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Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

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Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

You can join the Greenmedinfo newsletter here for updates and more information about the world of health

References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

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Awareness

“I Tried Every Diet & Nothing Worked” How Mucus Free Living Saved This Woman’s Life

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In Brief

  • The Facts:

    After a year on a high-fat/high-protein lifestyle, Livia Macdonald nearly died. After adopting a 'mucus-free' lifestyle, a diet rich in fresh fruit and vegetables, she cured her depression, anxiety, and health issues.

  • Reflect On:

    True healing takes time and commitment, and a willingness to face the emotions and trauma buried beneath our eating habits.

In 2011, Livia Macdonald was looking for answers to her health. At nearly 300 lbs and stuck in the despairs of chronic illness, she was ready to make a big change. The first step—divorcing allopathic medicine all together. Like many others stepping away from conventional medicine, Livia found herself enveloped by the siren of holistic healthcare, adopting the protocols laid out by natural-health celebrity and functional medicine doctor, Mark Hyman.

Following Hyman’s vitality guidelines, Livia cut out grains, starches, and processed sugars, while incorporating more vegetables, ‘healthy’ fats and animal products into her diet.

I was told that high protein and high fats is the way to go because our brain needs fat. I even made my own ghee and ate loads of coconut oil and eggs every day,” she told Collective Evolution.

At first the high-fat diet did wonders for Livia’s health. She felt more energized, had more mental clarity, and even began to drop weight. “I lost almost 80 lbs the first year on the [high-fat] diet,” she said.

But after twelve months of a high-fat lifestyle, Livia said her body began to shut down.

“I started to feel awful. Like everything turned on me. I got severe depression, anxiety, shaking, internal tremors, my organs started to really hurt, I had them checked and my pancreas had so many fat deposits all over it and my cholesterol was through the roof after being optimal. My entire body started to shut down and I became bed ridden for an entire year.”

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During this difficult time Livia came across the work of Dr. Robert Morse, a regenerative detoxification specialist well known in the natural health world. One of the foundations of Dr. Morse’s teachings is that man is a part of the primate family, and therefore we are primarily a frugivore species whose bodies thrive off of fruit, some vegetables and herbs. Livia says that a lightbulb went off in her head immediately upon reading Dr. Morse’s work.

My intuition was screaming that this was the missing piece of my puzzle, and that he speaks the absolute truth.”

Arnold Ehret wrote “The Mucusless Diet Healing System,” a resource for the chronically ill. Ehret’s protocols implement systematic fasting, as well as a diet of raw fruit and vegetables.

Next, Livia discovered the work of a 19th century natural health educator named Arnold Ehret. Ehret’s rise to fame came through his in depth knowledge about the body, specifically in healing chronic disease through systematic fasting and a diet similar to what Morse prescribes—raw fruit and vegetables.

His magnum opus, The Mucusless Diet Healing System, detailed his many years working in a clinic for the chronically ill while implementing his detox protocols to cure their diseases. Ehret’s work garnered a cult-following throughout the early 20th century and inspired the works of well-known detox specialists like Robert Morse himself, Paul Braggs, and Alfredo Bowman.

Adopting A Mucus-Free Lifestyle

But Livia said her biggest aha moment did not come until she discovered the work of South-African detox specialist  Alexandra Cousins. Inspired by the teachings of Robert Morse and Arnold Ehret, Cousins takes their healing principles and merges them with the shamanic and emotional work which she feels is the missing piece for those seeking full-bodied healing.

What I am witnessing is that trauma, PTSD, OCD, addictions are running everyone’s lives,” she writes in her Facebook group, Living Mucus Free. “The degree will vary but we all have it unless we have specifically addressed it. It is safe to say that all my clients, especially the chronically ill suffer from some form of unresolved trauma. If you have adrenal, hormonal, thyroid, or CFS issues, you are dealing with trauma residue. Living mucus free tends to bring up all our unresolved trauma. As we no longer consume foods that numb us or stimulate us, trauma rises to the surface so that it can be felt and dealt with.”

Having endured years of ill-health herself and having tried almost every diet trend out there, Cousins eventually found solace through a lifestyle termed Living Mucus Free (LMF). Mucus, for those wondering, is the residue which builds in the body from eating non-species-specific food, i.e., animal products, grains, or most cooked food. This mucus putrefies and plaques to the intestinal walls, eventually causing acids to build up in the body and damage our organs and glands.

LMF does away with mucus-causing foods while utilizing fruit, vegetables, herbs, systematic fasting, lymphatic movement, and various trauma-release therapies. Today, Cousins teaches what she’s learned at detox retreats around the globe and inspires thousands through her fierce social media presence.

Alexandra Cousins; founder ‘Living Mucus Free’. Cousins teaches people how to heal their chronic illness through the principles of cellular detoxification.

Sweet potato pizza via Living Mucus Free.

Photo by Livia Macdonald.

Livia says she has dedicated herself to the Living Mucus Free principles with great results, incorporating daily intermittent fasting, herbal tinctures, movement and breathing practices targeted at draining the lymphatic system, as well as raw food diet.

“I have been vegan one year and living mucus free for 10 months now. My anxiety and depression cleared up within two months, never to return. I have so much more clarity and mental focus now and that is getting better with time, not worse. I am slowly healing my endocrine system and gaining more energy back, I am no longer bed ridden since the first couple of months on this lifestyle.. all my spiritual and emotional stuff has surfaced to be healed and it’s truly a fascinating and incredible journey to learn the truth and realize just how wrongly we have been conditioned in such a deep way.”

The emphasis in Living Mucus Free is elimination—getting out of the body’s way and allowing it to do its job of eliminating acids, toxins, undigested food material and mucoid plaque. This is primarily achieved through daily dry fasting and eating watery, astringent fruit, which pulls out toxins as it transits the digestive tract.

Another principle to the Living Mucus Free lifestyle is eating little to no fat while detoxing, a principle that goes against many of the high-fat diet trends of today. But as Alexandra Cousins explains, in the case of those who are cellularly degenerate, fats only serve to cover up their issues. Fats are anti-inflammatory, buffering the acidity in the body but never pulling the acids out. A temporary bandaid for true healing.

Livia feels this is what happened in her case, and it is why she thinks so many initially feel great adopting a high-fat diet.

“I feel the high fat diet works for some because it suppresses and clogs their lymphatic system so naturally they will feel instant relief. But now that I understand how the body actually works, of course you are going to show improvement at the beginning if you remove junk food, sugars/grains, dairy etc.”

Cousins also speaks much to the notion that fats, salts, animal products, and processed foods are stimulating to our nervous system which cover up our emotional wounds, so when we begin to remove these foods and focus on detoxifying the body, we are suddenly faced with old emotions or traumatic memories, and this, Alex says, is mostly what Living Mucus Free is about.

“When we detox on a cellular level, we are consistently clearing old information, old cellular memory in the form of emotion which is held in physical waste stored in the body, replacing it with new cellular information,” Alex Cousins, Living Mucus Free.

For those looking for a quick fix, Living Mucus Free probably isn’t the right fit. Those living the Mucus Free lifestyle don’t make false promises that you will be healed after a 30 day detox. The journey is slow and steady, one with bumps along the way known as healing crises. During a healing crisis any number of uncomfortable symptoms can arise as the body expels old debris and toxins. But as Livia says, walking through the discomfort is the only way towards true healing.

I believe that our society has everything so backwards,” says Livia. “We are taught to chase feeling good, and run away from feeling bad, and Living Mucus Free isn’t going to feel good in the beginning as it brings up our weaknesses for healing.”

The reward, as promised by Cousins, Morse, Ehret, and thousands of others who have healed through regenerative detox principles, is beyond anything we can imagine:

Unimaginable health and vitality, weight loss and reversed ageing, improved energy levels, mental clarity and confidence, liberation from anxiety, mood swings and self-doubt, resolution of stored trauma and a deeper connection to source, vastly improved sex life and orgasms.”

Is Living Mucus Free really the key to such incredible feats? The answer, it seems, is to be discovered only by those willing to walk through the fire to find out.

For more information about Living Mucus Free, visit Alexandra Cousins’ website, Living Mucus Free.

For amazing mucus free recipes and to continue following Livia’s journey, check her out Instagram or Facebook, or her website, LiveAlittleRaw.

Help Support Collective Evolution

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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Two Doctors Explain Autophagy, How To Induce It (Fasting) & What It Does To The Human Body (Video)

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In Brief

  • The Facts:

    Dr. Guido Kroemer and Rhonda Patrick sit down and discuss autophagy, how to induce it and it's health benefits.

  • Reflect On:

    Why do we never hear about fasting interventions as an 'official' treatment for certain from our federal health regulatory agencies when there is so much scientific proof?

Fasting and caloric restriction, if done correctly in a healthy and appropriate manner, combined with a healthy diet can have tremendous benefits for the human body. Interventions like fasting are gaining tremendous amounts of popularity, and that is in large part due to the fact that this information is being spread across the world via alternative media outlets and independent websites, youtube channels, etc. It’s not really a health topic that we’re hearing from mainstream media sources or our federal health regulatory agencies. Why? Because you can’t make money off of fasting. Perhaps when drugs are developed that mimic the effects of fasting, that’s when its popularity will skyrocket; but unfortunately, modern day health authorities don’t really seem to be as concerned with our health and wellbeing as they are about profiting and making money, and nobody is going to make any money if people starting eating less. That being said, the information revolution cannot be stopped, and fasting is now on the minds of many, and for good reason.

On October 3rd, 2016, the Nobel Assembly at Karolinska Institutet awarded the Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy, a term that translates to “self-eat.” In short, autophagy is the body’s self-cleaning system, a mechanism in which cells get rid of all the broken down, old cell machinery (organelles, proteins and cell membranes). It is a regulated, orderly process to degrade and recycle cellular components.

The process of autophagy is like replacing parts in a car—sometimes we need a new engine or battery for the car to function better. The same thing happens within each of our cells. During autophagy, old cellular debris is sent to specialized compartments within the cell called “lysosomes.” Lysosomes contain enzymes that degrade the old debris, breaking it down into smaller components to be reused again by the cell.

Scientists have found that fasting for 12 to 24+ hours triggers autophagy, which is thought to be one of the reasons that fasting is associated with longevity. There is a large body of research that connects fasting to improved blood sugar control, reduced inflammationweight loss, and improved brain function, and Oshumi’s findings provide greater insight into this research.

“Sporadic short-term fasting, driven by religious and spiritual beliefs, is common to many cultures and has been practiced for millennia, but scientific analyses of the consequences of caloric restriction are more recent… short-term food restriction induces a dramatic upregulation of autophagy in cortical and Purkinje neurons. As noted above, disruption of autophagy can cause neurodegenerative disease, and the converse also may hold true: upregulation of autophagy may have a neuroprotective effect.

Food restriction is a simple, reliable, inexpensive and harmless alternative to drug ingestion and, therefore, we propose that short-term food restriction may represent an attractive alternative to the prophylaxis and treatment of diseases in which candidate drugs are currently being sought.”

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If you look at the plethora of studies that’ve been published regarding caloric restriction and fasting, the benefits are overwhelming. These benefits are seen across the board, not just in humans, but in animals as well. Some of these benefits are talked about below in a fascinating interview and discussion between Dr. Rhonda Patrick  and Dr. Guido Kroemer. Dr. Patrick, as her website states, “is dedicated to the pursuit of longevity and optimal health and shares the latest research on nutrition, aging, and disease prevention with her audience. She has a gift for translating scientific topics into understandable takeaways for all levels of education and interest.” She has a lot of great content on her Youtube channel with some very interesting people who are leaders in their respective field.

Dr. Guido Kroemer is currently a Professor at the Faculty of Medicine of the University of Paris Descartes, Director of the research team “Apoptosis, Cancer and Immunity” of the French Medical Research Council (INSERM), Director of the Metabolomics and Cell Biology platforms of the Gustave Roussy Comprehensive Cancer Center, Deputy Director of the Cordeliers Research Center, and Hospital Practitioner at the Hôpital Européen George Pompidou, Paris, France. He is also a Foreign Adjunct Professor at the Karolinska Institutet, Stockholm, Sweden.

The Takeaway

The takeaway here is to recognize the potential of dietary interventions for certain ailments. It’s also to recognize the importance of seeking out knowledge and wisdom, and not just relying on your doctor for advice or prescription medications.

Related CE Articles on Fasting

How To Activate Autophagy: Your Body’s Self-Cleansing System

Autophagy, Fasting & Exercise: Scientist Reveal Multiple Ways You Can Slow Down The Process of Aging

The Complete Guide To Fasting & Reversing Type 2 Diabetes: A Special Interview With Dr. Jason Fung

Neuroscientist Shows What Fasting Does To Your Brain & Why Big Pharma Won’t Study It

Scientists Explain How Fasting Fights Cancer, Triggers Stem Cell Regeneration & Changes Your Brain (In A Good Way)

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Awareness

Ladies, Ditch the Bra

Published

on

In Brief

  • The Facts:

    There is evidence of a relationship between bras and breast cancer may rethink the societal convention of wearing bras.

  • Reflect On:

    Have you looked into the research about how bras can be contributing to poor health?

I realize it may feel some combination of uncomfortable, unprofessional, or unnecessarily provocative. Societal convention has most of us trussing up before going out.

If you are reading this at home, do me a favor and unhook. Then keep reading.

There’s Some Evidence of a Relationship Between Bras and Breast Cancer Yes, seriously.

Dressed To Kill: The Link Between Breast Cancer and Bras

Sydney Ross Singer and Soma Grismaijer authored a book called Dressed To Kill. They interviewed 4,000+ women in five major U.S. cities over two years. Half the women had been diagnosed with breast cancer. They found:

  • 75% of women who slept in their bras developed breast cancer
  • 1 in 7 who wore their bras 12+ hours per day developed breast cancer
  • 1 in 168 who did not wear a bra developed breast cancer
  • Within one month of ditching their bras, women with cysts, breast pain, or tenderness found their symptoms disappeared.

Breast Size, Handedness, and Breast Cancer Risk

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A 1991 article in the European Journal of Cancer found that premenopausal women who do not wear bras had half the risk of breast cancer compared with bra users. The data also suggest that bra cup size (and breast size) may be a risk factor for breast cancer.

Cancer Is Not a Disease

Andreas Moritz revealed that Japanese, Fijians, and women from other cultures were found to have a significantly higher likelihood of developing breast cancer when they began wearing bras. His book explains how cancer is an adaptive healing mechanism, arguing that people would die more quickly if the body did not form cancer cells.

Bras and Girdles Can Reduce Melatonin Levels

Japanese researchers found they can lower melatonin by 60%. Melatonin has anti-cancer properties. And Spanish researchers wrote about the use of melanonin in breast cancer prevention and treatment.

There’s No Downside to Being Cautious.

Am I suggesting this scanty fact base offers definitive proof of a causal relationship? No.

Am I suggesting you should be comforted that the National Cancer Institute, the American Cancer Society, and the New York Times all believe it to be bunk? No.

That’s a longer discussion, but it’s sufficient to say that politics and economics create active bedfellows and the absence of a commercial imperative might have something to do with the dearth of research.

Many of us don’t need to wait in order to do something that intuitively seems to make a lot of sense. Frankly, in view of the alarming rate of breast cancer prevalence in this country (12.3% of women) and the growing trend to remove body parts in an attempt to improve our odds, it seems we might be receptive to a bit of behavior modification.

Things to Consider Doing:

Go braless as much as possible.

It actually gets easier. When these muscles and ligaments are forced to bear the weight of our breasts, muscle tone returns. The more you wear a bra, the more you need to wear a bra. Chest muscles and breast ligaments atrophy, which then makes it feel uncomfortable to go braless.

15 year French study conducted by Besancon CHU professor Jean-Denis Rouillon found that “medically, phyisiologically, and anatomically, breasts gained no benefit from their weight being supported in a bra.” There was some evidence that eliminating bra use helped ease back pain. He described bra wearing as a “false need.”

Remove your bra when you get home. Don’t wear a bra to bed. And if you’re self-conscious when going out, try wearing camisoles, thicker material, or nipple pads. It does make sense to wear a support bra while exercising.

Wear Loose Bras in Softer Materials and Avoid Underwires

Tight bras and underwires restrict lymphatic drainage, promoting congestion and stagnation of toxic waste materials that are supposed to be flowing out for excretion. Further, the closing of lymphatic vessels reduces the delivery of oxygen and nutrients to the cells.

Michael Schachter, MD, FACAM wrote that bras and tight clothing can impede lymph flow and contribute to the development of breast cancer.

John MacDougall, MD wrote in The Lancet that repeated inflammation from constricting bras are implicated in painful breast cysts and lumps, scar tissue develops, and milk ducts become plugged, all of which is associated with a higher risk of breast cancer.

The metal in underwire bras can create an “Antenna Effect” according to the father of Applied Kinesiology, George Goodheart, DC. Repeated pressing of metal over an acupuncture point can cause longer-term stimulation of neuro-lymphatic reflex points corresponding to the liver, gallbladder, and stomach. “It will likely make her sick; slowly and quietly,” said John Andre, ND, DC.

Here’s a list of no-underwire bras recommended by Donna Eden, Vicki Mathews, and Titanya Dahlin. Donna adds that plastic underwires have the same negative impact as metal underwires.

Slide the Wires Out!

There’s no need to toss your expensive underwire bras. If you cut a small opening at one end of the wire, you can manually remove it from each cup. You’ll probably find that your bra supports you nearly as well without them. Oh, and don’t be fooled. They make look like plastic, but they’re actually plastic-coated metal. If you find you still need the support, you can buy and insert plastic wires. Andre explains how.

For additional research on the harms of bras read our article Breast Cancer Cover-Up Continues or get the book “Dressed To Kill: The Link between Breast Cancer and Bras.”


Originally published: 2014-07-14 13:06:54 -0500

Article updated: 2019-03-10


Louise Kuo Habakus is the co-author of Vaccine Epidemic, the Executive Director and co-founder of the Center for Personal Rights, the founder of Fearless Parent, and the Executive Director of Health Freedom Action.


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