. Mainstream media has done a great job at not acknowledging many aspects of this pandemic, like clinically proven treatments other than a vaccine, and therefore the masses are completely unaware of it.

Is this what we would call ethical? When trying to explain this to a friend or family member, the fact that they are not aware of these other pieces of information, because they may be avid mainstream news watchers, has them in disbelief and perhaps even sometimes labelling such assertions as a “conspiracy theory.” This Brings me to my next point.

The Takeaway: As I’ve said in a number of articles before, society is failing to have conversations about “controversial” topics and viewpoints. This is in large part due to the fact that mainstream media does such a poor job at covering these viewpoints let alone acknowledging them. The fact that big media has such a stranglehold over the minds of many is also very concerning, because we are living in a time where independent research may be more useful. There seems to be massive conflicts of interest within mainstream media, and the fact that healthy conversation and debate is being shut down by mainstream media contributes to the fact that we can’t even have normal conversations about controversial topics in our everyday lives.

Why does this happen? Why can’t we see the perspective of another? To be honest, I still sometimes struggle with this. When it comes to COVID, things clearly aren’t as black and white as they’re being made out to be, and as I’ve said many times before when things aren’t clear, and when government mandates oppose the will of so many people, it reaches a point where they become authoritarian and overreaching.

In such circumstances I believe governments should simply be making recommendations and explaining why certain actions might be important, and then leave it to the people to decide for themselves what measures they’d like to take, if any. What do you think? One thing is for certain, COVID has been a catalyst for more and more people to question the world we live in, and why we live the way that we do.

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