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Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

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Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

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References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

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Real Salt, Celtic Salt and Himalayan Salt

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In Brief

  • The Facts:

    This article was originally written by Dr. Mark Sircus, Ac., OMD, DM (P) (acupuncturist, doctor of oriental and pastoral medicine) and published at Greenmedinfo.com. Posted here with permission.

  • Reflect On:

    Do you know the difference between refined salt and unrefined salt?

This is what real salt looks like—we all know what regular white salt looks like—and we mistakenly think it is real salt when it is not. The fact is that refined white salt, such as commercial table salt is bad, very bad stuff. Unrefined natural salt on the other hand is good, very good stuff providing many health benefits.

Unrefined sea salt is healthy. The blood-pressure-raising effect of table salt can be due to its high content of sodium with not enough magnesium to balance it. This has a magnesium-lowering effect that can constrict the arteries and raise blood pressure. Real salt (of various kinds) contains plenty of magnesium and other important minerals, which is why it usually does not affect blood pressure in a negative way.[1]

Sodium is an essential nutrient required by the body for maintaining levels of fluids and for providing channels for nerve signaling. Some sodium is needed in your body to regulate fluids and blood pressure, and to keep muscles and nerves running smoothly.

Without appropriate amounts of sodium, your body may have a difficult time cooling down after intense exercise or activity. When the body is hot, you sweat. If you do not have enough sodium, your body may not sweat as much and you may then become overheated. This could result in a stroke or exhaustion as well as dehydration.

Sodium is an energy carrier. It is also responsible for sending messages from the brain to muscles through the nervous system so that muscles move on command. When you want to move your arm or contract any muscle in your body, your brain sends a message to a sodium molecule that passes it to a potassium molecule and then back to a sodium molecule etc., etc., until it gets to its final destination and the muscle contracts. This is known as the sodium-potassium ion exchange. Therefore, without sodium, you would never be able to move any part of your body.

Excess sodium (such as that obtained from dietary sources) is excreted in the urine.[2]Most of the sodium in the body (about 85%) is found in blood and lymph fluid. Sodium levels in the body are partly controlled by a hormone called aldosterone, which is made by the adrenal glands. Aldosterone levels determine whether the kidneys hold sodium in the body or pass it into the urine.

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Dr. David Brownstein weighs in heavily on this matter saying, “Nobody makes a distinction between unrefined and refined salt. They ‘lump’ all salt together as a bad substance. This is a terrible mistake. There are two forms of salt available in the market place: refined and unrefined. Refined salt has had its minerals removed and has been bleached to give it the white appearance that we are accustomed to seeing with salt. It is the fine, white salt that is available at almost any restaurant or grocery store. Refined salt has been bleached and exposed to many toxic chemicals in order to get it to its final product. It has aluminum, ferrocyanide, and bleach in it. I believe this refining process has made it a toxic, devitalized substance that needs to be avoided.”

Link to book: http://www.drbrownstein.com/Salt-Your-Way-to-Health-p/salt.htm

“Unrefined salt, on the other hand,” Brownstein continues, “has not been put through a harsh chemical process. It contains the natural minerals that were originally part of the product. Its mineral content gives it a distinct color. The colors of unrefined salt can vary depending on where it is taken from. This is due to the changing mineral content of the various brands of salt. It is the minerals in unrefined salt that provide all the benefits of this product. The minerals supply the body with over 80 trace elements needed to maintain and sustain health.

Furthermore, the minerals elevate the pH (correct acidity) and lower blood pressure. Our maker gave us salt to use in our diet—unrefined salt—with its full complement of minerals. It should be the salt of choice. It is a vital ingredient that needs to be part of everyone’s diet.”

Dr. Brownstein says, “Years ago salt manufacturers decided that pure white salt is prettier than off-white salt and that consumers prefer pretty white salt. So they started bleaching it. They also added anti-clumping agents to increase its shelf life. The problem is that the chemicals added to keep salt from absorbing moisture on the shelf interfere with one of salt’s main functions: to regulate hydration in your body. The sodium chloride in table salt is highly concentrated, denatured, and toxic to your body. Ever put salt on an open cut? It burns!!!

Refined salt has the same effect on internal tissues and causes a negative reaction: your body retains water to protect itself, and your cells release water to help dilute, neutralize, and break down the salt. This loss of water dehydrates and weakens your cells and can even cause them to die prematurely. Natural sea salt is far superior to chemically-treated iodized table salts as it contains all 92 trace minerals, and it’s only 84% sodium chloride while table salt is almost 98%”.

All this adds up to one thing. Table salt, whether marine or not, is toxic—it’s poisonous to the body and is responsible, in great part, to the onset of many terrible diseases including thyroid and metabolic dysfunction.

In addition to sodium and chloride, Celtic Sea Salt® provides other nutrients that naturally occur in salt beds, including trace amounts of calcium, magnesium potassium, iron and zinc.

In accordance with standards set by The World Health Organization and the Food and Agriculture Organization, independent analysis indicates that levels of heavy metals are non-detectable (e.g. arsenic, cadmium, mercury) or well below published safe limits in Celtic Sea Salt®. Perhaps most importantly, Celtic Sea Salt® is not exposed to refinement and bleaching used to manufacture typical table salt and there are no additives. Celtic Sea Salt® is harvested from the ocean using the sun, the wind and shallow clay ionizing ponds, a method passed down through the generations.

Many Americans over consume refined salt by eating processed foods, fast foods and canned foods with salt added. Celtic Sea Salt® is a good alternative as part of a healthier diet. Recommended use is a half teaspoon per day.

Himalayan crystal salt that is mined 5,000 feet deep below the Himalayan mountain range was subject to enormous pressure over millions of years and is over 99% pure. The higher the amount of pressure the more superior or excellent the state of order within the crystalline structure of salt. Many Himalayan salts are sold cheaply but are collected from higher up near the tops of the Himalayan Mountains instead of from the deeper mines. These salts contain more impurities, do not have the same structure and are not as easily assimilated by the body.

Himalayan salt contains 84 minerals and trace elements in ionic state and is a delightful pink color. People often state that they use less of this salt than of other types. Many sizes are available from 3 oz in a salt grinder to larger 1-kg bags (2.2 lb). Salt chunks are also available for making your own “sole,” which is a saturated solution of purified water with Himalayan salt. A specific recipe (see below) must be followed to make sole and results in a solution that has much less sodium than just adding salt to water would have. Daily use of sole is believed to stimulate the peristalsis of the digestive organs, balance the stomach acid, support the production of digestive fluids in the liver and pancreas, regulate the metabolism and harmonize the acid-alkaline balance.

Start Each Day with a Healthy Sole

The ideal way to use Himalayan Crystal Salt is in the form of a sole (so-LAY). Drinking the sole when you awake each morning is like getting up on the right side of the bed. It provides the energizing minerals you need daily to recharge your body, and it helps set the stage for a day of vitality.

Essentially, a sole is water saturated with Himalayan Crystal Salt. The sole contains about approximately 26 parts of salt to 100 parts of water. Prepare the water and salt combination in advance (see directions to the right). Each morning place a teaspoon of the sole mixture in a glass and fill with 8 ounces of pure spring water. Drink it immediately or sip it while getting dressed, checking emails or preparing breakfast. The water helps transport the electrolytes throughout the body to all the many places they are needed.

How to Prepare Sole

Sole is a mixture of water and salt. The object is to saturate the water with dissolved salt so it can’t hold anymore. You’ll know that you’ve created sole when there are undissolved salt crystals in the water. You can’t oversaturate the water with salt. The crystals will simply drop to the bottom of the container.

Place several Himalayan Crystal Salt stones or Himalayan Crystal Salt granules about an inch deep in a glass container. (A canning jar works well.)

Cover the salt with two to three inches of pure, spring water. Let the salt dissolve for 24 hours.

If all the salt dissolves in 24 hours, add more salt to the container. The sole is finished when the water can no longer dissolve the salt and the salt crystals drop to the bottom of the container. There will always be salt crystals in the jar. It doesn’t matter if you have only a few crystals or many. The water is saturated and is now sole.

Cover the container to prevent the water from evaporating. Since salt is a natural preservative, the sole will keep forever. It can’t spoil or go “bad.”

The vibrational energy of the Himalayan Crystal Salt remains in your body for 24 hours.

A teaspoon of sole contains 480 mg of sodium, or 20% of the Daily Reference Value of 2400 mg based on a 2,000 calorie per day diet.

Redmond Real Salt is mined in the United States and is another good unrefined salt that I also recommend. It can be used as a table salt and for cooking and is available in coarse and fine grinds and in a variety of sizes.

Real Salt comes from a mineral rich salt deposit formed by an ancient sea in Utah. It contains 62 trace minerals, and is without additives, chemicals, or heat processing of any kind. Real Salt’s unique pinkish appearance and flecks of color come from the more than 60 naturally occurring trace minerals. The result is a delicate “sweet salt” flavor that you may not have experienced before.

Special Note: I was very disappointed to hear Dr. Max Gerson’s daughter Charlotte Gerson saying, “That sodium is never good, never in any form!” I have put Gerson in the best light in my writings and his organization does hold the high ground for organic raw juicing but there are some things they say that have no grounding in medical science or clinical reality. Talk to Dr. David Brownstein and he will tell you that often the first thing a patient needs is water and salt but its real salt not table salt he is talking about and prescribing for his patients.

I have written a full essay addressing this communication from Charlotte. And I have another essay on using seawater as a medicine and that will be seen in my Treatment Essentials book that is now finished and ready for publication on the 15th of February. To even think of discounting the medical miracles from the sea, which Charlotte is clearly doing, makes me shudder.


Resources

  • [2] These processes in the body, especially in the brain, nervous system, and muscles, require electrical signals for communication. The movement of sodium is critical in the generation of these electrical signals. Too much or too little sodium therefore can cause cells to malfunction, and extremes in the blood sodium levels (too much or too little) can be fatal – http://www.medicinenet.com/electrolytes/article.htm

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AMA Says Mature 12-Year-Olds Can Consent to Vaccination Without Parents

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At the recently concluded annual meeting of the American Medical Association (AMA) in Chicago, AMA delegates adopted a doozy of a new policy. The powerful trade group agreed to develop model legislation that pressures state legislatures into allowing minors to “override refusenik parents on vaccination.”

In 2000, the Supreme Court reasserted the fundamental right of parents to oversee the care, custody and control of their children, a right recognized by states until children reach age 18. Where vaccines are concerned, the National Childhood Vaccine Injury Act—passed in 1986—legally requires health care providers to distribute vaccine information materials to the parent or legal guardian of any child to whom the provider intends to administer a vaccine “prior to the administration of such vaccine” [emphasis added].

Does it trouble the AMA that its pronouncement goes against legal precedent as well as social custom? Apparently unconcerned about “chipping away at parental rights,” AMA representatives are gung-ho about the organization’s new policy position. Not only do they want minors as young as 12 to be able to consent to vaccination regardless of their parents’ “flawed beliefs”—while still expecting parents to pay for the vaccines—they also believe that doctors should be the ones declaring a child “mature enough” to consent to vaccination. A question that anyone familiar with the AMA’s history should be asking is, why would we trust the AMA to make such vital decisions in parents’ stead?

… one-fourth of the AMA’s total revenues were CPT-related [the medical services coding system]—representing double what the organization received from membership dues. This gigantic conflict of interest, according to the Forbeseditorialist, makes the AMA more a tool of Washington’s interests than those of doctors.

Outsized influence

The AMA’s membership has been plummeting in recent decades. A 2011 analysis of its membership “woes” estimated that the Association captures just 15% of practicing doctors, down from 75% in the early 1950s. The AMA’s membership challenges do not mean that the organization lacks clout, however. In fact, the AMA has a variety of potent tools at its disposal to ensure that it “remain[s] relevant at the national level.” These include a political action committee and a vast lobbying war chest (with upwards of $20 million spent in 2018), all of which translates into outsized influence over both health care policy and public perceptions.

A 2016 report on Capitol Hill lobbyists rated the AMA one of the top “movers and shakers” in Washington, ranking among the “select few [that] have shown an ability to get things done.” A former AMA president modestly admitted as much, stating that “What the AMA does, and does best, is in the advocacy arena.” An analysis of the top 20 health care lobbyists found that the AMA ranked the highest in terms of “all-time spending” and ranked number five in spending “among all lobbyists, regardless of industry.”

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The lobbying firms that the AMA hires are often the same as those used by the pharmaceutical industry. The AMA Foundation’s roster of high-level Corporate Roundtable members consists almost entirely of pharmaceutical industry members—including the four companies that manufacture all childhood vaccines in the U.S. (Merck, GlaxoSmithKline, Pfizer and Sanofi). Drug company advertising also dominates the pages of the AMA’s flagship journal JAMA, even though many are “the very same drugs that are…killing tens of thousands of Americans each year, according to senior drug safety researchers at the FDA.” Nor does the AMA hesitate to provide a “seal of approval” for products and drugs—earning sizeable advertising fees—“despite the fact that the organization has no capacity to test such drugs.”

In 2011, Forbes pointed out that the AMA reaps huge financial rewards through its Current Procedural Terminology (CPT) medical services coding system, used by health care providers, payers, and facilities across the U.S. Given the CPT system’s importance to large public programs such as Medicare, the system essentially amounts to a “government-granted monopoly” and AMA “windfall.” In 2010, one-fourth of the AMA’s total revenues were CPT-related—representing double what the organization received from membership dues. This “gigantic conflict of interest,” according to the Forbes editorialist, makes the AMA “more a tool of Washington’s interests than those of doctors.”

The AMA also has a sordid history of racketeering. Economist Milton Friedman wrote some years ago of the AMA’s concerted attacks on chiropractors and osteopathic physicians, and in a 1987 antitrust lawsuit brought by chiropractors, the judge agreed that the AMA had conspired “to contain and eliminate a profession that was licensed in all fifty states.” The judge also decried the Association’s “long history of illegal behavior.” In the early 2000s, the courts again found the AMA (along with managed care companies) guilty of racketeering through manipulation of the AMA’s coding software.

Did the zealous school nurse who recently administered a human papillomavirus (HPV) vaccine to an 11-year-old boy without parental consent—while telling the mother that all he got was an ice pack—follow “legal, ethical, and professional guidelines”?

Undermining parents

Efforts to circumvent parents’ involvement in their children’s health care have been underway for quite some time, notably in the reproductive health arena. For services related to contraception and sexually transmitted infections, health providers are only too happy to shout down parental objections, arguing that young people’s need for confidential medical services is “more important” than parents’ right to be informed of their child’s condition.

Now, researchers are laying down the train tracks to make the same case for vaccines. In 2014, top-tier adolescent health experts described parental consent as a “barrier to vaccination” and called for “strategies that increase the ability of unaccompanied minors…to receive vaccines within the context of legal, ethical, and professional guidelines.” Did the zealous school nurse who recently administered a human papillomavirus (HPV) vaccine to an 11-year-old boy without parental consent—while telling the mother that all he got was an ice pack—follow “legal, ethical, and professional guidelines”?

AMA critics argue that the organization has spearheaded a push for a “totalitarian medical pharmaceutical police state” almost since its inception in the mid-1850s. While such rhetoric is strong, it seems clear that on vaccine issues, the AMA is only too willing to stake out a draconian policy position. After the AMA announced its intent to ignore parents’ wishes, one conservative writer underscored the contradictions: “So while individuals need to be 21 years old before they are allowed to drink, and 18 years old before they are allowed to purchase cigarettes and elect a president, children at any age can make a decision to partake in vaccinations, regardless of the associated risks, of which there are enough to warrant the need for a National Vaccine Injury Compensation Program.” Legislators tempted to jump on the AMA’s bandwagon might want to think twice before throwing parental rights under the bus in such a cavalier manner.

Sign up for free news and updates from Robert F. Kennedy, Jr. and the Children’s Health Defense. CHD is planning many strategies, including legal, in an effort to defend the health of our children and obtain justice for those already injured. Your support is essential to CHD’s successful mission.

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Awareness

Studies Show We Can Heal With Sound, Frequency & Vibration

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In Brief

  • The Facts:

    Multiple studies and examples have shown how sound, frequency and vibration can literally alter physical material matter. Research has also shown that sound, frequencies and vibration can be used as a significant healing method for various ailments.

  • Reflect On:

    How plausible would it be for these interventions to become a regular part of therapy, just as much as pharmaceutical drugs are now?

Cymatics is a very interesting topic. It illustrates how sound frequencies move through a particular medium such as water, air, or sand and as a result directly alter physical matter. There are a number of pictures all over the internet as well as youtube videos that demonstrate how matter (particles) adjust to different sounds and different frequencies of sound.

When it comes to ancient knowledge, sound, frequency and vibration have always been perceived as powerful forces that can influence and alter life all the way down to the cellular level. Sound healing methods are often used by Shamans, who employ drums and singing to access trance states. Research has even demonstrated that drumming and singing can can be used to slow fatal brain disease, and it can generate a sense of oneness with the universe . Sound therapy is getting more popular, and it can have many medical applications, especially within the psychological and mental health realms.

Sound, frequency and vibration are used all throughout the animal kingdom, and there are many examples. If we look at the wasp, they use antennal drumming to alter the caste development or phenotype of their larvae. Conventional thinking has held for quite some time that differential nutrition alone can explain why one larvae develops into a non-reproductive worker and one into a reproductive female (gyne).  However, this is not the case, according to a 2011 study:

“But nutrition level alone cannot explain how the first few females to be produced in a colony develop rapidly yet have small body sizes and worker phenotypes. Here, we provide evidence that a mechanical signal biases caste toward a worker phenotype. In Polistes fuscatus, the signal takes the form of antennal drumming (AD), wherein a female trills her antennae synchronously on the rims of nest cells while feeding prey-liquid to larvae. The frequency of AD occurrence is high early in the colony cycle, when larvae destined to become workers are being reared, and low late in the cycle, when gynes are being reared. Subjecting gyne-destined brood to simulated AD-frequency vibrations caused them to emerge as adults with reduced fat stores, a worker trait. This suggests that AD influences the larval developmental trajectory by inhibiting a physiological element that is necessary to trigger diapause, a gyne trait.”

This finding indicates that the acoustic signals produced through drumming within certain species carry biologically meaningful information (literally: ‘to put form into’) that operate epigenetically (i.e. working outside or above the genome to affect gene expression).

Pretty fascinating, isn’t it? Like many other ancient lines of thought, this has been backed by modern day scientific research.

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Cancer 

Another example comes from cancer research. In his Tedx talk, “Shattering Cancer with Resonant Frequencies,” Associate Professor and Director of Music at Skidmore College, Anthony Holland, tells the audience that he has a dream. That dream is to see a future where children no longer have to suffer from the effects of toxic cancer drugs or radiation treatment, and today he and his team believe they have found the answer, and that answer is sound. Holland and his team wondered if they could affect a cell by sending a specific electric signal, much like we do with LCD technology. After searching the patent database for a device that could accomplish this, they came across a therapeutic device invented by New Mexico physician Dr. James Bare. The device uses a plasma antenna that pulses on and off, which, as Holland explains, is important because a constant pulse of electricity would produce too much heat and therefore destroy the cell. For the next 15 months, Holland and his team searched for the exact frequency that would directly shatter a living microorganism. The magic number finally came in the form of two inputs, one high frequency and one low. The high frequency had to be exactly eleven times higher than the low, which in music is known as the 11th harmonic. At the 11th harmonic, micro organisms begin to shatter like crystal glass.

After consistently practicing until they became efficient at the procedure, Holland began working with a team of cancer researchers in an attempt to destroy targeted cancer cells. First they looked at pancreatic cancer cells, eventually discovering these cells were specifically vulnerable between 100,000 – 300,000 Hz.

Next they moved onto leukemia cells, and they were able to shatter the leukemia cells before they could divide. But, as Holland explains in his talk, he needed bigger stats in order to make the treatment a viable option for cancer patients.

In repeated and controlled experiments, the frequencies, known as oscillating pulsed electric field (OPEF) technology, killed an average of 25% to 40% of leukemia cells, going as high as 60% in some cases. Furthermore, the intervention even slowed cancer cell growth rates up to 65%.

You can read more about the story, find sources, and watch that TEDx talk here.

Another example occurred in  1981, when biologist Helene Grimal partnered with composer Fabien Maman to study the relationship of sound waves to living cells. For 18 months, the pair worked with the effects of 30-40 decibel sounds on human cells. With a camera mounted on a microscope, the researchers observed uterine cancer cells exposed to different acoustic instruments (guitar, gong, xylophone) as well as the human voice for 20-minute sessions.

They discovered that, when exposed to sound, cancer cells lost structural integrity until they exploded at the 14-minute mark. Far more dramatic was the sound of a human voice — the cells were destroyed at the nine-minute mark.

After this, they decided to work with two women with breast cancer. For one month, both of the women gave three-and-a-half-hours a day to “toning” or singing the scale. Apparently, the woman’s tumor became undetectable, and the other woman underwent surgery. Her surgeon reported that her tumor had shrunk dramatically and “dried up.” It was removed and the woman had a complete recovery and remission.

These are only a few out of multiple examples that are floating around out there.

Let’s not forget about when Royal Rife first identified the human cancer virus using the world’s most powerful microscope. After identifying and isolating the virus, he decided to culture it on salted pork. At the time this was a very good method for culturing a virus. He then took the culture and injected it into 400 rats, which, as you might expect, created cancer in all 400 rats very quickly. The next step for Rife was where things took an interesting turn. He later found a frequency of electromagnetic energy that would cause the cancer virus to diminish completely when entered into the energy field.  You can read more about that story here.

More Research

A 2014 study published in the Journal of Huntington’s Disease found that two months of drumming intervention in Huntington’s patients (considered an irreversible, lethal neurodegenerative disease) resulted in “improvements in executive function and changes in white matter microstructure, notably in the genu of the corpus callosum that connects prefrontal cortices of both hemispheres.” The study authors concluded that the pilot study provided novel preliminary evidence that drumming (or related targeted behavioral stimulation) may result in “cognitive enhancement and improvements in callosal white matter microstructure.”

A 2011 Finnish study observed that stroke patients who were given access to music as cognitive therapy had improved recovery. Other research has shown that patients suffering from loss of speech due to brain injury or stroke regain it more quickly by learning to sing before trying to speak. The phenomenon of music facilitating healing in the brain after a stroke is called the “Kenny Rogers Effect.”

A 2012 study published in Evolutionary Psychology found that active performance of music (singing, dancing and drumming) triggered endorphin release (measured by post-activity increases in pain tolerance), whereas merely listening to music did not. The researchers hypothesized that this may contribute to community bonding in activities involving dance and music-making.

According to a study published by the National Institute of Health, “Music effectively reduces anxiety for medical and surgical patients and often reduces surgical and chronic pain. [Also,] Providing music to caregivers may be a strategy to improve empathy, compassion, and care.” In other words, music is not only good for patients, it’s good for those who care for them as well.

Below is an interesting interview with Dr. Bruce Lipton. You can view his curriculum vitae here.

The Takeaway

The information presented in this article isn’t even the tip of the iceberg when it comes the the medical applications of sound, frequency and vibration, which are all obviously correlated. One thing is clear, however, which is that there are many more methods out there, like the ones discussed in this article, that should be taken more seriously and given more attention from the medical establishment. It seems all mainstream medicine is concerned about is making money and developing medications that don’t seem to be representative of our fullest potential to heal. “Alternative” therapies shouldn’t be labelled as alternative, they should be incorporated into the norm.

Help Support Collective Evolution

The demand for Collective Evolution's content is bigger than ever, except ad agencies and social media keep cutting our revenues. This is making it hard for us to continue.

In order to stay truly independent, we need your help. We are not going to put up paywalls on this website, as we want to get our info out far and wide. For as little as $3 a month, you can help keep CE alive!

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