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Epigenetic Memories Are Passed Down 14 Successive Generations, Game-Changing Research Reveals

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In Brief

  • The Facts:

    It's amazing how much information can be passed on to our offspring. Scientist have discovered that our DNA has memories, and these can also be passed down. We are talking about thoughts, feelings, emotions and perceptions.

  • Reflect On:

    Biological changes are shaped by our environment, as well as our thoughts, feelings, emotions and reaction to that environment. Our DNA can be changed with belief, the placebo is a great example. Thoughts feelings and emotions are huge in biology.

This article was written by the Greenmedinfo research group, from Greenmedinfo.com. Posted here with permission.

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Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

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Epigenetics: The Demise of Biological Determinism

Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. Translated literally to mean “in addition to changes in genetic sequence,” epigenetics includes processes such as methylation, acetylation, phosphorylation, sumolyation, and ubiquitylation which can be transmitted to daughter cells upon cell division (1). Methylation, for example, is the attachment of simple methyl group tags to DNA molecules, which can repress transcription of a gene when it occurs in the region of a gene promoter. This simple methyl group, or a carbon bound to three hydrogen molecules, effectively turns the gene off.

Post-translational modifications of histone proteins is another epigenetic process. Histones help to package and condense the DNA double helix into the cell nucleus in a complex called chromatin, which can be modified by enzymes, acetyl groups, and forms of RNA called small interfering RNAs and microRNAs (1). These chemical modifications of chromatin influence its three-dimensional structure, which in turn governs its accessibility for DNA transcription and dictates whether genes are expressed or not.

We inherit one allele, or variant, of each gene from our mother and the other from our father. If the result of epigenetic processes is imprinting, a phenomenon where one of the two alleles of a gene pair is turned off, this can generate a deleterious health outcome if the expressed allele is defective or increases our susceptibility to infections or toxicants (1). Studies link cancers of nearly all types, neurobehavioral and cognitive dysfunction, respiratory illnessesautoimmune disorders, reproductive anomalies, and cardiovascular disease to epigenetic mechanisms (1). For example, the cardiac antiarrhythmic drug procainamide and the antihypertensive agent hydralazine can cause lupus in some people by causing aberrant patterns of DNA methylation and disrupting signalling pathways (1).

Genes Load the Gun, Environment Pulls the Trigger

Pharmaceuticals, however, are not the only agents that can induce epigenetic disturbances. Whether you were born via vaginal birth or Cesarean section, breastfed or bottle-fed, raised with a pet in the house, or infected with certain childhood illnesses all influence your epigenetic expression. Whether you are sedentary, pray, smoke, mediate, do yoga, have an extensive network of social support or are alienated from your community—all of your lifestyle choices play into your risk for disease operating through mechanisms of epigenetics.

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In fact, the Centers for Disease Control (CDC) states that genetics account for only 10% of disease, with the remaining 90% owing to environmental variables (2). An article published in the Public Library of Science One (PLoS One) entitled “Genetic factors are not the major causes of chronic diseases” echoes these claims, citing that chronic disease is only 16.4% genetic, and 84.6% environmental (3). These concepts make sense in light of research on the exposome, the cumulative measure of all the environmental insults an individual incurs during their life course that determines susceptibility to disease (4)

In delineating the totality of exposures to which an individual is subjected over their lifetime, the exposome can be subdivided into three overlapping and intertwined domains. One segment of the exposome called the internal environment is comprised of processes innate to the body which impinge on the cellular milieu. This encompasses hormones and other cellular messengers, oxidative stress, inflammation, lipid peroxidation, bodily morphology, the gut microbiotaaging and biochemical stress (5).

Another portion of the exposome, the specific external environment, consists of exposures including pathogens, radiation, chemical contaminants and pollutants, and medical interventions, as well as dietary, lifestyle, and occupational elements (5). At an even broader sociocultural and ecological level is the segment of the exposome called the general external environment, which may circumscribe factors such as psychological stress, socioeconomic status, geopolitical variables, educational attainment, urban or rural residence, and climate (5).

Transgenerational Inheritance of Epigenetic Change: Endocrine Disruptors Trigger Infertility in Future Generations

Scientists formerly speculated that epigenetic changes disappear with each new generation during gametogenesis, the formation of sperm and ovum, and after fertilization. However, this theory was first challenged by research published in the journal Science which demonstrated that transient exposure of pregnant rats to the insecticide methoxychlor, an estrogenic compound, or the fungicide vinclozolin, an antiandrogenic compound, resulted in increased incidence of male infertility and decreased sperm production and viability in 90% of the males of four subsequent generations that were tracked (1).

Most notably, these reproductive effects were associated with derangements in DNA methylation patterns in the germ line, suggesting that epigenetic changes are passed on to future generations. The authors concluded, “The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology” (6, p. 1466). This may suggest that the endocrine-disrupting, fragrance-laden personal care products and commercial cleaning supplies to which we are all exposed may trigger fertility problems in multiple future generations.

Transgenerational Inheritance of Traumatic Episodes: Parental Experience Shapes Traits of Offspring

In addition, traumatic experiences may be transmitted to future generations via epigenetics as a way to inform progeny about salient information needed for their survival (7). In one study, researchers wafted the cherry-like chemical acetophenone into the chambers of mice while administering electric shocks, conditioning the mice to fear the scent (7). This reaction was passed onto two successive generations, which shuddered significantly more in the presence of acetophenone despite never having encountered it compared to descendants of mice that had not received this conditioning (7).

The study suggests that certain characteristics of the parental sensory environment experienced before conception can remodel the sensory nervous system and neuroanatomy in subsequently conceived generations (7). Alterations in brain structures that process olfactory stimuli were observed, as well as enhanced representation of the receptor that perceives the odor compared to control mice and their progeny (7). These changes were conveyed by epigenetic mechanisms, as illustrated by evidence that the acetophenone-sensing genes in fearful mice were hypomethylated, which may have enhanced expression of odorant-receptor genes during development leading to acetophenone sensitivity (7).

The Human Experience of Famine and Tragedy Spans Generations

The mouse study, which illustrates how germ cells (egg and sperm) exhibit dynamic plasticity and adaptability in response to environmental signals, is mirrored by human studies. For instance, exposures to certain stressors such as starvation during the gestational period are associated with poor health outcomes for offspring. Women who undergo famine before conception of her offspring have been demonstrated to give birth to children with lower self-reported mental health and quality of life, for example (8).

Studies similarly highlight that, “Maternal famine exposure around the time of conception has been related to prevalence of major affective disorders, antisocial personality disorders, schizophrenia, decreased intracranial volume, and congenital abnormalities of the central nervous system” (8). Gestational exposure to the Dutch Famine of the mid-twentieth century is also associated with lower perceived health (9), as well as enhanced incidence of cardiovascular disease, hypertension, and obesity in offspring (8). Maternal undernourishment during pregnancy leads to neonatal adiposity, which is a predictor of future obesity (10), in the grandchildren (11).

The impact of epigenetics is also exemplified by research on the intergenerational effects of trauma, which illuminates that descendants of people who survived the Holocaust exhibit abnormal stresshormone profiles, and low cortisol production in particular (12). Because of their impaired cortisol response and altered stress reactivity, children of Holocaust survivors are often at enhanced risk for post-traumatic stress disorder (PTSD), anxiety, and depression (13).

Intrauterine exposure to maternal stress in the form of intimate partner violence during pregnancy can also lead to changes in the methylation status of the glucocorticoid receptor (GR) of their adolescent offspring (14). These studies suggest that an individual’s experience of trauma can predispose their descendants to mental illness, behavioral problems, and psychological abnormalities due to “transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis,” a complex set of interactions among endocrine glands which determine stress response and resilience (14).

Body Cells Pass Genetic Information Directly Into Sperm Cells

Not only that, but studies are illuminating that genetic information can be transferred through the germ line cells of a species in real time. These paradigm-shifting findings overturn conventional logic which postulates that genetic change occurs over the protracted time scale of hundreds of thousands or even millions of years. In a relatively recent study, exosomes were found to be the medium through which information was transferred from somatic cells to gametes.

This experiment entailed xenotransplantation, a process where living cells from one species are grafted into a recipient of another species. Specifically, human melanoma tumor cells genetically engineered to express genes for a fluorescent tracer enzyme called EGFP-encoding plasmid were transplanted into mice. The experimenters found that information-containing molecules containing the EGFP tracer were released into the animals’ blood (15). Exosomes, or “specialized membranous nano-sized vesicles derived from endocytic compartments that are released by many cell types” were found among the EGFP trackable molecules (16, p. 447).

Exosomes, which are synthesized by all plant and animal cells, contain distinct protein repertoires and are created when inward budding occurs from the membrane of multivesicular bodies (MVBs), a type of organelle that serves as a membrane-bound sorting compartment within eukaryotic cells (16). Exosomes contain microRNA (miRNA) and small RNA, types of non-coding RNA involved in regulating gene expression (16). In this study, exosomes delivered RNAs to mature sperm cells (spermatozoa) and remained stored there (15).

The researchers highlight that this kind of RNA can behave as a “transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny” (15). In other words, the RNA carried to sperm cells by exosomes can preside over gene expression in a way that changes the observable traits and disease risk of the offspring as well as its morphology, development, and physiology.

This study was the first to elucidate RNA-mediated transfer of information from somatic to germ cells, which fundamentally overturns what is known as the Weisman barrier, a principle which states that the movement of hereditary information from genes to body cells is unidirectional, and that the information transmitted by egg and sperm to future generations remains independent of somatic cells and parental experience (15).

Further, this may bear implications for cancer risk, as exosomes contain vast amounts of genetic information which can be source of lateral gene transfer (17) and are abundantly liberated from tumor cells (18). This can be reconciled with the fact that exosome-resembling vesicles have been observed in various mammals (15), including humans, in close proximity to sperm in anatomical structures such as the epididymis as well as in seminal fluid (19). These exosomes may thereafter be propagated to future generations with fertilization and augment cancer risk in the offspring (20).

The researchers concluded that sperm cells can act as the final repositories of somatic cell-derived information, which suggests that epigenetic insults to our body cells can be relayed to future generations. This notion is confirmatory of the evolutionary theory of “soft inheritance” proposed by French naturalist Jean-Baptiste Lamarck, whereby characteristics acquired over the life of an organism are transmitted to offspring, a concept which modern genetics previously rejected before the epigenetics arrived on the scene. In this way, the sperm are able to spontaneously assimilate exogenous DNA and RNA molecules, behaving both as vector of their native genome and of extrachromosomal foreign genetic material which is “then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals” (15).

Epigenetic Changes Endure Longer Than Ever Predicted

In a recent study, nematode worms were manipulated to harbor a transgene for a fluorescent protein, which made the worms glow under ultraviolet light when the gene was activated (21). When the worms were incubated under the ambient temperature of 20° Celsius (68° Fahrenheit), negligible glowing was observed, indicating low activity of the transgene (21). However, transferring the worms to a warmer climate of 25°C (77° F) stimulated expression of the gene, as the worms glowed brightly (21).

In addition, this temperature-induced alteration in gene expression was found to persist for at least 14 generations, representing the preservation of epigenetic memories of environmental change across an unprecedented number of generations (21). In other words, the worms transmitted memories of past environmental conditions to their descendants, through the vehicle of epigenetic change, as a way to prepare their offspring for prevailing environmental conditions and ensure their survivability.

Future Directions: Where Do We Go From Here?

Taken cumulatively, the aforementioned research challenges traditional Mendelian laws of genetics, which postulate that genetic inheritance occurs exclusively through sexual reproduction and that traits are passed to offspring through the chromosomes contained in germ line cells, and never through somatic (bodily) cells. Effectively, this proves the existence of non-Mendelian transgenerational inheritance, where traits separate from chromosomal genes are transmitted to progeny, resulting in persistent phenotypes that endure across generations (22).

This research imparts new meaning to the principle of seven generation stewardship taught by Native Americans, which mandates that we consider the welfare of seven generations to come in each of our decisions. Not only should we embody this approach in practices of environmental sustainability, but we would be wise to consider how the conditions to which we subject our bodies—the pollution and toxicants which permeate the landscape and pervade our bodies, the nutrient-devoid soil that engenders micronutrient-poor food, the disruptions to our circadian rhythm due to the ubiquity of electronic devices, our divorce from nature and the demise of our tribal affiliations—may translate into ill health effects and diminished quality of life for a previously unfathomed number of subsequent generations.

Hazards of modern agriculture, the industrial revolution, and contemporary living are the “known or suspected drivers behind epigenetic processes…including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients” (1, p. A160). Serendipitously, however, many inputs such as exercise, mindfulness, and bioactive components in fruits and vegetables such as sulforaphane in cruciferous vegetables, resveratrol from red grapes, genistein from soy, diallyl sulphide from garlic, curcumin from turmeric, betaine from beets, and green tea catechin can favorably modify epigenetic phenomena “either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions” (23, p. 8).

This quintessentially underscores that the air we breathe, the food we eat, the thoughts we allow, the toxins to which we are exposed, and the experiences we undergo may persevere in our descendants and remain in our progeny long after we are gone. We must be cognizant of the effects of our actions, as they elicit a ripple effect through the proverbial sands of time.

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References

1. Weinhold, B. (2006). Epigenetics: The Science of Change. Environmental Health Perspectives, 114(3), A160-A167.

2. Centers for Disease Control and Prevention. (2014). Exposome and Exposomics. Retrieved from https://www.cdc.gov/niosh/topics/exposome/

3. Rappaport, S.M. (2016). Genetic factors are not the major causes of chronic diseases. PLoS One, 11(4), e0154387.

4. Vrijheid, M. (2014). The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), 876-878. doi: 10.1136/thoraxjnl-2013-204949.

5. Wild, C.P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41, 24–32. doi:10.1093/ije/dyr236

6. Anway, M.D. et al. (2005). Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727), 1466-1469.

7. Dias, B.G., & Ressler, K.J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience, 17(1), 89-98.

8. Stein, A.D. et al. (2009). Maternal exposure to the Dutch Famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology, 20(6), doi:  10.1097/EDE.0b013e3181b5f227.

9. Roseboom, T.J. et al. (2003). Perceived health of adults after prenatal exposure to the Dutch famine. Paediatrics Perinatal Epidemiology, 17, 391–397.

10. Badon, S.E. et al. (2014). Gestational Weight Gain and Neonatal Adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Study-North American Region. Obesity (Silver Spring), 22(7), 1731–1738.

11. Veenendaal, M.V. et al. (2013). Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG, 120(5), 548-53. doi: 10.1111/1471-0528.

12. Yehuda, R., & Bierer, L.M. (2008). Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research, 167, 121-135.

13. Aviad-Wilcheck, Y. et al. (2013). The effects of the survival characteristics of parent Holocaust survivors on offsprings’ anxiety and depression symptoms. The Israel Journal of Psychiatry and Related Sciences, 50(3), 210-216.

14. Radke, K.M. et al. (2011). Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry, 1, e21. doi: 10.1038/tp.2011.21.

15. Cossetti, C. et al. (2014). Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes. PLoS One, https://doi.org/10.1371/journal.pone.0101629.

16. Zomer, A. et al. (2010). Exosomes: Fit to deliver small RNA. Communicative and Integrative Biology, 3(5), 447–450.

17. Balaj, L. et al. (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Natural Communications, 2, 180.

18. Azmi, A.S., Bao, B., & Sarkar, F.H. (2013). Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Review, 32, 623-643

19. Poliakov, A. et al. (2009). Structural heterogeneity and protein composition of exosomes-like vesicles (prostasomes) in human semen. Prostate, 69, 159-167.

20. Cheng, R.Y. et al. (2004) Epigenetic and gene expression changes related to transgenerational carcinogenesis. Molecular Carcinogenesis, 40, 1–11.

21. Klosin, A. et al. (2017). Transgenerational transmission of environmental information in C. elegans. Science, 356(6335).

22. Lim, J.P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

23. Choi, S.-W., & Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health Advances in Nutrition: An International Review Journal, 1(1), 8-16. doi:10.3945/an.110.1004.

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Awareness

How A Nasal Obstruction & Tongue Tie Affects Sleep, Learning, Attention and Mood

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In Brief

  • The Facts:

    When breathing isn’t proper, many things can go wrong. Some nasal obstruction symptoms include mouth breathing, low energy, chewing with the mouth open, teeth grinding, and sleep apnea.

  • Reflect On:

    Do you or a loved one have a nasal obstruction and/or tongue tie?

Has your child gone down every treatment and therapy route with little success? Could it be that all the doctors and therapists you have previously consulted with missed this? Absolutely, Yes! Both my children had multiple tongue ties and an airway obstruction that contributed to learning difficulty, speech problems, ADHD, sleep disturbances, and mood issues.

Sadly, emotional, social, and physical impairments are all too common. Nearly one in 12 children ages 3–17 have a disorder related to voice, speech, language, feeding, or swallowing. Almost one in 10 children have ADHD. One in six children has a developmental disability. One in two-hundred children has an intellectual disability. Up to 50% of children will experience a sleep problem, which can lead to daytime sleepiness, irritability, behavioral problems, learning difficulties, and poor academic performance.

Airway Obstruction – Poor Nasal Breathing

When breathing isn’t proper, many things can go wrong. Breathing through the nose is essential. It filters the air going into your lungs and regulates the amount of air that comes into the body. Breathing correctly through the nose allows the body to take in the proper amount of oxygen, the body and brain needs. Getting enough oxygen helps to calm the mind and increase our energy level. The nose also houses olfactory bulbs, which are direct extensions of part of the brain called the hypothalamus. The hypothalamus is responsible for many functions in our body, including generating neurotransmitters that influence memory and emotion.

Some nasal obstruction symptoms include mouth breathing, low energy, chewing with the mouth open, teeth grinding, and sleep apnea. Other symptoms are a forward head posture, a tongue that rests on the bottom of the mouth, snoring, memory problems, coughing during sleep, daytime fatigue, weight problems, hyperactivity, and trouble concentrating. Sleep Disordered Breathing is one potential root cause of poor growth, development impairments, a lower intellect, poor cognition, affecting school performance, and more.

In the Journal of Sleep, “Studies show that nasal obstruction may dramatically affect breathing in sleep, and consequentially daytime vigilance and behavior.”

There is an interesting phenomenon when the airway is blocked. The body will overcompensate by increasing the adrenaline (fight or flight) in the body to stimulate breathing and open up nasal passages. This increased adrenaline can cause a child to feel very anxious, angry, hyper, and unfocused. In adults, this can lead to hypertension, heart attacks, strokes, fatigue, and more.  Many go undiagnosed for years. Doctors may miss a diagnosis because the obstruction is more pronounced during sleep. And, sometimes, we believe our allergies are causing our congestion alone. When, in fact, there is an obstruction affecting our breathing.

What Causes a Nasal Obstruction?

There are many possible causes of nasal airway obstruction. Deformities or irregularities are primarily genetic unless there is an injury to the nose. A trained Ear, Nose, and Throat doctor (ENT) or a Functional Dentist can do a CT scan to determine if there is a problem. Such issues are narrow mouth pallet, a septal deviation, a collapsed nostril, enlarged bone/tissue turbinates, or a sizeable egg-like air sac in the nose. Nasal congestion can also be due to a condition called vasomotor rhinitis (VMR). Without an allergy present, excessive blood flow causes congestion in the nose. The ENT will also look for large adenoids, allergies, and nasal polyps, causing an obstruction. Typically, a person with a blockage has multiple factors at play.

Treatment Options Depending on Causation

  • Pallet expansion
  • Adenoids and Tonsil removal (typically the first and possibly only thing we did in hopes of correcting sleep disturbances – before the medical community recognized the many other possible causes)
  • Aggressive and more invasive nasal surgery (cure rate is not too high)
  • Minimally invasive surgical procedure called MIST (minimally invasive sinus technique)

Initially introduced in the 1990s, MIST revolutionized nasal surgery. It takes less than an hour to complete by an experienced surgeon. There are no incisions, scars, or nasal packing. Discomfort is minimal and has a higher success rate than the older methods.

 Tongue or Lip Tie

 A tongue or lip-tie affects up to 11% of all newborns. According to the 2017 Cochrane review, and it is often overlooked. This condition restricts the range of motion in a baby’s tongue. It presents as a concise and thick band of tissue that tethers the bottom of the tongue’s tip to the roof of the mouth. A tongue-tie or lip-tie may interfere with breastfeeding, speech, eating, swallowing, and the jaw’s oral motor development. Some of the risk factors for developing a tie in utero are often genetic. However, smoking and alcohol use, medication, chemicals, viral infections, methylation issues, and chronic stress may also cause it. A surgical procedure is sometimes required. However, some ties can be resolved with chiropractic manipulation, myofascial release, or exercises alone. An early indication of a tongue or lip tie is the inability to latch on a bottle or breastfeed. A child may appear to latch correctly, and so the condition is not discovered. However, if your child suffers from colic, sleep disturbances, excessive drooling, or spitting up, this may be the cause. Allopathic physicians may insist that the child has an aversion to the breast milk or that you are eating something too gassy. Synthetic formula and Prevacid or other antacid is often prescribed without checking for this condition.

Takeaway

Suppose you or your child is struggling and are exhibiting any signs of an obstruction or tongue tie. In that case, I encourage you to explore it with your ENT or functional dentist before resorting to medication. If you would like more info on how you and your family can overcome anxiety, I am offering a FREE downloadable PDF of an online presentation I recently gave containing these tips and much more. Learn why eating protein is essential and why microbiome diversity is critical. SIGN UP HERE to receive your free download today. And to purchase my award-winning book Healing Without Hurting, click here.

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Alternative News

COVID-19 Survival Rates Have Many Scientists/Doctors Questioning Masks & Lockdown

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In Brief

  • The Facts:

    All restrictions on restaurants and other business in Florida have been lifted, and so have local fines against people who refuse to wear masks after the CDC released new survival rates.

  • Reflect On:

    Why are opinions and narratives that oppose the WHO being censored, ridiculed, and largely ignored? Why aren't they discussed openly and transparently?

What Happened: Florida Governor Ron DeSantis recently lifted all restrictions on restaurants and other business in Florida and banned local fines against people who refuse to wear masks. He did so after showing new statistics just released by the Centers for Disease Control (CDC) showing very high survival rates, as you can see from the picture picture above. The CDC has a page on their website titled “Covid-19 Pandemic Planning Scenarios.” According to them, “Each scenario is based on a set of numerical values for biological and epidemiological characteristics of COVID-19 illness, which is caused by the SARS-CoV-2 virus. These values—called parameter values—can be used in models to estimate the possible effects of COVID-19 in U.S. states and localities. That’s where the numbers come from.

Questioning Lockdown & Masks, A Theme From The Very Beginning: The world’s leading scientists in the field and from other fields have been questioning lockdown measures from the very beginning of this pandemic, due to the fact that many of them believe and have believed that we are dealing with a virus similar, and even less severe than viruses that have been circling the globe for decades, infecting hundreds of millions and killings tens of millions of people every single year.

For example, did you know that metapneumovirus has been shown to have worldwide circulation with nearly universal infection by age 5? Did you know that outbreaks of metapneumovirus have been well documented every single year, especially in long term care facilities with mortality rates of up to 50%? () Did you know that human metapneumovirus infection results in a large number of hospitalizations of children every single year? Did you know it has a substantial morbidity rate, again in the elderly, but also among children as well? Did you know nearly 1-2 million children every single year die of these types of respiratory illnesses because they lead to acute respiratory illness? (source)

At the beginning of the pandemic, multiple professors from Stanford criticized the World Health Organization for creating unnecessary fear and hysteria.

They make it quite clear that if the projections being given by the World Health Organization are correct, then “the extraordinary measures being carried out in cities and states around the country are surely justified.” But they also make the point that “there’s little evidence to confirm that premise – and projections of the death toll could plausibly be orders of magnitude too high.” It turns out that they were right.

John P. A. Ioannidis, a professor of medicine and epidemiology, recently published an article entitled “A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data. In the article, he also argues that there is simply not enough data to make claims about reported case fatality rate.

He stated that rates, “like the official 3.4% rate from the World Health Organization, cause horror — and are meaningless. He was right. Prior to the recent CDC update, he emphasized that the infection fatality rate is close to 0 percent for people under the age of 45 years old.

Michael Levitt, a Biophysicist and a professor of structural biology at Stanford University, criticized the WHO as well as Facebook for censoring different information and informed perspectives regarding the Coronavirus. This is another strong point, why are/were social media outlets censoring information and opinions that did not match that which was given by the WHO? These actions have only raised more eyebrows, as we now have a digital authoritarian Orwellian “fact-checker”
patrolling the internet.

Almost all of the science we were hearing, for example like organizations like the World Health Organization (WHO) was wrong…This has been a disgraceful situation for science..Reports were released openly, shared by email, and all I got back was abuse. And you got to see that everything I said in that first six weeks was actually true and for political reasons, we as scientists let our views be corrupted. The data had very clear things to say. Nobody said to be “let me check your numbers” they all just said “stop talking like that.” – Levitt

When Dr. Ron Paul shared his opinion a few months ago that “People should ask themselves whether this coronavirus “pandemic” could be a big hoax, with the actual danger of the disease massively exaggerated by those who seek to profit – financially or politically – from the ensuing panic” he was censored and marked as false news, having his social media distribution limited.

More than 500 German doctors & scientists have signed on as representatives of an organization called the “Corona Extra-Parliamentary Inquiry Committee” to investigate what’s happening on our planet with regards to COVID-19, expressing the same sentiment. They came together to investigate the severity of the virus, and whether or not the actions taken by governments around the world, and in this case the German government, are  justified and not causing more harm than good.

You can access the full english transcripts on the organizations website if interested.

This group has been giving multiple conferences in Germany, in one of the most recent, Dr. Heiko Schöning, one of the organizations leaders, stated that “We have a lot of evidence that it (the new coronavirus) is a fake story all over the world.”  To put it in context, he wasn’t referring to the virus being fake, but simply that it’s no more dangerous than the seasonal flu (or just as dangerous) and that there is no justification for the measures being taken to combat it.  You can read more about the story here

Another example would be a recent report published in the British Medical Journal  has suggested that quarantine measures in the United Kingdom as a result of the new coronavirus may have already killed more UK seniors than the coronavirus has during the peak of the virus.

Are masks even effective? Many studies claim yes, but many also claim no.

Many scientists and doctors in North America are also expressing the same sentiments. For example, The Physicians For Informed Consent (PIC) recently published a report titled  “Physicians for Informed Consent (PIC) Compares COVID-19 to Previous Seasonal and Pandemic Flu Periods.” According to them, the infection/fatality rate of COVID-19 is 0.26%. You can read more about that and access their resources and reasoning here.

Dr. Sucharit Bhakdi, a specialist in microbiology and one of the most cited research scientists in German history is also part of Corona Extra-Parliamentary Inquiry Committee mentioned above and has also expressed the same thing, multiple times early on in the pandemic all the way up to today.

Implementation of the current draconian measures that are so extremely restrict fundamental rights can only be justified if there is reason to fear that a truly, exceptionally dangerous virus is threatening us. Do any scientifically sound data exist to support this contention for COVID-19? I assert that the answer is simply, no. – Bhakdi. You can read more about him here.

And there is the issue of exaggerated death counts. For example, Toronto Public Health tweeted in late June that “Individuals who have died with COVID-19, but not as a result of COVID-19, are included in the case counts for COVID-19 deaths in Toronto.” There are multiple examples from different countries. You can read more about that here.

Vittorio Sgarbi, Italian politician Mayor of Sutri, gave an emotional speech at a hearing on the 24th of April where he emphasized that the number of deaths in Italy due to COVID-19 are completely false and that the people are being lied to. You can watch that and read more about it here.

A chemistry professor at the University of Waterloo has distributed a course outline to students, saying his in-class exams aren’t mandatory “because of the COVID fake emergency.”  Ronald B. Brown, Ph.D., from the School of Public Health and Health Systems at the University of Waterloo recently stated that the COVID-19 fatality rate is the “worst miscalculation in the history of humanity.” Brown is currently completing his second doctorate degree, this time in epidemiology at the University of Waterloo. Not long ago, Brown published a paper in Disaster Medicine and Public Health Preparedness, titled “Public health lessons learned from biases in coronavirus mortality overestimation.”

Below is a statement Brown recently gave to John C. A. Manley, a journalist who was the first to cover the story:

The subject of this article is disruptive, to say the least, although it is not as obvious from the title. The manuscript cites the smoking-gun, documented evidence showing that the public’s overreaction to the coronavirus pandemic was based on the worst miscalculation in the history of humanity, in my opinion. My manuscript underwent an intensive peer-review process. You are the first media guy who has responded to my invitation.

The examples above aren’t even the tip of the ice-berg, but they are ones I’ve used many times in previous articles. I am posting them above just to hammer home the point.

Why This Is Important: This information is important because it highlights that the measures we are being mandated & forced to take are being done using flawed data to justify it. What also has more people concerned is that the opinions and research of many doctors and scientists around the world, some of them quite renowned, are being banned and censored from social media platforms for simply contradicting the information given to us by the World Health Organization (WHO). Why are people like Julian Assange really in jail? Why are people exposing war crimes and other misdoings within the WHO, as Assange has, punished, and the ones committing the actual crimes are the ones we identify with? Should we not have the right to examine information openly and freely, and determine for ourselves what is and what isn’t? A common theme with regards to this pandemic seems to be using fear and hysteria to make the threat seem much greater than it actually is, and then to propose the solution. Perhaps Edward Snowden was right when he said that governments are using the coronavirus to take away more of our rights and freedoms, and they won’t come back, just as they didn’t come back after 9/11. Is there anybody politically and financially gaining from this pandemic? What’s going on here?

The Takeaway: 

At the end of the day, we have to keep asking ourselves if our designated government and global health authorities actually have our best interests at hand. If not, why do we continue to support it?

There are many examples that show these institutions do not work to make humanity thrive, but instead oppress humanity. When it comes to the World Health Organization (WHO) for example, Wikileaks exposed how much they are influenced by pharmaceutical companies. Vimeo also recently completely banned a documentary that exposed the same thing. That particular documentary featured many scientists, doctors and even officials from within the WHO.

It’s quite clear to many that government doesn’t really put the citizens it claims to represent first, but instead corporations and big money. So why do we constantly listen to their advice? Why do we constantly rely on them for truth and information? Why do we rely on them for guidance? Would we not be better off determining for ourselves what is appropriate, especially in the face of such controversial times when so much is being exposed?

Is it time humanity becomes self-governed? Is it time we steep away from the need for such parental figures like government? It seems like we are currently in the process of doing this, with many of us beginning to awaken. Collectively, we will be creating a new world, that matches a consciousness of self-governance, and the key is to operate from a place of oneness and peace within, which is a journey of awakening to who we truly are, as opposed to what we have been taught to think. We are in a time of a consciousness renaissance.

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Alternative News

CDC Director: ‘Masks May Offer More Protection From COVID-19 Than The Vaccine’

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In Brief

  • The Facts:

    CDC director Robert Redfield said on Wednesday that wearing a mask might be "more guaranteed" to protect an individual from the coronavirus than a vaccine.

  • Reflect On:

    Why is there so much conflicting information out there? Why is it so difficult to arrive at any concrete truth? How does the politicization of science play a role?

What Happened: Centers For Disease Control (CDC) Director Robert Redfield recently stated that wearing a mask may be “more guaranteed” to protect an individual from the coronavirus than a vaccine. This calls into question the efficacy of the vaccine, which is set to make its way into the public domain at the end of this year, or shortly after that. We thought we’d cover this story to bring up the efficacy of vaccines in general, and the growing vaccine hesitancy that now exists within a number of people, scientists and physicians across the world.

“I’m not gonna comment directly about the president, but I am going to comment as the CDC director that face masks, these face masks, are the most important powerful public health tool we have.” – Redfield

Not long ago, many scientists presented facts about vaccines and vaccine safety at the recent Global Health Vaccine Safety summit hosted by the World Health Organization in Geneva, Switzerland. At the conference, Professor Heidi Larson, a Professor of Anthropology and the Risk and Decision Scientist Director at the Vaccine Confidence Project emphasized the issue of growing vaccine hesitancy.

The other thing that’s a trend, and an issue, is not just confidence in providers but confidence of health care providers, we have a very wobbly health professional frontline that is starting to question vaccines and the safety of vaccines. That’s a huge problem, because to this day any study I’ve seen… still, the most trusted person on any study I’ve seen globally is the health care provider…”

Redfield’s comments came after President Trump downplayed the effectiveness of wearing mask, and Trump also stated that Covid would probably go away without a vaccine, referring to the concept of ‘herd immunity’ as practiced in Sweden, but has also been quite outspoken about the fact that a vaccine may arrive by November.

When it comes to the COVID vaccine, multiple clinical trials for COVID-19 vaccines have shown severe reactions within 10 days after taking the vaccine. You can read more about that here.  The US government and Yale University also recently collaborated in a clinical trial to determine the best messaging to persuade Americans to take the COVID-19 vaccine. You can read more about that here.

Are Masks Effective?

Multiple studies have claimed to show definitively  that mask-wearing effectively prevents transmission of the coronavirus, especially recent ones. This seems to be the general consensus and the information that’s come from our federal health regulatory agencies. There are also multiple studies calling the efficacy of masks into question. For example, a fairly recent study published in the New England Medical Journal  by a group of Harvard doctors outlines how it’s already known that masks provide little to zero benefit when it comes to protection a public setting. According to them,

We know that wearing a mask outside health care facilities offers little, if any, protection from infection. Public health authorities define a significant exposure to Covid-19 as face-to-face contact within 6 feet with a patient with symptomatic Covid-19 that is sustained for at least a few minutes (and some say more than 10 minutes or even 30 minutes). The chance of catching Covid-19 from a passing interaction in a public space is therefore minimal. In many cases, the desire for widespread masking is a reflexive reaction to anxiety over the pandemic.

You can read more about that story here and find other complimenting studies.

When it comes to masks, there are multiple studies on both sides of the coin.

Then we have many experts around the world calling into question everything from masks to lockdown. For example, The Physicians For Informed Consent (PIC) recently published a report titled “Physicians for Informed Consent (PIC) Compares COVID-19 to Previous Seasonal and Pandemic Flu Periods.” According to them, the infection/fatality rate of COVID-19 is 0.26%.

They are one of many who have emphasized this point.

More than 500 German doctors & scientists have signed on as representatives of an organization called the “Corona Extra-Parliamentary Inquiry Committee” to investigate what’s happening on our planet with regards to COVID-19, and also make similar points. You can read more about that story here.

Again, there are many examples from all over the world from various academics, doctors and scientists in the field.

This is why there is so much confusion surrounding this pandemic, because there is so much conflicting information that opposes what we are hearing from our health authorities. Furthermore, a lot of information that opposes the official narrative has been censored from social media platforms, also raising suspicion among the general public.

How Effective Are Vaccines?

Vaccines have been long claimed to be a miracle, and the most important health intervention for the sake of disease prevention of our time. But as mentioned above, vaccine hesitancy is growing, and it’s growing fast.

According to a study published in the journal EbioMedicine,

Over the past two decades several vaccine controversies have emerged in various countries, including France, inducing worries about severe adverse effects and eroding confidence in health authorities, experts, and science. These two dimensions are at the core of the vaccine hesitancy (VH) observed in the general population. These two dimensions are at the core of the vaccine hesitancy (VH) observed in the general population. VH is defined as delay in acceptance of vaccination, or refusal, or even acceptance with doubts about its safety and benefits, with all these behaviors and attitudes varying according to context, vaccine, and personal profile, despite the availability of vaccine services. VH presents a challenge to physicians who must address their patients’ concerns about vaccines..

In the United States, the Vaccine Adverse Event Reporting System (VAERS) shows what vaccines have resulted in deaths, injury, permanent disabilities and hospitalizations. The National Childhood Vaccine Injury act has also paid out nearly $4 billion dollars to families of vaccine injured children.

According to a MedAlerts, the cumulative raw count of adverse events from measles, mumps, and rubella vaccines alone was: 93,929 adverse events, 1,810 disabilities, 6,902 hospitalizations, and 463 deaths. What is even more disturbing about these numbers is that VAERS is a voluntary and passive reporting system that has been found to only capture 1% of adverse events.

The measles vaccine has also been plagued with a lack of effectiveness, with constant measles outbreaks in heavily vaccinated population pointing towards a failing vaccine. You can read more about that in-depth and access more science on it here. In 2015, nearly 40 percent of measles cases analyzed in the US were a result of the vaccine.

It’s not just the MMR vaccine that shows a lack of effectiveness. For example, a new study published in The Royal Society of Medicine is one of multiple studies over the years that has emerged questioning the efficacy of the HPV vaccine. The researchers conducted an appraisal of published phase 2 and 3 efficacy trials in relation to the prevention of cervical cancer and their analysis showed “the trials themselves generated significant uncertainties undermining claims of efficacy” in the data they used. The researchers emphasized that “it is still uncertain whether human papillomavirus (HPV) vaccination prevents cervical cancer as trials were not designed to detect this outcome, which takes decades to develop.”  The researchers point out that the trials used to test the vaccine may have “overestimated” the efficacy of the vaccine.

It’s one of multiple studies to call into question the efficacy and safety of the HPV vaccine. It’s also been responsible for multiple deaths and permanent disabilities.

Another point to make regarding vaccine injury is that data was collected from June 2006 through October 2009 on 715,000 patients, and 1.4 million doses (of 45 different vaccines) were given to 376,452 individuals. Of these doses, 35,570 possible reactions (2.6 percent of vaccinations) were identified. This is an average of 890 possible events, an average of 1.3 events per clinician, per month. This data was presented at the 2009 AMIA conference. This data comes 2010 HHS pilot study by the Federal Agency for Health Care Research (AHCR) that found that 1 in every 39 vaccines causes injury, a shocking comparison to the claims from the CDC of 1 in every million. You can access that report and read more about it here.

The Takeaway: 

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